The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers

Regulatory Peptides

Volumn 90, Issue 1-3, 2000, Pages 77-84

  Sun, Baodong ^a,b   Schally, Andrew V ^a,b   Halmos, Gabor ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bombesin receptor; BRS 3; Cancer therapy; GRPR; Hormone analogs; NMBR; Ovarian cancer metastasis; RT PCR

Indexed keywords

BOMBESIN RECEPTOR; GASTRIN RECEPTOR; GASTRIN RELEASING PEPTIDE; GASTRIN RELEASING PEPTIDE RECEPTOR; MEMBRANE RECEPTOR; NEUROMEDIN B; NEUROMEDIN RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CANCER STAGING; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN TISSUE; METASTASIS; NONHUMAN; OVARY CANCER; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOGRAFT;

AGED; ANIMALS; BOMBESIN; FEMALE; HUMANS; MICE; MICE, NUDE; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; OVARY; RADIOLIGAND ASSAY; RECEPTORS, BOMBESIN; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0034733778     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(00)00114-2     Document Type: Article

References (32)

1. Cuttitta F., Carney D.N., Mulshine J., Moody T.W., Fedorko J., Fishler A., Minna J.D. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature (London). 316:1985;823-826.
2. Avis I., Jett M., Kasprzyk P.G., Cuttitta F., Treston A.M., Maneckjee R., Mulshine J.L. Effect of gastrin-releasing peptide on the pancreatic tumor cell line (Capan). Mol Carcinog. 8:1993;214-220.
3. Nelson J., Donnelly M., Walker B., Gray J., Shaw C., Murphy R.F. Bombesin stimulates proliferation of human breast cancer cells in culture. Br J Cancer. 63:1991;933-936.
4. Yano T., Pinski J., Groot K., Schally A.V. Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer Res. 52:1992;4545-4547.
5. Bologna M., Festuccia C., Muzi P., Biordi L., Ciomei M. Bombesin stimulates growth of human prostatic cancer cells in vitro. Cancer. 63:1989;1714-1720.
6. Pinski J., Halmos G., Yano T., Szepeshazi K., Qin Y., Ertl T., Schally A.V. Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing peptide antagonist (RC-3095) and somatostatin analog RC-160. Int J Cancer. 57:1994;574-580.
7. Fathi Z., Corjay M.H., Shapira H., Wada E., Benya R., Jensen R., Viallet J., Sausville E.A., Battey J.F. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J Biol Chem. 268:1993;5979-5984.
8. Mantey S.A., Weber H.C., Sainz E., Akeson M., Ryan R.R., Pradhan T.K., Searles R.P., Spindel E.R., Battey J.F., Coy D.H., Jensen R.T. Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem. 272:1997;26062-26071.
9. Feldman R.I., Bartholdi M.F., Wu J.M. Bombesin-like peptide receptor subtypes promote mitogenesis which requires persistent receptor signaling. Mol Pharmacol. 50:1996;1346-1354.
10. Schally A.V., Comaru-Schally A.M. Hypothalamic and other peptide hormones. Holland J.F., Frei E. III, Bast R.C. Jr., Kufe D.E., Morton D.L., Weichselbaum R.R. Cancer medicine. 4th ed. 1997;1067-1085 Williams & Wilkins, Baltimore.
11. 2 show high binding affinity to bombesin/GRP receptors on CFPAC-1 human pancreatic cancer cells. Int J Oncol. 6:1995;1165-1172.
12. Sarri W.S., Heimbrook D.C., Friedman A., Fisher T.W., Oliff A. A gastrin-releasing peptide antagonist containing a ψ(CH20) amine bond surrogate. Biochem Biophys Res Commun. 165:1989;114-117.
13. Mahmoud S., Staley J., Taylor J., Bogden A., Moreau J.P., Coy D., Avis I., Cuttitta F., Mulshine J.L., Moody T.W. (Psi 13,14) bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo. Cancer Res. 51:1991;1798-1802.
