메뉴 건너뛰기




Volumn 15, Issue 9, 2005, Pages 1221-1239

Nicotinic acetylcholine receptor ligands as potential therapeutics

Author keywords

Alzheimer's disease; Epibatidine; Neurodegenerative disease; Nicotine; Nicotinic acetylcholine receptor (nAChR); Pain; Parkinson's disease

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM IODIDE; ANTINOCICEPTIVE AGENT; AR R17779; BICYCLO[2.2.2]OCTANE DERIVATIVE; BICYCLO[3.2.0]HEPTANE DERIVATIVE; BICYCLO[3.2.1]OCTANE DERIVATIVE; BICYCLO[3.3.1]NONANE DERIVATIVE; BICYCLO[4.2.0]OCTANE DERIVATIVE; BORNEOL; CAMPHOR; CYCLOALKANE DERIVATIVE; GUANIDINE DERIVATIVE; INDOLE DERIVATIVE; N (4 ACETYL 1 PIPERAZINYL) 4 FLUOROBENZAMIDE; N METHYL 4 (3 PYRIDINYL) 3 BUTENAMINE; NICOTINE DERIVATIVE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NORBORNANE DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SSR 180711A; TACRINE; TETRAHYDROISOQUINOLINE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARENICLINE; VENLAFAXINE;

EID: 25444481876     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.15.9.1221     Document Type: Review
Times cited : (15)

References (89)
  • 2
    • 0032970174 scopus 로고    scopus 로고
    • International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits
    • LUKAS RJ, CHANGEUX JP, NOVERE NL et al.: International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol. Rev. (1999) 51:397-401.
    • (1999) Pharmacol. Rev. , vol.51 , pp. 397-401
    • Lukas, R.J.1    Changeux, J.P.2    Novere, N.L.3
  • 3
    • 0027398069 scopus 로고
    • The diversity of neuronal nicotinic acetylcholine receptors
    • SARGENT PB: The diversity of neuronal nicotinic acetylcholine receptors. Ann. Rev. Neurosci. (1993) 16:403-443.
    • (1993) Ann. Rev. Neurosci. , vol.16 , pp. 403-443
    • Sargent, P.B.1
  • 4
    • 0029006150 scopus 로고
    • Nicotinic receptor: An allosteric protein specialized for intracellular communication
    • BERTRAND D, CHANGEUX JP: Nicotinic receptor: an allosteric protein specialized for intracellular communication. Semin. Neurosci. (1995) 7:75-90.
    • (1995) Semin. Neurosci. , vol.7 , pp. 75-90
    • Bertrand, D.1    Changeux, J.P.2
  • 5
    • 0028922693 scopus 로고
    • Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells
    • LE NOVÈRE N, CHANGEUX JP: Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J. Mol. Evol. (1995) 40:155-172.
    • (1995) J. Mol. Evol. , vol.40 , pp. 155-172
    • Le Novère, N.1    Changeux, J.P.2
  • 7
    • 0032215090 scopus 로고    scopus 로고
    • Allosteric receptors after 30 years
    • CHANGEUX JP, EDELSTEIN SJ: Allosteric receptors after 30 years. Neuron (1998) 21:959-980.
    • (1998) Neuron , vol.21 , pp. 959-980
    • Changeux, J.P.1    Edelstein, S.J.2
  • 8
    • 1642321246 scopus 로고    scopus 로고
    • Design of ligands for the nicotinic acetylcholine receptors: The quest for selectivity
    • BUNNELLE WH, DART MJ, SCHRIMPF MR: Design of ligands for the nicotinic acetylcholine receptors: the quest for selectivity. Curr. Topics Med. Chem. (2004) 4:299-334.
    • (2004) Curr. Topics Med. Chem. , vol.4 , pp. 299-334
    • Bunnelle, W.H.1    Dart, M.J.2    Schrimpf, M.R.3
  • 9
    • 0030818328 scopus 로고    scopus 로고
    • Biological functions of keratinocyte cholinergic receptors
    • GRANDO SA: Biological functions of keratinocyte cholinergic receptors. J. Investig. Dermatol. Symp. Proc. (1997) 2:41-48.
