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Volumn 42, Issue 5, 2004, Pages 387-396

Hepatitis C-virus - Virus kinetics and resistance mechanisms;Hepatitis-C-virus - Viruskinetik und resistenzmechanismen

Author keywords

E2; Hepatitis C; Interferon ; ISDR; Mutations; NS3; NS4A; NS5A; Resistance mechanism; Viral kinetics

Indexed keywords

AMANTADINE; ANTIVIRUS AGENT; ENZYME INHIBITOR; INTERFERON; NUCLEOSIDE DERIVATIVE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN;

EID: 2642536919     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-813128     Document Type: Review
Times cited : (5)

References (95)
  • 1
    • 0032547938 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
    • Hepatitis Interventional Therapy Group
    • McHutchison JG, Gordon SC, Schiff ER et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 1998; 339: 1485-1492
    • (1998) N Engl J Med , vol.339 , pp. 1485-1492
    • McHutchison, J.G.1    Gordon, S.C.2    Schiff, E.R.3
  • 2
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns MP, McHutchison JG, Gordon SC et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-965
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 3
    • 0032585237 scopus 로고    scopus 로고
    • Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
    • International Hepatitis Interventional Therapy Group (IHIT)
    • Poynard T, Marcellin P, Lee SS et al. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT). Lancet 1998; 352: 1426-1432
    • (1998) Lancet , vol.352 , pp. 1426-1432
    • Poynard, T.1    Marcellin, P.2    Lee, S.S.3
  • 4
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-982
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 5
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon alfa2a (40 kD) and ribavirin combination therapy in chronic hepatitis C: A randomized study of the effect of treatment duration and ribavirin dose
    • Hadziyannis SJ, Dunant H, Sette HJ et al. Peginterferon alfa2a (40 kD) and ribavirin combination therapy in chronic hepatitis C: a randomized study of the effect of treatment duration and ribavirin dose. Ann Intern Med 2004; 140: 346-355
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Dunant, H.2    Sette, H.J.3
  • 6
    • 0028905430 scopus 로고
    • Variability of hepatitis C virus
    • Simmonds P. Variability of hepatitis C virus. Hepatology 1995; 21: 570-583
    • (1995) Hepatology , vol.21 , pp. 570-583
    • Simmonds, P.1
  • 7
    • 0030039045 scopus 로고    scopus 로고
    • Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo
    • Zeuzem S, Schmidt JM, Lee JH et al. Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo. Hepatology 1996; 23: 366-371
    • (1996) Hepatology , vol.23 , pp. 366-371
    • Zeuzem, S.1    Schmidt, J.M.2    Lee, J.H.3
  • 8
    • 0031009603 scopus 로고    scopus 로고
    • Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa
    • Lam NP, Neumann AU, Gretch DR et al. Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa. Hepatology 1997; 26: 226-231
    • (1997) Hepatology , vol.26 , pp. 226-231
    • Lam, N.P.1    Neumann, A.U.2    Gretch, D.R.3
  • 9
    • 0031807791 scopus 로고    scopus 로고
    • Hepatitis C virus dynamics in vivo: Effect of ribavirin and interferon alfa on viral turnover
    • Zeuzem S, Schmidt JM, Lee JH et al. Hepatitis C virus dynamics in vivo: effect of ribavirin and interferon alfa on viral turnover. Hepatology 1998; 28: 245-252
    • (1998) Hepatology , vol.28 , pp. 245-252
    • Zeuzem, S.1    Schmidt, J.M.2    Lee, J.H.3
  • 10
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • Neumann AU, Lam NP, Dahari H et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 1998; 282: 103-107
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3
  • 11
    • 0030094066 scopus 로고    scopus 로고
    • Fluctuations in viral load (HCV RNA) are relatively insignificant in untreated patients with chronic HCV infection
    • Nguyen TT, Sedghi-Vaziri A, Wilkes LB et al. Fluctuations in viral load (HCV RNA) are relatively insignificant in untreated patients with chronic HCV infection. J Viral Hepat 1996; 3: 75-78
    • (1996) J Viral Hepat , vol.3 , pp. 75-78
    • Nguyen, T.T.1    Sedghi-Vaziri, A.2    Wilkes, L.B.3
  • 12
    • 0037806029 scopus 로고    scopus 로고
    • Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon
    • Herrmann E, Lee JH, Marinos G et al. Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon. Hepatology 2003; 37: 1351-1358
    • (2003) Hepatology , vol.37 , pp. 1351-1358
    • Herrmann, E.1    Lee, J.H.2    Marinos, G.3
  • 13
    • 0000218138 scopus 로고    scopus 로고
    • Clinical implications of a new triphasic model of hepatitis C viral kinetics during IFN-alpha therapy
    • Bergmann C, Layden JE, Levy-Drummer RS et al. Clinical implications of a new triphasic model of hepatitis C viral kinetics during IFN-alpha therapy. Hepatology 2001; 33 (Suppl): 345A
    • (2001) Hepatology , vol.33 , Issue.SUPPL.
