Multiorgan autonomic dysfunction in mice lacking the β2 and the β4 subunits of neuronal nicotinic acetylcholine receptors

Journal of Neuroscience

Volumn 19, Issue 21, 1999, Pages 9298-9305

  Xu, Wei ^a   Orr Urtreger, Avi ^c   Nigro, Filippo ^a   Gelber, Shari ^b   Sutcliffe, Cara Ballard ^a   Armstrong, Dawna ^a   Patrick, James W ^a   Role, Lorna W ^b   Beaudet, Arthur L ^a   De Biasi, Mariella ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Columbia University ^*  (United States)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Autonomic dysfunction; Autonomic ganglia; Bladder; Eye; Knock out mice; Neuronal nicotinic subunits

Indexed keywords

CHOLINERGIC RECEPTOR; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; AUTONOMIC DYSFUNCTION; BLADDER MUCOSA; BLADDER STONE; GENOTYPE; KNOCKOUT MOUSE; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; SUPERIOR CERVICAL GANGLION; SYNAPTIC TRANSMISSION;

EID: 0033232716     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-21-09298.1999     Document Type: Article

References (40)

1. Anand R, Conroy WG, Schoepfer R, Whiting P, Lindstrom J (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J Biol Chem 266:11192-11198.
2. Anneren G, Meurling S, Olsen L (1991) Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS), an autosomal recessive disorder: clinical reports and review of the literature. Am J Med Genet 41:251-254.
3. Boulter J, O'Shea-Greenfield A, Duvoisin RM, Connolly JG, Wada E, Jensen A, Gardner PD, Ballivet M, Deneris ES, McKinnon D, et al. (1990) Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J Biol Chem 265:4472-4482.
4. Bradley A (1987) Teratocarcinomas and embryonic stem cells; a practical approach. Oxford: IRL.
5. Colquhoun LM, Patrick JW (1997) Alpha3, beta2, and beta4 form heterotrimeric neuronal nicotinic acetylcholine receptors in Xenopus oocytes. J Neurochem 69:2355-2362.
6. Cooper E, Couturier S, Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350:235-238.
7. Covernton PJ, Kojima H, Sivilotti LG, Gibb AJ, Colquhoun D (1994) Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes. J Physiol (Lond) 481:27-34.
8. deGroat WC, Booth AM (1980) Physiology of the urinary bladder and urethra. Ann Intern Med 92:312-315.
9. Dineley-Miller K, Patrick J (1992) Gene transcripts for the nicotinic acetylcholine receptor subunit, beta4, are distributed in multiple areas of the rat central nervous system. Brain Res Mol Brain Res 16:339-344.
10. Duvoisin RM, Deneris ES, Patrick J, Heinemann S (1989) The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4. Neuron 3:487-496.
11. Ekstrom J, Elmer M (1980) Compensatory increase of responses to nerve stimulation of the partially denervated rat urinary bladder. Acta Physiol Scand 110:21-29.
12. Flores CM, Hulihan-Giblin BA, Hornby PJ, Lumpkin MD, Kellar KJ (1992) Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin. Neuroendocrinology 55:519-528.
13. Fucile S, Matter JM, Erkman L, Ragozzino D, Barabino B, Grassi F, Alema S, Ballivet M, Eusebi F (1998) The neuronal alpha6 subunit forms functional heteromeric acetylcholine receptors in human transfected cells. Eur J Neurosci 10:172-178.
14. Gerzanich V, Kuryatov A, Anand R, Lindstrom J (1997) "Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor. Mol Pharmacol 51:320-327.
15. Goldman D, Deneris E, Luyten W, Kochhar A, Patrick J, Heinemann S (1987) Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system. Cell 48:965-973.
16. Henning SJ (1981) Postnatal development: coordination of feeding, digestion, and metabolism. Am J Physiol 241:G199-G214.
17. Kacser H, Burns JA (1981) The molecular basis of dominance. Genetics 97:639-689.
18. Listerud M, Brussaard AB, Devay P, Colman DR, Role LW (1991) Functional contribution of neuronal AChR subunits revealed by antisense oligonucleotides. Science 254:1518-1521.
