Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells

Journal of Lipid Research

Volumn 42, Issue 7, 2001, Pages 1062-1071

  Mohammadi, A ^a   Perry, R J ^a   Storey, M K ^a   Cook, H W ^a   Byers, D M ^a   Ridgway, N D ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cholesterol; Golgi apparatus; Niemann Pick type C

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; BINDING PROTEIN; CHOLESTEROL; FILIPIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE PROTEIN; NEIMANN PICK C PROTEIN; OXYSTEROL; OXYSTEROL BINDING PROTEIN; SERINE; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DISSOCIATION; ELECTROPHORETIC MOBILITY; FIBROBLAST; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; LIPID TRANSPORT; LYSOSOME; NIEMANN PICK DISEASE; NONHUMAN; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ANDROSTENES; ANIMALS; CHO CELLS; CHOLESTEROL; CHOLESTEROL, LDL; CHOLINERGIC ANTAGONISTS; CRICETINAE; FIBROBLASTS; GOLGI APPARATUS; HUMANS; MUTAGENESIS, SITE-DIRECTED; NIEMANN-PICK DISEASES; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, STEROID;

EID: 0034947717     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Regulation of the mevalonate pathway
2. Intracellular cholesterol transport
3. Quantitation of the pool of cholesterol associated with acyl-CoA:cholesterol acyltransferase in human fibroblasts
4. Plasma membrane contains half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured fibroblasts
5. Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane
6. Intracellular trafficking of cholesterol monitored with cyclodextrins
7. Role of Niemann-Pick Type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol
8. Transport of cholesterol form the endoplasmic reticulum to the plasma membrane
9. Depletion of plasma membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membrane and intracellular pools in cultured fibroblasts
10. Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin
11. Sterol resistance in CHO cells traced to a point mutation in SREBP cleavage activating protein
12. Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis
13. The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo
14. Mutations in the leucine zipper motif and sterol sensing domain inactivate the Niemann-Pick C1 protein
15. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane
16. Caveolin moves from the caveolae to the Golgi apparatus in response to cholesterol oxidation
17. Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol binding protein phosphorylation and Golgi localization
18. Cholesterol regulates oxysterol binding protein phosphorylation and Golgi localization in Chinese hamster ovary cells: Correlation with stimulation of sphingomyelin synthesis
19. Abnormal cholesterol and cholesterol ester synthesis in Chinese hamster ovary cells overexpressing the oxysterol binding protein is dependent on the pleckstrin homology domain
20. Translocation of oxysterol binding protein to the Golgi apparatus triggered by ligand binding
21. The caveolae membrane system
22. Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport to the cell surface
23. Heterogenous distribution of filipin-cholesterol complexes across the cisternae of the Golgi apparatus
24. Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: A cytochemical freeze-fracture study
25. Cholesterol is required for surface transport of influenza virus hemagluttinin
26. Cholesterol depletion in enterocytes: Effect of the Golgi complex and apical membrane trafficking
27. LDL-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts
28. Receptor-mediated endocytosis of LDL in cultured cells
29. Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A
30. Effects of 3β-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures
31. Niemann-Pick C: A disorder of cellular cholesterol trafficking
32. Casein kinase I: Spatial organization and positioning of a multifunctional protein kinase family
33. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes
34. The fate of cholesterol exiting lysosomes
35. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane domain
36. Loss of transcriptional activation of three sterol-regulated genes in mutant hamster cells
37. The pleckstrin homology domain of oxysterol binding protein recognizes a determinant specific to Golgi membranes
38. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
39. Regulation of intracellular cholesterol metabolism is defective in lymphoblasts form Niemann-Pick type C and D patients