    • Bergmann, C.1    Layden, J.E.2    Levy-Drummer, R.S.3
  • 14
    • 0041764925 scopus 로고    scopus 로고
    • Dynamics of alanine aminotransferase during hepatitis C virus treatment
    • Ribeiro RM, Layden-Almer J, Powers KA et al. Dynamics of alanine aminotransferase during hepatitis C virus treatment. Hepatology 2003; 38: 509-517
    • (2003) Hepatology , vol.38 , pp. 509-517
    • Ribeiro, R.M.1    Layden-Almer, J.2    Powers, K.A.3
  • 15
    • 0041317673 scopus 로고    scopus 로고
    • Modeling viral and drug kinetics: Hepatitis C virus treatment with pegylated interferon alfa-2b
    • Powers KA, Dixit NM, Ribeiro RM et al. Modeling viral and drug kinetics: hepatitis C virus treatment with pegylated interferon alfa-2b. Semin Liver Dis 2003; 23 (Suppl 1): 13-18
    • (2003) Semin Liver Dis , vol.23 , Issue.SUPPL. 1 , pp. 13-18
    • Powers, K.A.1    Dixit, N.M.2    Ribeiro, R.M.3
  • 16
    • 0038185313 scopus 로고    scopus 로고
    • Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line
    • Zhu H, Zhao H, Collins CD et al. Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line. Hepatology 2003; 37: 1180-1188
    • (2003) Hepatology , vol.37 , pp. 1180-1188
    • Zhu, H.1    Zhao, H.2    Collins, C.D.3
  • 17
    • 0035859916 scopus 로고    scopus 로고
    • Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system
    • Chung RT, He W, Saquib A et al. Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system. Proc Natl Acad Sci U S A 2001; 98: 9847-9852
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9847-9852
    • Chung, R.T.1    He, W.2    Saquib, A.3
  • 18
    • 0033914625 scopus 로고    scopus 로고
    • Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus
    • Neumann AU, Lam NP, Dahari H et al. Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus. J Infect Dis 2000; 182: 28-35
    • (2000) J Infect Dis , vol.182 , pp. 28-35
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3
  • 19
    • 0036378296 scopus 로고    scopus 로고
    • Induction therapy with consensus interferon (CIFN) does not improve sustained virologic response in chronic hepatitis C
    • Layden TJ, Layden JE, Reddy KR et al. Induction therapy with consensus interferon (CIFN) does not improve sustained virologic response in chronic hepatitis C. J Viral Hepat 2002; 9: 334-339
    • (2002) J Viral Hepat , vol.9 , pp. 334-339
    • Layden, T.J.1    Layden, J.E.2    Reddy, K.R.3
  • 20
    • 0036380991 scopus 로고    scopus 로고
    • First phase viral kinetic parameters as predictors of treatment response and their influence on the second phase
    • Layden JE, Layden TJ, Reddy KR et al. First phase viral kinetic parameters as predictors of treatment response and their influence on the second phase. J Viral Hepat 2002; 9: 340-345
    • (2002) J Viral Hepat , vol.9 , pp. 340-345
    • Layden, J.E.1    Layden, T.J.2    Reddy, K.R.3
  • 21
    • 0344643418 scopus 로고    scopus 로고
    • Early viral kinetics on treatment with pegylated interferon-alpha-2a in chronic hepatitis C virus genotype 1 infection
    • Jessner W, Stauber R, Hackl F et al. Early viral kinetics on treatment with pegylated interferon-alpha-2a in chronic hepatitis C virus genotype 1 infection. J Viral Hepat 2003; 10: 37-42
    • (2003) J Viral Hepat , vol.10 , pp. 37-42
    • Jessner, W.1    Stauber, R.2    Hackl, F.3
  • 22
    • 0035050182 scopus 로고    scopus 로고
    • Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha2a
    • Zeuzem S, Herrmann E, Lee JH et al. Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha2a. Gastroenterology 2001; 120: 1438-1447
    • (2001) Gastroenterology , vol.120 , pp. 1438-1447
    • Zeuzem, S.1    Herrmann, E.2    Lee, J.H.3
  • 23
    • 0141762689 scopus 로고    scopus 로고
    • Slow viral dynamics of hepatitis C virus genotype 4
    • Halfon P, Neumann AU, Bourliere M et al. Slow viral dynamics of hepatitis C virus genotype 4. J Viral Hepat 2003; 10: 351-353
    • (2003) J Viral Hepat , vol.10 , pp. 351-353
    • Halfon, P.1    Neumann, A.U.2    Bourliere, M.3
  • 24
    • 0036208536 scopus 로고    scopus 로고
    • Viral kinetics in genotype 1 chronic hepatitis C patients during therapy with 2 different doses of peginterferon alfa-2b plus ribavirin
    • Buti M, Sanchez-Avila F, Lurie Y et al. Viral kinetics in genotype 1 chronic hepatitis C patients during therapy with 2 different doses of peginterferon alfa-2b plus ribavirin. Hepatology 2002; 35: 930-936
    • (2002) Hepatology , vol.35 , pp. 930-936
