Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin

Cell Cycle

Volumn 4, Issue 5, 2005, Pages 717-726

  Robbins, April R ^a   Jablonski, Sandra A ^b   Yen, Tim J ^b   Yoda, Kinya ^c   Robey, Rob ^d   Bates, Susan E ^d   Sackett, Dan L ^e  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Fox Chase Center   (United States)

^c NAGOYA UNIVERSITY   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Aurora B; CENP E; FR901228; HP1 ; Trichostatin

Indexed keywords

AURORA B KINASE; BUB1 PROTEIN; CELL PROTEIN; CENTROMERE PROTEIN E; CENTROMERE PROTEIN F; FR 901228; HETEROCHROMATIN PROTEIN 1BETA; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; NUCLEAR PROTEIN; PHOSPHOTRANSFERASE; PROTEIN; TOXIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CENTROMERE; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; GENE EXPRESSION; HETEROCHROMATIN; HUMAN; HUMAN CELL; IN VITRO STUDY; METAPHASE; MICROTUBULE; MITOSIS INHIBITION; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE;

EID: 25144496594     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.5.1690     Document Type: Article

References (46)

1. Demain AL, Fang A. The natural functions of secondary metabolites. Adv Biochem Eng Biotechnol 2000; 69:1-39.
2. Hamel E. Antimitotic natural products and their interactions with tubulin. Med Res Rev 1996; 16:207-31.
3. Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293:1074-80.
4. Van Lint C, Emiliani S, Verdin E. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr 1996; 5:245-53.
5. Ragione FD, Criniti V, Pietra VD, Borrielo A, Oliva A, Indaco S, Yamamoto T, Zappia V. Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett 2001; 499:199-204.
6. Sando V, Robbins AR, Robey R, Myers T, Sausville E, Bates SE, Sackett DL. FR901228 causes mitotic arrest but does not alter microtubule polymerization. Anticancer Drugs 2000; 11:445-54.
7. Ando S, Yang H, Nozaki N, Okazaki T, Yoda K. CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells. Mol Cell Biol 2002; 22:2229-41.
8. Jablonski SA, Chan GK, Cooke CA, Earnshaw WC, Yen TJ. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma 1998; 107:386-96.
9. Richon VM, Sandhoff TW, Rifkind RA, Marks PA. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA 2000; 97:10014-9.
10. Bonner WM, Laskey RA. A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem 1974; 46:83-8.
11. 2 phases by trichostatin A. Exp Cell Res 1988; 177:122-31.
12. Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 1998; 241:126-33.
13. Sandor V, Senderowicz A, Mertins S, Sackett D, Sausville E, Blagosklonny MV, Bates SE. P21-dependent G, arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer 2000; 83:817-25.
14. 2 checkpoint in normal cells that is defective in tumor cells. Mol Biol Cell 2000; 11:2069-83.
15. Taddei A, Maison C, Roche D, Almouzni G. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. Nat Cell Biol 2001; 3:114-20.
16. Maison C, Bailly D, Peters AH, Quivy JP, Roche D, Taddei A, Lachner M, Jenuwein T, Almouzni G. Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet 2002; 30:329-34.
17. Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001; 410:116-20.
18. Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 2000; 406:593-9.
19. 2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997; 106:348-60.
20. Goto H, Tomono Y, Ajiro K, Kosako H, Fujita M, Sakurai M, Okawa K, Iwamatsu A, Okigaki T, Takahashi T, Inagaki M. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem 1999; 274:25543-9.
21. Goto H, Yasui Y, Nigg EA, Inagaki M. Aurora-B phosphorylates histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells 2002; 7:11-7.
22. Hsu JY, Sun ZW, Li X, Reuben M, Tatchell K, Bishop DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, Lin R, Smith MM, Allis CD. Mitotic phosphorylation of histone H3 is governed by Ipl1/Aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 2000; 102:279-91.
23. Speliotes EK, Uren A, Vaux D, Horvitz HR. The survivin-like C elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Mol Cell 2000; 6:211-23.
24. Giet R, Glover DM. Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol 2001; 152:669-82.
25. Adams RR, Carmena M, Earnshaw WC. Chromosomal passengers and the (Aurora) ABCs of mitosis. Trends Cell Biol 2001; 11:49-54.
26. Adams RR, Maiato H, Earnshaw WC, Carmena M. Essential roles of Drosophila inner centromere protein (INCENP) and Aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol 2001; 153:865-80.
27. Terada Y, Tatsuka M, Suzuki F, Yasuda Y, Fujita S, Otsu M. AIM-1: A mammalian mid-body-associated protein required for cytokinesis. Embo J 1998; 17:667-76.
28. 2/M. J Cell Sci 2001; 114:653-61.
29. Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 2002; 22: 874-85.
30. Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC, Cleveland DW. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J 1991; 10:1245-54.
31. Witt PL, Ris, H, Borisy GG. Origin of kinetochore microtubules in Chinese hamster ovary cells. Chromosoma 1980; 81:483-505.
32. De Brabander M, Geuens G, De Mey J, Joniau M. Nucleated assembly of mitotic microtubules in living PTK2 cells after release from nocodazole treatment. Cell Motil 1981; 1:469-83.
33. Maiato H, Rieder CL, Khodjakov A. Kinetochore driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. J Cell Biol 2004; 167:831-840.
34. Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem 2001; 8:1505-11.
35. Blagosklonny MV, Robey R, Sackett DL, Du L, Traganos F, Darzynkiewicz Z, Fojo T, Bates SE. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest and cytotoxicity. Mol Cancer Ther 2002; 1:937-41.
36. Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 2001; 410:120-4.
37. Jacobs SA, Taverna SD, Zhang Y, Briggs SD, Li J, Eissenberg JC, Allis CD, Khorasanizadeh S. Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J 2001; 30:5232-41.
38. Brasher SV, Smith BO, Fogh RH, Nietlispach D, Thiru A, Nielsen PR, Broadhurst RW, Ball LJ, Murzina NV, Laue ED. The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J 2000; 19:1587-97.
39. Zeitlin SG, Shelby RD, Sullivan KF. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 2001; 155:1147-57.
40. Kellum R, Raff JW, Alberts BM. Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos. J Cell Sci 1995; 108:1407-18.
41. Hsβ (p25β) and its localization with centromeres in mitosis. Chromosoma 1997; 106:11-9.
42. Van Hooser AA, Ouspenski II, Gregson HC, Star DA, Yen TJ, Goldberg ML, Yokomori K, Earnshaw WC, Sullivan KF, Brinkley BR. Specification of kinetochore forming chromatin by the histone H3 variant CENP-A. J Cell Sci 2001; 114:3529-42.
43. Yao X, Abrieu A, Zheng Y, Sullivan KF, Cleveland DW. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol 2000; 2:484-91.
44. Schaar BT, Chan GK, Maddox P, Salmon ED, Yen TJ. CENP-E function at kinetochores is essential for chromosome alignment. J Cell Biol 1997; 139:1373-82.
45. McEwen BF, Chan GK, Zubrowski B, Savoian MS, Sauer MT, Yen TJ. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell 2001; 12:2776-89.
46. Murata-Hori M, Wang YL. The kinase activity of Aurora B is required for kinetochore-microtubule interactions during mitosis. Curr Biol 2002; 12:894-9.