    • (1997) J. Investig. Dermatol. Symp. Proc. , vol.2 , pp. 41-48
    • Grando, S.A.1
  • 10
    • 0031723751 scopus 로고    scopus 로고
    • Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors
    • MAUS AD, PEREIRA EF, KARACHUNSKI PI et al.: Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol. Pharmacol. (1998) 54:779-788.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 779-788
    • Maus, A.D.1    Pereira, E.F.2    Karachunski, P.I.3
  • 11
    • 0034438346 scopus 로고    scopus 로고
    • Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia
    • NGUYEN VT, HALL LL, GALLACHER G et al.: Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. J. Dent. Res. (2000) 79:939-949.
    • (2000) J. Dent. Res. , vol.79 , pp. 939-949
    • Nguyen, V.T.1    Hall, L.L.2    Gallacher, G.3
  • 12
    • 0141569322 scopus 로고    scopus 로고
    • Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines
    • SKOK MV, KALASHNIK EN, KOVAL LN et al.: Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines. Mol. Pharmacol. (2003) 64:885-889.
    • (2003) Mol. Pharmacol. , vol.64 , pp. 885-889
    • Skok, M.V.1    Kalashnik, E.N.2    Koval, L.N.3
  • 14
    • 1642457187 scopus 로고    scopus 로고
    • 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras
    • 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras. Mol. Pharmacol. (2004) 65:453-460.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 453-460
    • Baker, E.R.1    Zwart, R.2    Sher, E.3    Millar, N.S.4
  • 15
    • 0028171296 scopus 로고
    • 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
    • 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell (1994) 79:705-715.
    • (1994) Cell , vol.79 , pp. 705-715
    • Elgoyhen, A.B.1    Johnson, D.S.2    Boulter, J.3    Vetter, D.E.4    Heinemann, S.5
  • 17
    • 17144413330 scopus 로고
    • Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
    • PICCIOTTO MR, ZOLI M, LENA C et al.: Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature (1995) 374:65-67.
    • (1995) Nature , vol.374 , pp. 65-67
    • Picciotto, M.R.1    Zoli, M.2    Lena, C.3
  • 18
    • 0033614401 scopus 로고    scopus 로고
    • Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
    • MARUBIO LM, DEL MAR ARROYO-JIMENEZ M et al.: Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature (1999) 398:805-810.
    • (1999) Nature , vol.398 , pp. 805-810
    • Marubio, L.M.1    Del Mar Arroyo-Jimenez, M.2
  • 19
    • 0034280436 scopus 로고    scopus 로고
    • 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse
    • 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J. Neurosci. (2000) 20:6431-6441.
    • (2000) J. Neurosci. , vol.20 , pp. 6431-6441
    • Ross, S.A.1    Wong, J.Y.2    Clifford, J.J.3
  • 20
    • 0037083377 scopus 로고    scopus 로고
    • 6-containing nicotinic acetylcholine receptors analyzed with mutant mice
    • 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J. Neurosci. (2002) 22:1208-1217.
    • (2002) J. Neurosci. , vol.22 , pp. 1208-1217
    • Champtiaux, N.1    Han, Z.Y.2    Bessis, A.3
  • 23
    • 0037203840 scopus 로고    scopus 로고
    • 7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures
    • 7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain Res. Mol. Brain Res. (2002) 98:29-40.
    • (2002) Brain Res. Mol. Brain Res. , vol.98 , pp. 29-40
    • Franceschini, D.1    Paylor, R.2    Broide, R.3
  • 24
    • 0033125179 scopus 로고    scopus 로고
    • 9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation
    • 9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron (1999) 23:93-103.
    • (1999) Neuron , vol.23 , pp. 93-103
    • Vetter, D.E.1    Liberman, M.C.2    Mann, J.3
  • 26
    • 0033232716 scopus 로고    scopus 로고
    • 4 subunits of neuronal nicotinic acetylcholine receptors
    • 4 subunits of neuronal nicotinic acetylcholine receptors. J. Neurosci. (1999) 19:9298-9305.