    • Buti, M.1    Sanchez-Avila, F.2    Lurie, Y.3
  • 25
    • 0041317671 scopus 로고    scopus 로고
    • Pharmacokinetics of peginterferons
    • Zeuzem S, Welsch C, Herrmann E. Pharmacokinetics of peginterferons. Semin Liver Dis 2003; 23 (Suppl 1): 23-28
    • (2003) Semin Liver Dis , vol.23 , Issue.SUPPL. 1 , pp. 23-28
    • Zeuzem, S.1    Welsch, C.2    Herrmann, E.3
  • 26
    • 0001124802 scopus 로고    scopus 로고
    • Effect of intermittent interferon (IFN), daily IFN and IFN plus ribavirin induction therapy on hepatitis C virus (HCV) genotype 1b replication kinetics and clearance
    • Pawlotsky JM, Dahari H, Conrad A et al. Effect of intermittent interferon (IFN), daily IFN and IFN plus ribavirin induction therapy on hepatitis C virus (HCV) genotype 1b replication kinetics and clearance. Hepatology 1998; 28: 288A
    • (1998) Hepatology , vol.28
    • Pawlotsky, J.M.1    Dahari, H.2    Conrad, A.3
  • 27
    • 0000049360 scopus 로고    scopus 로고
    • Early prediction and mechanismen of the ribavirin/IFN - A dual therapy effect on chronic hepatitis C virus (HCV)
    • Neumann AU, Dahari H, Conrad A et al. Early prediction and mechanismen of the ribavirin/IFN-a dual therapy effect on chronic hepatitis C virus (HCV). Hepatology 1999; 30: 309A
    • (1999) Hepatology , vol.30
    • Neumann, A.U.1    Dahari, H.2    Conrad, A.3
  • 28
    • 0037280587 scopus 로고    scopus 로고
    • Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon
    • Lake-Bakaar G, Ruffini L, Kuzmic P. Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon. Dig Dis Sci 2003; 48: 126-139
    • (2003) Dig Dis Sci , vol.48 , pp. 126-139
    • Lake-Bakaar, G.1    Ruffini, L.2    Kuzmic, P.3
  • 29
    • 0038820380 scopus 로고    scopus 로고
    • Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin
    • Layden-Almer JE, Ribeiro RM, Wiley T et al. Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin. Hepatology 2003; 37: 1343-1350
    • (2003) Hepatology , vol.37 , pp. 1343-1350
    • Layden-Almer, J.E.1    Ribeiro, R.M.2    Wiley, T.3
  • 30
    • 0033667057 scopus 로고    scopus 로고
    • Einfluss von ribavirin auf die dynamik der hepatitis-C-virämie bei interferon-(-behandelten patienten mit response oder nonresponse
    • Berg T, Kaul T, Naumann U et al. Einfluss von Ribavirin auf die Dynamik der Hepatitis-C-Virämie bei Interferon-(-behandelten Patienten mit Response oder Nonresponse. Z Gastroenterol 2000; 38: 881-886
    • (2000) Z Gastroenterol , vol.38 , pp. 881-886
    • Berg, T.1    Kaul, T.2    Naumann, U.3
  • 31
    • 0034975914 scopus 로고    scopus 로고
    • Clearance kinetics of hepatitis C virus under different antiviral therapies
    • Torre F, Giusto R, Grasso A et al. Clearance kinetics of hepatitis C virus under different antiviral therapies. J Med Virol 2001; 64: 455-459
    • (2001) J Med Virol , vol.64 , pp. 455-459
    • Torre, F.1    Giusto, R.2    Grasso, A.3
  • 32
    • 0000674684 scopus 로고    scopus 로고
    • Safety, tolerability and antiviral effect of BILN 2061, a novel HCV serine protease inhibitor, after oral treatment over 2 days in patients with chronic hepatitis C genotype 1, with advanced liver fibrosis
    • Benhamou Y, Hinrichsen H, Sentjens R et al. Safety, tolerability and antiviral effect of BILN 2061, a novel HCV serine protease inhibitor, after oral treatment over 2 days in patients with chronic hepatitis C genotype 1, with advanced liver fibrosis. Hepatology 2002; 36: 304A
    • (2002) Hepatology , vol.36
    • Benhamou, Y.1    Hinrichsen, H.2    Sentjens, R.3
  • 33
    • 2642544814 scopus 로고    scopus 로고
    • First report on the antiviral efficacy of BILN 2061, a novel oral serine protease inhibitor, in patients with chronic hepatitis C genotype 1
    • in press
    • Hinrichsen H, Benhamou Y, Wedemeyer H et al. First report on the antiviral efficacy of BILN 2061, a novel oral serine protease inhibitor, in patients with chronic hepatitis C genotype 1. Gastroenterology 2004; 126: (in press)
    • (2004) Gastroenterology , vol.126
    • Hinrichsen, H.1    Benhamou, Y.2    Wedemeyer, H.3
  • 34
    • 0344201903 scopus 로고    scopus 로고
    • An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
    • Lamarre D, Anderson PC, Bailey M et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 2003; 426: 186-189
    • (2003) Nature , vol.426 , pp. 186-189
    • Lamarre, D.1    Anderson, P.C.2    Bailey, M.3
  • 35
    • 0037300878 scopus 로고    scopus 로고
    • New therapies on the horizon for hepatitis C: Re we close?
