Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rat

Critical Care Medicine

Volumn 33, Issue 10, 2005, Pages 2294-2301

  Suzuki, Takeshi ^a   Morisaki, Hiroshi ^a   Serita, Ryohei ^a   Yamamoto, Michiko ^a   Kotake, Yoshifumi ^a   Ishizaka, Akitoshi ^a   Takeda, Junzo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hyperdynamic sepsis; Tumor necrosis factor ; Working heart preparation; 1 adrenergic receptor

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOKINE; ESMOLOL; INTERLEUKIN 1BETA; LACTIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INFUSION; HEART MUSCLE OXYGEN CONSUMPTION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMIC PARAMETERS; IMMUNE SYSTEM; LACTATE BLOOD LEVEL; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; TREATMENT OUTCOME;

EID: 26444537359     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000182796.11329.3B     Document Type: Article

References (41)

1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
2. Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999; 27:1369-1377
3. Rivers E, Nguyen B, Havstad S, et al: Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-1377
4. Price S, Anning PB, Mitchell JA, et al: Myocardial dysfunction in sepsis: Mechanisms and therapeutic implications. Eur Heart J 1999; 20:715-724
5. Krishnagopalan S, Kumar A, Parrillo JE, et al: Myocardial dysfunction in the patients with sepsis. Curr Opin Crit Care 2002; 8:376-388
6. Kumar A, Thota V, Dee L, et al: Tumor necrosis factor-α and interleukin 1β are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med 1996; 183:949-958
7. Carlson DL, Willis MS, White DJ, et al: Tumor necrosis factor-α-induced caspase activation mediates endotoxin-related cardiac dysfunction. Crit Care Med 2005; 33:1021-1028
8. Bernardin G, Strosberg AD, Bernard A, et al: β-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med 1998; 24:1315-1322
9. Mangano DT, Layug EI, Wallace A, et al: Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery: Multicenter study of perioperative ischemia research group. N Engl J Med 1996; 335:1713-1720
10. Poldermans D, Boersma E, Bax JJ, et al: The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. N Engl J Med 1999; 341:1789-1794
11. Zaugg M, Schaub MC, Pasch T, et al: Modulation of δ-adrenergic receptor subtype activities in perioperative medicine: Mechanisms and sites of action. Br J Anaesth 2002; 88:101-123
12. Cain BS, Meldrum DR, Dinarello CA, et al: Tumor necrosis factor-alpha and interleukin-1 beta synergistically depress human myocardial function. Crit Care Med 1999; 27:1309-1318
13. Gulick T, Chung MK, Pieper SJ, et al: Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness. Proc Natl Acad Sci U S A 1989; 86:6753-6757
14. Heilbrunn SM, Shah P, Bristow MR, et al: Increased β-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy. Circulation 1989; 79:483-490
15. Morisaki H, Sibbald W, Martin C, et al: Hyperdynamic sepsis depresses circulatory compensation to normovolemic anemia in conscious rats. J Appl Physiol 1996; 80:656-664
16. Martin CM, Sibbald WJ: Modulation of hemodynamics and organ blood flow by nitric oxide synthase inhibition is not altered in normotensive septic rats. Am J Respir Crit Care Med 1994; 150:1539-1544
17. Serita R, Morisaki H, Ai K, et al: Sevoflurane preconditions stunned myocardium in septic but not healthy isolated rat hearts. Br J Anaesth 2002; 89:896-903
18. Panas D, Khadour FH, Szabo C, et al: Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism. Am J Physiol 1998; 275:H1016-H1023
19. Vincent JL: The international sepsis forum's frontiers in sepsis: High cardiac output should be maintained in severe sepsis. Crit Care 2003; 4:276-278
20. Gattinoni L, Brazzi L, Pelosi P, et al: A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 1995; 333:1025-1032
21. Hayes MA, Yau EH, Timmins AC, et al: Response of critically ill patients to treatment aimed at achieving supranormal oxygen delivery and consumption Relationship to outcome. Chest 1993; 103:886-895
22. Dellinger RP, Carlet JM, Masur H, et al: Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873
23. Cunnion RE, Schaer GL, Parker MM, et al: The coronary circulation in human septic shock. Circulation 1986; 73:637-644
24. Morisaki H, Bloos F, Keys J, et al: Compared with crystalloid, colloid therapy slows progression of extrapulmonary tissue injury in septic sheep. J Appl Physiol 1994; 77:1507-1518
25. Solomon MA, Correa R, Alexander HR, et al: Myocardial energy metabolism and morphology in a canine model of sepsis. Am J Physiol 1994; 266:H757-H768
26. Boulos M, Astiz ME, Barua RS, et al: Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly (ADP-ribose) synthase. Crit Care Med 2003; 31:353-358
27. Parker MM, Shelhamer JH, Bacharach SL, et al: Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984; 100:483-490
28. Parrillo JE, Parker MM, Natanson C, et al: Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1990; 113:227-242
29. Kovarik MF, Jones SB, Romano FD: Plasma catecholamines following cecal ligation and puncture in the rat. Circ Shock 1987; 22:281-290
30. Bryant D, Becker L, Richardson J, et al: Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α. Circulation 1998; 97:1375-1381
31. Meldrum DR: Tumor necrosis factor in the heart. Am J Physiol 1998; 274:R577-R595
32. Maass DL, Hybki DP, White J, et al: The time course of cardiac NF-κB activation and TNF-α secretion by cardiac myocytes after burn injury Contribution to burn-related cardiac contractile dysfunction. Shock 2002; 17:293-299
33. Kapadia S, Lee J, Amione GT, et al: Tumor necrosis factor-α gene and protein expression in adult feline myocardium after endotoxin toxin administration. J Clin Invest 1995; 96:1042-1052
34. Goto T, Ishizaka A, Kobayashi P, et al: Importance of tumor necrosis factor-a cleavage process in post-transplantation lung injury in rats. Am J Respir Crit Care Med 2004; 170:1-8
35. Ohtsuka T, Hamada M, Hiasa G, et al: Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. J Am Coll Cardiol 2001; 37:412-417
36. Prabhu SD, Chandrasekar B, Murray DR, et al: β-adrenergic blockade in developing heart failure: Effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. Circulation 2000; 101:2103-2109
37. Tang C, Liu MS: Initial externalization followed by internalization of β-adrenergic receptors in rat heart during sepsis. Am J Physiol 1996; 270:R254-263
38. Trzeciak S: Lac-time? Crit Care Med 2004; 32:1785-1786
39. James JH, Luchette FA, McCarter FD, et al: Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999; 354:505-508
40. Bakker J, Cofferenils M, Leon M, et al: Blood lactate concentrations are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1991; 99:956-962
41. Nguyen HB, Rivers EP, Knoblich BP, et al: Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004; 32:1637-1642