FK506 requires stimulation of the extracellular signal-regulated kinase 1/ 2 and the steroid receptor chaperone protein p23 for neurite elongation

NeuroSignals

Volumn 13, Issue 3, 2004, Pages 122-129

  Gold, Bruce G ^a   Zhong, Yong Ping ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chaperone proteins; Extracellular signal regulated kinase; FK506; Immunophilin; Mitogen activated protein kinase; Nerve regeneration; Steroid hormone receptor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CHAPERONE; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN P23; STEROID RECEPTOR; TACROLIMUS;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NEURITE; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STIMULATION;

BLOTTING, WESTERN; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DRUG INTERACTIONS; FLAVONOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NEURITES; NEUROBLASTOMA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TACROLIMUS; TIME FACTORS;

EID: 1842507643     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076565     Document Type: Article

References (59)

1. Aletsee C, Beros A, Mullen L, Palacios S, Pak K, Dazert S, Ryan AF: Ras/MEK but not p38 signaling mediates NT-3-induced neurite extension from spiral ganglion neurons. J Assoc Res Otolaryngol 2001;2:377-387.
2. Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV: Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 2001;18:183-196.
3. Boglári G, Szeberényi J: Nerve growth factor in combination with second messenger analogues causes neuronal differentiation of PC12 cells expressing a dominant inhibitory Ras protein without inducing activation of extracellular signal-regulated kinases. Eur J Neurosci 2001;14:1445-1454.
4. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME: Cell survival promoted by the ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999;286:1358-1362.
5. Chen JK, Capdevila J, Harris RC: Overexpression of C-terminal Src kinase blocks 14,15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. J Biol Chem 2000;275:13789-13792.
6. Chen S, Sullivan WP, Toft DO, Smith DF: Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants. Cell Stress Chaperones 1998;3:118-129.
7. Costantini LC, Cole D, Chaturvedi P, Isacson O: Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease. Eur J Neurosci 2001;13:1085-1092.
8. Cox MB, Miller CA: The p23 co-chaperone facilitates dioxin receptor signaling in a yeast model system. Toxicol Lett 2002;129:13-21.
9. Dittmar KD, Demady DR, Stancato LF, Krishna P, Pratt WB: Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. J Biol Chem 1997;272:21213-21220.
10. Dubernard J-M, Owen E, Herzberg G, Lanzetta M, Martin X, Kapila H, Dawahra M, Hakim NS: Human hand allograft: Report on first 6 months. Lancet 1999;353:1315-1320.
11. Freeman BC, Felts SJ, Toft DO, Yamamoto KR: The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev 2000;14:422-434.
12. Freeman BC, Yamamoto KR: Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 2002;296:2232-2235.
13. Gold BG: FK506 and the role of immunophilins in nerve regeneration. Mol Neurobiol 97;15:285-306.
14. Gold BG: FK506 and the role of the immunophilin FKBP-52 in nerve regeneration. Drug Metab Rev 99;31:649-663.
15. Gold BG: The neurotrophic activity of the immunophilin ligands and benzoquinone ansamycins is mediated by dissociation of the FKBP-52/HSP-90/ steroid receptor complex augmenting the mitogen-associated protein (MAP) kinase signaling pathway. Abstr Soc Neurosci 1999;25:1039.
16. Gold BG: Compositions and methods for promoting nerve regeneration. Patent No 5,968,921, Oct 19, 1999.
17. Gold BG: Neuroimmunophilin ligands and the role of steroid hormone chaperone proteins in nerve regeneration; in Gold BG, Fischer G, Herdegen T (ed): Immunophilins in the Brain. FKBP-Ligands: Novel Strategies for the Treatment of Neurodegenerative Disorders. Barcelona, Prous Science, 2000, pp 3-22.
18. Gold BG: Neuroimmunophilin ligands: Evaluation of their therapeutic potential for the treatment of neurological disorders. Expert Opin Investig Drugs 2000;9:2331-2342.
19. Gold BG: Compositions and methods for promoting nerve regeneration. US patent No 5968921 (MAPKinase, bastidins, radicicols in nerve regeneration). PCT US18539 (WO 0103692 A1), 2001.
20. Gold BG: FKB506/Hsp-90 steroid receptor chaperones and ERK signaling in the regulation of nerve regeneration. J Rehabil Res Dev 2001;38:S9-S10.
21. Gold BG, Bogardus B: The immunophilin FKBP-52, a component of mature steroid receptor complexes, mediates the neurotrophic action of FK506. J Neuropathol Exp Neurol 1999;58:545.
22. Gold BG, Bogardus B: The neurotrophic action of FK506 is mediated by the immunophilin FKBP-52, a component of mature steroid receptor complexes. J Peripher Nerv Syst 1999;4:183.
23. Gold BG, Densmore V, Shou W, Matzuk MM, Gordon HS: Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther 1999;289:1202-1210.
