메뉴 건너뛰기




Volumn 10, Issue 1, 2003, Pages 60-71

Biologic relevance of mammalian bombesin-like peptides and their receptors in human malignancies

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN DERIVATIVE; BOMBESIN LIKE PEPTIDE; BOMBESIN RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 25444521559     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-200302000-00010     Document Type: Review
Times cited : (17)

References (177)
  • 3
    • 0035819547 scopus 로고    scopus 로고
    • The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter
    • Xiao D, Wang J, Hampton LL, et al.: The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. Gene 2001, 264:95-103.
    • (2001) Gene , vol.264 , pp. 95-103
    • Xiao, D.1    Wang, J.2    Hampton, L.L.3
  • 4
    • 0030795260 scopus 로고    scopus 로고
    • Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3′ to the SDC2 gene
    • Ishikawa-Brush Y, Powell JF, Bolton P, et al.: Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3′ to the SDC2 gene. Hum Mol Genet 1997, 6:1241-1250.
    • (1997) Hum Mol Genet , vol.6 , pp. 1241-1250
    • Ishikawa-Brush, Y.1    Powell, J.F.2    Bolton, P.3
  • 5
    • 0035051948 scopus 로고    scopus 로고
    • The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer
    • Jensen JA, Carroll RE, Benya RV: The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer. Peptides 2001, 22:689-699.
    • (2001) Peptides , vol.22 , pp. 689-699
    • Jensen, J.A.1    Carroll, R.E.2    Benya, R.V.3
  • 6
    • 0030662465 scopus 로고    scopus 로고
    • Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
    • Ohki-Hamazaki H, Watase K, Yamamoto K, et al.: Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature 1997, 390:165-169.
    • (1997) Nature , vol.390 , pp. 165-169
    • Ohki-Hamazaki, H.1    Watase, K.2    Yamamoto, K.3
  • 7
    • 0035993847 scopus 로고    scopus 로고
    • Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3
    • Weber D, Berger C, Heinrich T, et al.: Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3. J Pept Sci 2002, 8:461-475. This study investigates further the structural requirements of a previously identified synthetic peptide selectively binding to the human BRS-3. A tripeptide with selective agonist properties on the human BRS-3 is identified.
    • (2002) J Pept Sci , vol.8 , pp. 461-475
    • Weber, D.1    Berger, C.2    Heinrich, T.3
  • 8
    • 0037118711 scopus 로고    scopus 로고
    • Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)
    • Liu J, Lao ZJ, Zhang J, et al.: Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). Biochemistry 2002, 41:8954-8960. This report on the molecular cloning and pharmacology of the rat BRS-3 suggests that ligand binding of a synthetic BRS-3 peptide is species-specific and may involve extracellular domain 3.
    • (2002) Biochemistry , vol.41 , pp. 8954-8960
    • Liu, J.1    Lao, Z.J.2    Zhang, J.3
  • 9
    • 0032545948 scopus 로고    scopus 로고
    • Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes
    • Pradhan TK, Katsuno T, Taylor JE, et al.: Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes. Eur J Pharmacol 1998, 343:275-287.
    • (1998) Eur J Pharmacol , vol.343 , pp. 275-287
    • Pradhan, T.K.1    Katsuno, T.2    Taylor, J.E.3
  • 10
    • 0032577689 scopus 로고    scopus 로고
    • Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3
    • Ryan RR, Weber HC, Hou W, et al.: Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. J Biol Chem 1998, 273:13613-13624.
    • (1998) J Biol Chem , vol.273 , pp. 13613-13624
    • Ryan, R.R.1    Weber, H.C.2    Hou, W.3
  • 11
    • 0030867843 scopus 로고    scopus 로고
    • Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors
    • Mantey SA, Weber HC, Sainz E, et al.: Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem 1997, 272:26062-26071.
    • (1997) J Biol Chem , vol.272 , pp. 26062-26071
    • Mantey, S.A.1    Weber, H.C.2    Sainz, E.3
  • 12
    • 0015224130 scopus 로고
    • Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes
    • Anastasi A, Erspamer V, Bucci M: Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 1971, 27:166-167.
    • (1971) Experientia , vol.27 , pp. 166-167
    • Anastasi, A.1    Erspamer, V.2    Bucci, M.3
  • 13
    • 0018663357 scopus 로고
    • Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue
    • McDonald TJ, Jornvall H, Nilsson G, et al.: Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys Res Commun 1979, 90:227-233.
    • (1979) Biochem Biophys Res Commun , vol.90 , pp. 227-233
    • McDonald, T.J.1    Jornvall, H.2    Nilsson, G.3
  • 14
    • 0023095608 scopus 로고
    • Human gastrin-releasing peptide gene is located on chromosome 18
    • Naylor SL, Sakaguchi AY, Spindel E, et al.: Human gastrin-releasing peptide gene is located on chromosome 18. Somat Cell Mol Genet 1987, 13:87-91.
    • (1987) Somat Cell Mol Genet , vol.13 , pp. 87-91
    • Naylor, S.L.1    Sakaguchi, A.Y.2    Spindel, E.3
  • 15
    • 0023129257 scopus 로고
    • Human gastrin-releasing peptide gene maps to chromosome band 18q21
    • Lebacq-Verheyden AM, Bertness V, Kirsch I, et al.: Human gastrin-releasing peptide gene maps to chromosome band 18q21. Somat Cell Mol Genet 1987, 13:81-86.
    • (1987) Somat Cell Mol Genet , vol.13 , pp. 81-86
    • Lebacq-Verheyden, A.M.1    Bertness, V.2    Kirsch, I.3
  • 16
    • 0021144604 scopus 로고
    • Cloning and characterization of cDNAs encoding human gastrin-releasing peptide
    • Spindel ER, Chin WW, Price J, et al.: Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A 1984, 81:5699-5703.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 5699-5703
    • Spindel, E.R.1    Chin, W.W.2    Price, J.3
  • 17
    • 0023038791 scopus 로고
    • Expression of the gastrin-releasing peptide gene in human small cell lung cancer: Evidence for alternative processing resulting in three distinct mRNAs
    • Sausville EA, Lebacq-Verheyden AM, Spindel ER, et al.: Expression of the gastrin-releasing peptide gene in human small cell lung cancer: evidence for alternative processing resulting in three distinct mRNAs. J Biol Chem 1986, 261:2451-2457.
    • (1986) J Biol Chem , vol.261 , pp. 2451-2457
    • Sausville, E.A.1    Lebacq-Verheyden, A.M.2    Spindel, E.R.3
  • 18
    • 0019849075 scopus 로고
    • Translocation of proteins across the endoplasmic reticulum, I: Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein
    • Walter P, Ibrahimi I, Blobel G: Translocation of proteins across the endoplasmic reticulum, I: signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol 1981, 91:545-550.
    • (1981) J Cell Biol , vol.91 , pp. 545-550
    • Walter, P.1    Ibrahimi, I.2    Blobel, G.3
  • 19
    • 0020615510 scopus 로고
    • Proteolytic processing of presecretory proteins is required for development of biologic activities in pancreatic exocrine proteins
    • Scheele G, Jacoby R: Proteolytic processing of presecretory proteins is required for development of biologic activities in pancreatic exocrine proteins. J Biol Chem 1983, 258:2005-2009.
    • (1983) J Biol Chem , vol.258 , pp. 2005-2009
    • Scheele, G.1    Jacoby, R.2
  • 20
    • 0020079479 scopus 로고
    • Mechanism of C-terminal amide formation by pituitary enzymes
    • Bradbury AF, Finnie MD, Smyth DG: Mechanism of C-terminal amide formation by pituitary enzymes. Nature 1982, 298:686-688.
    • (1982) Nature , vol.298 , pp. 686-688
    • Bradbury, A.F.1    Finnie, M.D.2    Smyth, D.G.3
  • 21
    • 0021827560 scopus 로고
    • Peptidyl-glycine alpha-amidation activity in tissues and serum of the adult rat
    • Eipper BA, Myers AC, Mains RE: Peptidyl-glycine alpha-amidation activity in tissues and serum of the adult rat. Endocrinology 1985, 116:2497-2504.
    • (1985) Endocrinology , vol.116 , pp. 2497-2504
    • Eipper, B.A.1    Myers, A.C.2    Mains, R.E.3
  • 22
    • 0018039345 scopus 로고
    • Bomebesin: Specific binding to rat brain membranes
    • Moody TW, Pert CB, Rivier J, et al.: Bomebesin: specific binding to rat brain membranes. Proc Natl Acad Sci U S A 1978, 75:5372-5376.
    • (1978) Proc Natl Acad Sci U S A , vol.75 , pp. 5372-5376
    • Moody, T.W.1    Pert, C.B.2    Rivier, J.3
  • 23
    • 0021706940 scopus 로고
    • Isolation and sequence analysis of human bombesin-like peptides
    • Orloff MS, Reeve JR Jr, Ben-Avram CM, et al.: Isolation and sequence analysis of human bombesin-like peptides. Peptides 1984, 5:865-870.
    • (1984) Peptides , vol.5 , pp. 865-870
    • Orloff, M.S.1    Reeve Jr., J.R.2    Ben-Avram, C.M.3
  • 24
    • 0021873626 scopus 로고
    • Catabolism of substance P in the stomach wall of the rat
    • Bunnett NW, Orloff MS, Turner AJ: Catabolism of substance P in the stomach wall of the rat. Life Sci 1985, 37:599-606.
