Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: Role in fluoroquinolone resistance

Journal of Bacteriology

Volumn 178, Issue 14, 1996, Pages 4060-4069

  Pan, Xiao Su ^a   Mark Fisher, L ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CIPROFLOXACIN; DNA TOPOISOMERASE; NOVOBIOCIN; PLASMID DNA; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ANTIBIOTIC RESISTANCE; ARTICLE; CHROMOSOME MAP; DNA HYBRIDIZATION; ENZYME ACTIVITY; ENZYME SUBUNIT; ESCHERICHIA COLI; GENE INSERTION; GENE LOCUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 8944237982     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.14.4060-4069.1996     Document Type: Article

References (40)

1. Adams, D. E., E. M. Shekhtman, E. L. Zechiedrich, M. B. Schmid, and N. R. Cozzarelli. 1992. The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication. Cell 71:277-288.
2. Alonso, J. C., and L. M. Fisher. 1995. Nucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants. Mol. Gen. Genet. 246:680-686.
3. Belland, R. J., S. G. Morrison, C. Ison, and W. M. Huang. 1994. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol. Microbiol. 14:371-380.
4. Brown, P. O., and N. R. Cozzarelli. 1980. A sign inversion mechanism for enzymatic supercoiling of DNA. Science 206:1081-1083.
5. Cullen, M. E., A. W. Wyke, R. Kuroda, and L. M. Fisher. 1989. Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones. Antimicrob. Agents Chemother. 33:886-894.
6. Eliopoulos, G. M. 1995. In vitro activity of fluoroquinolones against gram positive bacteria. Drugs 49(Suppl. 2):48-57.
7. Ferrero, L., B. Cameron, and J. Crouzet. 1995. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 39:1554-1558.
8. Ferrero, L., B. Cameron, B. Manse, D. Lagneux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target for fluoroquinolones. Mol. Microbiol. 13:641-653.
9. Finch, R. G. 1995. The role of new quinolones in the treatment of respiratory tract infections. Drugs 49(Suppl. 2):144-151.
10. Fisher, L. M., M. Oram, and S. Sreedharan. 1992. DNA gyrase: mechanism and resistance to 4-quinolone antibacterial agents, p. 145-155. In T. Andoh, H. Ikeda, and M. Oguro (ed.). Molecular biology of DNA topoisomerases and its application to chemotherapy. CRC Press, Boca Raton, Fla.
11. Gellert, M., K. Mizuuchi, M. H. O'Dea, T. Itoh, and J. I. Tomizawa. 1977. Nalidixic acid resistance: a second character involved in DNA gyrase activity. Proc. Natl. Acad. Sci. USA 74:4772-4776.
12. Geliert, M., K. Mizuuchi, M. H. O'Dea, and H. A. Nash. 1976. DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc. Natl. Acad. Sci. USA 73:3872-3876.
13. Gellert, M., M. H. O'Dea, T. Itoh, and J. I. Tomizawa. 1976. Novobiocin and coumermycin inhibit DNA supercoiling by DNA gyrase. Proc. Natl. Acad. Sci. USA 73:4474-4478.
14. Hanahan, D. 1985. Techniques for transformation of Escherichia coli. In D. Glover (ed.), DNA cloning: a practical approach. IRL Press, Oxford.
15. Hopewell, R., M. Oram, R. Briesewitz, and L. M. Fisher. 1990. DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance. J. Bacteriol. 172:3481-3484.
16. Horowitz, D. S., and J. C. Wang. 1987. Mapping the active site tyrosine of Escherichia coli DNA gyrase. J. Biol. Chem. 269:5339-5344.
17. Hoshino, K., A. Kitamura, I. Morrissey, K. Sato, J. I. Kato, and H. Ikeda. 1994. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob. Agents Chemother. 38:2623-2627.
18. Kato, J., Y. Nishimura, R. Imamura, H. Niki, S. Higara, and H. Suzuki. 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63:393-404.
19. Khodursky, A. B., E. L. Zechiedrich, and N. R. Cozzarelli. 1995. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. USA 92:11801-11805.
20. Klugman, K. P. 1990. Pneumococcal resistance to antibiotics. Clin. Microbiol. Rev. 3:171-196.
21. Korten, V., W. M. Huang, and B. E. Murray. 1994. Analysis by PCR and direct DNA sequencing of gyrA mutations associated with ftuoroquinolone resistance in Enterococcus faecatis. Antimicrob. Agents Chemother. 38:2091-2094.
22. Margerrison, E. E. C., R. Hopewell. and L. M. Fisher. 1992. Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteins. J. Bacteriol. 174:1596-1603.
23. Mizuuchi, K., L. M. Fisher, M. H. O'Dea, and M. Gellert. 1980. DNA gyrase action involves the introduction of transient double-strand DNA breaks into DNA. Proc. Natl. Acad. Sci. USA 77:1847-1851.
24. Mizuuchi, K, M. Mizuuchi, M. H. O'Dea, and M. Gellert. 1984. Cloning and simplified purification of Escherichia coli DNA gyrase A and B proteins. J. Biol. Chem. 259:9199-9201.
25. Moriya, S., N. Ogasawara, and H. Yoshikawa. 1985. Structure and function of the region of the replication origin of the Bacillus subtilis chromosome. Nucleotide sequence of some 10,000 base pairs in the origin region. Nucleic Acids Res. 13:2251-2265.
26. Morona, J. K., A. Guidolin, R. Morona, D. Hansman, and J. C. Paton. 1994. Isolation, characterization, and nucleotide sequence of IS/202, an insertion sequence of Streptococcus pneumoniae. J. Bacteriol. 176:4437-4443.
27. Muñoz, R., M. Bustamante, and A. G. de la Campa. 1995. Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance. J. Bacteriol. 177:4166-4170.
28. Gram, M., and L. M. Fisher. 1991. 4-quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. Antimicrob. Agents Chemother. 35:387-389.
29. 28a.Pan, X. S., and L. M. Fisher. Unpublished data.
30. Peng, H., and K. J. Marians. 1993. DNA topoisomerasc IV: purification, characterization, subunit structure and subunit interactions. J. Biol. Chem. 268:24481-24490.
31. Piddock, L. J. V. 1994. New quinolones and gram-positive bacteria. Antimicrob. Agents Chemother. 38:163-169.
32. Rubens, C. E., L. M. Heggen, and J. M. Kupers. 1989. IS867, a group B streptococcal insertion sequence related to IS/50 and IS3 of Escherichia coli. J. Bacteriol. 171:5531-5535.
33. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
34. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
35. Sreedharan, S., M. Oram, B. Jensen, L. R. Peterson, and L. M. Fisher. 1990. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J. Bacteriol. 172:7260-7262.
36. Sugino, A., N. P. Higgins, P. O. Brown, C. L. Peebles, and N. R. Cozzarelli. 1978. Energy coupling in DNA gyrase and the mechanism of action of novobiocin. Proc. Natl. Acad. Sci. USA 75:4838-4842.
37. Tanaka, M., K. Sato, Y. Kimura, I. Hayakawa, Y. Osada, and T. Nishino. 1991. Inhibition by quinolones of DNA gyrase from Staphylococcus aureus. Antimicrob. Agents Chemother. 35:1489-1491.
38. Willmott, C. J. R., and A. Maxwell. 1993. A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex. Antimicrob. Agents Chemother. 37:126-127.
39. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.
40. Yoshida, H., M. Nakamura, M. Bogaki, H. Ito, T. Kojima, H. Hattori, and S. Nakamura. 1993. Mechanism of action of quinolones against Escherichia coli DNA gyrase. Antimicrob. Agents Chemother. 37:839-845.