메뉴 건너뛰기




Volumn 26, Issue 4, 2004, Pages 371-380

Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies

Author keywords

FK506; FKBP; Immunosuppressant; Inflammatory; Nerve regeneration; Neuroprotection; Sciatic nerve

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; DRUG DERIVATIVE; FK 506 BINDING PROTEIN; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; NEUROIMMUNOPHILIN; TACROLIMUS; UNCLASSIFIED DRUG; V 10367;

EID: 2942565668     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164104225013734     Document Type: Review
Times cited : (37)

References (119)
  • 1
    • 0023245677 scopus 로고
    • FK-506, a novel immunosuppressant isolated from a streptomyces. I. Fermentation, isolation, and physio-chemical and biological characteristics
    • Kino T, Hatanaka H, Hashimoto M, Nishiyama H. FK-506, a novel immunosuppressant isolated from a streptomyces. I. Fermentation, isolation, and physio-chemical and biological characteristics. J Antibiot 1987; 40: 1249-1255
    • (1987) J Antibiot , vol.40 , pp. 1249-1255
    • Kino, T.1    Hatanaka, H.2    Hashimoto, M.3    Nishiyama, H.4
  • 2
    • 0023261356 scopus 로고
    • FK-506, a novel immunosuppressant isolated from a streptomyces. II. Immunosuppressive effect of FK-506 in vitro
    • Kino T, Hatanaka H, Miyata S, et al. FK-506, a novel immunosuppressant isolated from a streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J Antibiot 1987; 40: 1256-1265
    • (1987) J Antibiot , vol.40 , pp. 1256-1265
    • Kino, T.1    Hatanaka, H.2    Miyata, S.3
  • 3
    • 0025270425 scopus 로고
    • The use of FK-506 for small intestine allotransplantation: Inhibition of acute rejection and prevention of fatal graft-versus-host disease
    • Hoffman AL, Makowka L, Banner B, et al. The use of FK-506 for small intestine allotransplantation: Inhibition of acute rejection and prevention of fatal graft-versus-host disease. Transplantation 1990; 49: 483-490
    • (1990) Transplantation , vol.49 , pp. 483-490
    • Hoffman, A.L.1    Makowka, L.2    Banner, B.3
  • 4
    • 0002740007 scopus 로고
    • FK-506: A potential breakthrough in immunosuppression
    • Starzl TE, Makowka L, Todo S. FK-506: A potential breakthrough in immunosuppression. Transplant Proc 1987; 19: S3-S104
    • (1987) Transplant Proc , vol.19
    • Starzl, T.E.1    Makowka, L.2    Todo, S.3
  • 6
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today 1992; 13: 136-142
    • (1992) Immunol Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 7
    • 0032142911 scopus 로고    scopus 로고
    • Immunophilins in the nervous system
    • Snyder SH, Lai MM, Burnett PE. Immunophilins in the nervous system. Neuron 1998; 21: 283-294
    • (1998) Neuron , vol.21 , pp. 283-294
    • Snyder, S.H.1    Lai, M.M.2    Burnett, P.E.3
  • 8
    • 0032776433 scopus 로고    scopus 로고
    • FK506 and the role of the immunophilin FKBP-52 in nerve regeneration
    • Gold BG. FK506 and the role of the immunophilin FKBP-52 in nerve regeneration. Drug Metab Rev 1999; 31: 649-663
    • (1999) Drug Metab Rev , vol.31 , pp. 649-663
    • Gold, B.G.1
  • 9
    • 0026030568 scopus 로고
    • Chemistry and biology of the immunophilins and their immunosuppressive ligands
    • Schreiber SL. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 1991; 251: 283-287
    • (1991) Science , vol.251 , pp. 283-287
    • Schreiber, S.L.1
  • 10
    • 0027184498 scopus 로고
    • Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein
    • Alnemri ES, Fernandes-Alnemri T, Nelki DS, Dudley K, DuBois GC, Litwack G. Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc Natl Acad Sci USA 1993; 90: 6839-6843
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6839-6843
    • Alnemri, E.S.1    Fernandes-Alnemri, T.2    Nelki, D.S.3    Dudley, K.4    DuBois, G.C.5    Litwack, G.6
  • 11
    • 0026748870 scopus 로고
    • Cyclosporin A, FK-506, and Rapamycin: Pharmacologic probes of lymphocyte signal transduction
    • Sigal NH, Dumont FJ. Cyclosporin A, FK-506, and Rapamycin: Pharmacologic probes of lymphocyte signal transduction. Ann Rev Immunol 1992; 10: 519-560
    • (1992) Ann Rev Immunol , vol.10 , pp. 519-560
    • Sigal, N.H.1    Dumont, F.J.2
  • 12
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
    • Freman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686-3690
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3686-3690
    • Freman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 13
    • 0026768730 scopus 로고
    • The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin
    • Dumont FJ, Staruch MJ, Koprak SL, et al. The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin. J Exp Med 1992; 176: 751-760
    • (1992) J Exp Med , vol.176 , pp. 751-760
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3
  • 14
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807-815
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 15
    • 0026629246 scopus 로고
    • Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction
    • Walsh CT, Zydowsky LD, McKeon FD. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem 1992; 267: 13115-13118
    • (1992) J Biol Chem , vol.267 , pp. 13115-13118
    • Walsh, C.T.1    Zydowsky, L.D.2    McKeon, F.D.3
  • 16
    • 0026744641 scopus 로고
    • Transcription of IL-4 genes is not inhibited by cyclosporin A in competent T cells