    • (1985) Life Sci , vol.37 , pp. 599-606
    • Bunnett, N.W.1    Orloff, M.S.2    Turner, A.J.3
  • 25
    • 0022974336 scopus 로고
    • Peptide transmitters of primary sensory neurons: Similar actions of tachykinins and bombesin-like peptides
    • Bishop JF, Moody TW, O'Donohue TL: Peptide transmitters of primary sensory neurons: similar actions of tachykinins and bombesin-like peptides. Peptides 1986, 7:835-842.
    • (1986) Peptides , vol.7 , pp. 835-842
    • Bishop, J.F.1    Moody, T.W.2    O'Donohue, T.L.3
  • 26
    • 0018600091 scopus 로고
    • The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract
    • Dockray GJ, Vaillant C, Walsh JH: The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract. Neuroscience 1979, 4:1561-1568.
    • (1979) Neuroscience , vol.4 , pp. 1561-1568
    • Dockray, G.J.1    Vaillant, C.2    Walsh, J.H.3
  • 27
    • 0020318635 scopus 로고
    • Bombesin-like immunoreactivity in developing human lung
    • Track NS, Cutz E: Bombesin-like immunoreactivity in developing human lung. Life Sci 1982, 30:1553-1556.
    • (1982) Life Sci , vol.30 , pp. 1553-1556
    • Track, N.S.1    Cutz, E.2
  • 28
    • 0021160504 scopus 로고
    • Bombesin-like immunoreactivity in human gastrointestinal tract
    • Price J, Penman E, Wass JA, et al.: Bombesin-like immunoreactivity in human gastrointestinal tract. Regul Pept 1984, 9:1-10.
    • (1984) Regul Pept , vol.9 , pp. 1-10
    • Price, J.1    Penman, E.2    Wass, J.A.3
  • 29
    • 0022551233 scopus 로고
    • Secretin/vasoactive intestinal peptide-stimulated secretion of bombesin/gastrin releasing peptide from human small cell carcinoma of the lung
    • Korman LY, Carney DN, Citron ML, et al.: Secretin/vasoactive intestinal peptide-stimulated secretion of bombesin/gastrin releasing peptide from human small cell carcinoma of the lung. Cancer Res 1986, 46:1214-1218.
    • (1986) Cancer Res , vol.46 , pp. 1214-1218
    • Korman, L.Y.1    Carney, D.N.2    Citron, M.L.3
  • 30
    • 0024166690 scopus 로고
    • Somatostatin inhibits the secretion of bombesin-like peptides from small cell lung cancer cells
    • Kee KA, Finan TM, Korman LY, et al.: Somatostatin inhibits the secretion of bombesin-like peptides from small cell lung cancer cells. Peptides 1988, 9:257-261.
    • (1988) Peptides , vol.9 , pp. 257-261
    • Kee, K.A.1    Finan, T.M.2    Korman, L.Y.3
  • 31
    • 0025733387 scopus 로고
    • Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells
    • Taylor JE, Moreau JP, Baptiste L, et al.: Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells. Peptides 1991, 12:839-843.
    • (1991) Peptides , vol.12 , pp. 839-843
    • Taylor, J.E.1    Moreau, J.P.2    Baptiste, L.3
  • 32
    • 0028212642 scopus 로고
    • Corticotropin-releasing factor stimulates cyclic AMP, arachidonic acid release, and growth of lung cancer cells
    • Moody TW, Zia F, Venugopal R, et al.: Corticotropin-releasing factor stimulates cyclic AMP, arachidonic acid release, and growth of lung cancer cells. Peptides 1994, 15:281-285.
    • (1994) Peptides , vol.15 , pp. 281-285
    • Moody, T.W.1    Zia, F.2    Venugopal, R.3
  • 33
    • 0036570522 scopus 로고    scopus 로고
    • Elevated serum progastrin-releasing peptide (31-98) in metastatic and androgen-independent prostate cancer patients
    • Yashi M, Muraishi O, Kobayashi Y1 et al.: Elevated serum progastrin-releasing peptide (31-98) in metastatic and androgen-independent prostate cancer patients. Prostate 2002, 51:84-97. This clinical study showed that the serum proGRP levels were positively correlated with the prostate-specific antigen values in patients with untreated prostate cancer. ProGRP values increased transiently when the cancer progressed to an androgen-independent state. It was suggested that GRP may be a growth factor potentially upregulated by androgen.
    • (2002) Prostate , vol.51 , pp. 84-97
    • Yashi, M.1    Muraishi, O.2    Kobayashi, Y.3
  • 34
    • 0020558866 scopus 로고
    • Neuromedin B: A novel bombesin-like peptide identified in porcine spinal cord
    • Minamino N, Kangawa K, Matsuo H: Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem Biophys Res Commun 1983, 114:541-548.
    • (1983) Biochem Biophys Res Commun , vol.114 , pp. 541-548
    • Minamino, N.1    Kangawa, K.2    Matsuo, H.3
  • 35
    • 0021710159 scopus 로고
    • Neuromedin B is a major bombesin-like peptide in rat brain: Regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord
    • Minamino N, Kangawa K, Matsuo H: Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord. Biochem Biophys Res Commun 1984, 124:925-932.
    • (1984) Biochem Biophys Res Commun , vol.124 , pp. 925-932
    • Minamino, N.1    Kangawa, K.2    Matsuo, H.3
  • 36
    • 0022366368 scopus 로고
    • Presence of neuromedin B-like immunoreactivity in the brain and gut of rat and guinea-pig
    • Namba M, Ghatei MA, Bishop AE, et al.: Presence of neuromedin B-like immunoreactivity in the brain and gut of rat and guinea-pig. Peptides 1985, 6:257-263.
    • (1985) Peptides , vol.6 , pp. 257-263
    • Namba, M.1    Ghatei, M.A.2    Bishop, A.E.3
  • 37
    • 0023547151 scopus 로고
    • Immunoreactive neuromedin B and neuromedin C: Distribution and molecular heterogeneity in rat and human tissue extracts
    • Sakamoto A, Kitamura K, Haraguchi Y, et al.: Immunoreactive neuromedin B and neuromedin C: distribution and molecular heterogeneity in rat and human tissue extracts. Am J Gastroenterol 1987, 82:1035-1041.
    • (1987) Am J Gastroenterol , vol.82 , pp. 1035-1041
    • Sakamoto, A.1    Kitamura, K.2    Haraguchi, Y.3
  • 38
    • 0023866829 scopus 로고
    • Localization of 7B2, neuromedin B, and neuromedin U in specific cell types of rat, mouse, and human pituitary, in rat hypothalamus, and in 30 human pituitary and extrapituitary tumors
    • Steel JH, Van Noorden S, Ballesta J, et al.: Localization of 7B2, neuromedin B, and neuromedin U in specific cell types of rat, mouse, and human pituitary, in rat hypothalamus, and in 30 human pituitary and extrapituitary tumors. Endocrinology 1988, 122:270-282.
    • (1988) Endocrinology , vol.122 , pp. 270-282
    • Steel, J.H.1    Van Noorden, S.2    Ballesta, J.3
  • 39
    • 0023681303 scopus 로고
    • Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B: Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin
    • Krane IM, Naylor SL, Helin-Davis D, et al.: Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B: chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. J Biol Chem 1988, 263:13317-13323.
    • (1988) J Biol Chem , vol.263 , pp. 13317-13323
    • Krane, I.M.1    Naylor, S.L.2    Helin-Davis, D.3
  • 40
    • 0026709439 scopus 로고
    • Neuromedin B binds with high affinity, elevates cytosolic calcium and stimulates the growth of small-cell lung cancer cell lines
    • Moody TW, Staley J, Zia F, et al.: Neuromedin B binds with high affinity, elevates cytosolic calcium and stimulates the growth of small-cell lung cancer cell lines. J Pharmacol Exp Ther 1992, 263:311-317.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 311-317
    • Moody, T.W.1    Staley, J.2    Zia, F.3
  • 41
    • 0032724509 scopus 로고    scopus 로고
    • Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer
    • Siegfried JM, Krishnamachary N, Gaither Davis A, et al.: Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer. Pulm Pharmacol Ther 1999, 12:291-302.
    • (1999) Pulm Pharmacol Ther , vol.12 , pp. 291-302
    • Siegfried, J.M.1    Krishnamachary, N.2    Gaither Davis, A.3
  • 42
    • 0026069878 scopus 로고
    • Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines
    • Cardona C, Rabbitts PH, Spindel ER, et al.: Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. Cancer Res 1991, 51:5205-5211.
    • (1991) Cancer Res , vol.51 , pp. 5205-5211
    • Cardona, C.1    Rabbitts, P.H.2    Spindel, E.R.3
  • 43
    • 0022383308 scopus 로고
    • Gastrin releasing peptide in human neuroendocrine tumors
    • Bostwick DG, Bensch KG: Gastrin releasing peptide in human neuroendocrine tumors. J Pathol 1985, 147:237-244.
    • (1985) J Pathol , vol.147 , pp. 237-244
    • Bostwick, D.G.1    Bensch, K.G.2
  • 44
    • 0026006645 scopus 로고
    • Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas
    • Sunday ME, Choi N, Spindel ER, et al.: Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas. Hum Pathol 1991, 22:1030-1039.
    • (1991) Hum Pathol , vol.22 , pp. 1030-1039
    • Sunday, M.E.1    Choi, N.2    Spindel, E.R.3
  • 45
    • 0026510177 scopus 로고
    • Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines
    • Verbeeck MA, Elands JP, de Leij LF, et al.: Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines. Pathobiology 1992, 60:136-142.
