Astroglial trophic support and neuronal cell death: Influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 925-933

  Ohgoh, Makoto ^a   Shimizu, Hiroki ^a   Ogura, Hiroo ^a   Nishizawa, Yukio ^a  

^a EISAI CO LTD   (Japan)

Author keywords

3 Nitropropionic acid; Apoptosis; ATP; Caspase; Necrosis; Rat cortical neurons

Indexed keywords

3 NITROPROPIONIC ACID; CASPASE; DNA FRAGMENT;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; CELL ENERGY; CELL FUNCTION; CELL SURVIVAL; ENZYME ACTIVATION; MACROGLIA; MITOCHONDRION; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; ASTROCYTES; CASPASES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; ELECTRON TRANSPORT COMPLEX II; ENERGY METABOLISM; FETUS; MITOCHONDRIA; MULTIENZYME COMPLEXES; NEURONS; NEUROTOXINS; NITRO COMPOUNDS; OXIDOREDUCTASES; PROPIONIC ACIDS; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE;

EID: 0033844723     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0750925.x     Document Type: Article

References (26)

1. 3-Nitropropionate, the toxic substance of indigofera, is a suicide inactivator of succinate dehydrogenase
2. Does impairment of energy metabolism result in excitotoxic neuronal cell death in neurodegenerative illness?
3. Aging, energy, and oxidative stress in neurodegenerative disease
4. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
5. Glia modulate NMDA-mediated signaling in primary cultures of cerebellar granule cells
6. 3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons
7. Programmed cell death in the developing nervous system
8. Inactivation of succinate dehydrogenase by 3-nitropropionate
9. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
10. Energy and glutamate dependency of 3-nitropropionic acid neurotoxicity in culture
11. Mitochondria and apoptosis
12. Determination of pyridine dinucleotides in cell extracts by high-performance liquid chromatography
13. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
14. Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support
15. Local support cells promote survival of substantia nigra dopaminergic neurons in culture
16. Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture
17. Cell death during development of the nervous system
18. Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: Acute excitotoxic necrosis and delayed apoptosis
19. Evidence for apoptotic cell death in Huntington's disease and excitotoxic animal models
20. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex
21. Glutamate disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture
22. Evidence for apoptotic cell death in Alzheimer's disease
23. Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus
24. Mesencephalic type I astrocytes rescue dopaminergic neurons from death induced by serum deprivation
25. DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions
26. 3-Nitropropionic acid is an indirect excitotoxin to cultured cerebellar granule neurons