Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 9, 2005, Pages 3403-3410

  Zhou, Jie ^a   Deo, Baljit K ^a   Hosoya, Kenichi ^b   Terasaki, Tetsuya ^c   Obrosova, Irina G ^d   Brosius III, Frank C ^a   Kumagai, Arno K ^a,e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TOYAMA   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^e Box 0678 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLOROMETHYL 2',7' DICHLORODIHYDROFLUORESCEIN DIACETATE ACETYL ESTER; 6 CHLOROMETHYL 2',7' DICHLORODIHYDROFLUORESCEIN DIACETATE ACETYL ESTER; BINDING PROTEIN; COMPLEMENTARY DNA; ESTER; FLUORESCEIN DIACETATE; GLUCOSE; GLUCOSE TRANSPORTER 1; JNK INTERACTING PROTEIN 1; LIPID; REACTIVE OXYGEN METABOLITE; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; GLUCOSE TRANSPORTER; MAPK8IP PROTEIN, RAT; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLC2A1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL LEVEL; CELL LINE; CONTROLLED STUDY; CYTOPLASM; DIABETIC RETINOPATHY; DNA MICROARRAY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; IMMUNOPRECIPITATION; LIPID PEROXIDATION; NONHUMAN; NORTHERN BLOTTING; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; GENE EXPRESSION PROFILING; METABOLISM; PHOSPHORYLATION; RETINA BLOOD VESSEL; VASCULAR ENDOTHELIUM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; MONOSACCHARIDE TRANSPORT PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES; RETINAL VESSELS;

EID: 27244458524     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-1064     Document Type: Article

References (61)