    • (1992) Pathobiology , vol.60 , pp. 136-142
    • Verbeeck, M.A.1    Elands, J.P.2    De Leij, L.F.3
  • 46
    • 0033967885 scopus 로고    scopus 로고
    • Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells
    • lnase N, Horita K, Tanaka M, et al.: Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells. Int J Cancer 2000, 85:716-719.
    • (2000) Int J Cancer , vol.85 , pp. 716-719
    • Lnase, N.1    Horita, K.2    Tanaka, M.3
  • 47
    • 0036554956 scopus 로고    scopus 로고
    • Bombesin receptor subtypes in human cancers: Detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14)
    • Reubi JC, Wenger S, Schmuckli-Maurer J, et al.: Bombesin receptor subtypes in human cancers: detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14). Clin Cancer Res 2002, 8:1139-1146. A large number of various human cancer tissues was investigated for the expression of all bombesin receptor subtypes using in vitro radio-ligand binding assays with a synthetic universal peptide ligand.
    • (2002) Clin Cancer Res , vol.8 , pp. 1139-1146
    • Reubi, J.C.1    Wenger, S.2    Schmuckli-Maurer, J.3
  • 48
    • 0029802367 scopus 로고    scopus 로고
    • Nonconstitutive expression of the gastrin-releasing peptide autocrine growth system in human small cell lung carcinoma NCI-H345 cells
    • Aguayo SM, Miller Y, Boose D, et al.: Nonconstitutive expression of the gastrin-releasing peptide autocrine growth system in human small cell lung carcinoma NCI-H345 cells. Cell Growth Differ 1996, 7:563-572.
    • (1996) Cell Growth Differ , vol.7 , pp. 563-572
    • Aguayo, S.M.1    Miller, Y.2    Boose, D.3
  • 49
    • 0029839482 scopus 로고    scopus 로고
    • GRP receptors are present in non small cell lung cancer cells
    • Moody TW, Zia F, Venugopal R, et al.: GRP receptors are present in non small cell lung cancer cells. J Cell Biochem Suppl 1996, 24:247-256.
    • (1996) J Cell Biochem Suppl , vol.24 , pp. 247-256
    • Moody, T.W.1    Zia, F.2    Venugopal, R.3
  • 50
    • 0026504729 scopus 로고
    • Characterization of ligand binding and processing by gastrin-releasing peptide receptors in a small-cell lung cancer cell line
    • Cardona C, Bleehen NM, Reeve JG: Characterization of ligand binding and processing by gastrin-releasing peptide receptors in a small-cell lung cancer cell line. Biochem J 1992, 281:115-120.
    • (1992) Biochem J , vol.281 , pp. 115-120
    • Cardona, C.1    Bleehen, N.M.2    Reeve, J.G.3
  • 51
    • 0025369701 scopus 로고
    • Expression of gastrin-releasing peptide (human bombesin) gene in large cell undifferentiated carcinoma of the lung
    • Hamid QA, Corrin B, Dewar A, et al.: Expression of gastrin-releasing peptide (human bombesin) gene in large cell undifferentiated carcinoma of the lung. J Pathol 1990, 161:145-151.
    • (1990) J Pathol , vol.161 , pp. 145-151
    • Hamid, Q.A.1    Corrin, B.2    Dewar, A.3
  • 52
    • 0028469083 scopus 로고
    • Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells
    • DeMichele MA, Davis AL, Hunt JD, et al.: Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells. Am J Respir Cell Mol Biol 1994, 11:66-74.
    • (1994) Am J Respir Cell Mol Biol , vol.11 , pp. 66-74
    • DeMichele, M.A.1    Davis, A.L.2    Hunt, J.D.3
  • 53
    • 0026015967 scopus 로고
    • Expression of the gastrin-releasing peptide gene in carcinomas of the breast
    • Pagani A, Papotti M, Sanfilippo B, et al.: Expression of the gastrin-releasing peptide gene in carcinomas of the breast. Int J Cancer 1991, 47:371-375.
    • (1991) Int J Cancer , vol.47 , pp. 371-375
    • Pagani, A.1    Papotti, M.2    Sanfilippo, B.3
  • 54
    • 0026331914 scopus 로고
    • Gastrin releasing peptide GRP(14-27) in human breast cancer cells and in small cell lung cancer
    • Vangsted AJ, Andersen EV, Nedergaard L, et al.: Gastrin releasing peptide GRP(14-27) in human breast cancer cells and in small cell lung cancer. Breast Cancer Res Treat 1991, 19:119-128.
    • (1991) Breast Cancer Res Treat , vol.19 , pp. 119-128
    • Vangsted, A.J.1    Andersen, E.V.2    Nedergaard, L.3
  • 55
    • 0036095760 scopus 로고    scopus 로고
    • Co-expressed peptide receptors in breast cancer as a molecular basis for in vivo multireceptor tumor targeting
    • Reubi C, Gugger M, Waser B: Co-expressed peptide receptors in breast cancer as a molecular basis for in vivo multireceptor tumor targeting. Eur J Nucl Med Mol Imaging 2002, 29:855-862.
    • (2002) Eur J Nucl Med Mol Imaging , vol.29 , pp. 855-862
    • Reubi, C.1    Gugger, M.2    Waser, B.3
  • 56
    • 0032804044 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast
    • Gugger M, Reubi JC: Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast. Am J Pathol 1999, 155:2067-2076.
    • (1999) Am J Pathol , vol.155 , pp. 2067-2076
    • Gugger, M.1    Reubi, J.C.2
  • 57
    • 0025006482 scopus 로고
    • Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells
    • Giacchetti S, Gauville C, de Cremoux P, et al.: Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells. Int J Cancer 1990, 46:293-298.
    • (1990) Int J Cancer , vol.46 , pp. 293-298
    • Giacchetti, S.1    Gauville, C.2    De Cremoux, P.3
  • 58
    • 0037133576 scopus 로고    scopus 로고
    • Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes
    • Bajo AM, Schally AV, Krupa M, et al.: Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes. Proc Natl Acad Sci U S A 2002, 99:3836-3841.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3836-3841
    • Bajo, A.M.1    Schally, A.V.2    Krupa, M.3
  • 59
    • 0023353272 scopus 로고
    • Detection of gastrin-releasing peptide mRNA in small cell lung carcinomas and medullary thyroid carcinomas using synthetic oligodeoxyribonucleotide probes
    • Suzuki M, Yamaguchi K, Abe K, et al.: Detection of gastrin-releasing peptide mRNA in small cell lung carcinomas and medullary thyroid carcinomas using synthetic oligodeoxyribonucleotide probes. Jpn J Clin Oncol 1987, 17:157-163.
    • (1987) Jpn J Clin Oncol , vol.17 , pp. 157-163
    • Suzuki, M.1    Yamaguchi, K.2    Abe, K.3
  • 60
    • 0025151051 scopus 로고
    • Immunoreactive gastrin-releasing peptide in medullary thyroid carcinoma
    • Modigliani E, Casanova S, Chayvialle JA, et al.: Immunoreactive gastrin-releasing peptide in medullary thyroid carcinoma. J Clin Endocrinol Metab 1990, 71:831-835.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 831-835
    • Modigliani, E.1    Casanova, S.2    Chayvialle, J.A.3
  • 61
    • 0037091015 scopus 로고    scopus 로고
    • Medullary thyroid carcinomas in cell culture-models for future therapies
    • Pfragner R, Wirnsberger GH, Ingolic E, et al.: Medullary thyroid carcinomas in cell culture-models for future therapies. Wien Klin Wochenschr 2002, 114:279-283.
    • (2002) Wien Klin Wochenschr , vol.114 , pp. 279-283
    • Pfragner, R.1    Wirnsberger, G.H.2    Ingolic, E.3
  • 62
    • 0032799814 scopus 로고    scopus 로고
    • Characterization of gastrin-releasing peptide receptors aberrantly expressed by non-antral gastric adenocarcinomas
    • Carroll RE, Carroll R, Benya RV: Characterization of gastrin-releasing peptide receptors aberrantly expressed by non-antral gastric adenocarcinomas. Peptides 1999, 20:229-237.
    • (1999) Peptides , vol.20 , pp. 229-237
    • Carroll, R.E.1    Carroll, R.2    Benya, R.V.3
  • 63
    • 0031905924 scopus 로고    scopus 로고
    • A human gastric cancer cell line possesses a functional receptor for gastrin-releasing peptide
    • Bold RJ, Kim HJ, Ishizuka J, et al.: A human gastric cancer cell line possesses a functional receptor for gastrin-releasing peptide. Cancer Invest 1998, 16:12-17.
    • (1998) Cancer Invest , vol.16 , pp. 12-17
    • Bold, R.J.1    Kim, H.J.2    Ishizuka, J.3
  • 64
    • 0028098167 scopus 로고
    • Bombesin receptors in a human duodenal tumor cell line: Binding properties and function
    • Williams BY, Schonbrunn A: Bombesin receptors in a human duodenal tumor cell line: binding properties and function. Cancer Res 1994, 54:818-824.
    • (1994) Cancer Res , vol.54 , pp. 818-824
    • Williams, B.Y.1    Schonbrunn, A.2
  • 65
    • 0033851081 scopus 로고    scopus 로고
    • Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines
    • Carroll RE, Ostrovskiy D, Lee S, et al.: Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines. Mol Pharmacol 2000, 58:601-607.
    • (2000) Mol Pharmacol , vol.58 , pp. 601-607
    • Carroll, R.E.1    Ostrovskiy, D.2    Lee, S.3
  • 66
    • 0033986991 scopus 로고    scopus 로고
    • Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa
    • Chave HS, Gough AC, Palmer K, et al.: Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa. Br J Cancer 2000, 82:124-130.
