Inhibition of the canonical Wnt signaling pathway in cytoplasm: A novel property of the carboxyl terminal domains of two Xenopus ELL genes

Zoological Science

Volumn 21, Issue 4, 2004, Pages 407-416

  Sakurai, Kenji ^a   Michiue, Tatsuo ^b   Kikuchi, Akira ^c   Asashima, Makoto ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Dvl; ELL; Localization; Wnt; Xenopus

Indexed keywords

DISHEVELLED PROTEINS; DNA BINDING PROTEIN; ELL1 PROTEIN, XENOPUS; ELL2 PROTEIN, XENOPUS; MESSENGER RNA; PHOSPHOPROTEIN; PRIMER DNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR; XENOPUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; COMPARATIVE STUDY; CYTOPLASM; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; MICROINJECTION; MOLECULAR GENETICS; PHENOTYPE; PHYSIOLOGY; PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CYTOPLASM; DNA PRIMERS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PHOSPHOPROTEINS; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; XENOPUS; XENOPUS PROTEINS;

ANIMALIA; EUKARYOTA; VERTEBRATA;

EID: 2642513390     PISSN: 02890003     EISSN: None     Source Type: Journal    
DOI: 10.2108/zsj.21.407     Document Type: Article

References (55)

1. Amson RB, Nemani M, Roperch JP, Israeli D, Bougueleret L, Le Gall I, Medhioub M, Linares-Cruz G, Lethrosne F, Telerman A, et al. (1996) Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the Drosophila seven in absentia gene. Proc Natl Acad Sci USA 93: 3953-3957
2. Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I (2002) Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 16: 1066-1076
3. Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl M, Wedlich D, Birchmeier W (1998) Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β. Science 280: 596-599
4. Brannon M, Gomperts M, Sumoy L, Moon RT, Kimelman D (1997) A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev 11: 2359-2370
5. Cadigan KM, Nusse R (1997) Wnt signaling, a common theme in animal development. Genes Dev 11: 3286-3305
6. DiMartino JF, Miller T, Ayton PM, Landewe T, Hess JL, Cleary ML, Shilatifard A (2000) A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood 96: 3887-3893
7. Eissenberg JC, Ma J, Gerber MA, Christensen A, Kennison JA, Shilatifard A (2002) dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc Natl Acad Sci USA 99: 9894-9899
8. Farr GH III, Ferkey DM, Yost C, Pierce SB, Weaver C, Kimelman D (2000) Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol 48: 691-702
9. Fukui A, Kishida S, Kikuchi A, Asashima M (2000) Effects of rat Axin domains on axis formation in Xenopus embryos. Dev Growth Differ 42: 489-498
10. Funayama N, Fagotto F, McCrea P, Gumbiner BM (1995) Embryonic axis induction by the armadillo repeat domain of β-catenin: evidence for intracellular signaling. J Cell Biol 128: 959-968
11. Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, Perret C, Rubinfeld B, Margottin F, Benarous R, Polakis P (1999) The F-box protein beta-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell. Curr Biol 9:207-210
12. He X, Saint-Jeannet JP, Woodgett JR, Varmus HE, Dawid IB (1995) Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374: 617-622
13. Heasman J, Crawford A, Goldstone K, Garner-Hamrick P, Gumbiner B, McCrea P, Kintner C, Noro CY, Wylie C (1994) Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 79: 791-803
14. Heasman J, Kofron M, Wylie C (2000) β-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. Dev Biol 222: 124-134
15. Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl- binding protein. Mol Cell Biol 21: 330-342
16. Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin. EMBO J 17: 1371-1384
17. Kadoya T, Kishida S, Fukui A, Hinoi T, Michiue T, Asashima M, Kikuchi A (2000) Inhibition of Wnt signaling pathway by a novel axin-binding protein. J Biol Chem 275: 37030-37037
18. Kao KR, Elinson P (1988) The entire mesodermal mantle behaves as spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev Biol 127: 64-77
19. Khattak S, Im H, Park T, Ahnn J, Spoerel NA (2002) dELL, a drosophila homologue of transcription elongation factor ELL (Eleven-nineteen Lysine rich Leukemia), is required for early development. Cell Biochem Funct 20: 119-127
20. Kishida S, Yamamoto H, Ikeda S, Kishida M, Sakamoto I, Koyama S, Kikuchi A (1998) Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of β-catenin. J Biol Chem 273: 10823-10826
21. Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori K, Nakamichi I, Kikuchi A, Nakayama K, Nakayama K (1999) An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin. EMBO J 18: 2401-2410
22. Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT (1997) Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol 136: 1123-1136
23. Laurent MN, Blitz IL, Hashimoto C, Rothbacher U, Cho KW (1997) The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. Development 124: 4905-4916
