Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site

European Journal of Pharmacology

Volumn 380, Issue 2-3, 1999, Pages 183-195

  Heitz, Freddy ^a   Holzwarth, James A ^a   Gies, Jean Pierre ^b   Pruss, Rebecca M ^a   Trumpp Kallmeyer, Suzanne ^c   Hibert, Marcel F ^b   Guenet, Chantal ^a  

^a SANOFI   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c PFIZER INC   (United States)

Author keywords

G protein coupled receptor; Human; Muscarinic M2 receptor; Site directed mutagenesis

Indexed keywords

ARECOLINE; GUANINE NUCLEOTIDE BINDING PROTEIN; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; OXOTREMORINE; OXOTREMORINE M; PILOCARPINE; QUINUCLIDINYL BENZILATE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EMBRYO CELL; HUMAN; IMMUNOFLUORESCENCE; KIDNEY CELL; LIGAND BINDING; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUTAGENESIS, SITE-DIRECTED; MUTATION; N-METHYLSCOPOLAMINE; PEPTIDES; QUINUCLIDINYL BENZILATE; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; RECOMBINANT FUSION PROTEINS; TRITIUM;

EID: 0032837005     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00439-2     Document Type: Article

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