    • (2000) Br J Cancer , vol.82 , pp. 124-130
    • Chave, H.S.1    Gough, A.C.2    Palmer, K.3
  • 67
    • 0032895181 scopus 로고    scopus 로고
    • Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans
    • Carroll RE, Malkowskyj KA, Chakrabarti S, et al.: Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans. Am J Physiol 1999, 276:G655-G665.
    • (1999) Am J Physiol , vol.276
    • Carroll, R.E.1    Malkowskyj, K.A.2    Chakrabarti, S.3
  • 68
    • 0035976038 scopus 로고    scopus 로고
    • The proliferative response of HT-29 human colon adenocarcinoma cells Io bombesin-like peptides
    • Cassano G, Resta N, Gasparre G, et al.: The proliferative response of HT-29 human colon adenocarcinoma cells Io bombesin-like peptides. Cancer Lett 2001, 172:151-157.
    • (2001) Cancer Lett , vol.172 , pp. 151-157
    • Cassano, G.1    Resta, N.2    Gasparre, G.3
  • 69
    • 0032991986 scopus 로고    scopus 로고
    • High gastrin releasing peptide receptor mRNA level is related to tumor dedifferentiation and lymphatic vessel invasion in human colon cancer
    • Saurin JC, Rouault JP, Abello J, et al.: High gastrin releasing peptide receptor mRNA level is related to tumor dedifferentiation and lymphatic vessel invasion in human colon cancer. Eur J Cancer 1999, 35:125-132.
    • (1999) Eur J Cancer , vol.35 , pp. 125-132
    • Saurin, J.C.1    Rouault, J.P.2    Abello, J.3
  • 70
    • 0344628779 scopus 로고    scopus 로고
    • Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line
    • Saurin JC, Nemoz-Gaillard E, Sordat B, et al.: Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line. Cancer Res 1999, 59:962-967.
    • (1999) Cancer Res , vol.59 , pp. 962-967
    • Saurin, J.C.1    Nemoz-Gaillard, E.2    Sordat, B.3
  • 71
    • 0029034647 scopus 로고
    • High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa
    • Preston SR, Woodhouse LF, Jones-Blackett S1 et al.: High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa. Br J Cancer 1995, 71:1087-1089.
    • (1995) Br J Cancer , vol.71 , pp. 1087-1089
    • Preston, S.R.1    Woodhouse, L.F.2    Jones-Blackett, S.3
  • 72
    • 0026680851 scopus 로고
    • The binding of bombesin and somatostatin and their analogs to human colon cancers
    • Radulovic SS, Milovanovic SR, Cai RZ, et al.: The binding of bombesin and somatostatin and their analogs to human colon cancers. Proc Soc Exp Biol Med 1992, 200:394-401.
    • (1992) Proc Soc Exp Biol Med , vol.200 , pp. 394-401
    • Radulovic, S.S.1    Milovanovic, S.R.2    Cai, R.Z.3
  • 73
    • 0026576667 scopus 로고
    • Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells
    • Frucht H, Gazdar AF, Park JA, et al.: Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. Cancer Res 1992, 52:1114-1122.
    • (1992) Cancer Res , vol.52 , pp. 1114-1122
    • Frucht, H.1    Gazdar, A.F.2    Park, J.A.3
  • 74
    • 0024554552 scopus 로고
    • Bombesin stimulates growth of human prostatic cancer cells in vitro
    • Bologna M, Festuccia C, Muzi P, et al.: Bombesin stimulates growth of human prostatic cancer cells in vitro. Cancer 1989, 63:1714-1720.
    • (1989) Cancer , vol.63 , pp. 1714-1720
    • Bologna, M.1    Festuccia, C.2    Muzi, P.3
  • 75
    • 0034974363 scopus 로고    scopus 로고
    • GRP-receptor-mediated signal transduction, gene expression and DNA synthesis in the human pancreatic adenocarcinoma cell line HPAF
    • Burghardt B, Wenger C, Barabas K, et al.: GRP-receptor-mediated signal transduction, gene expression and DNA synthesis in the human pancreatic adenocarcinoma cell line HPAF. Peptides 2001, 22:1119-1128.
    • (2001) Peptides , vol.22 , pp. 1119-1128
    • Burghardt, B.1    Wenger, C.2    Barabas, K.3
  • 76
    • 0036331450 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase-9 and bombesin/gastrin-releasing peptide in human prostate cancers and their lymph node metastases
    • Ishimaru H, Kageyama Y, Hayashi T, et al.: Expression of matrix metalloproteinase-9 and bombesin/gastrin-releasing peptide in human prostate cancers and their lymph node metastases. Acta Oncol 2002, 41:289-296.
    • (2002) Acta Oncol , vol.41 , pp. 289-296
    • Ishimaru, H.1    Kageyama, Y.2    Hayashi, T.3
  • 77
    • 0033953894 scopus 로고    scopus 로고
    • Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers
    • Sun B, Halmos G, Schally AV, et al.: Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers. Prostate 2000, 42:295-303.
    • (2000) Prostate , vol.42 , pp. 295-303
    • Sun, B.1    Halmos, G.2    Schally, A.V.3
  • 78
    • 0032548868 scopus 로고    scopus 로고
    • In situ hybridization for gastrin-releasing peptide receptor (GRP receptor) expression in prostatic carcinoma
    • Bartholdi MF, Wu JM, Pu H, et al.: In situ hybridization for gastrin-releasing peptide receptor (GRP receptor) expression in prostatic carcinoma. Int J Cancer 1998, 79:82-90.
    • (1998) Int J Cancer , vol.79 , pp. 82-90
    • Bartholdi, M.F.1    Wu, J.M.2    Pu, H.3
  • 79
    • 0033104343 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptors in the human prostate: Relation to neoplastic transformation
    • Markwalder R, Reubi JC: Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Cancer Res 1999, 59:1152-1159.
    • (1999) Cancer Res , vol.59 , pp. 1152-1159
    • Markwalder, R.1    Reubi, J.C.2
  • 80
    • 0033929387 scopus 로고    scopus 로고
    • Gastrin releasing peptide-preferring bombesin receptors mediate growth of human renal cell carcinoma
    • Pansky A, De Weerth A, Fasler-Kan E, et al.: Gastrin releasing peptide-preferring bombesin receptors mediate growth of human renal cell carcinoma. J Am Soc Nephrol 2000, 11:1409-1418.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1409-1418
    • Pansky, A.1    De Weerth, A.2    Fasler-Kan, E.3
  • 81
    • 0036240839 scopus 로고    scopus 로고
    • Gastrin-releasing peptide is a growth factor for human neuroblastomas
    • discussion 629-630
    • Kim S, Hu W, Kelly DR, et al.: Gastrin-releasing peptide is a growth factor for human neuroblastomas. Ann Surg 2002, 235:621-629; discussion 629-630.
    • (2002) Ann Surg , vol.235 , pp. 621-629
    • Kim, S.1    Hu, W.2    Kelly, D.R.3
  • 82
    • 0008940093 scopus 로고    scopus 로고
    • Gastrin-releasing peptide: A potential growth factor expressed in human neuroblastoma tumors(1)
    • Sebesta JA, Young A, Bullock J, et al.: Gastrin-releasing peptide: a potential growth factor expressed in human neuroblastoma tumors(1). Curr Surg 2001, 58:86-89.
    • (2001) Curr Surg , vol.58 , pp. 86-89
    • Sebesta, J.A.1    Young, A.2    Bullock, J.3
  • 83
    • 0033812919 scopus 로고    scopus 로고
    • Immunodetection of gastrin-releasing peptide in malignant melanoma cells
    • Charitopoulos KN, Lazaris AC, Aroni K, et al.: Immunodetection of gastrin-releasing peptide in malignant melanoma cells. Melanoma Res 2000, 10:395-400.
    • (2000) Melanoma Res , vol.10 , pp. 395-400
    • Charitopoulos, K.N.1    Lazaris, A.C.2    Aroni, K.3
  • 84
    • 0031050454 scopus 로고    scopus 로고
    • Identification of functional GRP-preferring bombesin receptors on human melanoma cells
    • Pansky A, Peng F, Eberhard M, et al.: Identification of functional GRP-preferring bombesin receptors on human melanoma cells. Eur J Clin Invest 1997, 27:69-76.
    • (1997) Eur J Clin Invest , vol.27 , pp. 69-76
    • Pansky, A.1    Peng, F.2    Eberhard, M.3
  • 85
    • 0032100645 scopus 로고    scopus 로고
    • The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide
    • Lawlor ER, Lim JF, Tao W, et al.: The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide. Cancer Res 1998, 58:2469-2476.
    • (1998) Cancer Res , vol.58 , pp. 2469-2476
    • Lawlor, E.R.1    Lim, J.F.2    Tao, W.3
  • 86
    • 0034733778 scopus 로고    scopus 로고
    • The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers
    • Sun B, Schally AV, Halmos G: The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. Regul Pept 2000, 90:77-84.
    • (2000) Regul Pept , vol.90 , pp. 77-84
    • Sun, B.1    Schally, A.V.2    Halmos, G.3
  • 87
    • 0033834522 scopus 로고    scopus 로고
    • Inhibition of growth of OV-1063 human epithelial ovarian cancers and c-jun and c-fos oncogene expression by bombesin antagonists
    • Chalzistamou I, Schally AV, Sunday B, et al.: Inhibition of growth of OV-1063 human epithelial ovarian cancers and c-jun and c-fos oncogene expression by bombesin antagonists. Br J Cancer 2000, 83:906-913.
