메뉴 건너뛰기




Volumn 4, Issue 4, 2005, Pages 490-496

Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin

Author keywords

Bcr Abl; Chemotherapy; Geldanamycin; Hsp70; Hsp90; Imatinib; Leukemia; Raf 1

Indexed keywords

BCR ABL PROTEIN; GELDANAMYCIN; IMATINIB; PHOSPHOTRANSFERASE; RAF PROTEIN;

EID: 25144483367     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.4.4.1702     Document Type: Article
Times cited : (38)

References (57)
  • 2
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes GP, Naekyung Kim C, Liu L, Huang Y, Perkins CL, Green DR, Bhalla K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 1998; 91:1700-5.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Naekyung Kim, C.2    Liu, L.3    Huang, Y.4    Perkins, C.L.5    Green, D.R.6    Bhalla, K.7
  • 5
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deininger MWN, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000; 96:3343-56.
    • (2000) Blood , vol.96 , pp. 3343-3356
    • Deininger, M.W.N.1    Goldman, J.M.2    Melo, J.V.3
  • 6
    • 0032546266 scopus 로고    scopus 로고
    • Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with upregulation of Bcl-xL
    • Amarante-Mendes GP, McGahon AJ, Nishioka WK, Afar DE, Witte ON, Green DR. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with upregulation of Bcl-xL. Oncogene 1998; 16:1383-90.
    • (1998) Oncogene , vol.16 , pp. 1383-1390
    • Amarante-Mendes, G.P.1    McGahon, A.J.2    Nishioka, W.K.3    Afar, D.E.4    Witte, O.N.5    Green, D.R.6
  • 7
    • 0035266132 scopus 로고    scopus 로고
    • Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts
    • Nimmanapalli R, O'Bryan E, Bhalla K. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Cancer Res 2001; 61:1799-804.
    • (2001) Cancer Res , vol.61 , pp. 1799-1804
    • Nimmanapalli, R.1    O'Bryan, E.2    Bhalla, K.3
  • 9
    • 0030739208 scopus 로고    scopus 로고
    • Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
    • Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 1997; 17:5317-27.
    • (1997) Mol Cell Biol , vol.17 , pp. 5317-5327
    • Mosser, D.D.1    Caron, A.W.2    Bourget, L.3    Denis-Larose, C.4    Massie, B.5
  • 12
    • 0032526544 scopus 로고    scopus 로고
    • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant
    • Salomoni P, Wasik MA, Riedel RF, Reiss K, Choi JK, Skorski T, Calabretta B. Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J Exp Med 1998; 187:1995-2007.
    • (1998) J Exp Med , vol.187 , pp. 1995-2007
    • Salomoni, P.1    Wasik, M.A.2    Riedel, R.F.3    Reiss, K.4    Choi, J.K.5    Skorski, T.6    Calabretta, B.7
  • 13
    • 0033959620 scopus 로고    scopus 로고
    • The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: Roles for phosphatidylinositol 3-kinase and Raf
    • Neshat MS, Raitano AB, Wang HG, Reed JC, CL S. The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: Roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol 2000; 20:1179-86.
    • (2000) Mol Cell Biol , vol.20 , pp. 1179-1186
    • Neshat, M.S.1    Raitano, A.B.2    Wang, H.G.3    Reed, J.C.4    CL, S.5
  • 16
    • 0031869466 scopus 로고    scopus 로고
    • Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR - ABL tyrosine kinase, CGP 57148
    • Dan S, Naito M, Tsuruo T. Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR - ABL tyrosine kinase, CGP 57148. Cell Death Differ 1998; 5:710-715.
    • (1998) Cell Death Differ , vol.5 , pp. 710-715
    • Dan, S.1    Naito, M.2    Tsuruo, T.3
  • 18
    • 0034665903 scopus 로고    scopus 로고
    • CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-posi-tive human leukemia cells to apoptosis due to antileukemia drugs
    • Fang G, Kim CN, Perkins CL, Ramadevi N, Winton E, Wittmann S, Bhalla KN. CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-posi-tive human leukemia cells to apoptosis due to antileukemia drugs. Blood 2000; 96:2246-53.
    • (2000) Blood , vol.96 , pp. 2246-2253
    • Fang, G.1    Kim, C.N.2    Perkins, C.L.3    Ramadevi, N.4    Winton, E.5    Wittmann, S.6    Bhalla, K.N.7
  • 19
  • 20
    • 0036463948 scopus 로고    scopus 로고
    • Perspectives on the development of a molecularly targeted agent
