Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats

American Journal of Pathology

Volumn 150, Issue 2, 1997, Pages 523-531

  Stitt, Alan W ^a,b   Li, Yong M ^a   Gardiner, Thomas A ^b   Bucala, Richard ^a   Archer, Desmond B ^b   Vlassara, Helen ^a  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; GLYCOSYLATED PROTEIN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RECEPTOR PROTEIN; TRYPSIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETIC RETINOPATHY; MALE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RETINA BLOOD VESSEL; RETINA CELL; STREPTOZOCIN DIABETES; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAPILLARIES; DIABETES MELLITUS, EXPERIMENTAL; GLYCOSYLATION END PRODUCTS, ADVANCED; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; REFERENCE VALUES; RETINAL VESSELS; SERUM ALBUMIN, BOVINE; TISSUE DISTRIBUTION;

EID: 0031019612     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bucala R, Cerami A: Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv Pharmacol 1992, 23:1-34
2. Brownlee M, Vlassara H, Cerami A: Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 1988, 318:1315-1321
3. Monnier VM, Kohn RR, Cerami A: Accelerated agerelated browning of human in diabetes mellitus. Proc Natl Acad Sci USA 1984, 81:583-587
4. Doi T, Vlassara H, Kirstein M, Yamada Y, Striker GE, Striker LJ: Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor, Proc Natl Acad Sci USA 1992, 89:2873-2877
5. Bucala R, Tracey KJ, Cerami A: Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes, J Clin Invest 1991, 87:432-438
6. Vlassara H, Fun H, Makita Z, Krungkrai S, Cerami A, Bucala R: Exogenous advanced glycosylation endproducts induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications. Proc Natl Acad Sci USA 1992, 89:12043-12047
7. Vlassara H, Striker LJ, Teichberg S, Fuh H, Li YM, Steffes M: Advanced glycation endproducts induce glomerular sclerosis and albuminuria in normal rats, Proc Natl Acad Sci USA 1994, 91:11704-11708
8. Vlassara H, Fuh H, Donnelly T, Cybulsky M: Advanced glycation endproducts promote adhesion molecule (VCAM-1, ICAM-1) expression and atheroma formation in normal rabbits. Mol Med 1995, 1:447-456
9. Stitt AW, Friedman S, Scher L, Rossi P, Ong H, Founds H, Bucala R, Vlassara H: Carotid artery advanced glycation endproducts and their receptors correlate with severity of lesion and with plasma AGE-ApoB levels in non-diabetic patients. FASEB J 1996, 10:A616
10. Yamagishi S, Hsu C-C, Taniguchi M, Harada S, Yamamoto Y, Ohsawa K, Kobayashi K, Yamamoto H: Receptor mediated toxicity to pericytes of advanced glycosylation end products: a possible mechanism of pericyte loss in diabetic microangiopathy. Biochem Biophys Res Commun 1995, 213:681-687
11. Hammes HP, Martin S, Federlin K, Geisen K, Brownlee M: Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy, Proc Natl Acad Sci USA 1991, 88:11555-11558
12. Frank RN: Diabetic retinopathy. Prog Retinal Eye Res 1995, 14:361-392
13. Vlassara H, Brownlee M, Manogue KR, Dinarello C, Pasagian A: Cachectin/TNF and IL-1 induced by glucose modified proteins: role in normal tissue remodeling, Science 1988, 240:1546-1548
14. Vlassara H: Receptor mediated interactions of advanced glycosylation endproducts with cellular components within diabetic tissues. Diabetes 1992, 41: 52-56
15. Vlassara H, Bucala R, Striker LJ: Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 1994, 70:138-151
16. Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D: Cellular receptors for advanced glycation endproducts: implications for induction of oxidative stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb 1994, 14:1521- 1528
17. Vlassara H, Brownlee M, Cerami A: High-affinity receptor mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules. Proc Natl Acad Sci USA 1985, 82:5588-5592
