EGF receptor function is required in late G1 for cell cycle progression induced by bombesin and bradykinin

American Journal of Physiology - Cell Physiology

Volumn 281, Issue 3 50-3, 2001, Pages

  Santiskulvong, Chintda ^a   Sinnett Smith, James ^a   Rozengurt, Enrique ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Epidermal growth factor receptor transactivation; G protein coupled receptors; Mitogen activated protein kinases; Swiss 3T3 cells; Tyrphostin AG 1478

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BOMBESIN; BRADYKININ; CYCLIN D1; CYCLIN E; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; TYRPHOSTIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION;

ANIMALIA;

EID: 0034836953     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.281.3.c886     Document Type: Article

References (65)

1. Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells
2. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor
3. 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
4. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways
5. The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation
6. (raf-1) via a protein kinase C-independent pathway in Rat-1 cells
7. Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway
8. Signal characteristics of G protein-transactivated EGF receptor
9. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
10. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases
11. Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism
12. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
13. r = 80,000 protein kinase C substrate in permeabilized 3T3 cells. Effect of guanine nucleotides
14. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase
15. Biochemical and antiproliferative properties of 4-[ar(alk)ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor
16. Rescue of cyclin D1 deficiency by knockin cyclin E
17. 1 cell cycle progression
18. Epidermal growth factor receptors: Critical mediators of multiple receptor pathways
19. Oncogenic Ha-ras-dependent mitogen-activated protein kinase activity requires signaling through the epidermal growth factor receptor
20. q
21. Ral GTPases contribute to regulation of cyclin D1 through activation of NF-κB
22. Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion
23. Synergistic stimulation of DNA synthesis by bradykinin and vasopressin in Swiss 3T3 cells
24. Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc
25. q
26. Inhibition of platelet-derived growth factor and epidermal growth factor receptor signaling events after treatment of cells with specific synthetic inhibitors of tyrosine kinase phosphorylation
27. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
28. Differential control of cyclins D1 and D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss 3T3 cells
29. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
30. Differential modulation of bombesin-stimulated phospholipase C beta and mitogen-activated protein kinase activity by [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P
31. 2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin
32. 13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate
33. 11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cells
34. Perturbation of cell cycle regulators in human cancer
35. Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells
36. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
37. Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors
38. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
39. Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells
40. Early signals in the mitogenic response
41. Gastrointestinal peptide signaling through tyrosine phosphorylation of focal adhesion proteins
42. Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists
43. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells
44. Early signals underlying the induction of the c-fos and c-myc genes in quiescent fibroblasts: Studies with bombesin and other growth factors
45. Gastrin, CCK, signaling and cancer
46. Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells
47. [D-Arg1,D-Trp5,7,9,Leu11]Substance P coordinately and reversibly inhibits bombesin- and vasopressin-induced signal transduction pathways in Swiss 3T3 cells
48. The MAPK signaling cascade
49. Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor
50. Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin
51. 1-phase progression
52. 2+ mobilization, and the actin cytoskeleton
53. 13 stimulates rho-dependent activation of the cyclooxygenase-2 promoter
54. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
55. The bisindolylmaleimide GF-109203X is a potent and selective inhibitor of protein kinase-C
56. Regulation of transcription by MAP kinase cascades
57. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity
58. Control of EGF receptor signaling by clathrin-mediated endocytosis
59. Dissociation of cAMP-stimulated mitogenesis from activation of the mitogen-activated protein kinase cascade in Swiss 3T3 cells
60. Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells
61. Two classes of antagonist interact with receptors for the mitogenic neuropeptides bombesin, bradykinin, and vasopressin
62. Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells
63. q
64. Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linking
65. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate