Manifestations of ageing at the cytogenetic level

Journal of Applied Genetics

Volumn 44, Issue 3, 2003, Pages 383-399

  Wojda, Alina ^a   Witt, Michał ^a,b  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

Ageing; Chromosomal aberrations; DNA damage; FISH; Replicative senescence

Indexed keywords

AGING; APOPTOSIS; CHROMOSOME ABERRATION; CYTOGENETICS; DEREGULATION; DNA REPAIR; DNA REPLICATION; ENVIRONMENTAL FACTOR; HUMAN; MICROORGANISM; REVIEW; SENESCENCE; SOMATIC CELL;

ADOLESCENT; ADULT; AGING; CELL AGING; CHILD; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA REPAIR; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; MALE;

EID: 0141799801     PISSN: 12341983     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. ABRUZZO M.A., MAYER M., JACOBS P.A. (1985). Aging and aneuploidy: evidence for the preferential involvement of the inactive X chromosome. Cytogenet. Cell Genet. 39: 275-278.
2. BACKSCH C., WAGENBACH N., NONN M., LEISTRITZ S., STANBRIDGE E., SCHNEIDER A., DURST M. (2001). Microcell-mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity. Gene. Chromosomes Cancer. 31: 196-198.
3. BERDANIER C.D., EVERTS H.B. (2001). Mitochondrial DNA in aging and degenerative disease. Mutat. Res. Fundam. Mol. Mech. Mutagen. 475: 169-184.
4. BERTRAM M.J., BERUBE N.G., SWANSON X.H., PEREIRA-SMITH O.M. (1998). Assembly of a BAC conting of the complementation group B cell senescence gene candidate region at 4q33-q34.1 and identification of expressed sequences. Genomics 56: 353-354.
5. BERTRAM M.J., PEREIRA-SMITH O.M. (2001). Conservation of the MORF4-related gene family: identification of a new chromo domain subfamily and novel protein motif. Gene 266: 111-121.
6. BROWN T., FOX D.P., ROBERTSON F.W., BULLOCK I. (1983). Non-random chromosome loss in PHA stimulated lymphocytes from normal individuals. Mutat. Res. 122: 403-406.
7. BRYCE S.D., FORSYTH N.R., FITZSIMMONS S.A., CLARK L.J., BERTRAM M.J., CUTHBERT A.P., NEWBOLD R.F., PEREIRA-SMITH O.M., PARKINSON E.K. (1999). Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene. Cancer Res. 59: 2038-2046.
8. CAMPISI J. (1996). Replicative senescence: an old lives' tale? Cell 84: 497-500.
9. CATALAN J., AUTIO K., WESSMAN M., LINDHOLM C., KNUUTILA S., SORSA M., NORPPA H. (1995). Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women. Cytogenet. Cell Genet. 68: 11-16.
10. CATALAN J., SURRALLES J., FALCK G.C.M., AUTIO K., NORPPA H. (2000). Segregation of sex chromosomes in human lymphocytes. Mutagenesis 15: 251-255.
11. COTTLIAR A.S.H., SLAVUTSKY I.R. (2001). Telomeres and telomerase activity. Their role in senescence and in neoplastic development. Med. Buenos Aires. 61: 335-342.
12. COURT BROWN W.M., BUCKTON K.E., JACOBS P.A., TOUGH I.M., KUENSSBERG E.V., KNOX J.D.E. (1966). Chromosome Studies on Adults. London, Cambridge University Press.
13. CROWE D.L., NGUYEN D.C., TSANG K.J., KYO S. (2001). E2F represses transcription of the human telomerase reverse transcriptase gene. Nucleic. Acids. Res. 29: 2789-2794.
14. CUTHILL S., AGARWAL P., SARKAR S., SAVELIEVA E., REZNIKOFF C.A. (1999). Dominant genetic alterations in immortalization: role of 20q gain. Gene. Chromosomes Cancer. 26: 304-311.
15. DECARY S., BEN HAMIDA C., MOULY V., BARBET J.P., HENTATI F., BUTLER-BROWNE G.S. (2000). Shorter telomeres in dystrophic muscle consistent with extensive regeneration in young children. Neuromusc. Disord. 10: 113-120.
16. DELORME V.G.R., MCCABE P.F., KIM D.J., LEAVRE C.J. (2000). A matrix metalloproteinase gene is expressed at the boundary of senescence and programmed cell death in cucumber. Plant. Physiol. 123: 917-927.
17. FENECH M., MORLEY A. (1985). The effect of donor age on spontaneous and induced micronuclei. Mutat. Res. 148: 99-105.
18. FENECH M. (2000). A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division. Mutagenesis 15: 329-336.
19. FORD J.H., RUSSELL J.A. (1985) Differences in the error mechanisms affecting sex and autosomal chromosomes in women of different ages within the reproductive age group. Am. J. Hum. Genet. 37: 973-983.