    • De Francesco R, Rice CM. New therapies on the horizon for hepatitis C: re we close? Clin Liver Dis 2003; 7: 211-242, xi
    • (2003) Clin Liver Dis , vol.7 , pp. 211-242
    • De Francesco, R.1    Rice, C.M.2
  • 36
    • 0032841858 scopus 로고    scopus 로고
    • Racial differences in responses to therapy with interferon in chronic hepatitis C
    • Consensus Interferon Study Group
    • Reddy KR, Hoofnagle JH, Tong MJ et al. Racial differences in responses to therapy with interferon in chronic hepatitis C. Consensus Interferon Study Group. Hepatology 1999; 30: 787-793
    • (1999) Hepatology , vol.30 , pp. 787-793
    • Reddy, K.R.1    Hoofnagle, J.H.2    Tong, M.J.3
  • 37
    • 0034322373 scopus 로고    scopus 로고
    • The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C
    • The International Hepatitis Interventional Therapy Group
    • McHutchison JG, Poynard T, Pianko S et al. The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C. The International Hepatitis Interventional Therapy Group. Gastroenterology 2000; 119: 1317-1323
    • (2000) Gastroenterology , vol.119 , pp. 1317-1323
    • McHutchison, J.G.1    Poynard, T.2    Pianko, S.3
  • 38
    • 0041317672 scopus 로고    scopus 로고
    • Viral kinetics in hepatitis C virus: Special patient populations
    • Layden-Almer JE, Layden TJ. Viral kinetics in hepatitis C virus: special patient populations. Semin Liver Dis 2003; 23 (Suppl 1): 29-33
    • (2003) Semin Liver Dis , vol.23 , Issue.SUPPL. 1 , pp. 29-33
    • Layden-Almer, J.E.1    Layden, T.J.2
  • 39
    • 0001399081 scopus 로고    scopus 로고
    • Interferon pharmacokinetics and host factors: Effects on hepatitis C genotype 1 viral kinetics during treatment with consensus interferon
    • Neumann AU, Reddy KR, Levy-Drummer RS et al. Interferon pharmacokinetics and host factors: Effects on hepatitis C genotype 1 viral kinetics during treatment with consensus interferon. Hepatology 2001; 34: 428A
    • (2001) Hepatology , vol.34
    • Neumann, A.U.1    Reddy, K.R.2    Levy-Drummer, R.S.3
  • 40
    • 0345505664 scopus 로고    scopus 로고
    • First phase hepatitis c viral kinetics in previous nonresponders patients
    • Cotler SJ, Layden JE, Neumann AU et al. First phase hepatitis c viral kinetics in previous nonresponders patients. J Viral Hepat 2003; 10: 43-49
    • (2003) J Viral Hepat , vol.10 , pp. 43-49
    • Cotler, S.J.1    Layden, J.E.2    Neumann, A.U.3
  • 41
    • 0037542993 scopus 로고    scopus 로고
    • Hepatitis C virus genotypes and hepatic fibrosis regulate 24-h decline of serum hepatitis C virus RNA during interferon therapy in patients with chronic hepatitis C
    • Karino Y, Toyota J, Sugawara M et al. Hepatitis C virus genotypes and hepatic fibrosis regulate 24-h decline of serum hepatitis C virus RNA during interferon therapy in patients with chronic hepatitis C. J Gastroenterol Hepatol 2003; 18: 404-410
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 404-410
    • Karino, Y.1    Toyota, J.2    Sugawara, M.3
  • 42
    • 0346874143 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) dynamics during HCV treatment in HCV/HIV coinfection
    • Torriani FJ, Ribeiro RM, Gilbert TL et al. Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) dynamics during HCV treatment in HCV/HIV coinfection. J Infect Dis 2003; 188: 1498-1507
    • (2003) J Infect Dis , vol.188 , pp. 1498-1507
    • Torriani, F.J.1    Ribeiro, R.M.2    Gilbert, T.L.3
  • 43
    • 1642499256 scopus 로고    scopus 로고
    • Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV
    • Talal AH, Shata MT, Markatou M et al. Virus Dynamics and Immune Responses During Treatment in Patients Coinfected With Hepatitis C and HIV. J Acquir Immune Defic Syndr 2004; 35: 103-113
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 103-113
    • Talal, A.H.1    Shata, M.T.2    Markatou, M.3
  • 44
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale MJ Jr, Korth MJ, Tang NM et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997; 230: 217-227
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale Jr., M.J.1    Korth, M.J.2    Tang, N.M.3
  • 45
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • Taylor DR, Shi ST, Romano PR et al. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 1999; 285: 107-110
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3
  • 46
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E, Li K, Wang C et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003; 300: 1145-1148
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3
  • 47
    • 0035148472 scopus 로고    scopus 로고
    • Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain
