메뉴 건너뛰기




Volumn 60, Issue 4, 2000, Pages 367-378

The NS5a gene of hepatitis C virus in patients treated with interferon- α

Author keywords

Hepatitis C virus; Nucleotide sequencing; Response to interferon therapy; Single stranded conformation polymorphism

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; VIRUS PROTEIN;

EID: 0033996227     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(200004)60:4<367::AID-JMV2>3.0.CO;2-6     Document Type: Article
Times cited : (30)

References (35)
  • 1
    • 0030928381 scopus 로고    scopus 로고
    • Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East
    • Chamberlain RW, Adams N, Saeed AA, Simmonds P, Elliott RM. 1997. Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East. J Gen Virol 78:1341-1347.
    • (1997) J Gen Virol , vol.78 , pp. 1341-1347
    • Chamberlain, R.W.1    Adams, N.2    Saeed, A.A.3    Simmonds, P.4    Elliott, R.M.5
  • 4
    • 0030885469 scopus 로고    scopus 로고
    • Factors predictive of a beneficial response to therapy of hepatitis C
    • Davis GL, Lau JY. 1997. Factors predictive of a beneficial response to therapy of hepatitis C. Hepatology 26:122S-127S.
    • (1997) Hepatology , vol.26
    • Davis, G.L.1    Lau, J.Y.2
  • 5
    • 0031836249 scopus 로고    scopus 로고
    • Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity
    • Duverlie G, Khorsi H, Castelain S, Jaillon O, Izopet J, Lunel F, Eb F, Penin F Wychowski C. 1998. Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity. J Gen Virol 79:1373-1381.
    • (1998) J Gen Virol , vol.79 , pp. 1373-1381
    • Duverlie, G.1    Khorsi, H.2    Castelain, S.3    Jaillon, O.4    Izopet, J.5    Lunel, F.6    Eb, F.7    Penin, F.8    Wychowski, C.9
  • 6
    • 0028358840 scopus 로고
    • Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis
    • Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C. 1994. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. J Gen Virol 75:361-369.
    • (1994) J Gen Virol , vol.75 , pp. 361-369
    • Enomoto, N.1    Kurosaki, M.2    Tanaka, Y.3    Marumo, F.4    Sato, C.5
  • 7
    • 0029161576 scopus 로고
    • Comparison of fulllength sequences of interferon-sensitive and resistant hepatitis C virus 1b: Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, Marumo F, Sato C. 1995. Comparison of fulllength sequences of interferon-sensitive and resistant hepatitis C virus 1b: sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 96:224-230.
    • (1995) J Clin Invest , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Izumi, N.7    Marumo, F.8    Sato, C.9
  • 9
    • 0030598899 scopus 로고    scopus 로고
    • Differences in hypervariable region 1 quasispecies of hepatitis C virus between human serum and peripheral blood mononuclear cells
    • Fujii K, Hino K, Okazaki M, Okuda M, Kondoh S, Okita K. 1996. Differences in hypervariable region 1 quasispecies of hepatitis C virus between human serum and peripheral blood mononuclear cells. Biochem Biophys Res Commun 225:771-776.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 771-776
    • Fujii, K.1    Hino, K.2    Okazaki, M.3    Okuda, M.4    Kondoh, S.5    Okita, K.6
  • 10
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale MJ Jr, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, Polyak SJ, Gretch DR, Katze MG. 1997. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230:217-227.
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale M.J., Jr.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 12
    • 0344765507 scopus 로고    scopus 로고
    • Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: A potential mechanism of interferon resistance
