Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 19, 2003, Pages 10966-10971

  Harris, Faith M ^a,b   Brecht, Walter J ^a,b   Xu, Qin ^a,b   Tesseur, Ina ^a   Kekonius, Lisa ^a   Wyss Coray, Tony ^a,c   Fish, Jo Dee ^b   Masliah, Eliezer ^e   Hopkins, Paul C ^b   Scearce Levie, Kimberly ^a   Weisgraber, Karl H ^a,b,d   Mucke, Lennart ^a,c   Mahley, Robert W ^a,b,c,d   Huang, Yadong ^a,b,d  

^a GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CHYMOTRYPSIN; RECOMBINANT PROTEIN; SERINE PROTEINASE; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN CELL; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LEARNING DISORDER; MEMORY DISORDER; MOUSE; NERVE CELL; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RISK ASSESSMENT; SURVIVAL TIME;

AGED; ANIMALS; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BEHAVIOR, ANIMAL; BRAIN; HUMANS; HYDROLYSIS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON;

ANIMALIA; MUS MUSCULUS;

EID: 0141814636     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1434398100     Document Type: Article

References (61)

1. Mahley, R. W. (1988) Science 240, 622-630.
2. Mahley, R. W. & Huang, Y. (1999) Curr. Opin. Lipidol. 10, 207-217.
3. Huang, Y. & Mahley, R. W. (1999) in Plasma Lipids and Their Role in Disease, eds. Barter, P. J. & Rye, K.-A. (Harwood Academic, Amsterdam), pp. 257-284.
4. Mahley, R. W. & Rall, S. C., Jr. (2000) Annu. Rev. Genomics Hum. Genet. 1, 507-537.
5. Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S. & Roses, A. D. (1993) Proc. Natl. Acad. Sci. USA 90, 1977-1981.
6. Roses, A. D. (1994) J. Neuropathol. Exp. Neurol. 53, 429-437.
7. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L. & Pericak-Vance, M. A. (1993) Science 261, 921-923.
8. Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R., Myers, R. H., Pericak-Vance, M. A., Risch, N. & Van Duijn, C. M. (1997) J. Am. Med. Assoc. 278, 1349-1356.
9. Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L.-M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D. & Roses, A. D. (1993) Proc. Natl. Acad. Sci. USA 90, 8098-8102.
10. Ma, J., Yee, A., Brewer, H. B., Jr., Das, S. & Potter, H. (1994) Nature 372, 92-94.
11. Wisniewski, T., Castaño, E. M., Golabek, A., Vogel, T. & Frangione, B. (1994) Am. J. Pathol. 145, 1030-1035.
12. LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S. & Frail, D. E. (1994) J. Biol. Chem. 269, 23403-23406.
13. Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D. & Paul, S. M. (2000) Proc. Natl. Acad. Sci. USA 97, 2892-2897.
14. Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., et al. (1999) Proc. Natl. Acad. Sci. USA 96, 15233-15238.
15. Irizarry, M. C., Cheung, B. S., Rebeck, G. W., Paul, S. M., Bales, K. R. & Hyman, B. T. (2000) Acta. Neuropathol. 100, 451-458.
16. Miyata, M. & Smith, J. D. (1996) Nat. Genet. 14, 55-61.
17. Herz, J. & Beffert, U. (2000) Nat. Rev. Neurosci. 1, 51-58.
18. Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W. & Pitas, R. E. (1994) Science 264, 850-852.
19. Nathan, B. P., Chang, K.-C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W. & Pitas, R. E. (1995) J. Biol. Chem. 270, 19791-19799.
20. Strittmatter, W. J., Saunders, A. M., Goedert, M., Weisgraber, K. H., Dong, L.-M., Jakes, R., Huang, D. Y., Pericak-Vance, M., Schmechel, D. & Roses, A. D. (1994) Proc. Natl. Acad. Sci. USA 91, 11183-11186.
21. Tesseur, I., Van Dorpe, J., Spittaels, K., Van den Haute, C., Moechars, D. & Van Leuven, F. (2000) Am. J. Pathol. 156, 951-964.
22. Huang, Y., Liu, X. Q., Wyss-Coray, T., Brecht, W. J., Sanan, D. A. & Mahley, R. W. (2001) Proc. Natl. Acad. Sci. USA 98, 8838-8843.
23. Ljungberg, M. C., Dayanandan, R., Asuni, A., Rupniak, T. H., Anderton, B. H. & Lovestone, S. (2002) NeuroReport 13, 867-870.
24. Selkoe, D. J. (1991) Neuron 6, 487-498.
25. Crowther, R. A. (1993) Curr. Opin. Struct. Biol. 3, 202-206.
26. Roses, A. D. (1994) Curr. Neurol. 14, 111-141.
27. Tanzi, R. E. & Bertram, L. (2001) Neuron 32, 181-184.
28. Smith, M. A., Rudnicka-Nawrot, M., Richey, P. L., Praprotnik, D., Mulvihill, P., Miller, C. A., Sayre, L. M. & Perry, G. (1995). J. Neurochem. 64, 2660-2666.