    • (1999) J. Neurosci. , vol.19 , pp. 9298-9305
    • Xu, W.1    Orr-Urtreger, A.2    Nigro, F.3
  • 27
    • 0033104499 scopus 로고    scopus 로고
    • Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors
    • ZOLI M, PICCIOTTO MR, FERRARI R, COCCHI D, CHANGEUX JP: Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. EMBO (1999) 18:1235-1244.
    • (1999) EMBO , vol.18 , pp. 1235-1244
    • Zoli, M.1    Picciotto, M.R.2    Ferrari, R.3    Cocchi, D.4    Changeux, J.P.5
  • 28
    • 0032495515 scopus 로고    scopus 로고
    • 2 subunit are involved in the reinforcing properties of nicotine
    • 2 subunit are involved in the reinforcing properties of nicotine. Nature (1998) 391:173-177.
    • (1998) Nature , vol.391 , pp. 173-177
    • Picciotto, M.R.1    Zoli, M.2    Rimondini, R.3
  • 29
    • 0030980834 scopus 로고    scopus 로고
    • The molecular biology of neuronal nicotinic acetylcholine receptors
    • BOYD RT: The molecular biology of neuronal nicotinic acetylcholine receptors. Crit. Rev. Toxicol. (1997) 27:299-318.
    • (1997) Crit. Rev. Toxicol. , vol.27 , pp. 299-318
    • Boyd, R.T.1
  • 30
    • 0031466071 scopus 로고    scopus 로고
    • The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type
    • LEWIS TM, HARKNESS PC, SIVILOTTI LG, COLQUHOUN D, MILLAR NS: The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type. J. Physiol. (1997) 1:299-306.
    • (1997) J. Physiol. , vol.1 , pp. 299-306
    • Lewis, T.M.1    Harkness, P.C.2    Sivilotti, L.G.3    Colquhoun, D.4    Millar, N.S.5
  • 32
    • 0343131930 scopus 로고    scopus 로고
    • Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders
    • LENA C, CHANGEUX JP: Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Curr. Opin. Neurobiol. (1997) 7:674-82.
    • (1997) Curr. Opin. Neurobiol. , vol.7 , pp. 674-682
    • Lena, C.1    Changeux, J.P.2
  • 33
    • 0033485390 scopus 로고    scopus 로고
    • Nicotinic receptors in the brain: Correlating physiology with function
    • JONES S, SUDWEEKS S, YAKEL JL: Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci. (1999) 22:555-561.
    • (1999) Trends Neurosci. , vol.22 , pp. 555-561
    • Jones, S.1    Sudweeks, S.2    Yakel, J.L.3
  • 34
    • 0033960085 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors as novel drug targets
    • LLOYD GK, WILLIAMS M: Neuronal nicotinic acetylcholine receptors as novel drug targets. J. Pharmacol. Exp. Ther. (2000) 292:461-467.
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 461-467
    • Lloyd, G.K.1    Williams, M.2
  • 36
    • 0021816453 scopus 로고
    • Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine
    • HENNINGFIELD JE, MIYASATO K, JASINSKI DR: Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine. J. Pharmacol. Exp. Ther. (1985) 234:1-12.
    • (1985) J. Pharmacol. Exp. Ther. , vol.234 , pp. 1-12
    • Henningfield, J.E.1    Miyasato, K.2    Jasinski, D.R.3
  • 37
    • 0035899452 scopus 로고    scopus 로고
    • Synaptic plasticity and nicotine addiction
    • DANI JA, JI D, ZHOU FM: Synaptic plasticity and nicotine addiction. Neuron (2001) 31:349-352.
    • (2001) Neuron , vol.31 , pp. 349-352
    • Dani, J.A.1    Ji, D.2    Zhou, F.M.3
  • 38
    • 0012120951 scopus 로고    scopus 로고
    • Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure
    • GENTRY CL, LUKAS RJ: Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. Curr. Drug Target CNS Neurol. Disord. (2002) 1:359-385.