18. Esposito C, Gerlach H, Brett J, Stern D, Vlassara H: Endothelial receptor-mediated binding of glucosemodified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties. J Exp Med 1989, 170:1387-1407
19. Schmidt AM, Vianna M, Gerlach M, Brett J, Ryan J, Kao J: Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem 1992, 256:14987-14997
20. Yang Z, Makita Z, Horii Y, Brunelle S, Cerami A, Sehajpal P, Suthanthiran M, Vlassara H: Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins. J Exp Med 1991, 174:515- 524
21. Li YM, Wojciehowicz D, Mitsuhashi T, Gilmore R, Shimizu N, Li J, Stitt AW, He C, Vlassara H: Molecular identity and tissue distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and 80KH membrane proteins. Proc Natl Acad Sci USA 1996, 93:11047-11052
22. Silberstein S, Kelleher G, Gilmore R: The 48-kDa subunit of the mammalian oligosaccharyltransferase complex is homologous to the essential yeast protein WBP1. J Biol Chem 1992, 267:23658-23663
23. r 80000 from human epithelial cells and identification as proper substrates for protein kinase C. Genomics 1989, 5:309-315
24. Makita Z, Vlassara H, Cerami A, Bucala R: Immunological detection of advanced glycosylation end products in vivo. J Biol Chem 1992, 267:5133-5138
25. Nakamura Y, Horii Y, Nishino T, Shiiki H, Sakaguchi Y, Kagoshima T, Dohi K, Makita Z, Vlassara H, Bucala R: Immunohistochemical localization of advanced glycosylation endproducts (AGEs) in coronary atheroma and cardiac tissue in diabetes, Am J Pathol 1993, 143: 1649-1656
26. Kern TS, Engerman RL: Vascular lesions in diabetes are distributed non-uniformly within the retina, Exp Eye Res 1995, 13:863-867
27. Chakrabarti S, Sima AAF, Tze WJ, Tai J: Prevention of diabetic retinal capillary pericyte degeneration and loss by pancreatic islet allograft. Curr Eye Res 1987, 6:649-658
28. Robison WG, McCaleb ML, Feld LG, Michaelis OE IV, Laver N, Mercandetti M, Robison WG Jr: Degenerated intramural pericytes ("ghost cells") in the retinal capillaries of diabetic rats, Curr Eye Res 1991, 10:339-350
29. Diabetes Control and Complication Trial (DCCT) Research Group: The effect of intensive treatment of diabetes on the development and progression of longterm complications in insulin-dependent diabetes mellitus. N Engl J Med 1993, 329:977-986
30. Engerman RL, Kern TS: Progression of incipient diabetic retinopathy during good glycemie control, Diabetes 1987, 36:808-812 31.
31. Hammes HP, Ali SS, Uhlmann M, Weiss A, Federlin K, Geisen K, Brownlee M: Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in rats. Diabetologia 1995, 38:269-273
32. Cho HK, Kozu H, Peyman GA, Parry GJ, Khoobehi B: The effect of aminoguanidine on the blood-retinal barrier in streptozotocin-induced diabetic rats, Ophthalmic Surg 1991, 22:44-47
33. Stitt AW, Anderson HR, Gardiner TA, Archer DB: Diabetic retinopathy: quantitative variation in capillary basement membrane thickening in arterial or venous environments. Br J Ophthalmol 1994, 78:133-137
34. Fisher F, Gartner J: Morphometric analysis of basal laminae in rats with long-term streptozotocin diabetes 1. II. Retinal capillaries, Exp Eye Res 1983, 37:55-64
35. Sell DR, Carlson EC, Monnier VM: Differential effects of type 2 (non-insulin-dependent) diabetes mellitus on pentosidine formation in skin and glomerular basement membrane. Diabetologia 1993, 36:936-941
36. Makino H, Shikata K, Hironaka K, Kushiro M, Yamasaki Y, Sugimoto H, Ota Z, Araki N, Horiuchi S: Ultrastructure of nonenzymatically glycated mesangial matrix in diabetic nephropathy. Kidney Int 1995, 48:517-526
37. Kuwabara T, Cogan DG: Retinal vascular patterns, IV. / Mural cells of the retinal capillaries. Arch Ophthalmol 1963, 69:492-502
38. Kuwabara T, Cogan DG: Retinal vascular patterns. VII. Acellular change. Invest Ophthalmol Vis Sci 1965, 4:1049-1058
39. Gardiner TA, Stitt AW, Andersen HR, Archer DB: Selective loss of vascular smooth muscle in the retinal microcirculation of diabetic dogs. Br J Ophthalmol 1994, 78:54-60