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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4780-4785

Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists

(9) Cole, Derek C a Lennox, William J a Stock, Joseph R a Ellingboe, John W a Mazandarani, Hossein b Smith, Deborah L b Zhang, Guoming b Tawa, Gregory J b Schechter, Lee E b

a WYETH RESEARCH (United States)

b PFIZER INC (United States)

Author keywords

5 HT6; Antagonist; N1 Arylsulfonyltryptamine; Receptor; Serotonin

Indexed keywords

ARYLSULFONIC ACID DERIVATIVE; BETA CARBOLINE; CYCLIC AMP; N1 BENZENESULFONYL 3 (1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H INDOLE; N1 BENZENESULFONYL 3 PIPERIDIN 3 YL 1H INDOLE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG; ADENYLATE CYCLASE; SEROTONIN AGONIST; SEROTONIN RECEPTOR; TRYPTAMINE;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL; MODULATION; PHYSICAL CHEMISTRY; RECEPTOR BINDING; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; DRUG EFFECT; METABOLISM; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENYLATE CYCLASE; CYCLIC AMP; HUMANS; MOLECULAR CONFORMATION; PROTEIN BINDING; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTAMINES;

EID: 25144507676 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.07.028 Document Type: Article

Times cited : (33)

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