Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters

Journal of Medicinal Chemistry

Volumn 41, Issue 25, 1998, Pages 4973-4982

  Kozikowski, Alan P ^a   Araldi, Gian Luca ^a   Prakash, K R C ^a   Zhang, Mei ^b   Johnson, Kenneth M ^b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2BETA PHENYL 3ALPHA 4 TOLYLTROPANE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE; COCAINE ANTAGONIST; DOPAMINE TRANSPORTER; NARCOTIC ANTAGONIST; PAROXETINE; PARTIAL AGONIST; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; CORPUS STRIATUM; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; RAT; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NEOSTRIATUM; NERVE TISSUE PROTEINS; RADIOLIGAND ASSAY; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; SYNAPTOSOMES; TROPANES;

EID: 0032480909     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9802564     Document Type: Article

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