14. Jungwirth A., Galvan G., Pinski J., Halmos G., Szepeshazi K., Cai R.Z., Groot K., Schally A.V. LH-RH antagonist Cetrorelix (SB-75) and bombesin antagonist RC-3940-II inhibit the growth of androgen-independent PC-3 prostate cancer in nude mice. Prostate. 32:1997;164-172.
15. Radulovic S., Schally A.V., Reile H., Halmos G., Szepeshazi K., Groot K., Milovanovic S., Miller G., Yano T. Inhibitory effects of antagonists of bombesin/gastrin releasing peptide (GRP) and somatostatin analog (RC-160) on growth of HT-29 human colon cancers in nude mice. Acta Oncol. 33:1994;693-701.
16. Pinski J., Schally A.V., Halmos G., Szepeshazi K., Groot K., O'Byrne K., Cai R.-Z. Effects of somatostatin analog RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice. Br J Cancer. 70:1994;886-892.
17. Qin Y., Ertl T., Cai R.Z., Horvath J.E., Groot K., Schally A.V. Antagonists of bombesin/gastrin releasing peptide inhibit growth of SW-1990 human pancreatic adenocarcinoma and production of cyclic Amp. Int J Cancer. 63:1995;257-262.
18. Muñoz K.A., Harlan L.C., Trimble E.L. Patterns of care for women with ovarian cancer in the United States. J Clin Oncol. 15:1997;3408-3415.
19. Emons G., Schally A.V. The use of luteinizing hormone-releasing hormone agonists and antagonists in gynecological cancer. Hum Reprod. 9:1994;1364-1379.
20. Ozols R.F., Young R.C. Chemotherapy of ovarian cancer. Semin Oncol. 11:1984;251-263.
21. Halmos G., Wittliff J.L., Schally A.V. Characterization of bombesin/gastrin-releasing peptide receptors in human breast cancer and their relationship to steroid receptor expression. Cancer Res. 55:1995;280-287.
22. McPherson G.A. Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J Pharmacol Methods. 14:1985;213-228.
23. Frankel A., Tsao M.-S., Viallet J. Receptor subtype expression and responsiveness to bombesin in cultured human bronchial epithelial cells. Cancer Res. 54:1994;1613-1616.
24. Gordon A.W., Pegues J.C., Johnson G.R., Kannan B., Auesperg N., Stromberg K. mRNA phenotyping of the major ligands and receptors of the EGF superfamily in human ovarian epithelial cells. Cancer Lett. 89:1995;63-71.
25. Miyazaki M., Nagy A., Schally A.V., Lamharzi N., Halmos G., Szepeshazi Groot K., Armatis P. Growth inhibition of human ovarian cancers by cytotoxic analogues of luteinizing hormone-releasing hormone. J Natl Cancer Inst. 89:1997;1803-1809.
26. Fathi Z., Way J.W., Corjay M.H., Viallet J., Sausville E.A., Battey J.F. Bombesin receptor structure and expression in human lung carcinoma cell lines. J Cell Biochem Suppl. 24:1996;237-246.
27. Siegfried J.M., Guentert P.J., Gaither A.L. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat Rec. 236:1993;241-247.
28. DeMichele M.A., Gaither Davis A.L., Hunt J.D., Landreneau R.J., Siegfried J.M. Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 11:1994;66-74.
29. Koh S.M., Leyton J., Moody T.W. Bombesin activates MAP kinase in non-small cell lung cancer cells. Peptides. 20:1999;121-126.
30. Ryan R.R., Weber H.C., Hou W., Sainz E., Mantey S.A., Battey J.F., Coy D.H., Jensen R.T. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. J Biol Chem. 273:1998;13613-13624.
31. Nagy A., Armatis P., Cai R.-Z., Szepeshazi K., Halmos G., Schally A.V. Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin. Proc Natl Acad Sci USA. 94:1997;652-656.
32. Kiaris H., Schally A.V., Nagy A., Sun B., Armatis P., Szepeshazi K. Targeted cytotoxic analog of bombesin/gastrin-releasing peptide inhibits the growth of H69 human small cell lung carcinoma in nude mice. Br J Cancer. 81:1999;966-971.