20. FOSSLIEN E. (2001). Mitochondrial medicine-molecular pathology of defective oxidative phosphorylation. Ann. Clin. Lab. SCI. 31: 25-67.
21. GALLOWAY S.M., BUCKTON K.E. (1978). Aneuploidy and aging: chromosome studies on a random sample of the population using G-banding. Cytogenet. Cell. Genet. 20: 78-95.
22. GANGULY B.B. (1993). Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors: related to donor's age. Mutat. Res. 295: 135-148.
23. GUARENTE L. (1996). Do changes in chromosomes cause aging? Cell. 86: 9-12
24. GUTTENBACH M., SCHAKOWSKI R., SCHMID M. (1994). Aneuploidy and ageing: sex chromosome exclusion into micronuclei. Hum. Genet. 94: 295-298.
25. GUTTENBACH M., KOSCHORZ B., BERNTHALER U., GRIMM T., SCHMID M. (1995). Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei. Am. J. Hum. Genet. 57: 1143-1150.
26. HAHN W.C., MEYERSON M. (2001). Telomerase activation, cellular immortalization and cancer. Ann. Med. 33: 123-129.
27. HANDO J., NATH J., TUCKER J. (1994). Sex chromosomes, micronuclei and aging in women. Chromosoma 103: 186-192.
28. HANDO J.C., TUCKER J.D., DAVENPORT M., TEPPERBERG J., NATH J. (1997). X chromosome inactivation and micronuclei in normal and Turner individuals. Hum. Genet. 100: 624-628.
29. HORIKAWA I., PARKER E.S., SOLOMON G.G., BARRETT J.C. (2001). Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells. J. Cell. Biochem. 82: 415-421.
30. HORSMAN D.E., DILL F.J., MCGILLIVRAY B.C., KALOUSEK D.K. (1987). X chromosome aneuploidy in lymphocyte cultures from women with recurrent spontaneous abortions. Am. J. Med. Genet. 28: 981-987.
31. JACOBS P., COURT BROWN W. (1961). Distribution of human chromosome count in relation to age. Nature 191: 1178-1180.
32. JACOBS P. (1963). Change of human chromosome count distribution with age: evidence for a sex difference. Nature 197: 1080-1081.
33. JACOBS P.A., BRUNTON M., COURT BROWN W.M. (1964). Cytogenetic studies in leucocytes on the general population: Subjects by ages 65 years and more. Ann. Hum. Genet. 27: 353-362.
34. JOAQUIN AM., GOLLAPUDI S. (2001) Functional decline in aging and disease: a role for apoptosis. J. Am. Geriatr. Soc. 49: 1234-1240.
35. KARAYIANNI E., MAGNANINI C., ORPHANOS V., NEGRINI M., MANIATIS G.M., SPATHAS D.H., BARBANTI-BRODANO G., MORELLI C. (1999). Transcriptional map of chromosome region 6q16-q21. Cytogenet. Cell. Genet. 86: 263-266.
36. KIRSCH-VOLDERS M., FENECH M. (2001). Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 16:51-58.
37. KLAPPER W., PARWARESCH R., KRUPP G. (2001). Telomere biology in human aging and aging syndromes. Mech. Ageing. Dev. 122: 695-712.
38. KROEMER G., REED J.C. (2000). Mitochondrial control of cell death. Nature Medicine 6: 513-519.
39. KUSKE M.D.A., JOHNSON J.P. (2000). Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping. Cytogenet. Cell. Genet. 89: 1.
40. LEACH N.T., JACKSON-COOK C. (2001). The application of spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) technology to determine the chromosomal content(s) of micronuclei. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 495: 11-19.
41. LUDWIG B., BENDER E., ARNOLD S., HUTTEMANN M., LEE I., KADENBACH B. (2001). Cytochrome C oxidase and the regulation of oxidative phosphorylation. Chembiochem. 26: 392-403.
42. MATTSON M.P., FU W.M., ZHANG P.S. (2001). Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech. Ageing. Dev. 122: 659-671.
43. MORELLI C., MAGNANINI C., MUNGALL A.J., NEGRINI M., BARBANTI-BRODANO G. (2000). Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia. Gene 252: 217-225.
44. MUKHERJEE A.B., THOMAS S. (1997). A longitudinal study of human age-related chromosomal analysis in skin fibroblasts. Exp. Cell Res.235: 161-169.
45. MULLER F. (2000). The nature and mechanism of superoxide production by the electron transport chain: its relevance to aging. J. Am. Aging. Assoc. 23: 227-253.
46. MULTANI A.S., OZEN M., NARAYAN S., KUMAR V., CHANDRA J., MCCONKEY D.J., NEWMAN R.A., PATHAK S. (2000). Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia 2: 339-345.
47. NEURATH P., DEREMER K., BELL B., JARVIK L., KATO T. (1970). Chromosome loss compared with chromosome size, age and sex of subjects. Nature 225: 281-282.