    • (2000) Br J Cancer , vol.83 , pp. 906-913
    • Chalzistamou, I.1    Schally, A.V.2    Sunday, B.3
  • 88
    • 0024810059 scopus 로고
    • Human glioblastoma cell lines have neuropeptide receptors for bombesin/gastrin-releasing peptide
    • Moody TW, Mahmoud S, Staley J, et al.: Human glioblastoma cell lines have neuropeptide receptors for bombesin/gastrin-releasing peptide. J Mol Neurosci 1989, 1:235-242.
    • (1989) J Mol Neurosci , vol.1 , pp. 235-242
    • Moody, T.W.1    Mahmoud, S.2    Staley, J.3
  • 89
    • 0019812866 scopus 로고
    • High levels of intracellular bombesin characterize human small-cell lung carcinoma
    • Moody TW, Pert CB, Gazdar AF, et al.: High levels of intracellular bombesin characterize human small-cell lung carcinoma. Science 1981, 214:1246-1248.
    • (1981) Science , vol.214 , pp. 1246-1248
    • Moody, T.W.1    Pert, C.B.2    Gazdar, A.F.3
  • 90
    • 0025369701 scopus 로고
    • Expression of gastrin-releasing peptide (human bombesin) gene in large cell undifferentiated carcinoma of the lung
    • Hamid QA, Corrin B, Dewar A, et al.: Expression of gastrin-releasing peptide (human bombesin) gene in large cell undifferentiated carcinoma of the lung. J Pathol 1990, 161:145-151.
    • (1990) J Pathol , vol.161 , pp. 145-151
    • Hamid, Q.A.1    Corrin, B.2    Dewar, A.3
  • 91
    • 0036318706 scopus 로고    scopus 로고
    • Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma
    • Nowicki M, Miskowiak B: Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma. Folia Histochem Cytobiol 2002, 40:297-303.
    • (2002) Folia Histochem Cytobiol , vol.40 , pp. 297-303
    • Nowicki, M.1    Miskowiak, B.2
  • 92
    • 0025964088 scopus 로고
    • Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells
    • Battey JF, Way JM, Corjay MH, et al.: Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Proc Natl Acad Sci U S A 1991, 88:395-399.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 395-399
    • Battey, J.F.1    Way, J.M.2    Corjay, M.H.3
  • 93
    • 0025606853 scopus 로고
    • Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor
    • Spindel ER, Giladi E, Brehrn P, et al.: Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol Endocrinol 1990, 4:1956-1963.
    • (1990) Mol Endocrinol , vol.4 , pp. 1956-1963
    • Spindel, E.R.1    Giladi, E.2    Brehrn, P.3
  • 94
    • 0027570801 scopus 로고
    • Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides
    • Giladi E, Nagalla SR, Spindel ER: Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. J Mol Neurosci 1993, 4:41-54.
    • (1993) J Mol Neurosci , vol.4 , pp. 41-54
    • Giladi, E.1    Nagalla, S.R.2    Spindel, E.R.3
  • 95
    • 0033974466 scopus 로고    scopus 로고
    • Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter
    • Weber HC, Jensen RT, Battey JF: Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. Gene 2000, 244:137-149.
    • (2000) Gene , vol.244 , pp. 137-149
    • Weber, H.C.1    Jensen, R.T.2    Battey, J.F.3
  • 96
    • 0033842919 scopus 로고    scopus 로고
    • Two amino acids in the sixth transmembrane segment of the mouse gastrin-releasing peptide receptor are important for receptor activation
    • Lin Y, Jian X, Lin Z, et al.: Two amino acids in the sixth transmembrane segment of the mouse gastrin-releasing peptide receptor are important for receptor activation. J Pharmacol Exp Ther 2000, 294:1053-1062.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 1053-1062
    • Lin, Y.1    Jian, X.2    Lin, Z.3
  • 97
    • 0036262646 scopus 로고    scopus 로고
    • Molecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide
    • Tokita K, Hocart SJ, Coy DH, et al.: Molecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide. Mol Pharmacol 2002, 61:1435-1443.
    • (2002) Mol Pharmacol , vol.61 , pp. 1435-1443
    • Tokita, K.1    Hocart, S.J.2    Coy, D.H.3
  • 98
    • 0027239858 scopus 로고
    • Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization
    • Benya RV, Fathi Z, Battey JF, et al.: Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization. J Biol Chem 1993, 268:20285-20290.
    • (1993) J Biol Chem , vol.268 , pp. 20285-20290
    • Benya, R.V.1    Fathi, Z.2    Battey, J.F.3
  • 99
    • 0033664359 scopus 로고    scopus 로고
    • Glycosylation of the gastrin-releasing peptide receptor and its effect on expression, G protein coupling, and receptor modulatory processes
    • Benya RV, Kusui T, Katsuno T, et al.: Glycosylation of the gastrin-releasing peptide receptor and its effect on expression, G protein coupling, and receptor modulatory processes. Mol Pharmacol 2000, 58:1490-1501.
    • (2000) Mol Pharmacol , vol.58 , pp. 1490-1501
    • Benya, R.V.1    Kusui, T.2    Katsuno, T.3
  • 100
    • 0026094281 scopus 로고
    • Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells
    • Corjay MH, Dobrzanski DJ, Way JM, et al.: Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. J Biol Chem 1991, 266:18771-18779.
    • (1991) J Biol Chem , vol.266 , pp. 18771-18779
    • Corjay, M.H.1    Dobrzanski, D.J.2    Way, J.M.3
  • 101
    • 0024597924 scopus 로고
    • Neuromedin B receptor in esophagus: Evidence for subtypes of bombesin receptors
    • Von Schrenck T, Heinz-Erian P, Moran T, et al.: Neuromedin B receptor in esophagus: evidence for subtypes of bombesin receptors. Am J Physiol 1989, 256:G747-G758.
    • (1989) Am J Physiol , vol.256
    • Von Schrenck, T.1    Heinz-Erian, P.2    Moran, T.3
  • 102
    • 0026032388 scopus 로고
    • CDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor
    • Wada E, Way J, Shapira H, et al.: cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Neuron 1991, 6:421-430.
    • (1991) Neuron , vol.6 , pp. 421-430
    • Wada, E.1    Way, J.2    Shapira, H.3
  • 103
    • 0027503295 scopus 로고
    • BRS-3: A novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells
    • Fathi Z, Corjay MH, Shapira H, et al.: BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J Biol Chem 1993, 268:5979-5984.
    • (1993) J Biol Chem , vol.268 , pp. 5979-5984
    • Fathi, Z.1    Corjay, M.H.2    Shapira, H.3
  • 104
    • 0026701923 scopus 로고
    • Molecular cloning of a new bombesin receptor subtype expressed in uterus during pregnancy
    • Gorbulev V, Akhundova A, Buchner H, et al.: Molecular cloning of a new bombesin receptor subtype expressed in uterus during pregnancy. Eur J Biochem 1992, 208:405-410.
    • (1992) Eur J Biochem , vol.208 , pp. 405-410
    • Gorbulev, V.1    Akhundova, A.2    Buchner, H.3
  • 105
    • 0028273910 scopus 로고
    • Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus
    • Gorbulev V, Akhundova A, Grzeschik KH, et al.: Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. FEBS Lett 1994, 340:260-264.
    • (1994) FEBS Lett , vol.340 , pp. 260-264
    • Gorbulev, V.1    Akhundova, A.2    Grzeschik, K.H.3
  • 106
    • 0030748427 scopus 로고    scopus 로고
    • Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse
    • Ohki-Hamazaki H, Wada E, Matsui K, et al.: Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res 1997, 762:165-172.
    • (1997) Brain Res , vol.762 , pp. 165-172
    • Ohki-Hamazaki, H.1    Wada, E.2    Matsui, K.3
  • 107
    • 0032574666 scopus 로고    scopus 로고
    • Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene
    • Weber HC, Hampton LL, Jensen RT, et al.: Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene. Gene 1998, 211:125-131.
    • (1998) Gene , vol.211 , pp. 125-131
    • Weber, H.C.1    Hampton, L.L.2    Jensen, R.T.3
  • 108
    • 0024406888 scopus 로고
    • Bombesin: A potent mitogen for small cell lung cancer
    • Carney DN, Moody T, Cuttitta F: Bombesin: a potent mitogen for small cell lung cancer. Ann N Y Acad Sci 1988, 547:303-309.
    • (1988) Ann N Y Acad Sci , vol.547 , pp. 303-309
    • Carney, D.N.1    Moody, T.2    Cuttitta, F.3
  • 109
    • 0021920520 scopus 로고
    • Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro
    • Weber S, Zuckerman JE, Bostwick DG, et al.: Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro. J Clin Invest 1985, 75:306-309.
    • (1985) J Clin Invest , vol.75 , pp. 306-309
    • Weber, S.1    Zuckerman, J.E.2    Bostwick, D.G.3
  • 110
    • 0026802370 scopus 로고
    • Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines
    • Yano T, Pinski J, Groot K, et al.: Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer Res 1992, 52:4545-4547.
    • (1992) Cancer Res , vol.52 , pp. 4545-4547
    • Yano, T.1    Pinski, J.2    Groot, K.3
  • 111
    • 17744386907 scopus 로고    scopus 로고
    • Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions
    • Murphy LO, Cluck MW, Lovas S, et al.: Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions. Br J Cancer 2001, 84:926-935.
