Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon

Gastroenterology

Volumn 119, Issue 6, 2000, Pages 1649-1655

  Gerotto, Martina ^a   Dal Pero, Francesca ^a   Pontisso, Patrizia ^a   Noventa, Franco ^a   Gatta, Angelo ^a   Alberti, Alfredo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; COMPLEMENTARY DNA; MUTANT PROTEIN; PROTEIN KINASE; VIRUS PROTEIN; VIRUS RNA;

ADULT; ARTICLE; BINDING SITE; CLINICAL ARTICLE; DNA SEQUENCE; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MALE; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; PR INTERVAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; VIREMIA;

EID: 0034463295     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.20230     Document Type: Article

References (31)

1. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
2. Natural history of hepatitis C
3. The natural history of community-acquired hepatitis C in the United States
4. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
5. The pattern of response to interferon alpha (α-IFN) predicts sustained response to a 6 month α-IFN and ribavirin retreatment for chronic hepatitis C
6. Detection of hepatitis C virus by polymerase chain reaction and response to interferon alpha-therapy: Relationship to genotypes of hepatitis C virus
7. Hepatitis C genotypes: An investigation of type-specific differences in geographic origin and disease
8. The effect of interferon alpha and ribavirin combination therapy in naive patients with chronic hepatitis C
9. Comparison of full-length sequence of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A gene
10. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
11. Mutations in the non-structural 5A gene in chronic hepatitis C virus infected patients with interferon treatment
12. Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection
13. Why is the interferon sensitivity determining region (ISDR) system useful in Japan?
14. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
15. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation
16. Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis
17. Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alpha therapy in French patients
18. Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alpha
19. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alpha
20. Long-term response to interferon alpha is unrelated to "interferon sensitivity determining region" variability in patients with chronic hepatitis C virus-1b infection
21. Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
22. Mutations in the NS5A region do not predict interferon-responsiveness in American patients infected with genotype 1b hepatitis C virus
23. Inhibition of the interferon inducible protein kinase PKR by HCV E2 protein
24. Hepatitis C virus, the E2 envelope protein, and α-interferon resistance
25. Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response
26. Genotypes of hepatitis C virus in Italian patients with chronic hepatitis C
27. TREECON for Windows: A software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment
28. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
29. Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy
30. Improved correlation between multiple mutations within the NS5A region and virological response in European patients chronically infected with hepatitis C virus type 1b undergoing combination therapy
31. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis