Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection

Journal of Medical Virology

Volumn 53, Issue 4, 1997, Pages 361-365

  Komatsu, Haruki ^a   Fujisawa, Tomoo ^a   Inui, Ayano ^a   Miyagawa, Yoshihiro ^a   Onoue, Masahiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Acute leukemia; Blood transfusion; Children and adolescents; Direct sequencing; Polymerase chain reaction

Indexed keywords

ALPHA INTERFERON; GENE PRODUCT; NONSTRUCTURAL PROTEIN 5A; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ACUTE LEUKEMIA; ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ARTICLE; BLOOD TRANSFUSION; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; FEMALE; GENE MUTATION; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS C VIRUS 1B; HUMAN; IMMUNITY; MALE; VIRUS GENE; VIRUS STRAIN;

ADOLESCENT; ADULT; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; FEMALE; GENES, VIRAL; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; MALE; MUTATION; RNA, VIRAL; TREATMENT OUTCOME; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; HEPATITIS C VIRUS TYPE 1;

EID: 0031433238     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199712)53:4<361::AID-JMV8>3.0.CO;2-5     Document Type: Article

References (19)

1. Chomczynski P, Sacchi N (1987): Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162:156-159.
2. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, VanThiel DH, Tamburro C, Lefkowitch J, Albrecht J, Meschievitz C, Ortego TJ, Gibas A, Hepatitis Interventional Therapy Group (1989): Treatment of chronic hepatitis C with recombinant interferon alpha. New England Journal of Medicine 321:1501-1506.
3. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ (1994): Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology 19:1513-1520.
4. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Bank ST, Hoofnagle JH (1989): Recombinant interferon alpha therapy for chronic hepatitis C. A randomized double-blind, placebo controlled trial. New England Journal of Medicine 321:1506-1510.
5. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, Izumi N, Marumo F, Sato C (1996): Mutation in nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. New England Journal of Medicine 334:77-81.
6. Fujisawa T, Ohkawa T, Inui A, Yokota S (1994): Effect of interferon therapy on serum hepatitis C virus RNA levels in children with chronic hepatitis C. International Hepatology Communications 2: 316-320.
7. Fujisawa T, Inui A, Ohkawa T, Komatsu H, Miyakawa Y, Onoue M (1995): Response to interferon therapy in children with chronic hepatitis C. Journal of Pediatrics 127:660-662.
8. Garson JA, Brillanti S, Whiby K, Foli M, Deaville R, Masci C, Miglioli M, Barbara L (1995): Analysis of clinical and virological factors associated with response to alfa interferon therapy in chronic hepatitis C. Journal of Medical Virology 45:348-353.
9. Inui A, Fujisawa T, Komatsu H (1995): Rapid detection of hepatitis C virus by direct reverse transcription-polymerase chain reaction. International Hepatology Communications 3:126-130.
10. Ishiyama N, Katayama K, Ishimi N (1993): Quantitative detection of hepatitis C virus RNA by multicyclic RT-PCR. International Hepatology Communications 1:72-79.
11. Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ookoshi S, Sugimura T, Shimotohno K (1990): Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proceedings of the National Academy of Sciences of The United States of America 87:9524-9528.
12. Komatsu H, Fujisawa T, Inui A, Miyakawa Y, Onoue M, Sekine I, Hanada R, Yamamoto K (1996): Efficacy of interferon in treating chronic hepatitis C in children with a history of acute leukemia. Blood 87:4072-4075.
13. Mahaney K, Tedeschi V, Maertens G, Di Bisceglie A, Vergalla J, Hoofnagle JH, Richard S (1994): Genotypic analysis of hepatitis C virus in American patients. Hepatology 20:1405-1411.
14. Martinot-Peignoux M, Marcellin P, Pouteau M, Castelnau C, Boyer N, Poliquin M, Degott C, Descombes I, Breton VL, Milotova V, Benhamou JP, Erlinger S (1995): Pretreatment serum hepatitis C RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C. Hepatology 22:1050-1056.
15. Noubaum JB, Pol S, Nalpas B, Berthelot P, Brechot C (1995): Hepatitis C virus type 1b (II) infection in France and Italy. Annals of Internal Medicine 122:165-168.
16. Okamoto H, Okada S, Sugiyama Y, Tanaka T, Sugai Y, Akahane Y, Machida A, Mishiro S, Yoshizawa H, Miyakawa Y, Mayumi M (1990): Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region. Japanese Journal of Experimental Medicine 60:215-222.
17. Okamoto H, Sugiyama Y, Okada S, Kurai K Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y, Mayumi M (1992): Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources. Journal of General Virology 73:673-679.
18. Ruiz-Moreno M, Rua MJ, Castillo I, Garcia-Novo, Santos M, Navas S, Carreno V: Treatment of children with chronic hepatitis C with recombinant interferon-α (1992): A pilot study. Hepatology 16: 882-885.
19. Takada N, Takase S, Takada A, Date T (1993): Differences in the hepatitis C virus genotype in different countries. Journal of Hepatology 17:277-283.