    • Terada N, Or R, Weinberg K, Domenico J, Lucas JJ, Gelfand EW. Transcription of IL-4 genes is not inhibited by cyclosporin A in competent T cells. J Biol Chem 1992; 267: 21207-21210
    • (1992) J Biol Chem , vol.267 , pp. 21207-21210
    • Terada, N.1    Or, R.2    Weinberg, K.3    Domenico, J.4    Lucas, J.J.5    Gelfand, E.W.6
  • 17
    • 0024412228 scopus 로고
    • The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes
    • Tocci MJ, Matkovich DA, Matkovich K, et al. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol 1989; 143: 718-726
    • (1989) J Immunol , vol.143 , pp. 718-726
    • Tocci, M.J.1    Matkovich, D.A.2    Matkovich, K.3
  • 18
    • 0028956418 scopus 로고
    • Neuronal regeneration enhances the expression of the immunophilin FKBP-12
    • Lyons WE, Steiner JP, Snyder SH, Dawson TM. Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J Neurosci 1995; 15: 2985-2994
    • (1995) J Neurosci , vol.15 , pp. 2985-2994
    • Lyons, W.E.1    Steiner, J.P.2    Snyder, S.H.3    Dawson, T.M.4
  • 19
    • 0007444835 scopus 로고
    • The immunosuppressant FK-506 enhances phosphorylation of GAP43: Implications for a role in modulation of growth cone function and neurotransmitter release
    • Steiner JP, Dawson TM, Fotuhi M, et al. The immunosuppressant FK-506 enhances phosphorylation of GAP43: Implications for a role in modulation of growth cone function and neurotransmitter release. Soc Neurosci Abstr 1992; 603
    • (1992) Soc Neurosci Abstr , pp. 603
    • Steiner, J.P.1    Dawson, T.M.2    Fotuhi, M.3
  • 20
    • 0028352763 scopus 로고
    • The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury
    • Gold BG, Storm-Dickerson T, Austin DR. The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor Neurol Neurosci 1994; 6: 287-296
    • (1994) Restor Neurol Neurosci , vol.6 , pp. 287-296
    • Gold, B.G.1    Storm-Dickerson, T.2    Austin, D.R.3
  • 21
    • 0028202076 scopus 로고
    • Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia
    • Lyons WE, George EB, Dawson TM, Steiner JP, Snyder SH. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc Natl Acad Sci USA 1994; 91: 3191-3195
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3191-3195
    • Lyons, W.E.1    George, E.B.2    Dawson, T.M.3    Steiner, J.P.4    Snyder, S.H.5
  • 23
    • 0028783373 scopus 로고
    • The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve
    • Gold BG, Katoh K, Storm-Dickerson T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J Neurosci 1995; 15: 7509-7516
    • (1995) J Neurosci , vol.15 , pp. 7509-7516
    • Gold, B.G.1    Katoh, K.2    Storm-Dickerson, T.3
  • 24
    • 0030839896 scopus 로고    scopus 로고
    • Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in rat sciatic nerve
    • Wang MS, Zeleny-Pooley M, Gold BG. Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in rat sciatic nerve. J Pharmacol Exp Ther 1997; 282: 1084-1093
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1084-1093
    • Wang, M.S.1    Zeleny-Pooley, M.2    Gold, B.G.3
  • 26
    • 0032536515 scopus 로고    scopus 로고
    • Oral administration of a non-immunosuppressant FKBP-12 ligand speeds nerve regeneration
    • Gold BG, Zeleny-Pooley M, Chaturvedi P, Wang M-S. Oral administration of a non-immunosuppressant FKBP-12 ligand speeds nerve regeneration. Neuroreport 1998; 9: 553-558
    • (1998) Neuroreport , vol.9 , pp. 553-558
    • Gold, B.G.1    Zeleny-Pooley, M.2    Chaturvedi, P.3    Wang, M.-S.4
  • 27
    • 0030975605 scopus 로고    scopus 로고
    • Neurotrophic actions of non-immunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
    • Steiner JP, Connolly MA, Valentine HL, et al. Neurotrophic actions of non-immunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat Med 1997; 3: 421-428
    • (1997) Nat Med , vol.3 , pp. 421-428
    • Steiner, J.P.1    Connolly, M.A.2    Valentine, H.L.3
  • 28
    • 0033014586 scopus 로고    scopus 로고
    • FK506 accelerates functional recovery following nerve grafting in a rat model
    • Doolabh VB, Mackinnon SE. FK506 accelerates functional recovery following nerve grafting in a rat model. Plast Reconstr Surg 1999; 103: 1928-1936
    • (1999) Plast Reconstr Surg , vol.103 , pp. 1928-1936
    • Doolabh, V.B.1    Mackinnon, S.E.2
  • 29
    • 0000818576 scopus 로고    scopus 로고
    • FK506 accelerates axonal regeneration through an artificial nerve guide in the rat sciatic nerve transection model
    • Archibald SJ, Wang M-S, Gold BG. FK506 accelerates axonal regeneration through an artificial nerve guide in the rat sciatic nerve transection model. J Peripheral Nerv Syst 1999; 4: 202
    • (1999) J Peripheral Nerv Syst , vol.4 , pp. 202
    • Archibald, S.J.1    Wang, M.-S.2    Gold, B.G.3
  • 30
    • 0032411557 scopus 로고    scopus 로고
    • Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats
    • Madsen JR, MacDonald P, Irwin N, et al. Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. Exp Neurol 1998; 154: 673-683
    • (1998) Exp Neurol , vol.154 , pp. 673-683
    • Madsen, J.R.1    MacDonald, P.2    Irwin, N.3
  • 31
    • 0032816454 scopus 로고    scopus 로고
    • The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: Neuroprotection and local regeneration
    • Bavetta S, Hamlyn PJ, Burnstock G, Lieberman AR, Anderson PN. The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. Exp Neurol 1999; 158: 382-393
    • (1999) Exp Neurol , vol.158 , pp. 382-393
    • Bavetta, S.1    Hamlyn, P.J.2    Burnstock, G.3    Lieberman, A.R.4    Anderson, P.N.5
  • 32