    • (2002) Curr. Drug Target CNS Neurol. Disord. , vol.1 , pp. 359-385
    • Gentry, C.L.1    Lukas, R.J.2
  • 39
    • 0042433479 scopus 로고    scopus 로고
    • The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development
    • TERRY AV, BUCCAFUSCO JJ: The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J. Pharmacol Exp. Ther. (2003) 306:821-827.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 821-827
    • Terry, A.V.1    Buccafusco, J.J.2
  • 40
    • 19244378105 scopus 로고    scopus 로고
    • Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
    • PERRY E, MARTIN-RUIZ C, LEE M et al.: Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. Eur. J. Pharmacol. (2000) 393:215-222.
    • (2000) Eur. J. Pharmacol. , vol.393 , pp. 215-222
    • Perry, E.1    Martin-Ruiz, C.2    Lee, M.3
  • 41
    • 0023818217 scopus 로고
    • 3H] nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: An autoradiographic study
    • 3H] nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology (1988) 38:720-723.
    • (1988) Neurology , vol.38 , pp. 720-723
    • Whitehouse, P.J.1    Martino, A.M.2    Wagster, M.V.3
  • 42
    • 0025898437 scopus 로고
    • Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease
    • SCHRÖDER H, GIACOBINI E, STRUBLE RG, ZILLES K, MAELICKE A: Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol. Aging (1991) 12:259-262.
    • (1991) Neurobiol. Aging , vol.12 , pp. 259-262
    • Schröder, H.1    Giacobini, E.2    Struble, R.G.3    Zilles, K.4    Maelicke, A.5
  • 43
    • 0034732302 scopus 로고    scopus 로고
    • Nicotinic receptors and Parkinson's disease
    • QUIK M, JEYARASASINGAM G: Nicotinic receptors and Parkinson's disease. Eur. J. Pharmacol. (2000) 393:223-230.
    • (2000) Eur. J. Pharmacol. , vol.393 , pp. 223-230
    • Quik, M.1    Jeyarasasingam, G.2
  • 44
    • 4344698859 scopus 로고    scopus 로고
    • Smoking, nicotine and Parkinson's disease
    • QUIK M: Smoking, nicotine and Parkinson's disease. Trends Neurosci. (2004) 27:561-568.
    • (2004) Trends Neurosci. , vol.27 , pp. 561-568
    • Quik, M.1
  • 45
    • 11344285967 scopus 로고    scopus 로고
    • Subunit composition of nicotinic receptors in monkey striatum: Effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA
    • QUIK M, VAILATI S, BORDIA T et al.: Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA. Mol. Pharmacol. (2005) 67:32-41.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 32-41
    • Quik, M.1    Vailati, S.2    Bordia, T.3
  • 46
    • 0032872325 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: α-bungarotoxin and nicotine binding in the thalamus
    • COURT J, SPURDEN D, LLOYD S et al.: Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: α-bungarotoxin and nicotine binding in the thalamus. J. Neurochem. (1999) 73:1590-1597.
    • (1999) J. Neurochem. , vol.73 , pp. 1590-1597
    • Court, J.1    Spurden, D.2    Lloyd, S.3
  • 49
    • 0030747590 scopus 로고    scopus 로고
    • Nicotine for the treatment of Tourette's syndrome
    • SANBERG PR, SILVER AA, SHYTLE RD et al.: Nicotine for the treatment of Tourette's syndrome. Pharmacol. Ther. (1997) 74:21-25.
    • (1997) Pharmacol. Ther. , vol.74 , pp. 21-25
    • Sanberg, P.R.1    Silver, A.A.2    Shytle, R.D.3
  • 50
    • 0032578304 scopus 로고    scopus 로고
    • Treatment of Tourette's syndrome with mecamylamine
    • SANBERG PR, SHYTLE RD, SILVER AA: Treatment of Tourette's syndrome with mecamylamine. Lancet (1998) 352:705-706.
