메뉴 건너뛰기




Volumn 924, Issue , 2000, Pages 42-52

A plasticity-based theory of the pathogenesis of Alzheimer's disease

Author keywords

Amyloid beta precursor protein; Estrogen; Neuroplasticity in AD; Plasticity, neuronal burden of; Presenilins, ApoE

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; ESTROGEN; PRESENILIN 1;

EID: 0034509333     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb05559.x     Document Type: Conference Paper
Times cited : (119)

References (49)
  • 1
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1
  • 3
    • 0030780381 scopus 로고    scopus 로고
    • Cerebral cortex pathology in aging and Alzheimer's disease: A quantitative survey of large hospital-based geriatric and psychiatric cohorts
    • (1997) Brain Res. Rev. , vol.25 , pp. 217-245
    • Giannakopoulos, P.1
  • 4
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
    • (1991) Cereb. Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1
  • 7
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 9
    • 0033230623 scopus 로고    scopus 로고
    • Neuroplasticity failure in Alzheimer's disease: Bridging the gap between plaques and tangles
    • (1999) Neuron , vol.24 , pp. 521-529
    • Mesulam, M.-M.1
  • 10
    • 0028071334 scopus 로고
    • Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid β/A4 protein precursor
    • (1994) Proc. Natl. Acad. Sci. (USA) , vol.91 , pp. 7450-7454
    • Roch, J.-M.1
  • 11
    • 0030797332 scopus 로고    scopus 로고
    • Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices
    • (1997) NeuroReport , vol.8 , pp. 2133-2137
    • Ishida, A.1
  • 12
    • 0030763739 scopus 로고    scopus 로고
    • Synaptic β-amyloid precursor proteins increase with learning capacity in rats
    • (1997) Neuroscience , vol.80 , pp. 313-320
    • Huber, G.1
  • 13
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • (1997) Physiol. Rev. , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 15
    • 0000473285 scopus 로고
    • Abnormal synaptic regeneration in hAPP695 transgenic and APOE knockout mice
    • Research Advances in Alzheimer's Disease and Related Disorders. K. Iqbal, J. A. Mortimer, B. Winblad et al., Eds.: John Wiley and Sons. New York
    • (1995) , pp. 406-414
    • Masliah, E.1
  • 16
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1
  • 17
    • 0033360356 scopus 로고    scopus 로고
    • Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
    • (1999) Nature Neurosci. , vol.2 , pp. 271-276
    • Chapman, P.F.1
  • 18
    • 0032100541 scopus 로고    scopus 로고
    • Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells
    • (1998) J. Neurosci. Res. , vol.52 , pp. 618-624
    • Furukawa, K.1
  • 19
    • 0033151570 scopus 로고    scopus 로고
    • Presenilin 1 facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer's disease-linked PS 1 mutants in the beta-catenin-signaling pathway
    • (1999) J. Neurosci. , vol.19 , pp. 4229-4237
    • Kang, D.E.1
  • 20
    • 0032531793 scopus 로고    scopus 로고
    • Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
    • (1998) Nature , vol.395 , pp. 698-702
    • Zhang, Z.1
  • 21
    • 0000138540 scopus 로고    scopus 로고
    • Effects of PS1 deficiency on membrane protein traf-ticking inneurons
    • (1998) Neuron , vol.21 , pp. 1213-1221
    • Naruse, S.1
  • 22
    • 0002611182 scopus 로고    scopus 로고
    • Apolipoprotein E role in maintaining the integrity of the aging central nervous system
    • Apolipoprotein E and Alzheimer's Disease. A.D. Roses, K.H. Weisgraber & Y. Christen.: Springer-Verlag, Berlin
    • (1996) , pp. 59-73
    • Masliah, E.1
  • 23
    • 0032937824 scopus 로고    scopus 로고
    • Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures
    • (1999) Neuroscience , vol.91 , pp. 1009-1016
    • Teter, B.1
  • 24
    • 0028232662 scopus 로고
    • Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
    • (1994) Science , vol.264 , pp. 850-852
    • Nathan, B.P.1
  • 25
    • 0031021296 scopus 로고    scopus 로고
    • Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein e4 allele
    • (1997) J. Neurosci. , vol.17 , pp. 516-529
    • Arendt, T.1
  • 26
  • 28
    • 0032080001 scopus 로고    scopus 로고
    • Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: Implications for Alzheimer's disease
    • (1998) J. Neurosci. , vol.18 , pp. 3180-3185
    • Stone, D.J.1
  • 29
    • 0030988498 scopus 로고    scopus 로고
    • Selective alteration of long-term potentiation-induced transcriptional response in hippocampus of aged, memory-impaired rats
    • (1997) J. Neurosci. , vol.17 , pp. 2876-2885
    • Lanahan, A.1
  • 30
    • 0027094211 scopus 로고
    • Toward understanding of the molecular basis of loss of neuronal plasticity in ageing
    • (1993) Age & Ageing , vol.22
    • Mori, N.1
  • 32
    • 0025302430 scopus 로고
    • Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: Alterations in normal aging and in Alzheimer's disease
    • (1990) Neurology , vol.40 , pp. 1028-1034
    • Palmert, M.R.1
  • 35
    • 0029922250 scopus 로고    scopus 로고
    • Tau is enriched on dynamic microtubules in the distal region of growing axons
    • (1996) J. Neurosci. , vol.16 , pp. 3601-3619
    • Black, M.M.1
  • 36
    • 0023555018 scopus 로고
    • An immunocytochemical and biochemical study of the microtubule-associated protein tau during post-lesion afferent reorganization in the hippocampus of adult rats
    • (1987) Brain. Res. , vol.419 , pp. 244-252
    • Busciglio, J.1
  • 38
    • 0027135874 scopus 로고
    • From pathological marker to potential mediator of neuronal dysfunction and degeneration in Alzheimer's disease
    • (1993) Clin. Neurosci. , vol.1 , pp. 184-191
    • Trojanowski, J.Q.1
  • 40
    • 0027691633 scopus 로고
    • Early and de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia
    • (1993) Glia , vol.9 , pp. 199-210
    • Banati, R.B.1
  • 41
    • 0031035006 scopus 로고    scopus 로고
    • Mab22C11 antibody to amyloid precursor protein recognizes a protein associated with specific astroglial cells of the rat central nervous system characterized by their capacity to support axonal outgrowth
    • (1997) J. Comp. Neurol. , vol.377 , pp. 550-564
    • Chauvet, N.1
  • 42
    • 0027182224 scopus 로고
    • Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8712-8716
    • Wallace, W.1
  • 43
    • 0028345162 scopus 로고
    • Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain
    • (1994) J. Comp. Neurol. , vol.342 , pp. 69-77
    • Beeson, J.G.1
  • 44
    • 0029671451 scopus 로고    scopus 로고
    • Water-soluble abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
    • (1996) J. Biol. Chem. , vol.271 , pp. 4077-4081
    • Kuo, Y.M.1
  • 45
    • 0025784849 scopus 로고
    • Re-examination of ex-boxer's brains using immunohistochemistry with antibodies to amyloid beta-protein and tau protein
    • (1991) Acta Neuropathologica , vol.82 , pp. 280-285
    • Tokuda, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.