    • Druker BJ. Perspectives on the development of a molecularly targeted agent. Cancer Cell 2002; 1:31-6.
    • (2002) Cancer Cell , vol.1 , pp. 31-36
    • Druker, B.J.1
  • 21
    • 1542299692 scopus 로고    scopus 로고
    • Do cells need CDK2 and ...Bcr-Abl?
    • Blagosklonny MV. Do cells need CDK2 and ...Bcr-Abl? Cell Death Differ 2004; 11:249-51.
    • (2004) Cell Death Differ , vol.11 , pp. 249-251
    • Blagosklonny, M.V.1
  • 22
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker BJ, Lydon NB. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 2000; 105:3-7.
    • (2000) J Clin Invest , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2
  • 23
    • 0642307264 scopus 로고    scopus 로고
    • Karnofsky Award lecture. Imatinib as a paradigm of targeted therapies
    • Druker BJ. David A. Karnofsky Award lecture. Imatinib as a paradigm of targeted therapies. J Clin Oncol 2003; 21:239s-45s.
    • (2003) J Clin Oncol , vol.21
    • Druker, B.J.1    David, A.2
  • 24
    • 12844268111 scopus 로고    scopus 로고
    • Imatinib: Paradigm or Anomaly?
    • Druker BJ. Imatinib: Paradigm or Anomaly? Cell Cycle 2004; 3:833-5.
    • (2004) Cell Cycle , vol.3 , pp. 833-835
    • Druker, B.J.1
  • 25
    • 0345184913 scopus 로고    scopus 로고
    • Opportunities and challenges in the development of kinase inhibitor therapy for cancer
    • Sawyers CL. Opportunities and challenges in the development of kinase inhibitor therapy for cancer. Genes Dev 2003; 17:2998-3010.
    • (2003) Genes Dev , vol.17 , pp. 2998-3010
    • Sawyers, C.L.1
  • 26
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers C. Targeted cancer therapy. Nature 2004; 432:294-7.
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 28
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI 571: Diverse mechanisms of resistance
    • Mahon FX, Deininger MWN, Schultheis B, Chabrol J, Reiffers J, Goldman JM, Melo JV. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI 571: Diverse mechanisms of resistance. Blood 2000; 96:1070-9.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.N.2    Schultheis, B.3    Chabrol, J.4    Reiffers, J.5    Goldman, J.M.6    Melo, J.V.7
  • 29
    • 0034210577 scopus 로고    scopus 로고
    • Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
    • Weisberg E, Griffin JD. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood 2000; 95:3498-3505.
    • (2000) Blood , vol.95 , pp. 3498-3505
    • Weisberg, E.1    Griffin, J.D.2
  • 30
    • 0037049766 scopus 로고    scopus 로고
    • Novel targeted therapies for Bcr-Abl positive acute leukemias: Beyond STI571
    • Nimmanapalli R, Bhalla K. Novel targeted therapies for Bcr-Abl positive acute leukemias: Beyond STI571. Oncogene 2002; 21:8584-90.
    • (2002) Oncogene , vol.21 , pp. 8584-8590
    • Nimmanapalli, R.1    Bhalla, K.2
  • 31
    • 0037108448 scopus 로고    scopus 로고
    • BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
    • Gorre ME, Ellwood-Yen K, Chiosis G, Rosen N, Sawyers CL. BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood 2002; 100:3041-4.
    • (2002) Blood , vol.100 , pp. 3041-3044
    • Gorre, M.E.1    Ellwood-Yen, K.2    Chiosis, G.3    Rosen, N.4    Sawyers, C.L.5
  • 32
    • 0141723426 scopus 로고    scopus 로고
    • Gleevec resistance: Lessons for target-directed drug development
    • Daley GQ. Gleevec resistance: Lessons for target-directed drug development. Cell Cycle 2003; 2:190-1.
    • (2003) Cell Cycle , vol.2 , pp. 190-191
    • Daley, G.Q.1
  • 33
    • 0037822071 scopus 로고    scopus 로고
    • Dodging the magic bullet: Understanding imatinib resistance
    • Daley GQ. Dodging the magic bullet: Understanding imatinib resistance. Cancer Biol Ther 2003; 2:109-10.
    • (2003) Cancer Biol Ther , vol.2 , pp. 109-110
    • Daley, G.Q.1
  • 35
    • 0030612135 scopus 로고    scopus 로고
    • Depletion of ErbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity
    • An WG, Schnur RC, Neckers LM, Blagosklonny MV. Depletion of ErbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity. Cancer Chemother Pharmacol 1997; 40:60-4.
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 60-64
    • An, W.G.1    Schnur, R.C.2    Neckers, L.M.3    Blagosklonny, M.V.4