    • (1998) Lancet , vol.352 , pp. 705-706
    • Sanberg, P.R.1    Shytle, R.D.2    Silver, A.A.3
  • 51
    • 0030588986 scopus 로고    scopus 로고
    • Smoking, smoking withdrawal and schizophrenia: Case reports and a review of the literature
    • DALACK GW, MEADOR-WOODRUFF JH: Smoking, smoking withdrawal and schizophrenia: case reports and a review of the literature. Schizophr. Res. (1996) 22:133-141.
    • (1996) Schizophr. Res. , vol.22 , pp. 133-141
    • Dalack, G.W.1    Meador-Woodruff, J.H.2
  • 52
    • 0029085870 scopus 로고
    • Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
    • FREEDMAN R, HALL M, ADLER LE, LEONARD S: Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol. Psychiatry (1995) 38:22-33.
    • (1995) Biol. Psychiatry , vol.38 , pp. 22-33
    • Freedman, R.1    Hall, M.2    Adler, L.E.3    Leonard, S.4
  • 53
    • 12644303225 scopus 로고    scopus 로고
    • Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
    • FREEDMAN R, COON H, MYLES-WORSLEY M et al.: Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl. Acad. Sci. USA (1997) 94:587-592.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 587-592
    • Freedman, R.1    Coon, H.2    Myles-Worsley, M.3
  • 54
    • 0034732116 scopus 로고    scopus 로고
    • Smoking and schizophrenia: Abnormal nicotinic receptor expression
    • LEONARD S, BREESE C, ADAMS C et al.: Smoking and schizophrenia: abnormal nicotinic receptor expression. Eur. J. Pharmacol. (2000) 393:237-242.
    • (2000) Eur. J. Pharmacol. , vol.393 , pp. 237-242
    • Leonard, S.1    Breese, C.2    Adams, C.3
  • 55
    • 0028980028 scopus 로고
    • A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy
    • STEINLEIN OK, MULLEY JC, PROPPING P et al.: A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat. Genet. (1995) 11:201-203.
    • (1995) Nat. Genet. , vol.11 , pp. 201-203
    • Steinlein, O.K.1    Mulley, J.C.2    Propping, P.3
  • 56
    • 0034732143 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors in human epilepsy
    • STEINLEIN OK: Neuronal nicotinic receptors in human epilepsy. Eur. J. Pharmacol. (2000) 393:243-247.
    • (2000) Eur. J. Pharmacol. , vol.393 , pp. 243-247
    • Steinlein, O.K.1
  • 57
    • 0028011992 scopus 로고
    • Autosomal dominant frontal epilepsy misdiagnosed as leep disorder
    • SCHEFFER IE, BHATIA KP, LOPES-CENDES I et al.: Autosomal dominant frontal epilepsy misdiagnosed as leep disorder. Lancet (1994) 343:515-517.
    • (1994) Lancet , vol.343 , pp. 515-517
    • Scheffer, I.E.1    Bhatia, K.P.2    Lopes-Cendes, I.3
  • 59
    • 0028230727 scopus 로고
    • Epibatidine, a potent analgetic and nicotinic agonist
    • BADIO B, DALY JW: Epibatidine, a potent analgetic and nicotinic agonist. Mol. Pharmacol. (1994) 45:563-569.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 563-569
    • Badio, B.1    Daly, J.W.2
  • 60
    • 0032105335 scopus 로고    scopus 로고
    • The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594
    • DECKER MW, CURZON P, HOLLADAY MW et al.: The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J. Physiol. Paris (1998) 92:221-224.
    • (1998) J. Physiol. Paris , vol.92 , pp. 221-224
    • Decker, M.W.1    Curzon, P.2    Holladay, M.W.3
  • 61
    • 0037128663 scopus 로고    scopus 로고
    • Pharmacological stimulation of the cholinergic antiinflammatory pathway
    • BERNIK TR, FRIEDMAN SG, OCHANI M et al.: Pharmacological stimulation of the cholinergic antiinflammatory pathway. J. Exp. Med. (2002) 195:781-788.
    • (2002) J. Exp. Med. , vol.195 , pp. 781-788
    • Bernik, T.R.1    Friedman, S.G.2    Ochani, M.3
  • 62
    • 0037461768 scopus 로고    scopus 로고
    • 7 subunit is an essential regulator of inflammation
    • 7 subunit is an essential regulator of inflammation. Nature (2003) 421:384-388.