    • Gale MJ Jr., Korth MJ, Katze MG. 1998. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. Clin Diagn Virol 10:157-162.
    • (1998) Clin Diagn Virol , vol.10 , pp. 157-162
    • Gale M.J., Jr.1    Korth, M.J.2    Katze, M.G.3
  • 14
    • 0030250029 scopus 로고    scopus 로고
    • Predictive factors regarding the responsiveness to inteferon therapy for patients with chronic hepatitis C: An assessment of the hypervariable region 1 quasispecies in genotype 1b of chronic hepatitis C
    • Harada K, Watanabe H, Shijo H ,Okumura M. 1996. Predictive factors regarding the responsiveness to inteferon therapy for patients with chronic hepatitis C: an assessment of the hypervariable region 1 quasispecies in genotype 1b of chronic hepatitis C. Int Hepatol Commun 5:215-220.
    • (1996) Int Hepatol Commun , vol.5 , pp. 215-220
    • Harada, K.1    Watanabe, H.2    Shijo, H.3    Okumura, M.4
  • 15
    • 1842327408 scopus 로고    scopus 로고
    • Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
    • Hofgartner WT, Polyak SJ, Sullivan DG, Carithers RL Jr., Gretch DR. 1997. Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b. J Med Virol 53:118-126.
    • (1997) J Med Virol , vol.53 , pp. 118-126
    • Hofgartner, W.T.1    Polyak, S.J.2    Sullivan, D.G.3    Carithers R.L., Jr.4    Gretch, D.R.5
  • 16
    • 0030571476 scopus 로고    scopus 로고
    • Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A
    • Ide Y, Zhang L, Chen M, Inchauspe G, Bahl C, Sasaguri Y, Padmanabhan R. 1996. Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A. Gene 182:203-211.
    • (1996) Gene , vol.182 , pp. 203-211
    • Ide, Y.1    Zhang, L.2    Chen, M.3    Inchauspe, G.4    Bahl, C.5    Sasaguri, Y.6    Padmanabhan, R.7
  • 17
    • 0025787597 scopus 로고
    • Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with American and Japanese isolates
    • Inchauspe G, Zebedee S, Lee DH, Sugitani M, Nasoff M, Prince AM. 1991. Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc Natl Acad Sci USA 88:10292-10296.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10292-10296
    • Inchauspe, G.1    Zebedee, S.2    Lee, D.H.3    Sugitani, M.4    Nasoff, M.5    Prince, A.M.6
  • 20
    • 0024973417 scopus 로고
    • Avoiding false positives with PCR
    • Kwok S, Higuchi R. 1989. Avoiding false positives with PCR. Nature 339:237-238.
    • (1989) Nature , vol.339 , pp. 237-238
    • Kwok, S.1    Higuchi, R.2
  • 21
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
    • Martell M, Esteban JI, Quer J, Genesca J, Weiner A, Esteban R, Guardia J, Gomez J. 1992. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J Virol 66:3225-3229.
    • (1992) J Virol , vol.66 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6    Guardia, J.7    Gomez, J.8
  • 23
    • 0031923838 scopus 로고    scopus 로고
    • Interferon resistance of hepatitis C virus genotype 1b: Relationship to nonstructural 5A gene quasispecies mutations
    • Pawlotsky JM, Germanidis G, Neumann AU, Pellerin M, Frainais PO, Dhumeaux D. 1998. Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations. J Virol 72:2795-2805.
    • (1998) J Virol , vol.72 , pp. 2795-2805
    • Pawlotsky, J.M.1    Germanidis, G.2    Neumann, A.U.3    Pellerin, M.4    Frainais, P.O.5    Dhumeaux, D.6
  • 24
    • 0031050609 scopus 로고    scopus 로고
    • Quasispecies analysis in hepatitis C virus infection by fluorescent single strand conformation polymorphism
    • Peters T, Schlayer HJ, Hiller B, Rosler B, Blum H, Rasenack J. 1997. Quasispecies analysis in hepatitis C virus infection by fluorescent single strand conformation polymorphism. J Virol Methods 64:95-102.
    • (1997) J Virol Methods , vol.64 , pp. 95-102
    • Peters, T.1    Schlayer, H.J.2    Hiller, B.3    Rosler, B.4    Blum, H.5    Rasenack, J.6