19. Mandelzys A, Pie B, Deneris ES, Cooper E (1994) The developmental increase in ACh current densities on rat sympathetic neurons correlates with changes in nicotinic ACh receptor alpha-subunit gene expression and occurs independent of innervation. J Neurosci 14:2357-2364.
20. Marubio LM, del Mar Arroyo-Jimenez M, Cordero-Erausquin M, Lena C, Le Novere N, de Kerchove d'Exaerde A, Huchet M, Damaj MI, Changeux JP (1999) Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398:805-810.
21. McGehee DS, Role LW (1995) Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu Rev Physiol 57:521-546.
22. Morris BJ, Hicks AA, Wisden W, Darlison MG, Hunt SP, Barnard EA (1990) Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain. Brain Res Mol Brain Res 7:305-315.
23. Oliveira G, Boechat MI, Ferreira MA (1983) Megacystis-microcolon-intestinal hypoperistalsis syndrome in a newborn girl whose brother had prune belly syndrome: common pathogenesis? Pediatr Radiol 13:294-296.
24. Picciotto MR, Zoli M, Lena C, Bessis A, Lallemand Y, LeNovere N, Vincent P, Pich EM, Brulet P, Changeux JP (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374:65-67.
25. Poth K, Nutter TJ, Cuevas J, Parker MJ, Adams DJ, Luetje CW (1997) Heterogeneity of nicotinic receptors class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia. J Neurosci 17:586-596.
26. Ramirez-Latorre J, Yu CR, Qu X, Perin F, Karlin A, Role L (1996) Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels. Nature 380:347-351.
27. Ramirez-Solis R, Liu P, Bradley A (1995) Chromosome engineering in mice. Nature 378:720-724.
28. Rust G, Burgunder JM, Lauterburg TE, Cachelin AB (1994) Expression of neuronal nicotinic acetylcholine receptor subunit genes in the rat autonomic nervous system. Eur J Neurosci 6:478-485.
29. Sargent PB (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16:403-443.
30. Sato A, Sato Y, Schmidt RF, Torigata Y (1983) Somatovesical reflexes in chronic spinal rats. J Auton Nerv Syst 7:351-362.
31. Selyanko AA (1995) Properties of nicotinic postsynaptic receptor channels in ganglia. In: Autonomic ganglia (McLachlan EM, ed), pp 213-258. Sidney, Australia: Harwood.
32. Sivilotti LG, McNeil DK, Lewis TM, Nassar MA, Schoepfer R, Colquhoun D (1997) Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J Physiol (Lond) 500:123-138.
33. Wada E, Wada K, Boulter J, Deneris E, Heinemann S, Patrick J, Swanson LW (1989) Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J Comp Neurol 284:314-335.
34. Wang F, Gerzanich V, Wells GB, Anand R, Peng X, Keyser K, Lindstrom J (1996) Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits. J Biol Chem 271:17656-17665.
35. Xu W, Gelber S, Orr-Urtreger A, Armstrong D, Lewis RA, Ou C-N, Patrick J, Role LW, De Biasi M, Beaudet AL (1999) Megacystis, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 96:5746-5751.
36. Yamashita T, Honjin R (1982) Fine structure, origin, and distribution density of the autonomic nerve endings in the tarsal muscle in the eyelid of the mouse. Cell Tissue Res 222:459-465.
37. Yamashita T, Takahashi A, Honjin R (1984) Fine structure, origin, and distribution density of the autonomic nerve endings in the sphincter and dilator muscles of the pupil of the mouse. Okajimas Folia Anat Jpn 61:173-181.
38. Zhang X, Liu C, Miao H, Gong ZH, Nordberg A (1998) Postnatal changes of nicotinic acetylcholine receptor alpha 2, alpha 3, alpha 4, alpha 7 and beta 2 subunits genes expression in rat brain. Int J Dev Neurosci 16:507-518.
39. Zoli M, Lena C, Picciotto MR, Changeux JP (1998) Identification of four classes of brain nicotinic receptors using beta2 mutant mice. J Neurosci 18:4461-4472.
40. Zoli M, Picciotto MR, Ferrari R, Cocchi D, Changeux JP (1999) Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. EMBO J 18:1235-1244.