    • (2003) Nature , vol.421 , pp. 384-388
    • Wang, H.1    Yu, M.2    Ochani, M.3
  • 63
    • 0020665529 scopus 로고
    • Cigarette smoking and ulcerative colitis
    • JICK H, WALKER AM: Cigarette smoking and ulcerative colitis. N. Engl. J. Med. (1983) 308:261-263.
    • (1983) N. Engl. J. Med. , vol.308 , pp. 261-263
    • Jick, H.1    Walker, A.M.2
  • 64
    • 0032865549 scopus 로고    scopus 로고
    • Nicotine treatment for ulcerative colitis
    • GUSLANDI M: Nicotine treatment for ulcerative colitis. Br. J. Clin. Pharmacol. (1999) 48:481-484.
    • (1999) Br. J. Clin. Pharmacol. , vol.48 , pp. 481-484
    • Guslandi, M.1
  • 65
    • 0030016767 scopus 로고    scopus 로고
    • Nicotine and gastrointestinal disease
    • THOMAS GA, RHODES J, GREEN J: Nicotine and gastrointestinal disease. QJM (1996) 89:485-488.
    • (1996) QJM , vol.89 , pp. 485-488
    • Thomas, G.A.1    Rhodes, J.2    Green, J.3
  • 67
    • 0034000239 scopus 로고    scopus 로고
    • Role of smoking in inflammatory bowel disease: Implications for therapy
    • THOMAS GA, RHODES J, GREEN JT, RICHARDSON C: Role of smoking in inflammatory bowel disease: implications for therapy. Postgrad. Med. J. (2000) 76:273-279.
    • (2000) Postgrad. Med. J. , vol.76 , pp. 273-279
    • Thomas, G.A.1    Rhodes, J.2    Green, J.T.3    Richardson, C.4
  • 68
    • 0029096914 scopus 로고
    • Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
    • MCGEHEE DS, HEATH MJ, GELBER S, DEVAY P, ROLE LW: Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science (1995) 269:1692-1696.
    • (1995) Science , vol.269 , pp. 1692-1696
    • Mcgehee, D.S.1    Heath, M.J.2    Gelber, S.3    Devay, P.4    Role, L.W.5
  • 69
    • 0029805769 scopus 로고    scopus 로고
    • Hippocampal synaptic transmission enhanced by low concentrations of nicotine
    • GRAY R, RAJAN AS, RADCLIFFE KA, YAKEHIRO M, DANI JA: Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature (1996) 383:713-716.
    • (1996) Nature , vol.383 , pp. 713-716
    • Gray, R.1    Rajan, A.S.2    Radcliffe, K.A.3    Yakehiro, M.4    Dani, J.A.5
  • 70
    • 0037560251 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor ligands as potential analgesics
    • BUNNELLE WH, DECKER MW: Neuronal nicotinic acetylcholine receptor ligands as potential analgesics. Expert Opin. Ther. Patents (2003) 13:1003-1021.
    • (2003) Expert Opin. Ther. Patents , vol.13 , pp. 1003-1021
    • Bunnelle, W.H.1    Decker, M.W.2
  • 71
  • 74
    • 0014934202 scopus 로고
    • Structure and activity of acetylcholine
    • BEERS WH, REICH E: Structure and activity of acetylcholine. Nature (1970) 228:917-922.
    • (1970) Nature , vol.228 , pp. 917-922
    • Beers, W.H.1    Reich, E.2
  • 75
    • 0022485091 scopus 로고
    • The ensemble approach to distance geometry: Application to the nicotinic pharmacophore
    • SHERIDAN RP, NILAKANTAN R, DIXON JS, VENKATARAGHAVAN R: The ensemble approach to distance geometry: application to the nicotinic pharmacophore. J. Med. Chem. (1986) 29:899-906.
