Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors

Journal of Neuroscience

Volumn 19, Issue 12, 1999, Pages 4748-4754

  Carvalho, Ana Luísa ^a   Kameyama, Kimihiko ^b   Huganir, Richard L ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA receptors; GluR4; Glutamate; Phosphorylation; PKA; PKC

Indexed keywords

AMPA RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMATE RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; SERINE; THREONINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

EID: 0033564041     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-12-04748.1999     Document Type: Article

References (42)

1. 2+/ calmodulin-dependent protein kinase II regulatory phosphorylation site in the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate-type glutamate receptor. J Biol Chem 272:32727-32730.
2. Barria A, Muller D, Derkach V, Griffith LC, Soderling TR (1997b) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science 276:2042-2045.
3. Bennett JA, Dingledine R (1995) Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop. Neuron 14:373-384.
4. Blackstone C, Murphy TH, Moss SJ, Baraban JM, Huganir RL (1994) Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors. J Neurosci 14:7585-7493.
5. Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
6. Carriedo SG, Yin HZ, Weiss JH (1996) Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J Neurosci 16:4069-4079.
7. Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-624.
8. Greengard P, Jen J, Nairn AC, Stevens CF (1991) Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science 253:1135-1138.
9. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
10. Hollmann M, Maron C, Heinemann S (1994) N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13:1331-1343.
11. Kameyama K, Lee H-K, Bear MF, Huganir RL (1998) Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron 21:1163-1175.
12. Keinänen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AM PA-sensitive glutamate receptors. Science 249:556-560.
13. Keller BU, Hollmann M, Heinemann S, Konnerth A (1992) Calcium influx through subunits GluR1/GluR3 of kainate/AMPA receptor channels is regulated by cAMP-dependent protein kinase. EMBO J 11:891-896.
14. Köhler M, Kornau H-C, Seeburg PH (1994) The organization of the gene for the functionally dominant α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GIuR-B. J Biol Chem 269:17367-17370.
15. Lee H-K, Kameyama K, Huganir RL, Bear MF (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21:1151-1162.
16. Liman ER, Knapp AG, Dowling JE (1989) Enhancement of kainategated currents in retinal horizontal cells by cyclic AMP-dependcnt protein kinase. Brain Res 481:399-402.
17. Linden DJ (1994) Long-term synaptic depression in the mammalian brain. Neuron 12:457-472.
18. Mammen A, Kameyama K, Roche KW, Huganir RL (1997) Phosphor-ylation of the a-amino-3-hydroxy-5-methyl isoxazole-4-propionic acid receptor GIuRl subunit by calcium-calmodulin-dependent kinase II. J Biol Chem 272:32528-32533.
19. Mammen A, Kamboj S, Huganir RL (1999) Protein phosphorylation of ligand-gatcd ion channels. Methods Enzymol 294:353-370.
20. Mano I, Teichberg VI (1998) A tetrameric subunit stoichiometry for a glutamate receptor channel complex. NeuroReport 9:327-331.
21. Monyer H, Seeburg PH, Wisden W (1991) Glutamate-operated chan-nels: developmentally early and mature forms arise by alternative splicing. Neuron 6:799-810.
22. Mosbacher J, Schoepfer R, Monyer H, Burnashev N, Seeburg PH, Ruppersberg JP (1994) A molecular determinant for submillisecond desensitization in glutamate receptors. Nature 266:1059-1062.
23. Moss SJ, Smart TG (1996) Modulation of amino acid-gated ion channels by protein phosphorylation. Int Rev Neurobiol 39:1-52.
24. Nakazawa K, Mikawa S, Hashikawa T, Ito M (1995) Transient and persistent phosphorylation of AMPA-type glutamate receptor subunits in cerebellar Purkinjc cells. Neuron 15:697-709.
25. Page KJ, Everitt BJ (1995) The distribution of neurons coexpressing immunoreactivity to AM PA-sensitive glutamate receptor subtypes (GluR1-4) and nerve growth factor receptor in the rat basal forebrain. Eur J Neurosci 7:1022-1033.
26. Pearson RB, Kemp BE (1991) Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. Methods Enzymol 200:62-81.
27. Raman IM, Zhang S, Trussel LO (1994) Pathway-specific variants of AMPA receptors and their contribution to neuronal signaling. J Neurosci 14:4998-5010.
28. Reimann ER, Behman RB (1983) Catalytic subunit of cAMP-dependent protein kinase. Methods Enzymol 99:51-55.
29. Roche KW, Tingley WG, Huganir RL (1994) Glutamate receptor phosphorylation and synaptic plasticity. Curr Opin Neurobiol 4:383-388.
30. Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL (1996) Characterization of multiple phosphorylation sites on the AMPA receptor GIuR1 subunit. Neuron 16:1179-1188.
31. Rosenmund C, Stern-Bach Y, Stevens CF (1998) The tetrameric structure of a glutamate receptor channel. Science 280:1596-1599.
32. Rubio ME, Wenthold RJ (1997) Glutamate receptors are selectively targeted to postsynaptic sites in neurons. Neuron 18:939-950.
33. Silver RA, Traynelis SF, Cull-Candy SG (1992) Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses. Nature 355:163-166.
34. Smith DO, Franke C, Rosenheimer J, Zufall F, Hatt H (1991) Glutamate-activated channels in adult rat spinal cord cells. J Neuro-physiol 66:369-379.
35. Swanson GT, Kamboj SK, Cull-Candy SG (1997) Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. J Neurosci 17:58-69.
36. Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, Riley CT, Huganir RL (1997) Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem 272:5157-5166.
37. Tomiyama M, Rodriguez-Puertas R, Cortés R, Christnacher A, Sommer B, Pazos A, Palacios JM, Mengod G (1996) Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization. Neuroscience 75:901-915.
38. Wang L-Y, Salter MW, MacDonald JF (1991) Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science 253:1132-1135.
39. Wo ZG, Oswald RE (1995) A topological analysis of goldfish kainate receptors predicts three transmembrane segments. J Biol Chem 270:2000-2009.
40. Woodgett JR, Hunter T (1987) Isolation and characterization of two distinct forms of protein kinase C. J Biol Chem 262:4836-4843.
41. Wyllie DJA, Traynelis SF, Cull-Candy SG (1993) Evidence for more than one type of non-NMDA receptor in outside-out patches from cerebellar granule cells of the rat. J Physiol (Lond) 463:193-226.
42. Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, Heintz N (1997) Neurodegeneration in Lurcher mice caused by mutation in D2 glutamate receptor gene. Nature 388:769-773.