Hyperdynamic sepsis depresses circulatory compensation to normovolemic anemia in conscious rats

Journal of Applied Physiology

Volumn 80, Issue 2, 1996, Pages 656-664

  Morisaki, Hiroshi ^a   Sibbald, William ^a,b   Martin, Claudio ^a   Doig, Gordon ^a   Inman, Kevin ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

hemodilution; hypoxia; oxygen delivery; regional blood flows; transfusion

Indexed keywords

OXYGEN;

ANEMIA; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART HEMODYNAMICS; HEART OUTPUT; HEMATOCRIT; HYPOXIA; MALE; MATHEMATICAL ANALYSIS; NONHUMAN; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RAT; SEPSIS;

EID: 0030049753     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.2.656     Document Type: Article

References (29)

1. ACCP/SCCM Consensus Conference Committee. Definition of sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20: 864-874, 1992.
2. Altura, D. M., D. T. Altura, A. Carella, P. D. Torlapaty, and J. Weinberg. Vascular smooth muscle and general anesthetics. Federation Proc. 39: 1584-1591, 1980.
3. Bernstein, D., and D. F. Teitel. Myocardial and systemic oxygen utilization during severe hypoxia in ventilated lambs. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H1856-H1864, 1990.
4. Bersten, A. D., and W. J. Sibbald. Circulatory disturbances in multiple systems organ failure. Crit. Care Clin. 5: 233-254, 1989.
5. Bersten, A. D., W. J. Sibbald, H. Hersch, H. Cheung, and F. S. Rutledge. Interaction of sepsis and sepsis plus sympathomimetics on myocardial oxygen availability. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1164-H1173, 1992.
6. Box, G. E. P., W. G. Hunter, and J. S. Hunter. Statistics for Experimenters: An Introduction to Design, Data Analysis and Modal Building. New York: Wiley, 1979, p. 352-368.
7. Cane, R. D. Hemoglobin: how much is enough? Crit. Care Med. 18: 1046-1047, 1990.
8. Chapler, C. K., and S. M. Cain. The physiologic reserve in oxygen carrying capacity: studies in experimental hemodilution. Can. J. Physiol. Pharmacol. 64: 7-12, 1986.
9. Dahn, M. S., P. Lange, K. Lobdell, B. Hans, L. A. Jacobs, and R. A. Mitchell. Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery St. Louis 101: 69-80, 1987.
10. Fan, F. C., R. Y. Z. Chen, G. B. Schuessler, and S. Chien. Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog. Am. J. Physiol. 238 (Heart Circ. Physiol. 7): H545-H557, 1980.
11. Greenberg, A. G. To transfuse or not to transfuse-that is the question (Editorial)? Crit. Care Med. 18: 1405, 1990.
12. Hersch, M., A. Gnidec, A. Bersten, M. Troster, F. S. Rutledge, and W. J. Sibbald. Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis. Surgery St. Louis 107: 397-410, 1990.
13. Jan, K. M., and S. Chien. Effect of hematocrit variations on coronary hemodynamics and oxygen utilization. Am. J. Physiol. 233 (Heart Circ. Physiol. 2): H106-H113, 1977.
14. Kiel, J. W., and A. P. Shepherd. Optimal hematocrit for canine gastric oxygenation. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H1472-H1477, 1989.
15. 2 uptake during hypoxia and recovery in hypermetabolic dogs. J. Appl. Physiol. 63: 381-386, 1987.
16. Lam, C., K. Tyml, C. Martin, and W. Sibbald. Microvascular perfusion is impaired in a rat model of normotensive sepsis J Clin. Invest. 94: 2077-2083, 1994.
17. Lipowsky, H. H., and J. C. Firrell. Microvascular hemodynamics during systemic hemodilution and hemoconcentration. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H908-H922, 1986.
18. Martin, C., and W. J. Sibbald. Modulation of hemodynamics and organ blood flow by nitric oxide synthase inhibition is not altered in normotensive, septic rats. Am. J. Respir. Crit. Care Med. 150: 1539-1544, 1994.
19. Martin, C. M., A. Yagbi, W. J. Sibbald, D. McCormack, and N. A. M. Paterson. Differential impairment of vascular reactivity of small pulmonary and systemic arteries in a rat model of hyperdynamic sepsis. Am. Rev. Respir. Dis. 148: 164-172, 1993.
20. Metting, P. J., J. R. Strader, and S. L. Briton. Evaluation of whole body autoregulation in conscious dogs. Am. J. Physiol. 255 (Heart Circ. Physiol. 24): H44-H52, 1988.
21. Office of Medical Applications, National Institutes of Health. Perioperative red cell transfusion. J. Am. Med. Assoc. 260: 2700-2703, 1988.
22. Shott, S. (Editor). Statistics For Health Professionals. Philadelphia, PA: Saunders, 1990, p. 145-202.
23. Tuchschmidt, J., J. Fried, M. Astiz, and E. Rackow. Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest 102: 216-220, 1992.
24. Walley, K. R., C. J. Becker, R. A. Hogan, K. Teplinsky, and L. D. H. Wood. Progressive hypoxemia limits left ventricular oxygen consumption and contractility. Circ. Res. 63: 849-859, 1988.
25. Wang, L. Plasma volume, cell volume, total blood volume, and F cell factor in the normal splenectomized Sherman rat. Am. J. Physiol. 196: 188-195, 1959.
26. Weg, J. G. Oxygen transport in adult respiratory distress syndrome and other acute circulatory problems: relationship of oxygen delivery and oxygen consumption. Crit. Care Med. 19: 650-657, 1991.
27. Welch, G. H., K. R. Meehan, and L. T. Goodnough. Prudent strategies for elective red blood cell transfusion. Ann. Intern. Med. 116: 393-402, 1992.
28. Wichterman, K. A., A. E. Baue, and I. H. Chaudry. Sepsis and septic shock-a review of laboratory models and a proposal. J. Surg. Res. 29: 189-201, 1980.
29. Woodson, R. D., and S. Auerbach. Effect of increased oxygen affinity and anemia on cardiac output and its distribution J. Appl. Physiol. 53: 1299-1306, 1982.