    • Taylor DR, Tian B, Romano PR et al. Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain. J Virol 2001; 75: 1265-1273
    • (2001) J Virol , vol.75 , pp. 1265-1273
    • Taylor, D.R.1    Tian, B.2    Romano, P.R.3
  • 48
    • 17144463221 scopus 로고    scopus 로고
    • Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation
    • Gale M Jr, Blakely CM, Kwieciszewski B et al. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol 1998; 18: 5208-5218
    • (1998) Mol Cell Biol , vol.18 , pp. 5208-5218
    • Gale Jr., M.1    Blakely, C.M.2    Kwieciszewski, B.3
  • 49
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto N, Sakuma I, Asahina Y et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334: 77-81
    • (1996) N Engl J Med , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 50
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • Enomoto N, Sakuma I, Asahina Y et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224-230
    • (1995) J Clin Invest , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 51
    • 0031042869 scopus 로고    scopus 로고
    • Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy
    • Kurosaki M, Enomoto N, Murakami T et al. Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy. Hepatology 1997; 25: 750-753
    • (1997) Hepatology , vol.25 , pp. 750-753
    • Kurosaki, M.1    Enomoto, N.2    Murakami, T.3
  • 52
    • 0031433238 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection
    • Komatsu H, Fujisawa T, Inui A et al. Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection. J Med Virol 1997; 53: 361-365
    • (1997) J Med Virol , vol.53 , pp. 361-365
    • Komatsu, H.1    Fujisawa, T.2    Inui, A.3
  • 53
    • 0031050892 scopus 로고    scopus 로고
    • Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection
    • Chayama K, Tsubota A, Kobayashi M et al. Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection. Hepatology 1997; 25: 745-749
    • (1997) Hepatology , vol.25 , pp. 745-749
    • Chayama, K.1    Tsubota, A.2    Kobayashi, M.3
  • 54
    • 0031056446 scopus 로고    scopus 로고
    • Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa
    • Zeuzem S, Lee JH, Roth WK. Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology 1997; 25: 740-744
    • (1997) Hepatology , vol.25 , pp. 740-744
    • Zeuzem, S.1    Lee, J.H.2    Roth, W.K.3
  • 55
    • 18344402297 scopus 로고    scopus 로고
    • Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients
    • Khorsi H, Castelain S, Wyseur A et al. Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients. J Hepatol 1997; 27: 72-77
    • (1997) J Hepatol , vol.27 , pp. 72-77
    • Khorsi, H.1    Castelain, S.2    Wyseur, A.3
  • 56
    • 0030753738 scopus 로고    scopus 로고
    • Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa
    • Squadrito G, Leone F, Sartori M et al. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa. Gastroenterology 1997; 113: 567-572
    • (1997) Gastroenterology , vol.113 , pp. 567-572
    • Squadrito, G.1    Leone, F.2    Sartori, M.3
  • 57
    • 0031851835 scopus 로고    scopus 로고
    • Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment
    • Odeberg J, Yun Z, Sonnerborg A et al. Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment. J Med Virol 1998; 56: 33-38
    • (1998) J Med Virol , vol.56 , pp. 33-38
    • Odeberg, J.1    Yun, Z.2    Sonnerborg, A.3
  • 58
    • 0032791543 scopus 로고    scopus 로고
    • Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus
    • Chung RT, Monto A, Dienstag JL et al. Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus. J Med Virol 1999; 58: 353-358
    • (1999) J Med Virol , vol.58 , pp. 353-358
    • Chung, R.T.1    Monto, A.2    Dienstag, J.L.3
  • 59
    • 1842327408 scopus 로고    scopus 로고
    • Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
    • Hofgärtner WT, Polyak SJ, Sullivan DG et al. Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b. J Med Virol 1997; 53: 118-126
    • (1997) J Med Virol , vol.53 , pp. 118-126
    • Hofgärtner, W.T.1    Polyak, S.J.2    Sullivan, D.G.3
  • 60
    • 0033996227 scopus 로고    scopus 로고
    • The NS5 a gene of hepatitis C virus in patients treated with interferon-alpha
    • McKechnie VM, Mills PR, McCruden EA. The NS5 a gene of hepatitis C virus in patients treated with interferon-alpha. J Med Virol 2000; 60: 367-378
    • (2000) J Med Virol , vol.60 , pp. 367-378
    • McKechnie, V.M.1    Mills, P.R.2    McCruden, E.A.3
  • 61
    • 0031923838 scopus 로고    scopus 로고
    • Interferon resistance of hepatitis C virus genotype 1b: Relationship to nonstructural 5A gene quasispecies mutations
    • Pawlotsky KM, Germanidis G, Neumann AU et al. Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations. J Virol 1998; 72: 2795-2805
