Activated PKA and PKC, but not CaMKIIα, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model

Pain

Volumn 117, Issue 3, 2005, Pages 259-270

  Jones, Toni L ^a   Sorkin, Linda S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AMPA; CaMKII ; Intrathecal; NMDA; PKA; PKC; Secondary mechanical allodynia; Spinal sensitization

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CALCIUM (CALMODULIN) DEPENDENT PROTEIN KINASE IIALPHA; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GLUTAMATE RECEPTOR 1; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SERINE; SODIUM CHLORIDE; SPIDER VENOM; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOSOL; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EVOKED SPINAL CORD RESPONSE; EXAMINATION; MALE; MECHANICAL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; RAT; SKIN SENSITIZATION; THERMAL STIMULATION; WESTERN BLOTTING;

2-AMINO-5-PHOSPHONOVALERATE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; AREA UNDER CURVE; BLOTTING, WESTERN; CAPSAICIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIAGNOSTIC IMAGING; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; HEAT; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; PAIN; PAIN MEASUREMENT; PHOSPHORYLATION; PHYSICAL STIMULATION; PROTEIN KINASE C; RATS; RECEPTORS, AMPA; SERINE; SPIDER VENOMS; SPINAL CORD;

EID: 25644439044     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2005.06.003     Document Type: Article

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