Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes

Blood

Volumn 106, Issue 8, 2005, Pages 2663-2670

  Schreurs, Marco W J ^a   Hermsen, Mario A J A ^a   Geltink, Ramon I Klein ^a   Scholten, Kirsten B J ^a   Brink, Antoinette A T P ^a   Kueter, Esther W M ^a   Tijssen, Marianne ^a   Meijer, Chris J L M ^a   Ylstra, Bauke ^a   Meijer, Gerrit A ^a   Hooijberg, Erik ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; MELANOMA ANTIGEN 1; TELOMERASE;

ARTICLE; CELL ACTIVITY; CELL PROTECTION; CELL SURVIVAL; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLONE; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOTOXIC T LYMPHOCYTE; GENE FUNCTION; GENETIC STABILITY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KARYOTYPING; LYMPHOCYTE CULTURE; MELANOMA; MOLECULAR RECOGNITION; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE; UTERINE CERVIX CARCINOMA;

EID: 27144545010     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2004-09-3742     Document Type: Article

References (49)

1. + T cell adoptive immunotherapy. Immunity. 2000;13:265-276.
2. Fontaine P, Roy-Proulx G, Knafo L, et al. Adoptive transfer of minor histocompatibility antigenspecific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease. Nat Med. 2001;7:789-794.
3. Ryan MH, Bristol JA, McDuffie E, Abrams SI. Regression of extensive pulmonary metastases in mice by adoptive transfer of antigen-specific CD8(+) CTL reactive against tumor cells expressing a naturally occurring rejection epitope. J Immunol. 2001;167:4286-4292.
4. +. T cells. J Exp Med. 2003;198:569-580.
5. + T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci U S A. 2002;99:16168-16173.
6. Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002;298:850-854.
7. Kessels HW, Wolkers MC, Schumacher TN. Adoptive transfer of T-cell immunity. Trends Immunol. 2002;23:264-269.
8. Alexander-Miller MA, Leggatt GR, Berzofsky JA. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc Natl Acad Sci U S A. 1996;93:4102-4107.
9. Yee C, Riddell SR, Greenberg PD. Prospects for adoptive T cell therapy. Curr Opin Immunol. 1997;9:702-708.
10. + T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol. 2000;165:4239-4245.
11. Schreurs MW, Scholten KB, Kueter EW, et al. In vitro generation and life span extension of human papillomavirus type 16-specific, healthy donorderived CTL clones. J Immunol. 2003;171:2912-2921.
12. Ducrest AL, Szutorisz H, Lingner J, Nabholz M. Regulation of the human telomerase reverse transcriptase gene. Oncogene. 2002;21:541-552.
13. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352.
14. Yang J, Chang E, Cherry AM, et al. Human endothelial cell life extension by telomerase expression. J Biol Chem. 1999;274:26141-26148.
15. Wootton M, Steeghs K, Watt D, et al. Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability. Hum Gene Ther. 2003;14:1473-1487.
16. Roy NS, Nakano T, Keyoung HM, et al. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol. 2004;22:297-305.
17. Rufer N, Migliaccio M, Antonchuk J, et al. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood. 2001;98:597-603.
18. Dagarag M, Ng H, Lubong R, Effros RB, Yang OO. Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol. 2003;77:3077-3083.
19. + helper and regulatory T-cell clones and confers resistance to oxidative stressinduced apoptosis. Blood. 2003;101:4512-4519.
20. Verra NC, Jorritsma A, Weijer K, et al. Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice. Cancer Res. 2004;64:2153-2161.
21. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266:2011-2015.
22. Blasco MA, Hahn WC. Evolving views of telomerase and cancer. Trends Cell Biol. 2003;13:289-294.
23. Hahn WC, Counter CM, Lundberg AS, et al. Creation of human tumour cells with defined genetic elements. Nature. 1999;400:464-468.
24. Pawelec G, Adibzadeh M, Rehbein A, et al. In vitro senescence models for human T lymphocytes. Vaccine. 2000;18:1666-1674.
25. Yssel H, De Vries JE, Koken M, Van Blitterswijk W, Spits H. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol Methods. 1984;72:219-227.
26. Bonini C, Grez M, Traversari C, et al. Safety of retroviral gene marking with a truncated NGF receptor. Nat Med. 2003;9:367-369.
27. Heemskerk MH, Hooijberg E, Ruizendaal JJ, et al. Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells. Cell Immunol. 1999;195:10-17.
28. Schrock E, du Manoir S, Veldman T, et al. Multicolor spectral karyotyping of human chromosomes. Science. 1996;273:494-497.
29. Fiegler H, Carr P, Douglas EJ, et al. DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer. 2003;36:361-374.
30. Knight SJ, Lese CM, Precht KS, et al. An optimized set of human telomere clones for studying telomere integrity and architecture. Am J Hum Genet. 2000;67:320-332.
31. Sanger Consortium BAC set. Human Ensembl CytoView. http://www.ensembl. org/Homo_ sapiens/cytoview. Accessed June 2004.
32. Caltech. OncoBAC Resource. http://informa.bio. caltech.edu/Bac_onc.html. Accessed June 2004.
33. BacPac Resources. Preparation of DNA Template for Direct Sequencing of Large Insert PAC and BAC Plasmids. http://bacpac.chori.org/dnaprep. htm. Accessed June 2004.
34. Snijders AM, Nowak N, Segraves R, et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet. 2001;29:263-264.
35. + T cells by a flow cytometric assay for degranulation. J Immunol Methods. 2003;281:65-78.
36. Rubio V, Stuge TB, Singh N, et al. Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nat Med. 2003;9:1377-1382.
37. Farwell DG, Shera KA, Koop JI, et al. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol. 2000;156:1537-1547.
38. Morales CP, Holt SE, Ouellette M, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet. 1999;21:115-118.
39. Vaziri H, Squire JA, Pandita TK, et al. Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol Cell Biol. 1999;19:2373-2379.
40. + T lymphocytes overexpressing hTERT. Blood. 2005;106:43-50.
41. DePinho RA. The age of cancer. Nature. 2000;408:248-254.
42. Hackett JA, Greider CW. Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene. 2002;21:619-626.
43. Hackett JA, Greider CW. End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol. 2003;23:8450-8461.
44. Wojda A, Witt M. Manifestations of ageing at the cytogenetic level. J Appl Genet. 2003;44:383-399.
45. Hacein-Bey-Abina S, Von Kalle C, Schmidt M, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003;302:415-419.
46. Verdijk RM, Wilke M, Beslier V, et al. Escherichia coli-nitroreductase suicide gene control of human telomerase reverse transcriptase-transduced minor histocompatibility antigen-specific cytotoxic T cells. Bone Marrow Transplant. 2004;33:963-967.
47. Lindvall C, Hou M, Komurasaki T, et al. Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res. 2003;63:1743-1747.
48. Milyavsky M, Shats I, Erez N, et al. Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res. 2003;63:7147-7157.
49. Canela A, Martin-Caballero J, Flores JM, Blasco MA. Constitutive expression of Tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Mol Cell Biol. 2004;24:4275-4293.