    • (1998) J Virol , vol.72 , pp. 2795-2805
    • Pawlotsky, K.M.1    Germanidis, G.2    Neumann, A.U.3
  • 62
    • 0035215781 scopus 로고    scopus 로고
    • Statistical analysis of combined substitutions in nonstructural 5A region of hepatitis C virus and interferon response
    • Witherell GW, Beineke P. Statistical analysis of combined substitutions in nonstructural 5A region of hepatitis C virus and interferon response. J Med Virol 2001; 63: 8-16
    • (2001) J Med Virol , vol.63 , pp. 8-16
    • Witherell, G.W.1    Beineke, P.2
  • 63
    • 0033063520 scopus 로고    scopus 로고
    • Improved correlation between multiple mutations within the NS5A region and virological response in European patients chronically infected with hepatitis C virus type 1b undergoing combination therapy
    • Sarrazin C, Berg T, Lee JH et al. Improved correlation between multiple mutations within the NS5A region and virological response in European patients chronically infected with hepatitis C virus type 1b undergoing combination therapy. J Hepatol 1999; 30: 1004-1013
    • (1999) J Hepatol , vol.30 , pp. 1004-1013
    • Sarrazin, C.1    Berg, T.2    Lee, J.H.3
  • 64
    • 0034101768 scopus 로고    scopus 로고
    • Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response
    • Sarrazin C, Berg T, Lee JH et al. Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response. J Infect Dis 2000; 181: 432-441
    • (2000) J Infect Dis , vol.181 , pp. 432-441
    • Sarrazin, C.1    Berg, T.2    Lee, J.H.3
  • 65
    • 0031958483 scopus 로고    scopus 로고
    • The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus
    • Saiz JC, Lopez-Labrador FX, Ampurdanes S et al. The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus. J Infect Dis 1998; 177: 839-847
    • (1998) J Infect Dis , vol.177 , pp. 839-847
    • Saiz, J.C.1    Lopez-Labrador, F.X.2    Ampurdanes, S.3
  • 66
    • 0031836249 scopus 로고    scopus 로고
    • Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity
    • Duverlie G, Khorsi H, Castelain S et al. Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity. J Gen Virol 1998; 79: 1373-1381
    • (1998) J Gen Virol , vol.79 , pp. 1373-1381
    • Duverlie, G.1    Khorsi, H.2    Castelain, S.3
  • 67
    • 0033807806 scopus 로고    scopus 로고
    • Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy
    • Nousbaum J, Polyak SJ, Ray SC et al. Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy. J Virol 2000; 74: 9028-9038
    • (2000) J Virol , vol.74 , pp. 9028-9038
    • Nousbaum, J.1    Polyak, S.J.2    Ray, S.C.3
  • 68
    • 0036839175 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein and interferon resistance: A new model for testing the reliability of mutational analyses
    • Sarrazin C, Herrmann E, Bruch K et al. Hepatitis C virus nonstructural 5A protein and interferon resistance: a new model for testing the reliability of mutational analyses. J Virol 2002; 76: 11079-11090
    • (2002) J Virol , vol.76 , pp. 11079-11090
    • Sarrazin, C.1    Herrmann, E.2    Bruch, K.3
  • 69
    • 0032861258 scopus 로고    scopus 로고
    • Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection
    • Murakami T, Enomoto N, Kurosaki M et al. Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection. Hepatology 1999; 30: 1045-1053
    • (1999) Hepatology , vol.30 , pp. 1045-1053
    • Murakami, T.1    Enomoto, N.2    Kurosaki, M.3
  • 70
    • 0036117777 scopus 로고    scopus 로고
    • Amino acid substitutions in the nonstructural region 5A of hepatitis C virus genotypes 2a and 2b and its relation to viral load and response to interferon
    • Kobayashi M, Watanabe K, Ishigami M et al. Amino acid substitutions in the nonstructural region 5A of hepatitis C virus genotypes 2a and 2b and its relation to viral load and response to interferon. Am J Gastroenterol 2002; 97: 988-998
    • (2002) Am J Gastroenterol , vol.97 , pp. 988-998
    • Kobayashi, M.1    Watanabe, K.2    Ishigami, M.3
  • 71
    • 0034116306 scopus 로고    scopus 로고
    • Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response
    • Sarrazin C, Kornetzky I, Rüster B et al. Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response. Hepatology 2000; 31: 1360-1370
    • (2000) Hepatology , vol.31 , pp. 1360-1370
    • Sarrazin, C.1    Kornetzky, I.2    Rüster, B.3
  • 72
    • 0031958483 scopus 로고    scopus 로고
    • The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus
    • Saiz JC, Lopez-Labrador FX, Ampurdanes S et al. The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus. J Infect Dis 1998; 177: 839-847
    • (1998) J Infect Dis , vol.177 , pp. 839-847