    • 0033289087 scopus 로고    scopus 로고
    • FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft
    • Wang M-S, Gold BG. FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft. J Spinal Cord Med 1999; 22: 287-296
    • (1999) J Spinal Cord Med , vol.22 , pp. 287-296
    • Wang, M.-S.1    Gold, B.G.2
  • 33
    • 0033576769 scopus 로고    scopus 로고
    • Immunosuppressants promote adult dorsal root regeneration into the spinal cord
    • Sugawara T, Itoh Y, Mizoi K. Immunosuppressants promote adult dorsal root regeneration into the spinal cord. Neuroreport 1999; 10: 3949-3953
    • (1999) Neuroreport , vol.10 , pp. 3949-3953
    • Sugawara, T.1    Itoh, Y.2    Mizoi, K.3
  • 34
    • 12644257556 scopus 로고    scopus 로고
    • Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
    • Steiner JP, Hamilton GS, Ross DT, et al. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc Natl Acad Sci USA 1997; 94: 2019-2024
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2019-2024
    • Steiner, J.P.1    Hamilton, G.S.2    Ross, D.T.3
  • 35
    • 0001590107 scopus 로고    scopus 로고
    • FK506 produces regeneration, but not neuroprotection, of nigrostriatal dopaminergic neurons in MPTP-treated mice
    • Gold BG, Gordon HS, Zeleny-Pooley M, Wang MS. FK506 produces regeneration, but not neuroprotection, of nigrostriatal dopaminergic neurons in MPTP-treated mice. Brain Pathol 1998; 8: 583
    • (1998) Brain Pathol , vol.8 , pp. 583
    • Gold, B.G.1    Gordon, H.S.2    Zeleny-Pooley, M.3    Wang, M.S.4
  • 36
    • 0031660913 scopus 로고    scopus 로고
    • A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease
    • Costantini LC, Chaturvedi P, Armistead DM, McCaffrey PG, Deacon TW, Isacson O. A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease. Neurobiol Dis 1998; 5: 97-106
    • (1998) Neurobiol Dis , vol.5 , pp. 97-106
    • Costantini, L.C.1    Chaturvedi, P.2    Armistead, D.M.3    McCaffrey, P.G.4    Deacon, T.W.5    Isacson, O.6
  • 37
    • 0035123909 scopus 로고    scopus 로고
    • Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys
    • Emborg ME, Shin P, Roitberg B, et al. Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys. Exp Neurol 2001; 168: 171-182
    • (2001) Exp Neurol , vol.168 , pp. 171-182
    • Emborg, M.E.1    Shin, P.2    Roitberg, B.3
  • 38
    • 85060564345 scopus 로고    scopus 로고
    • Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment
    • Zhang C, Steiner JP, Hamilton GS, Hicks TP, Poulter MO. Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment. J Neurosci 2001; 21: 1-6
    • (2001) J Neurosci , vol.21 , pp. 1-6
    • Zhang, C.1    Steiner, J.P.2    Hamilton, G.S.3    Hicks, T.P.4    Poulter, M.O.5
  • 39
    • 0033819704 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands: Evaluation of their therapeutic potential for the treatment of neurological disorders
    • Gold BG. Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. Exp Opinion Invest Drugs 2000; 9: 2331-2342
    • (2000) Exp Opinion Invest Drugs , vol.9 , pp. 2331-2342
    • Gold, B.G.1
  • 40
    • 0034961705 scopus 로고    scopus 로고
    • Neuroimmunophilins: Novel neuroprotective and neuroregenerative targets
    • Guo X, Dillman III JF, Dawson VL, Dawson TM. Neuroimmunophilins: novel neuroprotective and neuroregenerative targets. Ann Neurol 2001; 50: 6-16
    • (2001) Ann Neurol , vol.50 , pp. 6-16
    • Guo, X.1    Dillman III, J.F.2    Dawson, V.L.3    Dawson, T.M.4
  • 41
    • 0033577486 scopus 로고    scopus 로고
    • Human hand allograft: Report on first 6 months
    • Dubernard J-M, Owen E., Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet 1999; 353: 1315-1320
    • (1999) Lancet , vol.353 , pp. 1315-1320
    • Dubernard, J.-M.1    Owen, E.2    Herzberg, G.3
  • 43
    • 0034211286 scopus 로고    scopus 로고
    • A preliminary report of two cases of human hand allograft
    • Pei G, Gu L, Yu L. A preliminary report of two cases of human hand allograft. Zhonghua Yi Xue Za Zhi 2000; 80: 417-421
    • (2000) Zhonghua Yi Xue Za Zhi , vol.80 , pp. 417-421
    • Pei, G.1    Gu, L.2    Yu, L.3
  • 45
    • 0001084744 scopus 로고
    • FK506, an immunosuppressant, increases functional recovery and axonal regeneration in the rat following axotomy of the sciatic nerve
    • Gold BG, Storm-Dickerson T, Austin DR, Katoh K. FK506, an immunosuppressant, increases functional recovery and axonal regeneration in the rat following axotomy of the sciatic nerve. Soc Neurosci Abstr 1993; 19: 1316
    • (1993) Soc Neurosci Abstr , vol.19 , pp. 1316
    • Gold, B.G.1    Storm-Dickerson, T.2    Austin, D.R.3    Katoh, K.4
  • 46
    • 0033591398 scopus 로고    scopus 로고
    • Efficacy of delayed or discontinuous FK506 administrations on nerve regeneration in the rat sciatic nerve crush model: Lack of evidence for a conditioning lesion-like effect
    • Gold BG, Gordon HS, Wang M-S. Efficacy of delayed or discontinuous FK506 administrations on nerve regeneration in the rat sciatic nerve crush model: lack of evidence for a conditioning lesion-like effect. Neurosci Lett 1999; 267: 33-36
    • (1999) Neurosci Lett , vol.267 , pp. 33-36
    • Gold, B.G.1    Gordon, H.S.2    Wang, M.-S.3
  • 47
    • 0031714657 scopus 로고    scopus 로고
    • Immunophilin ligands for the treatment of neurological disorders
    • Hamilton GS. Immunophilin ligands for the treatment of neurological disorders. Exp Opin Ther Patents 1998; 8: 1109-1124
