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Volumn 23, Issue 12, 2003, Pages 4230-4246

Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL

Author keywords

[No Author keywords available]

Indexed keywords

LEUKEMIC PROTEIN MLL ELL; PROTEIN; PROTEIN CBP; PROTEIN P21; PROTEIN P300; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 0037641280     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.12.4230-4246.2003     Document Type: Article
Times cited : (40)

References (31)
  • 1
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton, P. M., and M. L. Cleary. 2001. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 20:5695-5707.
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 2
    • 0032984992 scopus 로고    scopus 로고
    • Mechanisms of p53-mediated apoptosis
    • Bates, S., and K. H. Vousden. 1999. Mechanisms of p53-mediated apoptosis. Cell Mol. Life Sci. 55:28-37.
    • (1999) Cell Mol. Life Sci. , vol.55 , pp. 28-37
    • Bates, S.1    Vousden, K.H.2
  • 3
    • 0030905542 scopus 로고    scopus 로고
    • The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures
    • Butler, L. H., R. Slany, X. Cui, M. L. Cleary, and D. Y. Mason. 1997. The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures. Blood 89:3361-3370.
    • (1997) Blood , vol.89 , pp. 3361-3370
    • Butler, L.H.1    Slany, R.2    Cui, X.3    Cleary, M.L.4    Mason, D.Y.5
  • 4
    • 0034548830 scopus 로고    scopus 로고
    • A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL
    • DiMartino, J. F., T. Miller, P. M. Ayton, T. Landewe, J. L. Hess, M. L. Cleary, and A. Shilatifard. 2000. A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood 96:3887-3893.
    • (2000) Blood , vol.96 , pp. 3887-3893
    • DiMartino, J.F.1    Miller, T.2    Ayton, P.M.3    Landewe, T.4    Hess, J.L.5    Cleary, M.L.6    Shilatifard, A.7
  • 5
    • 0029859318 scopus 로고    scopus 로고
    • Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: Physical association is dependent on the E region of the orphan receptors
    • Downes, M., L. J. Burke, P. J. Bailey, and G. E. Muscat. 1996. Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors. Nucleic Acids Res. 24:4379-4386.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4379-4386
    • Downes, M.1    Burke, L.J.2    Bailey, P.J.3    Muscat, G.E.4
  • 6
    • 0036139122 scopus 로고    scopus 로고
    • Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines
    • Fleckenstein, D. S., C. C. Uphoff, H. G. Drexler, and H. Quentmeier. 2002. Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines. Leukoc. Res. 26:207-214.
    • (2002) Leukoc. Res. , vol.26 , pp. 207-214
    • Fleckenstein, D.S.1    Uphoff, C.C.2    Drexler, H.G.3    Quentmeier, H.4
  • 7
    • 0034900310 scopus 로고    scopus 로고
    • Identification of novel polymorphisms in intron 7 of the human p53 gene in acute myeloid leukemia and healthy donors
    • Graf, J., B. Merk, U. Maurer, E. Muller, and L. Bergmann. 2001. Identification of novel polymorphisms in intron 7 of the human p53 gene in acute myeloid leukemia and healthy donors. Leukoc. Lymphoma 41:655-658.
    • (2001) Leukoc. Lymphoma , vol.41 , pp. 655-658
    • Graf, J.1    Merk, B.2    Maurer, U.3    Muller, E.4    Bergmann, L.5
  • 8
    • 0034824495 scopus 로고    scopus 로고
    • p300/CBP/p53 interaction and regulation of the p53 response
    • Grossman, S. R. 2001. p300/CBP/p53 interaction and regulation of the p53 response. Eur. J. Biochem. 268:2773-2778.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 2773-2778
    • Grossman, S.R.1
  • 9
    • 0033956689 scopus 로고    scopus 로고
    • Identification of a sequence element from p53 that signals for Mdm2-targeted degradation