    • Saiz, J.C.1    Lopez-Labrador, F.X.2    Ampurdanes, S.3
  • 73
    • 0034598914 scopus 로고    scopus 로고
    • Hepatitis C virus, the E2 envelope protein, and alpha-interferon resistance
    • Abid K, Quadri R, Negro F. Hepatitis C virus, the E2 envelope protein, and alpha-interferon resistance. Science 2000; 287: 1555
    • (2000) Science , vol.287 , pp. 1555
    • Abid, K.1    Quadri, R.2    Negro, F.3
  • 74
    • 0033837013 scopus 로고    scopus 로고
    • The protein kinase-interacting domain in the hepatitis C virus envelope glycoprotein-2 gene is highly conserved in genotype 1-infected patients treated with interferon
    • Polyak SJ, Nousbaum JB, Larson AM et al. The protein kinase-interacting domain in the hepatitis C virus envelope glycoprotein-2 gene is highly conserved in genotype 1-infected patients treated with interferon. J Infect Dis 2000; 182: 397-404
    • (2000) J Infect Dis , vol.182 , pp. 397-404
    • Polyak, S.J.1    Nousbaum, J.B.2    Larson, A.M.3
  • 75
    • 0035840801 scopus 로고    scopus 로고
    • Quasispecies heterogeneity of the carboxy-terminal part of the E2 gene including the PePHD and sensitivity of hepatitis C virus 1b isolates to antiviral therapy
    • Sarrazin C, Bruckner M, Herrmann E et al. Quasispecies heterogeneity of the carboxy-terminal part of the E2 gene including the PePHD and sensitivity of hepatitis C virus 1b isolates to antiviral therapy. Virology 2001; 289: 150-163
    • (2001) Virology , vol.289 , pp. 150-163
    • Sarrazin, C.1    Bruckner, M.2    Herrmann, E.3
  • 76
    • 0033653568 scopus 로고    scopus 로고
    • Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment
    • Berg T, Mas MA, Hohne M et al. Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment. Hepatology 2000; 32: 1386-1395
    • (2000) Hepatology , vol.32 , pp. 1386-1395
    • Berg, T.1    Mas, M.A.2    Hohne, M.3
  • 77
    • 0038649813 scopus 로고    scopus 로고
    • Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b
    • Saito T, Ito T, Ishiko H et al. Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b. Am J Gastroenterol 2003; 98: 1377-1383
    • (2003) Am J Gastroenterol , vol.98 , pp. 1377-1383
    • Saito, T.1    Ito, T.2    Ishiko, H.3
  • 78
    • 0141615503 scopus 로고    scopus 로고
    • Amino acid substitutions in PKR-elF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy
    • Watanabe H, Nagayama K, Enomoto N et al. Amino acid substitutions in PKR-elF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy. Hepatol Res 2003; 26: 268-274
    • (2003) Hepatol Res , vol.26 , pp. 268-274
    • Watanabe, H.1    Nagayama, K.2    Enomoto, N.3
  • 79
    • 0037443853 scopus 로고    scopus 로고
    • Mutations within the CD81-binding sites and hypervariable region 2 of the envelope 2 protein: Correlation with treatment response in hepatitis C virus-infected patients
    • Hofmann WP, Sarrazin C, Kronenberger B et al. Mutations within the CD81-binding sites and hypervariable region 2 of the envelope 2 protein: correlation with treatment response in hepatitis C virus-infected patients. J Infect Dis 2003; 187: 982-987
    • (2003) J Infect Dis , vol.187 , pp. 982-987
    • Hofmann, W.P.1    Sarrazin, C.2    Kronenberger, B.3
  • 80
    • 0034463295 scopus 로고    scopus 로고
    • Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon
    • Gerotto M, Dal Pero F, Pontisso P et al. Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon. Gastroenterology 2000; 119: 1649-1655
    • (2000) Gastroenterology , vol.119 , pp. 1649-1655
    • Gerotto, M.1    Dal Pero, F.2    Pontisso, P.3
  • 81
    • 0036277038 scopus 로고    scopus 로고
    • Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection
    • Murphy MD, Rosen HR, Marousek GI et al. Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection. Dig Dis Sci 2002; 47: 1195-1205
    • (2002) Dig Dis Sci , vol.47 , pp. 1195-1205
    • Murphy, M.D.1    Rosen, H.R.2    Marousek, G.I.3
  • 82
    • 0030663221 scopus 로고    scopus 로고
    • Nucleotide sequence variations in the internal ribosome entry site of hepatitis C virus-1b: No association with efficacy of interferon therapy or serum HCV-RNA levels
    • Yamamoto C, Enomoto N, Kurosaki M et al. Nucleotide sequence variations in the internal ribosome entry site of hepatitis C virus-1b: no association with efficacy of interferon therapy or serum HCV-RNA levels. Hepatology 1997; 26: 1616-1620
    • (1997) Hepatology , vol.26 , pp. 1616-1620
    • Yamamoto, C.1    Enomoto, N.2    Kurosaki, M.3
  • 83
    • 0033379678 scopus 로고    scopus 로고
    • Relationship between the effect of interferon therapy and the change of hepatitis C virus non-structural 5B gene