    • (1998) Exp Opin Ther Patents , vol.8 , pp. 1109-1124
    • Hamilton, G.S.1
  • 48
    • 0036720906 scopus 로고    scopus 로고
    • Genetically engineered analogs of ascomycin for nerve regeneration
    • Revill WP, Voda J, Reeves CR, et al. Genetically engineered analogs of ascomycin for nerve regeneration. J Pharmacol Exp Therap 2002; 302: 1278-1285
    • (2002) J Pharmacol Exp Therap , vol.302 , pp. 1278-1285
    • Revill, W.P.1    Voda, J.2    Reeves, C.R.3
  • 49
    • 0036730462 scopus 로고    scopus 로고
    • Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve
    • Udina E, Ceballos D, Verdu E, Gold BG, Navarro X. Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve. Muscle Nerve 2002; 26: 348-355
    • (2002) Muscle Nerve , vol.26 , pp. 348-355
    • Udina, E.1    Ceballos, D.2    Verdu, E.3    Gold, B.G.4    Navarro, X.5
  • 50
    • 0002668514 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands and the role of steroid hormone chaperone proteins in nerve regeneration
    • Gold BG, Fischer G, Herdegen T, eds, Barcelona: Prous Science
    • Gold BG. Neuroimmunophilin ligands and the role of steroid hormone chaperone proteins in nerve regeneration. In: Gold BG, Fischer G, Herdegen T, eds, Immunophilins in the brain. FKBP-ligands: Novel strategies for the treatment of neurodegenerative disorders, Barcelona: Prous Science, 2000: pp 3-22
    • (2000) Immunophilins in the Brain. FKBP-ligands: Novel Strategies for the Treatment of Neurodegenerative Disorders , pp. 3-22
    • Gold, B.G.1
  • 51
    • 0026696839 scopus 로고
    • r 90,000 heat shock protein: Main structural features of a mammalian p59 protein
    • r 90,000 heat shock protein: Main structural features of a mammalian p59 protein. Proc Natl Acad Sci USA 1992; 89: 6270-6274
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6270-6274
    • Callebaut, I.1    Renoir, J.-M.2    Lebeau, M.-C.3
  • 52
    • 0034022271 scopus 로고    scopus 로고
    • FK506 promotes functional recovery in crushed rat sciatic nerve
    • Lee M, Doolabh VB, Mackinnon SE, Jost S. FK506 promotes functional recovery in crushed rat sciatic nerve. Muscle Nerve 2000; 23: 633-640
    • (2000) Muscle Nerve , vol.23 , pp. 633-640
    • Lee, M.1    Doolabh, V.B.2    Mackinnon, S.E.3    Jost, S.4
  • 54
    • 0034975002 scopus 로고    scopus 로고
    • Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps
    • Navarro X, Udina E, Ceballos D, Gold BG. Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps. Muscle Nerve 2001; 24: 905-915
    • (2001) Muscle Nerve , vol.24 , pp. 905-915
    • Navarro, X.1    Udina, E.2    Ceballos, D.3    Gold, B.G.4
  • 55
    • 0033044078 scopus 로고    scopus 로고
    • The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting
    • Fansa H, Keilhoff G, Altmann S, Plogmeier K, Wolf G, Schneider W. The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting. J Hand Surg [Br] 1999; 24: 38-427
    • (1999) J Hand Surg [Br] , vol.24 , pp. 38-427
    • Fansa, H.1    Keilhoff, G.2    Altmann, S.3    Plogmeier, K.4    Wolf, G.5    Schneider, W.6
  • 56
    • 0042191634 scopus 로고    scopus 로고
    • Comparative dose-dependence study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft
    • Udina E, Voda J, Gold BG, Navarro X. Comparative dose-dependence study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft. J Peripher Nerv Syst 2003; 8: 145-154
    • (2003) J Peripher Nerv Syst , vol.8 , pp. 145-154
    • Udina, E.1    Voda, J.2    Gold, B.G.3    Navarro, X.4
  • 57
    • 2642539336 scopus 로고    scopus 로고
    • Comparison of continuous and discontinuous FK506 administrations of autograft or allograft repair of sciatic nerve resection
    • in press
    • Udina E, Gold BG, Navarro X. Comparison of continuous and discontinuous FK506 administrations of autograft or allograft repair of sciatic nerve resection. Muscle Nerve 2004; in press
    • (2004) Muscle Nerve
    • Udina, E.1    Gold, B.G.2    Navarro, X.3
  • 58
    • 0036237963 scopus 로고    scopus 로고
    • Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice
    • Grand AG, Myckatyn TM, Mackinnon SE, Hunter DA. Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice. J Neurosurg 2002; 96: 924-932
    • (2002) J Neurosurg , vol.96 , pp. 924-932
    • Grand, A.G.1    Myckatyn, T.M.2    Mackinnon, S.E.3    Hunter, D.A.4
  • 59
    • 0036144945 scopus 로고    scopus 로고
    • A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation
    • Höke A, Gordon T, Zochodne DW, Sulaiman OA. A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation. Exp Neurol 2002; 173: 77-85
    • (2002) Exp Neurol , vol.173 , pp. 77-85
    • Höke, A.1    Gordon, T.2    Zochodne, D.W.3    Sulaiman, O.A.4
  • 60
    • 0015939478 scopus 로고
    • An ultrastructural comparison of peripheral nerve allografts and autografts
    • Pollard JD, Fitzpatrick L. An ultrastructural comparison of peripheral nerve allografts and autografts. Acta Neuropathol (Berl) 1973; 23: 152-165
    • (1973) Acta Neuropathol (Berl) , vol.23 , pp. 152-165
    • Pollard, J.D.1    Fitzpatrick, L.2
  • 61
    • 0021340464 scopus 로고
    • Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts
    • Zalewski AA, Gulati AK. Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts. Exp Neurol 1984; 83: 659-663
    • (1984) Exp Neurol , vol.83 , pp. 659-663
    • Zalewski, A.A.1    Gulati, A.K.2
  • 62
    • 0026445124 scopus 로고
    • Immunosuppression in nerve allografting: Is it desirable?