    • Gu, J., D. Chen, J. Rosenblum, R. M. Rubin, and Z. M. Yuan. 2000. Identification of a sequence element from p53 that signals for Mdm2-targeted degradation. Mol. Cell. Biol. 20:1243-1253.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1243-1253
    • Gu, J.1    Chen, D.2    Rosenblum, J.3    Rubin, R.M.4    Yuan, Z.M.5
  • 10
    • 0035196861 scopus 로고    scopus 로고
    • Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
    • Gu, J., L. Nie, D. Wiederschain, and Z. M. Yuan. 2001. Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. Mol. Cell. Biol. 21:8533-8546.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8533-8546
    • Gu, J.1    Nie, L.2    Wiederschain, D.3    Yuan, Z.M.4
  • 13
    • 0033541390 scopus 로고    scopus 로고
    • An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry
    • Kalejta, R. F., A. D. Brideau, B. W. Banfield, and A. J. Beavis. 1999. An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry. Exp. Cell Res. 248:322-328.
    • (1999) Exp. Cell Res. , vol.248 , pp. 322-328
    • Kalejta, R.F.1    Brideau, A.D.2    Banfield, B.W.3    Beavis, A.J.4
  • 14
    • 0032570592 scopus 로고    scopus 로고
    • Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Ratl cells with dependence on the lysine-rich region
    • Kanda, Y., K. Mitani, M. Kurokawa, T. Yamagata, Y. Yazaki, and H. Hirai. 1998. Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Ratl cells with dependence on the lysine-rich region. J. Biol. Chem. 273:5248-5252.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5248-5252
    • Kanda, Y.1    Mitani, K.2    Kurokawa, M.3    Yamagata, T.4    Yazaki, Y.5    Hirai, H.6
  • 15
    • 0031213756 scopus 로고    scopus 로고
    • Subcellular localization of the MEN, MLL/MEN and truncated MLL proteins expressed in leukemic cells carrying the t(11;19)(q23;p13.1) translocation
    • Kanda, Y., K. Mitani, T. Tanaka, K. Tanaka, S. Ogawa, Y. Yazaki, and H. Hirai. 1997. Subcellular localization of the MEN, MLL/MEN and truncated MLL proteins expressed in leukemic cells carrying the t(11;19)(q23;p13.1) translocation. Int. J. Hematol. 66:189-195.
    • (1997) Int. J. Hematol. , vol.66 , pp. 189-195
    • Kanda, Y.1    Mitani, K.2    Tanaka, T.3    Tanaka, K.4    Ogawa, S.5    Yazaki, Y.6    Hirai, H.7
  • 16
    • 0034718552 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
    • Lavau, C., R. T. Luo, C. Du, and M. J. Thirman. 2000. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Proc. Natl. Acad. Sci. USA 97:10984-10989.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10984-10989
    • Lavau, C.1    Luo, R.T.2    Du, C.3    Thirman, M.J.4
  • 17
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 19
    • 0034928761 scopus 로고    scopus 로고
    • The elongation domain of ELL is dispensable but its ELL-associated factor I interaction domain is essential for MLL-ELL-induced leukemogenesis
    • Luo, R. T., C. Lavau, C. Du, F. Simone, P. E. Polak, S. Kawamata, and M. J. Thirman. 2001. The elongation domain of ELL is dispensable but its ELL-associated factor I interaction domain is essential for MLL-ELL-induced leukemogenesis. Mol. Cell. Biol. 21:5678-5687.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5678-5687
    • Luo, R.T.1    Lavau, C.2    Du, C.3    Simone, F.4    Polak, P.E.5    Kawamata, S.6    Thirman, M.J.7
  • 20
    • 0033562638 scopus 로고    scopus 로고
    • Transcriptional inhibition of p53 by the MLL/MEN chimeric protein found in myeloid leukemia
    • Maki, K., K. Mitani, T. Yamagata, M. Kurokawa, Y. Kanda, Y. Yazaki, and H. Hirai. 1999. Transcriptional inhibition of p53 by the MLL/MEN chimeric protein found in myeloid leukemia. Blood 93:3216-3224.
    • (1999) Blood , vol.93 , pp. 3216-3224
    • Maki, K.1    Mitani, K.2    Yamagata, T.3    Kurokawa, M.4    Kanda, Y.5    Yazaki, Y.6    Hirai, H.7
  • 21