48. NICHOLLS P., MARTIN J.M., KAHN J. (1978) A mathematical model predicting chromosome loss in cultured cells of young adults. J. Theor. Biol. 73: 237-245.
49. NOWINSKI G.P., VAN DYKE D.L., TILLEY B.C., JACOBSEN G., BABU V.R., WORSHAM M.J., WILSON G.N., WEISS L. (1990). The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history. Am. J. Hum. Genet. 46: 1101-1111.
50. OUELLETTE M.M., SAVRE-TRAIN I. (2000). Telomere-controlled senescence. M. S. Med. Sci. 16: 473-480.
51. PFEIFFER P., GOEDECKE W., OBE G. (2000). Mechanism of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis 15: 289-302.
52. 2 repair and aging: influence of donor age on chromosomal aberrations in human lymphocytes. Mutat. Res. 295: 55-62.
53. PRESSL S., EDWARDS A., STEPHAN G. (1999). The influence of age, sex and smoking habits on the background level of FISH-detected translocations. Mutat. Res. 442: 89-95.
54. RAMSEY M.J., MOORE D.H., BRINER J.F., LEE D.A., OLSEN L.A., SENFT J.R., TUCKER J.D. (1995). The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res. 338: 95-106.
55. REED J.C. (2001). Apoptosis-regulating proteins as targets for drug discovery. Trends Mol. Med. 7: 314-319.
56. RICHARD F., MULERIS M., DUTRILLAUX B. (1994). The frequency of micronuclei with X chromosome increases with age in human females. Mutat. Res. 316: 1-7.
57. RONEN A., GLICKMAN B.W. (2001). Human DNA repair genes. Environ. Mol. Mutagen. 37: 241-283.
58. SAMPER E., FLORES J.M., BLASCO M.A. (2001). Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc -/- mice. EMBO.
59. SEMSEI I. (2000). On the nature of aging. Mech. Ageing. Dev. 117: 93-108.
60. SHI Q.H., CHEN J.F., ADLER I.D., ZHANG J.X., MARTIN R., PAN S.J., ZHANG X.R., SHAN X.N. (2000). Increased nondysjunction of chromosome 21 with age human peripheral lymphocytes. Mutat. Res. Fundam. Mol. Mech. Mutagen. 452: 27-36.
61. SKULACHEV V.P. (2001). The programmed death phenomena, aging, and the Samurai law of biology. Exp. Gerontol. 36: 995-1024.
62. SMITH A., ELLIOTT G. (1980). Aneuploidy in culture. J. Ment. Defic. Res. 24: 159-165.
63. STALLARD R., HANEY N.R., FRANK P.A., STYRON P., JUBERG R.C. (1981). Leukocyte chromosomes from patients of cytogenetically abnormal offspring: preliminary observations. Cytogenet. Cell. Genet. 30: 50-53.
64. SURRALLES J., FALCK G., NORPPA H. (1996). In vivo cytogenetic damage revealed by FISH analysis of micronuclei in uncultured human T lymphocytes. Cytogenet. Cell. Genet. 75: 151-154.
65. TUCKER J.D., SPRUILL M.D., RAMSEY M.J., DIRECTOE A.D., NATH J. (1999). Frequency of spontaneous chromosome aberrations in mice: Effects of age. Mutat. Res. 425: 135-141.
66. VOJTA P.J., FUTREAL P.A., ANNAB L.A., KATO H., PEREIRA-SMITH O.M., BARRETT J.C. (1996) Evidence for two senescence loci on human chromosome 1. Genes Chromosomes Cancer. 16: 55-63.
67. VOROBTSOVA I., SEMENOV A., TIMOFEYEVA N., KANAYEVA A., ZVEREVA I. (2001). An investigation of the age-dependency of chromosome abnormalities in human populations exposed to low-dose ionising radiation. Mech. Ageing. Dev. 15: 1373-1382.
68. WALLACE D.C. (2001). Mouse models for mitochondrial disease. Am. J. Med. Genet. 106: 71-93.
69. WEIRICH-SCHWAIGER H., WEIRICH H.G., GRUBER B., SCHWEIGER M., HIRSCH-KAUFFMANN M. (1994). Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res. 316: 37-48.
70. WENG L.P., BROWN J.L., ENG C. (2001). PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and- independent pathways. Hum. Mol. Genet. 10: 337-342.
71. WENGER S.L., GOLDEN S.L., DENNIS S.P., STEELE M.W. (1984). Are the occasional aneuploid cells in peripheral blood cultures significant? Am. J. Med. Genet. 19: 715-719.
72. WHEELER W.J., CHERRY I.M., DOWNS T., HSU T.C. (1986). Mitotic inhibition and aneuploidy induction by naturally occurring and synthetic estrogens in Chinese hamster cells in vitro. Mutat. Res. 171: 31-41.
73. ZAHN R.K., ZAHN-DAIMLER G., AX S., REIFFERSCHEID G., WALDMANN P., FUJISAWA H., HOSOKAWA M. (2000). DNA damage susceptibility and repair in correlation to calendaric age and longevity. Mech. Ageing. Dev. 119: 101-112.