    • Ansselin AD, Pollard JD, Davey DF. Immunosuppression in nerve allografting: is it desirable? J Neurol Sci 1992; 112: 160-169
    • (1992) J Neurol Sci , vol.112 , pp. 160-169
    • Ansselin, A.D.1    Pollard, J.D.2    Davey, D.F.3
  • 65
    • 0028846836 scopus 로고
    • Peripheral nerve allograft transplantation with FK506: Functional, histological, and immunological results before and after discontinuation of immunosuppression
    • Büttemeyer R, Rao U, Jones NF. Peripheral nerve allograft transplantation with FK506: Functional, histological, and immunological results before and after discontinuation of immunosuppression. Ann Plast Surg 1995; 35: 396-401
    • (1995) Ann Plast Surg , vol.35 , pp. 396-401
    • Büttemeyer, R.1    Rao, U.2    Jones, N.F.3
  • 66
    • 0036644307 scopus 로고    scopus 로고
    • Histological and electrophysiological analysis of the peripheral nerve allografts using an immunosuppressive agent
    • Okajima S, Hojo T, Tamai K, Takai S, Hirasawa Y. Histological and electrophysiological analysis of the peripheral nerve allografts using an immunosuppressive agent. Microsc Res Tech 2002; 58: 52-58
    • (2002) Microsc Res Tech , vol.58 , pp. 52-58
    • Okajima, S.1    Hojo, T.2    Tamai, K.3    Takai, S.4    Hirasawa, Y.5
  • 67
    • 0026076286 scopus 로고
    • The effect of a new immunosuppressive agent, FK-506, on xenogenic neural transplantation in rodents
    • Sakai K, Date I, Yoshimoto Y, et al. The effect of a new immunosuppressive agent, FK-506, on xenogenic neural transplantation in rodents. Brain Res 1991; 565: 167-170
    • (1991) Brain Res , vol.565 , pp. 167-170
    • Sakai, K.1    Date, I.2    Yoshimoto, Y.3
  • 68
    • 0030034349 scopus 로고    scopus 로고
    • Influence of physical parameters of nerve chambers on peripheral nerve regeneration and reinnervation
    • Butí M, Verdú E, Labrador RO, Vilches JJ, Forés J, Navarro X. Influence of physical parameters of nerve chambers on peripheral nerve regeneration and reinnervation. Exp Neurol 1996; 137: 26-33
    • (1996) Exp Neurol , vol.137 , pp. 26-33
    • Butí, M.1    Verdú, E.2    Labrador, R.O.3    Vilches, J.J.4    Forés, J.5    Navarro, X.6
  • 70
    • 0020033340 scopus 로고
    • Nerve regeneration in silicone chambers: Influence of gap length and of distal stump components
    • Lundborg G, Dahlin LB, Danielsen N, etal. Nerve regeneration in silicone chambers: influence of gap length and of distal stump components. Exp Neurol 1982; 76: 361-375
    • (1982) Exp Neurol , vol.76 , pp. 361-375
    • Lundborg, G.1    Dahlin, L.B.2    Danielsen, N.3
  • 71
    • 0020515378 scopus 로고
    • Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: Parameters for a bioassay
    • Williams LR, Longo FM, Powell HC, Lundborg G, Varon S. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol 1983; 218: 460-470
    • (1983) J Comp Neurol , vol.218 , pp. 460-470
    • Williams, L.R.1    Longo, F.M.2    Powell, H.C.3    Lundborg, G.4    Varon, S.5
  • 72
    • 0028171974 scopus 로고
    • Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers
    • Navarro X, Verdu E, Buti M. Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers. Exp Neurol 1994; 129: 217-224
    • (1994) Exp Neurol , vol.129 , pp. 217-224
    • Navarro, X.1    Verdu, E.2    Buti, M.3
  • 73
    • 0031194115 scopus 로고    scopus 로고
    • Comparison of immunohistochemical and functional reinnervation of skin and muscle after peripheral nerve injury
    • Verdú E, Navarro X. Comparison of immunohistochemical and functional reinnervation of skin and muscle after peripheral nerve injury. Exp Neurol 1997; 146: 187-198
    • (1997) Exp Neurol , vol.146 , pp. 187-198
    • Verdú, E.1    Navarro, X.2
  • 74
    • 0042738107 scopus 로고    scopus 로고
    • FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers
    • Udina E, Ceballos D, Gold BG, Navarro X. FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers. Exp Neurol 2003; 183: 220-231
    • (2003) Exp Neurol , vol.183 , pp. 220-231
    • Udina, E.1    Ceballos, D.2    Gold, B.G.3    Navarro, X.4
  • 75
    • 0034775552 scopus 로고    scopus 로고
    • Immunophilin ligand FK506 is neuroprotective for penile innervation
    • Sezen SF, Hoke A, Burnett AL, Snyder SH. Immunophilin ligand FK506 is neuroprotective for penile innervation. Nat Med 2001; 7: 1073-1074
    • (2001) Nat Med , vol.7 , pp. 1073-1074
    • Sezen, S.F.1    Hoke, A.2    Burnett, A.L.3    Snyder, S.H.4
  • 77
    • 1842814246 scopus 로고    scopus 로고
    • The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy
    • in press
    • Gold BG, Voda J, Gordon H. The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy. Exp Neurol 2004; in press
