Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions

British Journal of Cancer

Volumn 84, Issue 7, 2001, Pages 926-935

  Murphy, L O ^a   Cluck, M W ^a   Lovas, S ^a   Otvos F ^a   Murphy, R F ^a   Schally, A V ^b   Permert, J ^c   Larsson, J ^c   Knezetic, J A ^a   Adrian, T E ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autocrine; EGF receltor; MAPK AP 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; AUTOCRINE GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EXTRACELLULAR REGULATED KINASE 1; EXTRACELLULAR REGULATED KINASE 2; GROWTH FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL CULTURE; CELL PROLIFERATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL DIVISION; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FLAVONOIDS; GASTRIN-RELEASING PEPTIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PANCREATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 17744386907     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1698     Document Type: Article

References (30)

1. Polymerase chain reaction based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears
2. Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth
3. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin
4. Induction and expression of amphiregulin in human pancreatic cancer
5. Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy
6. Stimulation of 3T3 cells induces transcription of the c-fas proto-oncogene
7. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
8. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line
9. Regulation of transforming growth factor α expression in a growth factor-independent cell line
10. Heparin oligosaccharides: Inhibitors of the biological activity of bFGF on Caco-2 cells
11. Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer
12. Induction and expression of amphiregulin in human pancreatic cancer
13. Growth factors and pancreatic cancer
14. Monoclonal antibodies to receptors for insulin and somatomedin C
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Cancer Statistics, 1999
17. The ras-JNK pathway is involved in shear-induced gene expression
18. Familial pancreatic cancer: A review
19. Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly-differentiated and well-differentiated human colon carcinoma cells
20. Amphiregulin is a potent mitogen in human pancreatic cancer cells: Correlation with patient survival
21. Insulin-like growth factors in human pancreatic cancer cell growth
22. Epidermal-growth-factor-dependent activation of the Src-family kinases
23. Coupling difficulty following replacement of Tyr with HOTic during synthesis of an analog of an EGF B-loop fragment
24. Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic cancer cells in vivo and in vitro
25. Antagonists of bombesin/gastrin-releasing peptide inhibit growth of SW-1990 human pancreatic adenocarcinoma and production of cyclic AMP
26. Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts
27. Amphireguln in lung branching morphogenesis: Interaction with heparin sulfate proteoglycan modulates cell proliferation
28. Humoral growth factors in plasma and liver tissue during liver regeneration and malnutrition
29. Expression of a truncated EGF receptor is associated with inhibition of pancreatic cancer cell growth and enhanced sensitivity to cisplatinum
30. Bombesin may stimulate proliferation of human pancreatic cancer cells through an autocrine pathway