    • (2001) Br J Cancer , vol.84 , pp. 926-935
    • Murphy, L.O.1    Cluck, M.W.2    Lovas, S.3
  • 112
    • 0028138316 scopus 로고
    • Bombesin stimulates the in vitro growth of a human gastric cancer cell line
    • Bold RJ, Lowry PS, Ishizuka J, et al.: Bombesin stimulates the in vitro growth of a human gastric cancer cell line. J Cell Physiol 1994, 161:519-525.
    • (1994) J Cell Physiol , vol.161 , pp. 519-525
    • Bold, R.J.1    Lowry, P.S.2    Ishizuka, J.3
  • 113
    • 0030758622 scopus 로고    scopus 로고
    • Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway
    • Sharif TR, Luo W, Sharif M: Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway. Mol Cell Endocrinol 1997, 130:119-130.
    • (1997) Mol Cell Endocrinol , vol.130 , pp. 119-130
    • Sharif, T.R.1    Luo, W.2    Sharif, M.3
  • 114
    • 0033604465 scopus 로고    scopus 로고
    • Inhibition of growth of human malignant glioblastoma in nude mice by antagonists of bombesin/gastrin-releasing peptide
    • Kiaris H, Schally AV, Sunday B, et al.: Inhibition of growth of human malignant glioblastoma in nude mice by antagonists of bombesin/gastrin-releasing peptide. Oncogene 1999, 18:7168-7173.
    • (1999) Oncogene , vol.18 , pp. 7168-7173
    • Kiaris, H.1    Schally, A.V.2    Sunday, B.3
  • 115
    • 0033859617 scopus 로고    scopus 로고
    • Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer
    • Carroll RE, Matkowskyj KA, Tretiakova MS, et al.: Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer. Cell Growth Differ 2000, 11:385-393.
    • (2000) Cell Growth Differ , vol.11 , pp. 385-393
    • Carroll, R.E.1    Matkowskyj, K.A.2    Tretiakova, M.S.3
  • 116
    • 0037063323 scopus 로고    scopus 로고
    • Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells
    • Qu X, Xiao D, Weber H: Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. FEBS Lett 2002, 527:109. Gastrin-releasing peptide receptor activation stimulated sustained CREB phosphorylation and transactivation in duodenal cancer cells through a PKC-dependent and partially p38 MAPK-dependent pathway. This novel signaling mechanism may be of importance for regulation of CREB-dependent gene expression in human cancers expressing functional GRP-R.
    • (2002) FEBS Lett , vol.527 , pp. 109
    • Qu, X.1    Xiao, D.2    Weber, H.3
  • 117
    • 0035933793 scopus 로고    scopus 로고
    • Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells
    • Guo YS, Hellmich MR, Wen XD, et al.: Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. J Biol Chem 2001, 276:22941-22947.
    • (2001) J Biol Chem , vol.276 , pp. 22941-22947
    • Guo, Y.S.1    Hellmich, M.R.2    Wen, X.D.3
  • 118
    • 27744591307 scopus 로고    scopus 로고
    • Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways: Evidence for involvement of ERK5 kinase and transactivation of EGF receptor
    • Guo YS, Cheng JZ, Jin GF, et al.: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways: evidence for involvement of ERK5 kinase and transactivation of EGF receptor. J Biol Chem 2002, 17:17.
    • (2002) J Biol Chem , vol.17 , pp. 17
    • Guo, Y.S.1    Cheng, J.Z.2    Jin, G.F.3
  • 119
    • 0029822869 scopus 로고    scopus 로고
    • Bombesin-mediated AP-1 activation in a human gastric cancer (SIIA)
    • discussion 136-137
    • Kim HJ, Evers BM, Guo Y, et al.: Bombesin-mediated AP-1 activation in a human gastric cancer (SIIA). Surgery 1996, 120:130-136; discussion 136-137.
    • (1996) Surgery , vol.120 , pp. 130-136
    • Kim, H.J.1    Evers, B.M.2    Guo, Y.3
  • 120
    • 0033860608 scopus 로고    scopus 로고
    • Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA
    • Kim HJ, Evers BM, Litvak DA, et al.: Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA. Am J Physiol Cell Physiol 2000, 279:C326-C334.
    • (2000) Am J Physiol Cell Physiol , vol.279
    • Kim, H.J.1    Evers, B.M.2    Litvak, D.A.3
  • 121
    • 0036551292 scopus 로고    scopus 로고
    • Neuropeptides as growth factors for normal and cancerous cells
    • Rozengurt E: Neuropeptides as growth factors for normal and cancerous cells. Trends Endocrinol Metab 2002, 13:128-134.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 128-134
    • Rozengurt, E.1
  • 122
    • 0029795986 scopus 로고    scopus 로고
    • Vivo MD, et al.: Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins
    • Wang JL, Kalyanaraman S. Vivo MD, et al.: Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins. Biochem J 1996, 320:87-91.
    • (1996) Biochem J , vol.320 , pp. 87-91
    • Wang, J.L.1    Kalyanaraman, S.2
  • 123
    • 0025924826 scopus 로고
    • 2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts
    • 2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts. J Biol Chem 1991, 266:1403-1409.
    • (1991) J Biol Chem , vol.266 , pp. 1403-1409
    • Takuwa, N.1    Iwamoto, A.2    Kumada, M.3
  • 124
    • 34347366980 scopus 로고    scopus 로고
    • Bombesin receptor structure and expression in human lung carcinoma cell lines
    • Fathi Z, Way JW, Corjay MH, et al.: Bombesin receptor structure and expression in human lung carcinoma cell lines. J Cell Biochem Suppl 1996, 24:237-246.
    • (1996) J Cell Biochem Suppl , vol.24 , pp. 237-246
    • Fathi, Z.1    Way, J.W.2    Corjay, M.H.3
  • 125
    • 0025139783 scopus 로고
    • 2+ efflux in human breast cancer cells by bombesin
    • 2+ efflux in human breast cancer cells by bombesin. Cancer Res 1990, 50:235-239.
    • (1990) Cancer Res , vol.50 , pp. 235-239
    • Patel, K.V.1    Schrey, M.P.2
  • 126
    • 0030889867 scopus 로고    scopus 로고
    • Calcium signaling in prostate cancer cells: Evidence for multiple receptors and enhanced sensitivity to bombesin/GRP
    • Wasilenko WJ, Cooper J, Palad AJ, et al.: Calcium signaling in prostate cancer cells: evidence for multiple receptors and enhanced sensitivity to bombesin/GRP. Prostate 1997, 30:167-173.
    • (1997) Prostate , vol.30 , pp. 167-173
    • Wasilenko, W.J.1    Cooper, J.2    Palad, A.J.3
  • 127
    • 0030014619 scopus 로고    scopus 로고
    • Bombesin specifically induces intracellular calcium mobilization via gastrin-releasing peptide receptors in human prostate cancer cells
    • Aprikian AG, Han K, Chevalier S, et al.: Bombesin specifically induces intracellular calcium mobilization via gastrin-releasing peptide receptors in human prostate cancer cells. J Mol Endocrinol 1996, 16:297-306.
    • (1996) J Mol Endocrinol , vol.16 , pp. 297-306
    • Aprikian, A.G.1    Han, K.2    Chevalier, S.3
  • 128
    • 0024238958 scopus 로고
    • Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80,000 protein kinase C substrate in permeabilized 3T3 cells: Effect of guanine nucleotides
    • Erusalimsky JD, Friedberg I, Rozengurt E: Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80,000 protein kinase C substrate in permeabilized 3T3 cells: effect of guanine nucleotides. J Biol Chem 1988, 263:19188-19194.
    • (1988) J Biol Chem , vol.263 , pp. 19188-19194
    • Erusalimsky, J.D.1    Friedberg, I.2    Rozengurt, E.3
  • 129
    • 0022815281 scopus 로고
    • Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide
    • Isacke CM, Meisenhelder J, Brown KD, et al.: Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide. EMBO J 1986, 5:2889-2898.
    • (1986) EMBO J , vol.5 , pp. 2889-2898
    • Isacke, C.M.1    Meisenhelder, J.2    Brown, K.D.3
  • 130
    • 0030760220 scopus 로고    scopus 로고
    • Bombesin-stimulated ceramide production and MAP kinase activation in rabbit rectosigmoid smooth muscle cells
    • Sbrissa D, Yamada H, Hajra A, et al.: Bombesin-stimulated ceramide production and MAP kinase activation in rabbit rectosigmoid smooth muscle cells. Am J Physiol 1997, 272:G1615-G1625.
    • (1997) Am J Physiol , vol.272
    • Sbrissa, D.1    Yamada, H.2    Hajra, A.3
  • 131
    • 0035979991 scopus 로고    scopus 로고
    • Rapid protein kinase D translocation in response to G protein-coupled receptor activation: Dependence on protein kinase C
    • Rey O, Young SH, Cantrell D, et al.: Rapid protein kinase D translocation in response to G protein-coupled receptor activation: dependence on protein kinase C. J Biol Chem 2001, 276:32616-32626.
    • (2001) J Biol Chem , vol.276 , pp. 32616-32626
    • Rey, O.1    Young, S.H.2    Cantrell, D.3
  • 132
    • 0025445735 scopus 로고
    • Multiple synergistic signal transduction pathways regulate c-fos expression in Swiss 3T3 cells: The role of cyclic AMP
    • Mehmet H, Morris C, Rozengurt E: Multiple synergistic signal transduction pathways regulate c-fos expression in Swiss 3T3 cells: the role of cyclic AMP. Cell Growth Differ 1990, 1:293-298.
    • (1990) Cell Growth Differ , vol.1 , pp. 293-298
    • Mehmet, H.1    Morris, C.2    Rozengurt, E.3
  • 133
    • 0029788699 scopus 로고    scopus 로고
    • Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin
    • Seufferlein T, Withers DJ, Rozengurt E: Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin. J Biol Chem 1996, 271:21471-21477.