    • (2004) Exp Neurol
    • Gold, B.G.1    Voda, J.2    Gordon, H.3
  • 78
    • 0032558184 scopus 로고    scopus 로고
    • Guillain-Barre syndrome
    • Hahn AF. Guillain-Barre syndrome. Lancet 1998; 352: 635-641
    • (1998) Lancet , vol.352 , pp. 635-641
    • Hahn, A.F.1
  • 80
    • 0034035378 scopus 로고    scopus 로고
    • New concepts of Guillain-Barre syndrome
    • Asbury AK. New concepts of Guillain-Barre syndrome. J Child Neurol 2000; 15: 183-191
    • (2000) J Child Neurol , vol.15 , pp. 183-191
    • Asbury, A.K.1
  • 81
    • 0035659389 scopus 로고    scopus 로고
    • Guillain Barre syndrome
    • Winer JB. Guillain Barre syndrome. Mol Pathol 2001; 54: 381-385
    • (2001) Mol Pathol , vol.54 , pp. 381-385
    • Winer, J.B.1
  • 82
    • 0036797548 scopus 로고    scopus 로고
    • Animal models of immune-mediated neuropathies
    • Maurer M, Gold R. Animal models of immune-mediated neuropathies. Curr Opin Neurol 2002; 15: 617-622
    • (2002) Curr Opin Neurol , vol.15 , pp. 617-622
    • Maurer, M.1    Gold, R.2
  • 83
    • 0036252055 scopus 로고    scopus 로고
    • Systematic reviews of treatment for inflammatory demyelinating neuropathy
    • Hughes RA. Systematic reviews of treatment for inflammatory demyelinating neuropathy. J Anat 2002; 200: 331-339
    • (2002) J Anat , vol.200 , pp. 331-339
    • Hughes, R.A.1
  • 84
    • 0026645854 scopus 로고
    • Immunosuppressive effect of FK506 on experimental allergic neuritis in Lewis rats: Change of T cell subsets
    • Adachi A, Araga S, Takahashi K. Immunosuppressive effect of FK506 on experimental allergic neuritis in Lewis rats: change of T cell subsets. Intern Med 1992; 31: 6-10
    • (1992) Intern Med , vol.31 , pp. 6-10
    • Adachi, A.1    Araga, S.2    Takahashi, K.3
  • 86
    • 0033034203 scopus 로고    scopus 로고
    • Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506
    • Gold BG, Densmore V, Shou W, Matzuk MM, Gordon HS. Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther 1999; 289: 1202-1210
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1202-1210
    • Gold, B.G.1    Densmore, V.2    Shou, W.3    Matzuk, M.M.4    Gordon, H.S.5
  • 88
    • 0025605444 scopus 로고
    • Hsp56: A novel heat shock protein associated with untransformed steroid receptor complexes
    • Sánchez ER. Hsp56: A novel heat shock protein associated with untransformed steroid receptor complexes. J Biol Chem 1990; 265: 22067-22070
    • (1990) J Biol Chem , vol.265 , pp. 22067-22070
    • Sánchez, E.R.1
  • 89
    • 0026710278 scopus 로고
    • Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex
    • Tai P-KK, Albers MW, Chang H, Faber LE, Schreiber SL. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 1992; 256: 1315-1318
    • (1992) Science , vol.256 , pp. 1315-1318
    • Tai, P.-K.K.1    Albers, M.W.2    Chang, H.3    Faber, L.E.4    Schreiber, S.L.5
  • 91
    • 0029889955 scopus 로고    scopus 로고
    • A model of protein targeting mediated by mmunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains
    • Owens-Grillo JK, Czar MJ, Hutchison KA, Hoffmann K, Perdew GH, Pratt WB. A model of protein targeting mediated by mmunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. J Biol Chem 1996; 271: 13468-13475
    • (1996) J Biol Chem , vol.271 , pp. 13468-13475
    • Owens-Grillo, J.K.1    Czar, M.J.2    Hutchison, K.A.3    Hoffmann, K.4    Perdew, G.H.5    Pratt, W.B.6
  • 92
    • 0028596331 scopus 로고
    • The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor
    • Czar MJ, Owens-Grillo JK, Yem AW, et al. The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor. Mol Endocrin 1994; 8: 1731-1741
    • (1994) Mol Endocrin , vol.8 , pp. 1731-1741
    • Czar, M.J.1    Owens-Grillo, J.K.2    Yem, A.W.3
  • 93
    • 0026781440 scopus 로고
    • P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody
    • Lebeau MC, Massol N, Herrick J, Faber LE, Renoin MJ, Radanyi C, Baulieu EE. P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody. J Biol Chem 1992; 267: 4281-4284
    • (1992) J Biol Chem , vol.267 , pp. 4281-4284
    • Lebeau, M.C.1    Massol, N.2    Herrick, J.3    Faber, L.E.4    Renoin, M.J.5    Radanyi, C.6    Baulieu, E.E.7
  • 94
    • 0029101382 scopus 로고
    • The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor
    • Owens-Grillo JK, Hoffmann K, Hutchison KA, et al. The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor. J Biol Chem 1995; 270: 20479-20484
    • (1995) J Biol Chem , vol.270 , pp. 20479-20484
    • Owens-Grillo, J.K.1    Hoffmann, K.2    Hutchison, K.A.3
  • 95
    • 0031215051 scopus 로고    scopus 로고
    • Effects of axotomy and testosterone on androgen receptor mRNA expression in hamster facial motoneurons