    • Horiike N, Michitaka K, Masumoto T et al. Relationship between the effect of interferon therapy and the change of hepatitis C virus non-structural 5B gene. J Gastroenterol Hepatol 1999; 14: 345-351
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 345-351
    • Horiike, N.1    Michitaka, K.2    Masumoto, T.3
  • 84
    • 0031683453 scopus 로고    scopus 로고
    • Relationship between interferon therapy and variability in nonstructural gene 5b of hepatitis C virus
    • Tao Q, Wei L, Chang J et al. Relationship between interferon therapy and variability in nonstructural gene 5b of hepatitis C virus. J Gastroenterol 1998; 33: 684-693
    • (1998) J Gastroenterol , vol.33 , pp. 684-693
    • Tao, Q.1    Wei, L.2    Chang, J.3
  • 85
    • 2642582387 scopus 로고    scopus 로고
    • Detection of mutations necessary for HCV replication in the in vitro replicon system in patients with chronic hepatitis C
    • Sarrazin C, Mihm U, Schönberger B et al. Detection of mutations necessary for HCV replication in the in vitro replicon system in patients with chronic hepatitis C. Journal of Hepatology 2003; 38 (Suppl 2): 169A
    • (2003) Journal of Hepatology , vol.38 , Issue.SUPPL. 2
    • Sarrazin, C.1    Mihm, U.2    Schönberger, B.3
  • 86
    • 0032738989 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response
    • Paterson M, Laxton CD, Thomas HC et al. Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response. Gastroenterology 1999; 117: 1187-1197
    • (1999) Gastroenterology , vol.117 , pp. 1187-1197
    • Paterson, M.1    Laxton, C.D.2    Thomas, H.C.3
  • 87
    • 0032899696 scopus 로고    scopus 로고
    • Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
    • Polyak SJ, Paschal DM, McArdle S et al. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication. Hepatology 1999; 29: 1262-1271
    • (1999) Hepatology , vol.29 , pp. 1262-1271
    • Polyak, S.J.1    Paschal, D.M.2    McArdle, S.3
  • 88
    • 0032921272 scopus 로고    scopus 로고
    • The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon
    • Song J, Fujii M, Wang F et al. The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon. J Gen Virol 1999; 80 (Pt 4): 879-886
    • (1999) J Gen Virol , vol.80 , Issue.PART 4 , pp. 879-886
    • Song, J.1    Fujii, M.2    Wang, F.3
  • 89
    • 0242422098 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis
    • Francois C, Duverlie G, Rebouillat D et al. Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis. J Virol 2000; 74: 5587-5596
    • (2000) J Virol , vol.74 , pp. 5587-5596
    • Francois, C.1    Duverlie, G.2    Rebouillat, D.3
  • 90
    • 0034969251 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    • Polyak SJ, Khabar KS, Paschal DM et al. Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J Virol 2001; 75: 6095-6106
    • (2001) J Virol , vol.75 , pp. 6095-6106
    • Polyak, S.J.1    Khabar, K.S.2    Paschal, D.M.3
  • 91
    • 1942535074 scopus 로고    scopus 로고
    • Correlation of serum IL8 levels with virologic response to antiviral therapy in patients with chronic hepatitis C
    • Mihm U, Hermann E, Sarrazin U et al. Correlation of serum IL8 levels with virologic response to antiviral therapy in patients with chronic hepatitis C. J Hepatol 2004; 40: 845-852
    • (2004) J Hepatol , vol.40 , pp. 845-852
    • Mihm, U.1    Hermann, E.2    Sarrazin, U.3
  • 92
    • 0031862855 scopus 로고    scopus 로고
    • Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
    • Moradpour D, Kary P, Rice CM et al. Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins. Hepatology 1998; 28: 192-201
    • (1998) Hepatology , vol.28 , pp. 192-201
    • Moradpour, D.1    Kary, P.2    Rice, C.M.3
  • 93
    • 0032824134 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway
    • Heim MH, Moradpour D, Blum HE. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J Virol 1999; 73: 8469-8475
    • (1999) J Virol , vol.73 , pp. 8469-8475
    • Heim, M.H.1    Moradpour, D.2    Blum, H.E.3
  • 94
    • 0037621934 scopus 로고    scopus 로고
    • Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice
    • Blindenbacher A, Duong FH, Hunziker L et al. Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology 2003; 124: 1465-1475
    • (2003) Gastroenterology , vol.124 , pp. 1465-1475
    • Blindenbacher, A.1    Duong, F.H.2    Hunziker, L.3
  • 95
    • 0346100572 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
    • Duong FH, Filipowicz M, Tripodi M et al. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 2004; 126: 263-277
    • (2004) Gastroenterology , vol.126 , pp. 263-277
    • Duong, F.H.1    Filipowicz, M.2    Tripodi, M.3


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