Clinical and subclinical intestinal inflammation assessed by the mucosal patch technique: Studies of mucosal neutrophil and eosinophil activation in inflammatory bowel diseases and irritable bowel syndrome

Gut

Volumn 53, Issue 12, 2004, Pages 1806-1812

  Kristjansson G ^a,b   Venge, P ^b   Wanders, A ^b   Loof L ^b,c   Hallgren R ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Central Hospital   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; MYELOPEROXIDASE;

ARTICLE; CELIAC DISEASE; COLLAGENOUS COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; FEMALE; HUMAN; HUMAN TISSUE; IRRITABLE COLON; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NEUTROPHIL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADULT; BIOLOGICAL MARKERS; EOSINOPHIL CATIONIC PROTEIN; EOSINOPHILS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; PATIENT COMPLIANCE; PEROXIDASE; RECTUM; SPECIMEN HANDLING;

EID: 9344258636     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.036418     Document Type: Article

References (34)

1. Heatley RV, James PD. Eosinophils in the rectal mucosa. A simple method of predicting the outcome of ulcerative proctocolitis? Gut 1979;20:787-91.
2. Allison MC, Poulter LW, Dhillon AP, et al. Immunohistological studies of surface antigen on colonic lymphoid cells in normal and inflamed mucosa. Comparison of follicular and lamina propria lymphocytes. Gastroenterology 1990;99:421-30.
3. MacDonald TT, Horton MA, Choy MY, et al. Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. J Clin Pathol 1990;43:313-15.
4. Nielsen OH, Gionchetti P, Ainsworth M, et al. Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis. Am J Gastroenterol 1999;94:2923-8.
5. Raab Y, Hällgren R, Knutson L, et al. A technique for segmental rectal and colonic perfusion in humans. Am J Gastroenterol 1992;87:1453-9.
6. Raab Y, Gerdin B, Ahlstedt S, et al. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. Gut 1993;34:1203-6.
7. Raab Y, Fredens K, Gerdin B, et al. Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents. Dig Dis Sci 1998;43:1061-70.
8. Knutson L, Odlind B, Hällgren R. A new technique for segmental jejunal perfusion in man. Am J Gastroenterol 1989;84:1278-84.
9. Binder V. A comparison between clinical state, macroscopic and microscopic appearances of rectal mucosa, and cytologic picture of mucosal exudate in ulcerative colitis. Scand J Gastroenterol 1970;5:627-32.
10. Baron JH CA, Lennard Jones JE. Variation between describing mucosal appearance in proctocolitis. BMJ 1904;1:89-92.
11. Thompson WG, Longstreth GF, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gut 1999;45(suppl 2):1143-7.
12. Venge P. Monitoring the allergic inflammation. Allergy 2004;59:26-32.
13. Carlson M, Raab Y, Seveus L, et al. Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis. Gut 2002;50:501-6.
14. Xu SY, Petersson CG, Carlson M, et al. The development of an assay for human neutrophil lipocalin (HNL) - to be used as a specific marker of neutrophil activity in vivo and vitro. J Immunol Methods 1994;171:245-52.
15. Geboes K, Riddell R, Öst Å, et al. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 2000;47:404-9.
16. Hendel J, Nielsen OH, Madsen S, et al. A simple filter-paper technique allows detection of mucosal cytokine levels in vivo in ulcerative colitis, Interleukin-1 and interleukin-1-receptor antagonist. Dig Dis Sci 1996;41:1775-9.
17. Saitoh H, Takagaki K, Nakamura T, et al. Characterization of mucin in whole-gut lavage fluid obtained from patients with inflammatory bowel disease. Dig Dis Sci 1996;41:1768-74.
18. Sangfelt P, Carlson M, Thörn M, et al. Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitis. Am J Gastroenterol 2001;96:1085-90.
19. Hällgren R, Colombel JF, Dahl R, et al. Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents. Am J Med 1989;86:56-64.
20. Peterson CG, Eklund E, Taha Y, et al. A new method for the quantification of neutrophil and eosinophil cationic proteins in feces: establishment of normal levels and clinical application in patients with inflammatory bowel disease. Am J Gastroenterol 2002;97:1755-62.
21. Bischoff SC, Grabowsky J, Manns MP. Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls. Dig Dis Sci 1997;42:394-403.
22. Wheeler PG, Menzies IS, Creamer B. Effect of hyperosmolar stimuli and coeliac disease on the permeability of the human gastrointestinal tract. Clin Sci Mol Med 1978;54:495-501.
23. Bernstein CN, Shanahan F, Anton PA, et al. Patchiness of mucosal inflammation in treated ulcerative colitis: a prospective study. Gastrointest Endosc 1995;42:232-7.
24. Kleer CG, Appelman HD. Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time. Am J Surg Pathol 1998;22:983-9.
25. Khan I CS. Is there an inflammatory basis for a subset of patients presenting with diarrhoea in the irritable bowel syndrome. Gastroenterology 1994;106:A523.
26. Lee E, Schiller LR, Fordtran JS. Quantification of colonic lamina propria cells by means of a morphometric point-counting method. Gastroenterology 1988;94:409-18.
27. Chadwick VS, Chen W, Shu D, et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002;122:1778-83.
28. Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000;47:804-11.
29. O'Sullivan M, Clayton N, Breslin NP, et al. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 2000;12:449-57.
30. Tibble J, Teahon K, Thjoaleifsson B, et al. A simple method for assessing intestinal inflammation in Crohn's disease. Gut 2000;47:506-13.
31. Breen EG, Coughlan G, Connolly CE, et al. Coeliac proctitis. Scand J Gastroenterol 1987;22:471-7.
32. Cellier C, Cervoni JP, Patey N, et al. Gluten-free diet induces regression of T-cell activation in the rectal mucosa of patients with celiac disease. Am J Gastroenterol 1998;93:1527-30.
33. Ensari A, Ager A, Marsh MN, et al. Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge. Clin Exp Immunol 1993;92:303-7.
34. Taha Y, Carlson M, Thörn M, et al. Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. Dig Dis Sci 2001;46:888-97.