Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton

Journal of Medicinal Chemistry

Volumn 41, Issue 11, 1998, Pages 1962-1969

  Kozikowski, Alan P ^a   Araldi, Gian Luca ^a   Boja, John ^b   Meil, William M ^b   Johnson, Kenneth M ^c   Flippen Anderson, Judith L ^d   George, Clifford ^d   Saiah, Eddine ^e  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d NAVAL RESEARCH LABORATORY   (United States)

^e Helios Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4BETA (4 CHLOROPHENYL) 1 METHYL 3BETA N PROPYLPIPERIDINE; COCAINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; DOPAMINE UPTAKE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; COCAINE; CORPUS STRIATUM; CRYSTALLOGRAPHY, X-RAY; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; PIPERIDINES; PROTEIN BINDING; RATS; STEREOISOMERISM; SYNAPTOSOMES; TROPANES;

EID: 0032554859     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980028+     Document Type: Article

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