    • (1986) J. Med. Chem. , vol.29 , pp. 899-906
    • Sheridan, R.P.1    Nilakantan, R.2    Dixon, J.S.3    Venkataraghavan, R.4
  • 76
    • 0031450275 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors as targets for drug discovery
    • HOLLADAY MW, DART MJ, LYNCH JK: Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J. Med. Chem. (1997) 40:4169-4194.
    • (1997) J. Med. Chem. , vol.40 , pp. 4169-4194
    • Holladay, M.W.1    Dart, M.J.2    Lynch, J.K.3
  • 77
    • 0000949429 scopus 로고
    • Epibatidine-aided studies toward definition of a nicotine receptor pharmacophore
    • GLENNON RA, HERNDON JL, DUKAT M: Epibatidine-aided studies toward definition of a nicotine receptor pharmacophore. Med. Chem. Res. (1994) 4:461-473.
    • (1994) Med. Chem. Res. , vol.4 , pp. 461-473
    • Glennon, R.A.1    Herndon, J.L.2    Dukat, M.3
  • 78
    • 0033927801 scopus 로고    scopus 로고
    • Exploring the nature of molecular recognition in nicotinic acetylcholine receptors
    • SCHMITT JD: Exploring the nature of molecular recognition in nicotinic acetylcholine receptors. Curr. Med. Chem. (2000) 7:749-800.
    • (2000) Curr. Med. Chem. , vol.7 , pp. 749-800
    • Schmitt, J.D.1
  • 79
    • 1642350377 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models
    • NICOLOTTI O, ALTOMARE C, PELLEGRINI-CALACE M, CAROTTI A: Neuronal nicotinic acetylcholine receptor agonists: pharmacophores, evolutionary QSAR and 3D-QSAR models. Curr. Topics Med. Chem. (2004) 4:335-360.
    • (2004) Curr. Topics Med. Chem. , vol.4 , pp. 335-360
    • Nicolotti, O.1    Altomare, C.2    Pellegrini-Calace, M.3    Carotti, A.4
  • 82
    • 0035102669 scopus 로고    scopus 로고
    • An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors
    • TONDER JE, OLESEN PH, HANSEN JB, BEGTRUP M, PETTERSSON I: An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors. J. Comput. Aided Mol. Des. (2001) 15:247-258.
    • (2001) J. Comput. Aided Mol. Des. , vol.15 , pp. 247-258
    • Tonder, J.E.1    Olesen, P.H.2    Hansen, J.B.3    Begtrup, M.4    Pettersson, I.5
  • 85
    • 25444435531 scopus 로고    scopus 로고
    • 7 nicotinic receptor partial agonist. I. Binding profile and in vitro functional characterization
    • Abst. 583.1
    • 7 nicotinic receptor partial agonist. I. Binding profile and in vitro functional characterization. Soc. Neurosci. Meeting (2004) Abst. 583.1.
    • (2004) Soc. Neurosci. Meeting
    • Biton, B.1    Bergis, O.E.2    Galli, F.3
  • 86
    • 25444475646 scopus 로고    scopus 로고
    • 7 nicotinic receptor partial agonist. II. Effects in models predictive of therapeutic activity on cognitive symptoms of Alzheimer's disease
    • Abst. 583.2
    • 7 nicotinic receptor partial agonist. II. Effects in models predictive of therapeutic activity on cognitive symptoms of Alzheimer's disease. Soc. Neurosci. Meeting (2004) Abst. 583.2.
    • (2004) Soc. Neurosci. Meeting
    • Bergis, O.E.1    Pichat, P.2    Santamaria, R.3
  • 87
    • 25444464503 scopus 로고    scopus 로고
    • 7 nicotinic receptor partial agonist. III. Effects in models predictive of therapeutic activity on cognitive symptoms of schizophrenia
    • Abst. 583.3
    • 7 nicotinic receptor partial agonist. III. Effects in models predictive of therapeutic activity on cognitive symptoms of schizophrenia. Soc. Neurosci. Meeting (2004) Abst. 583.3.
    • (2004) Soc. Neurosci. Meeting
    • Pichat, P.1    Bergis, O.E.2    Terranova, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.