  • 25
    • 0030828466 scopus 로고    scopus 로고
    • Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: Properties of the NS5A-associated kinase
    • Reed KE, Xu J, Rice CM. 1997. Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase. J Virol 71:7187-7197.
    • (1997) J Virol , vol.71 , pp. 7187-7197
    • Reed, K.E.1    Xu, J.2    Rice, C.M.3
  • 26
    • 0031958483 scopus 로고    scopus 로고
    • The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus
    • Saiz JC, Lopez-Labrador FX, Ampurdanes S, Dopazo J, Forns X, Sanchez-Tapias JM, Rodes J. 1998. The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus. J Infect Dis 177:839-847.
    • (1998) J Infect Dis , vol.177 , pp. 839-847
    • Saiz, J.C.1    Lopez-Labrador, F.X.2    Ampurdanes, S.3    Dopazo, J.4    Forns, X.5    Sanchez-Tapias, J.M.6    Rodes, J.7
  • 27
    • 0028216599 scopus 로고
    • Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a
    • Sakamoto M, Akahane Y, Tsuda F, Tanaka T, Woodfield DG, Okamoto H. 1994. Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a. J Gen Virol 75:1761-1768.
    • (1994) J Gen Virol , vol.75 , pp. 1761-1768
    • Sakamoto, M.1    Akahane, Y.2    Tsuda, F.3    Tanaka, T.4    Woodfield, D.G.5    Okamoto, H.6
  • 29
    • 0029908439 scopus 로고    scopus 로고
    • The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy
    • Shindo M, Hamada K, Koya S, Arai K, Sokawa Y, Okuno T. 1996. The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy. Hepatology 24:1018-1023.
    • (1996) Hepatology , vol.24 , pp. 1018-1023
    • Shindo, M.1    Hamada, K.2    Koya, S.3    Arai, K.4    Sokawa, Y.5    Okuno, T.6
  • 30
    • 0032921272 scopus 로고    scopus 로고
    • The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon
    • Song J, Fujii M, Wang F, Itoh M, Hotta H.1999. The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon. J Gen Virol 80:879-886
    • (1999) J Gen Virol , vol.80 , pp. 879-886
    • Song, J.1    Fujii, M.2    Wang, F.3    Itoh, M.4    Hotta, H.5
  • 31
    • 0030753738 scopus 로고    scopus 로고
    • Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa
    • Squadrito G, Leone F, Sartori M, Nalpas B, Berthelot P, Raimondo G, Pol S, Brechot C. 1997. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa. Gastroenterology 113:567-572.
    • (1997) Gastroenterology , vol.113 , pp. 567-572
    • Squadrito, G.1    Leone, F.2    Sartori, M.3    Nalpas, B.4    Berthelot, P.5    Raimondo, G.6    Pol, S.7    Brechot, C.8
  • 32
    • 0028978937 scopus 로고
    • Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A
    • Tanji Y, Kaneko T, Satoh S, Shimotohno K. 1995. Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol 69:3980-3986.
    • (1995) J Virol , vol.69 , pp. 3980-3986
    • Tanji, Y.1    Kaneko, T.2    Satoh, S.3    Shimotohno, K.4
  • 33
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM. 1999. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 285:107-110.
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.M.5
  • 34
    • 0030993616 scopus 로고    scopus 로고
    • Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus
    • Toyoda H, Fukada Y, Koyama Y, Takamatsu J, Saito H, Hayakawa T. 1997. Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus. J Hepataol 26: 975-982.
    • (1997) J Hepataol , vol.26 , pp. 975-982
    • Toyoda, H.1    Fukada, Y.2    Koyama, Y.3    Takamatsu, J.4    Saito, H.5    Hayakawa, T.6
  • 35
    • 0004071603 scopus 로고    scopus 로고
    • Genetics Computer Group (GCG) Madison, Wisconsin
    • Wisconsin Package Version 9.1. Genetics Computer Group (GCG) Madison, Wisconsin.
    • Wisconsin Package Version 9.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.