    • Drengler SM, Handa RJ, Jones KJ. Effects of axotomy and testosterone on androgen receptor mRNA expression in hamster facial motoneurons. Exp Neurol 1997; 146: 374-379
    • (1997) Exp Neurol , vol.146 , pp. 374-379
    • Drengler, S.M.1    Handa, R.J.2    Jones, K.J.3
  • 96
    • 0026322290 scopus 로고
    • Testosterone differentially regulates the regenerative properties of injured hamster facial motoneurons
    • Kujawa KA, Emeric E, Jones KJ. Testosterone differentially regulates the regenerative properties of injured hamster facial motoneurons. J Neurosci 1991; 11: 3898-3906
    • (1991) J Neurosci , vol.11 , pp. 3898-3906
    • Kujawa, K.A.1    Emeric, E.2    Jones, K.J.3
  • 97
    • 0027288283 scopus 로고
    • Testosterone regulation of the regenerative properties of injured rat sciatic motor neurons
    • Kujawa KA, Jacob JM, Jones KJ. Testosterone regulation of the regenerative properties of injured rat sciatic motor neurons. J Neurosci Res 1993; 35: 268-273
    • (1993) J Neurosci Res , vol.35 , pp. 268-273
    • Kujawa, K.A.1    Jacob, J.M.2    Jones, K.J.3
  • 98
    • 0028556884 scopus 로고
    • An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells
    • Lustig RH, Hua P, Smith LS, Wang C, Chang C. An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells. Mol Cell Neurosci 1994; 5: 587-596
    • (1994) Mol Cell Neurosci , vol.5 , pp. 587-596
    • Lustig, R.H.1    Hua, P.2    Smith, L.S.3    Wang, C.4    Chang, C.5
  • 99
    • 0019349967 scopus 로고
    • Effect of testosterone and 5α-dihydrotestosterone on regeneration of the hypoglossal nerve in rats
    • Yu WA, Srinivasan R. Effect of testosterone and 5α- dihydrotestosterone on regeneration of the hypoglossal nerve in rats. Exp Neurol 1981; 71: 431-435
    • (1981) Exp Neurol , vol.71 , pp. 431-435
    • Yu, W.A.1    Srinivasan, R.2
  • 100
    • 0026047799 scopus 로고
    • Estrogen-enhanced neurite growth: Evidence for a selective induction of tau and stable microtubules
    • Ferreria A, Caceres A. Estrogen-enhanced neurite growth: Evidence for a selective induction of tau and stable microtubules. J Neurosci 1991; 11: 392-400
    • (1991) J Neurosci , vol.11 , pp. 392-400
    • Ferreria, A.1    Caceres, A.2
  • 101
    • 0344678396 scopus 로고    scopus 로고
    • Increased expression of estrogen receptor in PC12 cells: Effects on neurite outgrowth
    • Gollapudi L, Oblinger MM. Increased expression of estrogen receptor in PC12 cells: Effects on neurite outgrowth. Soc Neurosci Abstr 1997; 23: 343
    • (1997) Soc Neurosci Abstr , vol.23 , pp. 343
    • Gollapudi, L.1    Oblinger, M.M.2
  • 102
    • 0028225403 scopus 로고
    • An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 cells
    • Lustig RH, Hua P, Yu W, Ahmad FJ, Bass PW. An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 cells. J Neurosci 1994; 14: 3945-3957
    • (1994) J Neurosci , vol.14 , pp. 3945-3957
    • Lustig, R.H.1    Hua, P.2    Yu, W.3    Ahmad, F.J.4    Bass, P.W.5
  • 103
    • 0027471560 scopus 로고
    • Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line
    • Ma ZQ, Spreafico E, Pollio G, Santagati S, Conti E, Cattaneo E. Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proc Natl Acad Sci USA 1993; 90: 3740-3744
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3740-3744
    • Ma, Z.Q.1    Spreafico, E.2    Pollio, G.3    Santagati, S.4    Conti, E.5    Cattaneo, E.6
  • 104
    • 0032973709 scopus 로고    scopus 로고
    • Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo
    • Sano M, Yoshida M, Fukui S, Kitajima S. Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo. J Neurochem 1999; 72: 2256-2263
    • (1999) J Neurochem , vol.72 , pp. 2256-2263
    • Sano, M.1    Yoshida, M.2    Fukui, S.3    Kitajima, S.4
  • 105
    • 0031895351 scopus 로고    scopus 로고
    • The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
    • Pratt WB. The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors. Proc Soc Exp Biol Med 1998; 217: 420-434
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 420-434
    • Pratt, W.B.1
  • 106
    • 0141595912 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands: The development of novel neuroregenerative/ neuroprotective compounds
    • Gold BG, Villafranca JE. Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds. Curr Top Med Chem 2003; 3: 1368-1375
    • (2003) Curr Top Med Chem , vol.3 , pp. 1368-1375
    • Gold, B.G.1    Villafranca, J.E.2
  • 107
    • 1842507643 scopus 로고    scopus 로고
    • FK506 requires stimulation of the extracellular signal regulated kinase 1/2 and the steroid receptor chaperone protein p23 for neurite elongation