24. Lemaire P, Garrett N, Gurdon JB (1995) Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell 81: 85-94
25. Li L, Yuan H, Weaver CD, Mao J, Farr GH III, Sussman DJ, Jonkers J Kimelman D, Wu D (1999) Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J 18: 4233-4240
26. Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N (2001) Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7: 927-936
27. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002) Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847
28. Luo RT, Lavau C, Du C, Simone F, Polak PE, Kawamata S, Thirman MJ (2001) The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Mol Cell Biol 21: 5678-5687
29. Luque CM, Correas I (2000) A constitutive region is responsible for nuclear targeting of 4.1R: modulation by alternative sequences results in differential intracellular localization. J Cell Sci 113: 2485-2495
30. Maki K, Mitani K, Yamagata T, Kurokawa M, Kanda Y, Yazaki Y, Hirai H (1999) Transcriptional inhibition of p53 by the MLL/MEN chimeric protein found in myeloid leukemia. Blood 93: 3216-3224
31. Miller JR, Rowning BA, Larabell CA, Yang-Snyder JA, Bates RL, Moon RT (1999) Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of Dishevelled that is dependent on cortical rotation. J Cell Biol 146:427-437
32. McKendry R, Hsu SC, Harland RM, Grosschedl R (1997) LEF-1/TCF proteins mediate Wnt-inducible transcription from the Xenopus nodal-related 3 promoter. Dev Biol 192: 420-431
33. Moon RT, Kimelman D (1998) From cortical rotation to organizer gene expression, toward a molecular explanation of axis specification in Xenopus. Bioessays 20: 536-545
34. Moon RT, Bowerman B, Boutros M, Perrimon N (2002) The promise and perils of Wnt signaling through beta-catenin. Science 296: 1644-1646
35. Niehrs C (1999) Head in the Wnt. The molecular nature of Spemann's head organizer. Trend Gen 15: 314-319
36. Peifer M, Polakis P (2000) Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287: 1606-1609
37. Peifer M, McEwen DG (2002) The ballet of morphogenesis: unveiling the hidden choreographers. Cell 109: 271-274
38. Peters JM, McKay RM, McKay JP, Graff JM (1999) Casein kinase I transduces Wnt signals. Nature 401: 345-350
39. Ren R, Mayer BJ, Cicchetti P, Baltimore D (1993) Identification of a ten-amino acid proline-rich SH3 binding site. Science 259: 1157-1161
40. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P (1996) Binding of GSKSβ to the APC-β-catenin complex and regulation of complex assembly. Science 272: 1023-1026
41. Rubnitz JE, Behm F, Curcio-Brint AM, Pinheiro RP, Carroll AJ, Raimondi SC, Shurtleff SA, Downing JR (1996) Molecular analysis of t(11;19) breakpoints in childhood acute leukemias. Blood 87: 4804-4808
42. Sakanaka C, Leong P, Xu L, Harrison, S. D. and Williams, L. T. (1999). Casein kinase le in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci USA 96: 12548-12552
43. Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM (1999) Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 283: 2089-2091
44. Shilatifard A, Lane WS, Jackson KW, Conaway RC, Conaway JW (1996) An RNA polymerase II elongation factor encoded by the human ELL gene. Science 271: 1873-1876
45. Shilatifard A, Haque D, Conaway RC, Conaway JW (1997) Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. J Biol Chem 272: 22355-22363
46. Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, Hatakeyama M (1999) Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J Biol Chem 274: 17003-17010
47. Sokol SY, Klingensmith J, Perrimon N, Itoh K (1995) Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development 121: 1637-1647
48. Sokol SY (1999) Wnt signaling and dorso-ventral axis specification in vertebrates. Curr Opin Genet Dev 9: 405-410
49. Taipale J, Beachy PA (2001) The Hedgehog and Wnt signaling pathways in cancer. Nature 411: 349-354
50. Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (1994) Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci USA 91: 12110-12114
51. Thirman MJ, Diskin EB, Bin SS, Ip HS, Miller JM, Simon MC (1997) Developmental analysis and subcellular localization of the murine homologue of ELL. Proc Natl Acad Sci USA 94: 1408-1413
52. Wallingford JB, Fraser SE, Harland RM (2002) Convergent extension: the molecular control of polarized cell movement during embryonic development. Dev Cell 2: 695-706
53. Wiederschain D, Kawai H, Gu J, Shilatifard A, Yuan ZM (2003) Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol 23: 4230-4246
54. Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman, D (1998) GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell 93: 1031-1041
55. Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner M, Costantini F (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90: 181-192