24. Gold BG, Katoh K, Storm-Dickerson T: The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J Neurosci 1995;15:7509-7516.
25. Gold BG, Storm-Dickerson T, Austin DR: The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor Neurol Neurosci 1994;6:287-296.
26. Gold BG, Villafranca JE: Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds. Curr Top Med Chem 2003;3:1368-1375.
27. Gold BG, Zeleny-Pooley M, Wang M-S, Chaturvedi P, Armistead DM: A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. Exp Neurol 1997;147:269-278.
28. Guo X, Dawson VL, Dawson TM: Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci 2001;13:1683-1693.
29. Hoffman AL, Makowka L, Banner B, Cai X, Cramer DV, Pascualone A, Todo S, Starzl TE: The use of FK-506 for small intestine allotransplantation: Inhibition of acute rejection and prevention of fatal graft-versus-host disease. Transplantation 1990;49:483-490.
30. Jin K, Mao XO, Zhu Y, Greenberg DA: MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J Neurochem 2002;80:119-125.
31. Johnson JL, Toft DO: A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem 1994;269:24989-24993.
32. Jones JW, Gruber SA, Barker JH, Breidenbach WC: Successful hand transplantation: One-year follow-up. N Engl J Med 2000;343:468-473.
33. Kaplan DR, Miller FD: Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000;10:381-391.
34. 2+/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation. J Neurosci 1999;19:8292-8299.
35. Liu JL, Blakesley VA, Gutkind JS, LeRoith D: The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor. J Biol Chem 1997;272:29438-29441.
36. Lyons WE, George EB, Dawson TM, Steiner JP, Snyder SH: Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc Natl Acad Sci USA 1994;91:3191-3195.
37. Mackinnon SE, Doolabh VB, Novak CB, Trulock EP: Clinical outcome following nerve allograft transplantation. Plast Reconstr Surg 2001;107:1419-1429.
38. Macleod MR, Allsopp TE, McLuckie J, Kelly JS: Serum withdrawal causes apoptosis in SHSY 5Y cells. Brain Res 2001;889:308-315.
39. r of 63,000, 56,000, and 50,000. J Biol Chem 1991;266:6708-6713.
40. Pratt WB, Toft DO: Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 1997;18:306-360.
41. 1 cells. J Biol Chem 1985;260:14009-14015.
42. Sánchez ER: Hsp56: A novel heat shock protein associated with untransformed steroid receptor complexes. J Biol Chem 1990;265:22067-22070.
43. Sánchez ER, Ning Y-M: Immunophilins, heat shock protein, and glucocorticoid receptor actions in vivo. Methods Enzymol 1996;9:188-200.
44. Sano M, Yoshida M, Fukui S, Kitajima S: Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo. J Neurochem 1999;72:2256-2263.
45. Setalo G Jr, Singh M, Guan X, Toran-Allerand CD: Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: The roles of heat shock protein 90 (Hsp90) and MEK2. J Neurobiol 2002;50:1-12.
46. Sezen SF, Hoke A, Burnett AL, Snyder SH: Immunophilin ligand FK506 is neuroprotective for penile innervation. Nat Med 2001;7:1073-1074.
47. Silverstein AM, Galigniana MD, Radanyi C, Renoir JM, Pratt WB: Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein. J Biol Chem 1999;274:36980-36986.
48. Singh M, Sétáló Jr G, Guan X, Warren M, Toran-Allerand CD: Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways. J Neurosci 1999;19:1179-1188.
49. Snyder SH, Lai MM, Burnett PE: Immunophilins in the nervous system. Neuron 1998;21:283-294.
50. Starzl TE, Makowka L, Todo S: FK-506:A potential breakthrough in immunosuppression. Transplant Proc 1987;19:S3-S104.
51. Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramman R, Jain A: FK-506 for liver, kidney, and pancreas transplantation. Lancet 1989;ii:1000-1004.
52. Steiner JP, Connolly MA, Valentine HL, Hamilton GS, Dawson TM, Hester L, Snyder SH: Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat Med 1997;3:421-428.
53. Steiner JP, Hamilton GS, Ross DT, Valentine HL, Guo H, Connolly MA, Liang S, Ramsey C, Li J, Huang W, Howorth P, Soni R, Fuller M, Sauer H, Nowotnik AC, Suzdak PD: Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc Natl Acad Sci USA 1997;94:2019-2024.
54. Tai P-KK, Albers MW, Chang H, Faber LE, Schreiber SL: Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 1992;256:1315-1318.
55. Tsuji M, Inanami O, Kuwabara M: Induction of neurite outgrowth in PC12 cells by α-phenyl-N-tert-butylnitron through activation of protein kinase C and the ras-extracellular signal-regluated kinase pathway. J Biol Chem 2001;276:32779-32785.
56. Villalonga P, Lopez-Alcala C, Bosch M, Chiloeches A, Rocamora N, Gil J, Marais R, Marshall CJ, Bachs O, Agell N: Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol Cell Biol 2001;21:7345-7354.
57. Volonte C, Angelastro JM, Greene LA: Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J Biol Chem 1993;268:21410-21415.
58. Wang MS, Zeleny-Pooley M, Gold BG: Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in rat sciatic nerve. J Pharmacol Exp Ther 1997;282:1084-1093.
59. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJS: Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 1998;392:622-626.