    • (1996) J Biol Chem , vol.271 , pp. 21471-21477
    • Seufferlein, T.1    Withers, D.J.2    Rozengurt, E.3
  • 134
    • 0027463579 scopus 로고
    • Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells
    • Pang L, Decker SJ, Saltiel AR: Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells. Biochem J 1993, 289:283-287.
    • (1993) Biochem J , vol.289 , pp. 283-287
    • Pang, L.1    Decker, S.J.2    Saltiel, A.R.3
  • 135
    • 0030919922 scopus 로고    scopus 로고
    • Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells
    • Charlesworth A, Rozengurt E: Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells. Oncogene 1997, 14:2323-2329.
    • (1997) Oncogene , vol.14 , pp. 2323-2329
    • Charlesworth, A.1    Rozengurt, E.2
  • 136
    • 0032414639 scopus 로고    scopus 로고
    • Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation
    • Fiorucci S, Bufalari A, Distrutli E, et al.: Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation. Scand J Gastroenterol 1998, 33:1310-1320.
    • (1998) Scand J Gastroenterol , vol.33 , pp. 1310-1320
    • Fiorucci, S.1    Bufalari, A.2    Distrutli, E.3
  • 137
    • 0031438076 scopus 로고    scopus 로고
    • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1 a fibroblasts: She phosphorylation and receptor endocytosis correlate with activation of Erk kinases
    • Luttrell LM, Daaka Y, Delia Rocca GJ, et al.: G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1 a fibroblasts: She phosphorylation and receptor endocytosis correlate with activation of Erk kinases. J Biol Chem 1997, 272:31648-31656.
    • (1997) J Biol Chem , vol.272 , pp. 31648-31656
    • Luttrell, L.M.1    Daaka, Y.2    Delia Rocca, G.J.3
  • 138
    • 0032952135 scopus 로고    scopus 로고
    • Bombesin activates MAP kinase in non-small cell lung cancer cells
    • Koh SW, Leyton J, Moody TW: Bombesin activates MAP kinase in non-small cell lung cancer cells. Peptides 1999, 20:121-126.
    • (1999) Peptides , vol.20 , pp. 121-126
    • Koh, S.W.1    Leyton, J.2    Moody, T.W.3
  • 139
    • 0035983108 scopus 로고    scopus 로고
    • Differential activation of p42ERK2 and p125FAK by cholecystokinin and bombesin in the secretion and proliferation of the pancreatic amphicrine cell line AR42J
    • Kiehne K, Herzig KH, Folsch UR: Differential activation of p42ERK2 and p125FAK by cholecystokinin and bombesin in the secretion and proliferation of the pancreatic amphicrine cell line AR42J. Pancreatology 2002, 2:46-53.
    • (2002) Pancreatology , vol.2 , pp. 46-53
    • Kiehne, K.1    Herzig, K.H.2    Folsch, U.R.3
  • 140
    • 0032988428 scopus 로고    scopus 로고
    • Activation of MAP kinases in growth responsive pancreatic cancer cells
    • Douziech N, Calvo E, Laine J, et al.: Activation of MAP kinases in growth responsive pancreatic cancer cells. Cell Signal 1999, 11:591-602.
    • (1999) Cell Signal , vol.11 , pp. 591-602
    • Douziech, N.1    Calvo, E.2    Laine, J.3
  • 141
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N, Zwick E, Daub H, et al.: EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999, 402:884-888.
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 142
    • 0034836953 scopus 로고    scopus 로고
    • EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin
    • Santiskulvong C, Sinnett-Smith J, Rozengurt E: EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin. Am J Physiol Cell Physiol 2001, 281:C886-C898.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Santiskulvong, C.1    Sinnett-Smith, J.2    Rozengurt, E.3
  • 143
    • 0022489875 scopus 로고
    • Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells, I: Activation of protein kinase C and inhibition of epidermal growth factor binding
    • Zachary I, Sinnett-Smith JW, Rozengurt E: Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells, I: activation of protein kinase C and inhibition of epidermal growth factor binding. J Cell Biol 1986, 102:2211-2222.
    • (1986) J Cell Biol , vol.102 , pp. 2211-2222
    • Zachary, I.1    Sinnett-Smith, J.W.2    Rozengurt, E.3
  • 144
    • 0037157854 scopus 로고    scopus 로고
    • The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
    • Van Y, Shirakabe K, Werb Z: The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol 2002, 158:221-226. This elegant article for the first time elucidates how metalloprotease-mediated shedding regulates signaling pathways and provides novel insights on EGFR transactivation mediated by G-protein-coupled receptors. It determines that ADAM 10(KUZ) is involved in GPCR-mediated Ras and Erk activation via EGFR transactivation.
    • (2002) J Cell Biol , vol.158 , pp. 221-226
    • Van, Y.1    Shirakabe, K.2    Werb, Z.3
  • 145
    • 0034681203 scopus 로고    scopus 로고
    • EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists
    • Carpenter G: EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. Sci STKE 2000, 2000:E1.
    • (2000) Sci STKE , vol.2000
    • Carpenter, G.1
  • 146
    • 0034072131 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor
    • Leopoldt D, Yee HF Jr, Saab S, et al.: Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor. J Cell Physiol 2000, 183:208-220.
    • (2000) J Cell Physiol , vol.183 , pp. 208-220
    • Leopoldt, D.1    Yee Jr., H.F.2    Saab, S.3
  • 147
    • 0029984390 scopus 로고    scopus 로고
    • The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation
    • Charlesworth A, Broad S, Rozengurt E: The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation. Oncogene 1996, 12:1337-1345.
    • (1996) Oncogene , vol.12 , pp. 1337-1345
    • Charlesworth, A.1    Broad, S.2    Rozengurt, E.3
  • 148
    • 0035834881 scopus 로고    scopus 로고
    • Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells
    • Leyton J, Garcia-Marin LJ, Tapia JA, et al.: Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells. Cancer Lett 2001, 162:87-95.
    • (2001) Cancer Lett , vol.162 , pp. 87-95
    • Leyton, J.1    Garcia-Marin, L.J.2    Tapia, J.A.3
  • 149
    • 0029994016 scopus 로고    scopus 로고
    • Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines
    • Tallett A, Chilvers ER, MacKinnon AC, et al.: Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines. Peptides 1996, 17:665-673.
    • (1996) Peptides , vol.17 , pp. 665-673
    • Tallett, A.1    Chilvers, E.R.2    MacKinnon, A.C.3
  • 150
    • 0030787791 scopus 로고    scopus 로고
    • Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins
    • Aprikian AG, Tremblay L, Man K, et al.: Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins. Int J Cancer 1997, 72:498-504.
    • (1997) Int J Cancer , vol.72 , pp. 498-504
    • Aprikian, A.G.1    Tremblay, L.2    Man, K.3
  • 151
    • 0030005414 scopus 로고    scopus 로고
    • Actin disruption inhibits bombesin stimulation of focal adhesion kinase (pp125FAK) in prostate carcinoma
    • Duncan MD, Harmon JW, Duncan LK: Actin disruption inhibits bombesin stimulation of focal adhesion kinase (pp125FAK) in prostate carcinoma. J Surg Res 1996, 63:359-363.
    • (1996) J Surg Res , vol.63 , pp. 359-363
    • Duncan, M.D.1    Harmon, J.W.2    Duncan, L.K.3
  • 152
    • 0029892628 scopus 로고    scopus 로고
    • Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin
    • Rinn HM, Ridley AJ: Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J Cell Sci 1996, 109:1133-1141.
    • (1996) J Cell Sci , vol.109 , pp. 1133-1141
    • Rinn, H.M.1    Ridley, A.J.2
  • 153
    • 0028236960 scopus 로고
    • The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both ppl 25FAK and protein kinase C-delta to focal adhesions
    • Barry ST, Critchley DR: The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both ppl 25FAK and protein kinase C-delta to focal adhesions. J Cell Sci 1994, 107:2033-2045.
    • (1994) J Cell Sci , vol.107 , pp. 2033-2045
    • Barry, S.T.1    Critchley, D.R.2
  • 154
    • 0034730536 scopus 로고    scopus 로고
    • [D-Arg(1),D-Trp(5,7, 9),Leu(11)]Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3cells
    • Sinnett-Smith J, Santiskulvong C, Duque J, et al.: [D-Arg(1),D-Trp(5,7, 9),Leu(11)]Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3cells. J Biol Chem 2000, 275:30644-30652.
    • (2000) J Biol Chem , vol.275 , pp. 30644-30652
    • Sinnett-Smith, J.1    Santiskulvong, C.2    Duque, J.3
  • 155
    • 0032485940 scopus 로고    scopus 로고
    • Galpha12 and GalphalS stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and pi 30 Crk-associated substrate
    • Needham LK, Rozengurt E: Galpha12 and GalphalS stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and pi 30 Crk-associated substrate. J Biol Chem 1998, 273:14626-14632.
    • (1998) J Biol Chem , vol.273 , pp. 14626-14632
    • Needham, L.K.1    Rozengurt, E.2
  • 156
    • 0027944638 scopus 로고
    • Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of pi 25FAK and paxillin induced by bombesin and endothelin
    • Rankin S, Morii N, Narumiya S, et al.: Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of pi 25FAK and paxillin induced by bombesin and endothelin. FEBS Lett 1994, 354:315-319.