    • Gold BG, Zhong YP. FK506 requires stimulation of the extracellular signal regulated kinase 1/2 and the steroid receptor chaperone protein p23 for neurite elongation. Neurosignals 2004; 13: 122-129
    • (2004) Neurosignals , vol.13 , pp. 122-129
    • Gold, B.G.1    Zhong, Y.P.2
  • 108
    • 0027384161 scopus 로고
    • Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors
    • Volonte C, Angelastro JM, Greene LA. Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J Biol Chem 1993; 268: 21410-21415
    • (1993) J Biol Chem , vol.268 , pp. 21410-21415
    • Volonte, C.1    Angelastro, J.M.2    Greene, L.A.3
  • 109
    • 0032499282 scopus 로고    scopus 로고
    • Rapl mediates sustained MAP kinase activation induced by nerve growth factor
    • York RD, Yao H, Dillon T, et al. Rapl mediates sustained MAP kinase activation induced by nerve growth factor. Nature 1998; 392: 622-626
    • (1998) Nature , vol.392 , pp. 622-626
    • York, R.D.1    Yao, H.2    Dillon, T.3
  • 110
    • 0035980023 scopus 로고    scopus 로고
    • Induction of neurite outgrowth in PC12 cells by α-phenyl-N-tert- butylnitron through activation of protein kinase C and the ras-extracellular signal-regulated kinase pathway
    • Tsuji M, Inanami O, Kuwabara M. Induction of neurite outgrowth in PC12 cells by α-phenyl-N-tert-butylnitron through activation of protein kinase C and the ras-extracellular signal-regulated kinase pathway. J Biol Chem 2001; 276: 32779-32785
    • (2001) J Biol Chem , vol.276 , pp. 32779-32785
    • Tsuji, M.1    Inanami, O.2    Kuwabara, M.3
  • 111
    • 0035784029 scopus 로고    scopus 로고
    • Nerve growth factor in combination with second messenger analogues causes neuronal differentiation of PC12 cells expressing a dominant inhibitory Ras protein without inducing activation of extracellular signal-regulated kinases
    • Boglári G, Szeberényi J. Nerve growth factor in combination with second messenger analogues causes neuronal differentiation of PC12 cells expressing a dominant inhibitory Ras protein without inducing activation of extracellular signal-regulated kinases. Eur J Neurosci 2001; 14: 1445-1454
    • (2001) Eur J Neurosci , vol.14 , pp. 1445-1454
    • Boglári, G.1    Szeberényi, J.2
  • 112
    • 0034846991 scopus 로고    scopus 로고
    • Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones
    • Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV. Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 2001; 18: 183-196
    • (2001) Mol Cell Neurosci , vol.18 , pp. 183-196
    • Averill, S.1    Delcroix, J.D.2    Michael, G.J.3    Tomlinson, D.R.4    Fernyhough, P.5    Priestley, J.V.6
  • 113
    • 0035682630 scopus 로고    scopus 로고
    • Ras/MEK but not p38 signaling mediates NT-3-induced neurite extension from spiral ganglion neurons
    • Aletsee C, Beros A, Mullen L, et al. Ras/MEK but not p38 signaling mediates NT-3-induced neurite extension from spiral ganglion neurons. J Ass Res Otolaryngol 2001; 2: 377-387
    • (2001) J Ass Res Otolaryngol , vol.2 , pp. 377-387
    • Aletsee, C.1    Beros, A.2    Mullen, L.3
  • 114
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000; 10: 381-391
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 116
    • 0034998137 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons
    • Guo X, Dawson VL, Dawson TM. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci 2001; 13: 1683-1693
    • (2001) Eur J Neurosci , vol.13 , pp. 1683-1693
    • Guo, X.1    Dawson, V.L.2    Dawson, T.M.3
  • 117
    • 0035946989 scopus 로고    scopus 로고
    • FK506, but not cyclosporin A, prevents mitochondrial dysfunction during hypoxia in rat hepatocytes
    • Kaibori M, Inoue T, Tu W, et al. FK506, but not cyclosporin A, prevents mitochondrial dysfunction during hypoxia in rat hepatocytes. Life Sci 2001; 69: 17-26
    • (2001) Life Sci , vol.69 , pp. 17-26
    • Kaibori, M.1    Inoue, T.2    Tu, W.3
  • 118
    • 0037352890 scopus 로고    scopus 로고
    • The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response
    • Klettner A, Herdegen T. The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. Br J Pharmacol 2003; 138: 1004-1012
    • (2003) Br J Pharmacol , vol.138 , pp. 1004-1012
    • Klettner, A.1    Herdegen, T.2
  • 119
    • 0036319568 scopus 로고    scopus 로고
    • Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia
    • Lu A, Ran R, Parmentier-Batteur S, Nee A, Sharp FR. Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. J Neurochem 2002; 81: 355-364
    • (2002) J Neurochem , vol.81 , pp. 355-364
    • Lu, A.1    Ran, R.2    Parmentier-Batteur, S.3    Nee, A.4    Sharp, F.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.