1. Robison WG, Kinoshita JH, Kador PF. The polyol pathway in retinal microangiopathy. Drugs. 1986;32:19-22.
2. Heath H, Paterson RA, Hart JC. Changes in the hydroxyproline, hexosamine and sialic acid of the diabetic human and beta, beta'-iminodipropionitrile- treated rat retinal vascular systems. Diabetologia. 1967;3:515-518.
3. Nakamura M, Barber AJ, Antonetti DA, et al. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem. 2001;276:43748-43755.
4. Stitt AW, Jenkins AJ, Cooper ME. Advanced glycation end products and diabetic complications. Expert Opin Investig Drugs. 2002;11:1205-1223.
5. Stitt AW, Li YM, Gardiner TA, Bucala R, Archer DB, Vlassara H. Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vascularure of diabetic and of AGE-infused rats. Am J Pathol. 1997;150:523-531.
6. King GL, Kunisaki M, Nishio Y, Inoguchi T, Shiba T, Xia P. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes. 1996;45:S105-S108.
7. Lorenzi M, Montisano DF, Toledo S, Barrieux A. High glucose induces DNA damage in cultured human endothelial cells. J Clin Invest. 1986;77:322-325.
8. Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787-790.
9. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol. 1984;102:527-532.
10. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol. 1984;102:520-526.
11. The Diabetes Control, Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
12. UKPDS. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837-853.
13. Cogan D, Toussaint D, Kuwabara T. Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol. 1961;66:366-378.
14. Kumagai AK, Glasgow BJ, Pardridge WM. GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye. Invest Ophthalmol Vis Sci. 1994;35:2887-2894.
15. Harik SI, Kalaria RN, Whitney PM, et al. Glucose transporters are abundant in cells with "occluding" junctions at the blood-eye barriers. Proc Natl Acad Sci U S A. 1990;87:4261-4264.
16. Takata K, Hirano H, Kasahara M. Transport of glucose across the blood-tissue barriers. Int Rev Cytol. 1997;172:1-53.
17. Berkowitz BA, Garner MH, Wilson CA, Corbett RJ. Nondestructive measurement of retinal glucose transport and consumption in vivo using NMR spectroscopy. J Neurochem. 1995;64:2325-2331.
18. Olgemoller B, Schleicher ED, Gerbitz KD. Differential kinetics of glucose metabolism in porcine retinal and aortic endothelial cells. J Clin Chem Clin Biochem. 1990;28:15-17.
19. Schmidt AM, Hori O, Cao R, et al. RAGE: a novel cellular receptor for advanced glycation end products. Diabetes. 1996;45:S77-S80.
20. Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem. 1997;272:17810-17814.
21. Yan SD, Schmidt AM, Anderson GM, et al. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem. 1994;269:9889-9897.
22. Min C, Kang E, Yu SH, Shinn SH, Kim YS. Advanced glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells. Diabetes Res Clin Pract. 1999;46:197-202.
23. Yamagishi S, Inagaki Y, Okamoto T, et al. Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells. J Biol Chem. 2002;277:20309-20315.
24. Kawamori D, Kajimoto Y, Kaneto H, et al. Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes. 2003;52:2896-2904.
25. Zhang L, Zalewski A, Lui Y, et al. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation. 2003;108:472-478.
26. Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996;87:929-939.
27. Gupta S, Campbell D, Derijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science. 1995;267:389-393.
28. Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science. 1998;281:1671-1674.
29. Dickens M, Rogers JS, Cavanagh J, et al. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 1997;277:693-696.
30. Carlson CJ, Koterski S, Sciotti RJ, Poccard GB, Rondinone CM. Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression. Diabetes. 2003;52:634-641.
31. Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420:333-336.
32. Fujishiro M, Gotoh Y, Katagiri H, et al. Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol Endocrinol. 2003;17:487-497.
33. Fernyhough P, Gallagher A, Averill SA, et al. Aberrant neurofilament phosphotylation in sensory neurons of rats with diabetic neuropathy. Diabetes. 1999;48:881-889.
34. Tai PK, Liao JF, Chen EH, Dietz J, Schwartz J, Carter-Su C. Differential regulation of two glucose transporters by chronic growth hormone treatment of cultured 3T3-F442A adipose cells. J Biol Chem. 1990;265:21828-21834.
35. Meyer D, Liu A, Margolis B. Interaction of c-Jun ammo-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem. 1999;274:35113-35118.
36. Hosoya K, Tomi M, Ohtsuki S, et al. Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat. Exp Eye Res. 2001;72:163-172.
37. Tanner FC, Carr DP, Nabel GJ, Nabel EG. Transfection of human endothelial cells. Cardiovasc Res. 1997;35:522-528.
38. Tomi M, Hosoya K, Takanaga H, Ohtsuki S, Terasaki T. Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci. 2002;43:774-779.
39. Hosoya K, Kondo T, Tomi M, Takanaga H, Ohtsuki S, Terasaki T. MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible for delivery of monocarboxylic acid drugs to the retina. Pharm Res. 2001;18:1669-1676.
40. Hosoya K, Minamizono A, Katayama K, Terasaki T, Tomi M. Vitamin C transport in oxidized form across the rat blood-retinal barrier. Invest Ophthalmol Vis Sci. 2004;45:1232-1239.
41. Hosoya K, Saeki S, Terasaki T. Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo. Microvasc Res. 2001;62:136-142.
42. Sone H, Deo BK, Kumagai AK. Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells. Invest Ophthalmol Vis Sci. 2000;41:1876-1884.
43. Guerrant G, Moss C. Determination of monosaccharides as aldononitrile, O-methyloxime, alditol, and cyclitol acetate derivatives by gas chromatography. Anal Chem. 1984;56:633-638.
44. Ho FM, Liu SH, Liau CS, Huang PJ, Lin-Shiau SY. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3. Circulation. 2000;101:2618-2624.
45. Bonny C, Nicod P, Waeber G. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. J Biol Chem. 1998;273:1843-1846.
46. Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ. The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999;19:7245-7254.
47. Matsuda S, Yasukawa T, Homma Y, et al. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci. 2001;21:6597-6607.
48. Gotthardt M, Trommsdorff M, Nevitt MF, et al. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem. 2000;275:25616-25624.
49. Verhey KJ, Meyer D, Deehan R, et al. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules [comment]. J Cell Biol. 2001;152:959-970.
50. Pieper GM, Langenstroer P, Siebeneich W. Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals. Cardiovasc Res. 1997;34:145-156.
51. Ha H, Lee HB. Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int Suppl. 2000;77:S19-S25.
52. Augustin AJ, Dick HB, Koch F, Schmidt-Erfurth U. Correlation of blood-glucose control with oxidative metabolites in plasma and vitreous body of diabetic patients. Eur J Ophthalmol. 2002;12:94-101.
53. Liu W, Schoenkerman A, Lowe WL Jr. Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells. Am J Physiol. 2000;279:E782-E790.
54. Purves T, Middlemas A, Agthong S, et al. A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy. FASEB J. 2001;15:2508-2514.
55. Waeber G, Delplanque J, Bonny C, et al. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet. 2000;24:291-295.
56. Curcio F, Ceriello A. Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell Dev Biol. 1992;28A:787-790.
57. Morishita R, Aoki M, Nakamura S, et al. Potential role of a novel vascular modulator, hepatocyte growth factor (HGF), in cardiovascular disease: characterization and regulation of local HGF system. J Atheroscler Thromb. 1997;4:12-19.
58. Lorenzi M, Nordberg JA, Toledo S. High glucose prolongs cell-cycle traversal of cultured human endothelial cells. Diabetes. 1987;36:1261-1267.
59. Stockinger W, Brandes C, Fasching D, et al. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J Biol Chem. 2000;275:25625-25632.
60. Filosto M, Tonin P, Vattemi G, Savio C, Rizzuto N, Tomelleri G. Transcription factors c-Jun/activator protein-1 and nuclear factor-kappa B in oxidative stress response in mitochondrial diseases. Neuropathol Appl Neurobiol. 2003;29:52-59.
61. Hojo Y, Saito Y, Tanimoto T, et al. Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circ Res. 2002;91:712-718.