    • (1994) FEBS Lett , vol.354 , pp. 315-319
    • Rankin, S.1    Morii, N.2    Narumiya, S.3
  • 158
    • 0035204477 scopus 로고    scopus 로고
    • Neuropeptide-induced androgen independence in prostate cancer cells: Roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase
    • Lee LF, Guan J, Qiu Y, et al.: Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase. Mol Cell Biol 2001, 21:8385-8397.
    • (2001) Mol Cell Biol , vol.21 , pp. 8385-8397
    • Lee, L.F.1    Guan, J.2    Qiu, Y.3
  • 159
    • 0029947181 scopus 로고    scopus 로고
    • Requirement for phosphatidylinositol 3′-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin
    • Rankin S, Hooshmand-Rad R, Claesson-Welsh L, et al.: Requirement for phosphatidylinositol 3′-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin. J Biol Chem 1996, 271:7829-7834.
    • (1996) J Biol Chem , vol.271 , pp. 7829-7834
    • Rankin, S.1    Hooshmand-Rad, R.2    Claesson-Welsh, L.3
  • 160
    • 0029914133 scopus 로고    scopus 로고
    • Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells: Dissociation from tyrosine phosphorylation of pi 25 focal adhesion kinase
    • Rodriguez-Fernandez JL, Rozengurt E: Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells: dissociation from tyrosine phosphorylation of pi 25 focal adhesion kinase. J Biol Chem 1996, 271:27895-27901.
    • (1996) J Biol Chem , vol.271 , pp. 27895-27901
    • Rodriguez-Fernandez, J.L.1    Rozengurt, E.2
  • 161
    • 0035955735 scopus 로고    scopus 로고
    • Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells
    • Zhukova E, Sinnett-Smith J, Rozengurt E: Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells. J Biol Chem 2001, 276:40298-40305.
    • (2001) J Biol Chem , vol.276 , pp. 40298-40305
    • Zhukova, E.1    Sinnett-Smith, J.2    Rozengurt, E.3
  • 162
    • 0033083095 scopus 로고    scopus 로고
    • Protein kinase D in small cell lung cancer cells: Rapid activation through protein kinase C
    • Paolucci L, Rozengurt E: Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C. Cancer Res 1999, 59:572-577.
    • (1999) Cancer Res , vol.59 , pp. 572-577
    • Paolucci, L.1    Rozengurt, E.2
  • 163
    • 0035966065 scopus 로고    scopus 로고
    • Regulated nucleocytoplasmic transport of protein kinase D in response to G protein-coupled receptor activation
    • Rey O, Sinnett-Smith J, Zhukova E, et al.: Regulated nucleocytoplasmic transport of protein kinase D in response to G protein-coupled receptor activation. J Biol Chem 2001, 276:49228-49235.
    • (2001) J Biol Chem , vol.276 , pp. 49228-49235
    • Rey, O.1    Sinnett-Smith, J.2    Zhukova, E.3
  • 164
    • 0035914392 scopus 로고    scopus 로고
    • Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13
    • Yuan J, Slice LW, Rozengurt E: Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13. J Biol Chem 2001, 276:38619-38627.
    • (2001) J Biol Chem , vol.276 , pp. 38619-38627
    • Yuan, J.1    Slice, L.W.2    Rozengurt, E.3
  • 165
    • 0034695691 scopus 로고    scopus 로고
    • Activation of protein kinase D by signaling through the alpha subunit of the heterotrimeric G protein G(q)
    • Yuan J, Slice L, Walsh JH, et al.: Activation of protein kinase D by signaling through the alpha subunit of the heterotrimeric G protein G(q). J Biol Chem 2000, 275:2157-2164.
    • (2000) J Biol Chem , vol.275 , pp. 2157-2164
    • Yuan, J.1    Slice, L.2    Walsh, J.H.3
  • 166
    • 0028967089 scopus 로고
    • Bombesin stimulates c-fos and c-jun mRNAs in small cell lung cancer cells
    • Draoui M, Chung P, Park M, et al.: Bombesin stimulates c-fos and c-jun mRNAs in small cell lung cancer cells. Peptides 1995, 16:289-292.
    • (1995) Peptides , vol.16 , pp. 289-292
    • Draoui, M.1    Chung, P.2    Park, M.3
  • 167
    • 0037111343 scopus 로고    scopus 로고
    • GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells
    • Xiao D, Qu X, Weber HC: GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells. Regul Pept 2002, 109:141-148.
    • (2002) Regul Pept , vol.109 , pp. 141-148
    • Xiao, D.1    Qu, X.2    Weber, H.C.3
  • 168
    • 0025175626 scopus 로고
    • Bombesin stimulation of c-fos expression and mitogenesis in Swiss 3T3 cells: The role of prostaglandin E2-mediated cyclic AMP accumulation
    • Mehmet H, Millar JB, Lehmann W, et al.: Bombesin stimulation of c-fos expression and mitogenesis in Swiss 3T3 cells: the role of prostaglandin E2-mediated cyclic AMP accumulation. Exp Cell Res 1990, 190:265-270.
    • (1990) Exp Cell Res , vol.190 , pp. 265-270
    • Mehmet, H.1    Millar, J.B.2    Lehmann, W.3
  • 169
    • 0031032369 scopus 로고    scopus 로고
    • Large induction of c-Myc is not essential for the mitogenic response of Swiss 3T3 fibroblasts
    • Mehmet H, Littlewood TD, Sinnett-Smith J, et al.: Large induction of c-Myc is not essential for the mitogenic response of Swiss 3T3 fibroblasts. Cell Growth Differ 1997, 8:187-193.
    • (1997) Cell Growth Differ , vol.8 , pp. 187-193
    • Mehmet, H.1    Littlewood, T.D.2    Sinnett-Smith, J.3
  • 170
    • 0021807624 scopus 로고
    • Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer
    • Cuttitta F, Carney DN, Mulshine J, et al.: Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature 1985, 316:823-826.
    • (1985) Nature , vol.316 , pp. 823-826
    • Cuttitta, F.1    Carney, D.N.2    Mulshine, J.3
  • 171
    • 0025922873 scopus 로고
    • [Psi 13,14] bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo
    • Mahmoud S, Staley J, Taylor J, et al.: [Psi 13,14] bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo. Cancer Res 1991, 51:1798-1802.
    • (1991) Cancer Res , vol.51 , pp. 1798-1802
    • Mahmoud, S.1    Staley, J.2    Taylor, J.3
  • 172
    • 0032754662 scopus 로고    scopus 로고
    • Phase I and imaging trial of a monoclonal antibody directed against gastrin-releasing peptide in patients with lung cancer
    • Chaudhry A, Carrasquillo JA, Avis IL, et al.: Phase I and imaging trial of a monoclonal antibody directed against gastrin-releasing peptide in patients with lung cancer. Clin Cancer Res 1999, 5:3385-3393.
    • (1999) Clin Cancer Res , vol.5 , pp. 3385-3393
    • Chaudhry, A.1    Carrasquillo, J.A.2    Avis, I.L.3
  • 173
    • 0037029025 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck
    • Lango MN, Dyer KF, Lui VW, et al.: Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. J Natl Cancer Inst 2002, 94:375-383.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 375-383
    • Lango, M.N.1    Dyer, K.F.2    Lui, V.W.3
  • 174
    • 0036253370 scopus 로고    scopus 로고
    • Inhibition of proliferation of human small cell lung cancer cells expressing an autocrine system for gastrin releasing peptide by antisense oligodeoxynucleotides to gastrin releasing peptide receptor
    • Langer DA, Kautzman D1 Kane MA: Inhibition of proliferation of human small cell lung cancer cells expressing an autocrine system for gastrin releasing peptide by antisense oligodeoxynucleotides to gastrin releasing peptide receptor. Lung Cancer 2002, 36:235-242.
    • (2002) Lung Cancer , vol.36 , pp. 235-242
    • Langer, D.A.1    Kautzman, D.2    Kane, M.A.3
  • 175
    • 0036124254 scopus 로고    scopus 로고
    • Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands
    • Gollan TJ, Green MR: Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands. J Virol 2002, 76:3564-3569. This report provides a novel strategy to target selectively human cancer cells expressing functional GRP-R by modifying a retroviral envelope protein with short GRP peptides. Pseudotype vims transduces successfully target cells with cognate GRP-R and causes cell death via delivery of thymidine kinase activity in the presence of ganciclovir.
    • (2002) J Virol , vol.76 , pp. 3564-3569
    • Gollan, T.J.1    Green, M.R.2
  • 176
    • 0036348351 scopus 로고    scopus 로고
    • Phase I trial of technetium [Leu13] bombesin as cancer seeking agent: Possible scintigraphic guide for surgery?
    • De Vincentis G, Scopinaro F, Varvarigou A, et al.: Phase I trial of technetium [Leu13] bombesin as cancer seeking agent: possible scintigraphic guide for surgery? Tumori 2002, 88:S28-S30. This article and [177] are two very small, preliminary studies on the tumor localization in vivo using a radiolabeled 99mTechnecium-bombesin compound and scintigraphy.
    • (2002) Tumori , vol.88
    • De Vincentis, G.1    Scopinaro, F.2    Varvarigou, A.3
  • 177
    • 17344375857 scopus 로고    scopus 로고
    • Breast cancer takes up 99mTc bombesin: A preliminary report
    • See [176]
    • Scopinaro F, Varvarigou A, Ussof W, et al.: Breast cancer takes up 99mTc bombesin: a preliminary report. Tumori 2002, 88:S25-S28. See [176].
    • (2002) Tumori , vol.88
    • Scopinaro, F.1    Varvarigou, A.2    Ussof, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.