29. Vickers, J. C., Riederer, B. M., Marugg, R. A., Buée-Scherrer, V., Buée, L., Delacourte, A. & Morrison, J. H. (1994) Neuroscience 62, 1-13.
30. Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E. & Ikeda, K. (1991) Brain Res. 541, 163-166.
31. Wisniewski, T. & Frangione, B. (1992) Neurosci. Lett. 135, 235-238.
32. Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W. & Mucke, L. (1998) Proc. Natl. Acad. Sci. USA 95, 10914-10919.
33. Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E. & Mucke, L. (2000) Nature 404, 352-354.
34. Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss-Coray, T., Mucke, L. & Mahley, R. W. (1999) J. Neurosci. 19, 4867-4880.
35. Beffert, U. & Poirier, J. (1996) Ann. N.Y. Acad. Sci. 777, 166-174.
36. Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G. W. & Brown, M. S. (1981) J. Biol. Chem. 256, 11923-11931.
37. Diedrich, J. F., Minnigan, H., Carp, R. I., Whitaker, J. N., Race, R., Frey, W., II, & Haase, A. T. (1991) J. Virol. 65, 4759-4768.
38. Han, S.-H., Einstein, G., Weisgraber, K. H., Strittmatter, W. J., Saunders, A. M., Pericak-Vance, M., Roses, A. D. & Schmechel, D. E. (1994) J. Neuropathol. Exp. Neurol. 53, 535-544.
39. Bao, F., Arai, H., Matsushita, S., Higuchi, S. & Sasaki, H. (1996) NeuroReport 7, 1733-1739.
40. Metzger, R. E., LaDu, M. J., Pan, J. B., Getz, G. S., Frail, D. E. & Falduto, M. T. (1996) J. Neuropathol. Exp. Neurol. 55, 372-380.
41. Xu, P.-T., Schmechel, D., Qiu, H.-L., Herbstreith, M., Rothrock-Christian, T., Eyster, M., Roses, A. D. & Gilbert, J. R. (1999) Neurobiol. Dis. 6, 63-75.
42. Xu, P.-T., Gilbert, J. R., Qiu, H.-L., Ervin, J., Rothrock-Christian, T. R., Hulette, C. & Schmechel, D. E. (1999) Am. J. Pathol. 154, 601-611.
43. Xu, P.-T., Schmechel, D., Rothrock-Christian, T., Burkhart, D. S., Qiu, H.-L., Popko, B., Sullivan, P., Maeda, N., Saunders, A. M., Roses, A. D. & Gilbert, J. R. (1996) Neurobiol. Dis. 3, 229-245.
44. Boschert, U., Merlo-Pich, E., Higgins, G., Roses, A. D. & Catsicas, S. (1999) Neurobiol. Dis. 6, 508-514.
45. Dekroon, R. M. & Armati, P. J. (2001) Glia 33, 298-305.
46. Dupont-Wallois, L., Soulié, C., Sergeant, N., Wavrant-de Wrieze, N., ChartierHarlin, M.-C., Delacourte, A. & Caillet-Boudin, M.-L. (1997) Neurobiol. Dis. 4, 356-364.
47. Aoki, K., Uchihara, T., Sanjo, N., Nakamura, A., Ikeda, K., Tsuchiya, K. & Wakayama, Y. (2003) Stroke 34, 875-880.
48. Raber, J., Akana, S. F., Bhatnagar, S., Dallman, M. F., Wong, D. & Mucke, L. (2000) J. Neurosci. 20, 2064-2071.
49. Stein, P. E. & Carrell, R. W. (1995) Struct. Biol. 2, 96-113.
50. Hutton, M., Lewis, J., Dickson, D., Yen, S.-H. & McGowan, E. (2001) Trends Mol. Med. 7, 467-470.
51. Tolar, M., Marques, M. A., Harmony, J. A. K. & Crutcher, K. A. (1997) J. Neurosci. 17, 5678-5686.
52. Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A. & Crutcher, K. A. (1999) J. Neurosci. 19, 7100-7110.
53. Cho, H. S., Hyman, B. T., Greenberg, S. M. & Rebeck, G. W. (2001) J. Neuropathol. Exp. Neurol. 60, 342-349.
54. Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W. & Taylor, J. M. (1985) J. Clitt. Invest. 76, 1501-1513.
55. Hartman, R. E., Wozniak, D. F., Nardi, A., Olney, J. W., Sartorius, L. & Holtzman, D. M. (2001) Exp. Neurol. 170, 326-344.
56. Ferreira, S., Dupire, M.-J., Delacourte, A., Najib, J. & Caillet-Boudin, M.-L. (2000) Exp. Neurol. 166, 415-421.
57. Poirier, J., Hess, M., May, P. C. & Finch, C. E. (1991) Mol. Brain Res. 11, 97-106.
58. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-766.
59. Schmidt, S., Barcellos, L. F., DeSombre, K., Rimmler, J. B., Lincoln, R. R., Bucher, P., Saunders, A. M., Lai, E., Martin, E. R., Vance, J. M., et al. (2002) Am. J. Hum. Genet. 70, 708-717.
60. Lacomblez, L., Doppler, V., Beucler, I., Costes, G., Salachas, F., Raisonnier, A., Le Forestier, N., Pradat, P.-F., Bruckert, E. & Meininger, V. (2002) Neurology 58, 1112-1114.
61. Zareparsi, S., Camicioli, R., Sexton, G., Bird, T., Swanson, P., Kaye, J., Nutt, J. & Payami, H. (2002) Am. J. Med. Genet. 107, 156-161.