Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport

Neuroscience Research

Volumn 45, Issue 1, 2003, Pages 33-40

  Lu, Yan Yan ^a,c   Wang, Li Jun ^a   Muramatsu, Shin Ichi ^a   Ikeguchi, Kunihiko ^a   Fujimoto, Ken Ichi ^a   Okada, Takashi ^a   Mizukami, Hiroaki ^a   Matsushita, Takashi ^a   Hanazono, Yutaka ^a   Kume, Akihiro ^a   Nagatsu, Toshiharu ^b   Ozawa, Keiya ^a   Nakano, Imaharu ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Adeno associated virus (AAV); Gene therapy; Glial cell line derived neurotrophic factor (GDNF); Intramuscular injection; Motoneurons; Retrograde transport

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HYBRID PROTEIN; RECOMBINANT PROTEIN;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TRANSPORT; EMBRYO; GASTROCNEMIUS MUSCLE; GENE SEQUENCE; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MOUSE; MUSCLE CELL; NERVE FIBER TRANSPORT; NERVE PROJECTION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOLEMMA; SPINAL CORD MOTONEURON;

ANIMALS; DEPENDOVIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAMUSCULAR; MICE; MOTOR NEURONS; MUSCLE, SKELETAL; NERVE GROWTH FACTORS; SPINAL CORD; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 0037221498     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(02)00195-5     Document Type: Article

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