    • 0031898443 scopus 로고    scopus 로고
    • The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23; p13.3): A cytogenetic and clinical profile of 53 patients
    • Moorman, A. V., A. Hagemeijer, C. Charrin, H. Rieder, and L. M. Secker-Walker. 1998. The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23; p13.3): a cytogenetic and clinical profile of 53 patients. Leukemia 12:805-810.
    • (1998) Leukemia , vol.12 , pp. 805-810
    • Moorman, A.V.1    Hagemeijer, A.2    Charrin, C.3    Rieder, H.4    Secker-Walker, L.M.5
  • 22
    • 0030712244 scopus 로고    scopus 로고
    • Novel receptor interaction and repression domains in the orphan receptor SHP
    • Seol, W., M. Chung, and D. D. Moore. 1997. Novel receptor interaction and repression domains in the orphan receptor SHP. Mol. Cell. Biol. 17:7126-7131.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7126-7131
    • Seol, W.1    Chung, M.2    Moore, D.D.3
  • 23
    • 0029879664 scopus 로고    scopus 로고
    • An RNA polymerase lI elongation factor encoded by the human ELL gene
    • Shilatifard, A., W. S. Lane, K. W. Jackson, R. C. Conaway, and J. W. Conaway. 1996. An RNA polymerase lI elongation factor encoded by the human ELL gene. Science 271:1873-1876.
    • (1996) Science , vol.271 , pp. 1873-1876
    • Shilatifard, A.1    Lane, W.S.2    Jackson, K.W.3    Conaway, R.C.4    Conaway, J.W.5
  • 24
    • 0033546189 scopus 로고    scopus 로고
    • Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53
    • Shinobu, N., T. Maeda, T. Aso, T. Ito, T. Kondo, K. Koike, and M. Hatakeyama. 1999. Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J. Biol. Chem. 274:17003-17010.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17003-17010
    • Shinobu, N.1    Maeda, T.2    Aso, T.3    Ito, T.4    Kondo, T.5    Koike, K.6    Hatakeyama, M.7
  • 25
    • 0036723650 scopus 로고    scopus 로고
    • MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function
    • So, C. W., and M. L. Cleary. 2002. MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol. Cell. Biol. 22:6542-6552.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6542-6552
    • So, C.W.1    Cleary, M.L.2
  • 26
    • 0034125087 scopus 로고    scopus 로고
    • Malignancy: Tumor suppressor gene aberrations in acute myelogenous leukemia
    • Stirewalt, D. L., and J. P. Radich. 2000. Malignancy: tumor suppressor gene aberrations in acute myelogenous leukemia. Hematology 5:15-25.
    • (2000) Hematology , vol.5 , pp. 15-25
    • Stirewalt, D.L.1    Radich, J.P.2
  • 28
    • 0028135353 scopus 로고
    • Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia
    • Thirman, M. J., D. A. Levitan, H. Kobayashi, M. C. Simon, and J. D. Rowley. 1994. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc. Natl. Acad. Sci. USA 91:12110-12114.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12110-12114
    • Thirman, M.J.1    Levitan, D.A.2    Kobayashi, H.3    Simon, M.C.4    Rowley, J.D.5
  • 29
    • 0033553505 scopus 로고    scopus 로고
    • Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression
    • Wadgaonkar, R., and T. Collins. 1999. Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression. J. Biol. Chem. 274:13760-13767.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13760-13767
    • Wadgaonkar, R.1    Collins, T.2
  • 31
    • 0035138170 scopus 로고    scopus 로고
    • Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to downregulate transcriptional activity of p53
    • Zhu, Q., G. Wani, M. A. Wani, and A. A. Wani. 2001. Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to downregulate transcriptional activity of p53. Cancer Res. 61:64-70.
    • (2001) Cancer Res. , vol.61 , pp. 64-70
    • Zhu, Q.1    Wani, G.2    Wani, M.A.3    Wani, A.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.