  • 36
    • 0037564865 scopus 로고    scopus 로고
    • Regulation of 17-AAG-induced apoptosis: Role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated downregulation of Akt, Raf-1, and Src kinases
    • Nimmanapalli R, O'Bryan E, Kuhn D, Yamaguchi H, Wang HG, Bhalla KN. Regulation of 17-AAG-induced apoptosis: Role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated downregulation of Akt, Raf-1, and Src kinases. Blood 2003; 102:269-75.
    • (2003) Blood , vol.102 , pp. 269-275
    • Nimmanapalli, R.1    O'Bryan, E.2    Kuhn, D.3    Yamaguchi, H.4    Wang, H.G.5    Bhalla, K.N.6
  • 37
    • 0033863883 scopus 로고    scopus 로고
    • The HSP90 antagonist geldanamycin alters chaperone association with p210BCR-ABL and v-src proteins prior to their degradation by the proteasome
    • An WG, Schulte TW, Neckers LM. The HSP90 antagonist geldanamycin alters chaperone association with p210BCR-ABL and v-src proteins prior to their degradation by the proteasome. Cell Growth Diff 2000; 11:355-60.
    • (2000) Cell Growth Diff , vol.11 , pp. 355-360
    • An, W.G.1    Schulte, T.W.2    Neckers, L.M.3
  • 38
    • 0031761118 scopus 로고    scopus 로고
    • Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
    • McCubrey JA, Steelman LS, Hoyle PE, Blalock WL, Weinstein-Oppenheimer C, Franklin RA, Cherwinski H, Bosch E, McMahon M. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia 1998; 12:1903-29.
    • (1998) Leukemia , vol.12 , pp. 1903-1929
    • McCubrey, J.A.1    Steelman, L.S.2    Hoyle, P.E.3    Blalock, W.L.4    Weinstein-Oppenheimer, C.5    Franklin, R.A.6    Cherwinski, H.7    Bosch, E.8    McMahon, M.9
  • 39
    • 5644252461 scopus 로고    scopus 로고
    • Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells
    • Shelton JG, Steelman LS, White ER, McCubrey JA. Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle 2004; 3:372-9.
    • (2004) Cell Cycle , vol.3 , pp. 372-379
    • Shelton, J.G.1    Steelman, L.S.2    White, E.R.3    McCubrey, J.A.4
  • 40
    • 2442678063 scopus 로고    scopus 로고
    • Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor
    • Demidenko ZN, Blagosklonny MV. Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. Cancer Res 2004; 64:3653-60.
    • (2004) Cancer Res , vol.64 , pp. 3653-3660
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 42
    • 0036581985 scopus 로고    scopus 로고
    • Rat-induced cell cycle progression in human TF-1 hematopoietic cells
    • Chang F, Steelman LS, McCubrey JA. Rat-induced cell cycle progression in human TF-1 hematopoietic cells. Cell Cycle 2002; 1:220-6.
    • (2002) Cell Cycle , vol.1 , pp. 220-226
    • Chang, F.1    Steelman, L.S.2    McCubrey, J.A.3
  • 43
    • 0029913172 scopus 로고    scopus 로고
    • Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-raf-1 and represents a novel c-Raf-1 signal transduction pathway
    • Blagosklonny MV, Schulte TW, Nguyen P, Trepel J, Neckers L. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 1996; 56:1851-4.
    • (1996) Cancer Res , vol.56 , pp. 1851-1854
    • Blagosklonny, M.V.1    Schulte, T.W.2    Nguyen, P.3    Trepel, J.4    Neckers, L.5
  • 44
    • 0034660865 scopus 로고    scopus 로고
    • E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents
    • Stiewe T, Parssanedjad K, Esche H, Opalka B, Putzer BM. E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents. Cancer Res 2000; 60:3957-64.
    • (2000) Cancer Res , vol.60 , pp. 3957-3964
    • Stiewe, T.1    Parssanedjad, K.2    Esche, H.3    Opalka, B.4    Putzer, B.M.5
  • 45
    • 0035080416 scopus 로고    scopus 로고
    • Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI 571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells
    • Topaly J, Zeller WJ, Fruehauf S. Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI 571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia 2001; 15:342-7.
    • (2001) Leukemia , vol.15 , pp. 342-347
    • Topaly, J.1    Zeller, W.J.2    Fruehauf, S.3
  • 47
    • 0035252537 scopus 로고    scopus 로고
    • Compensatory caspase activation: A cautionary tale
    • MacFarlane M. Compensatory caspase activation: A cautionary tale. Trends Pharmacol Sci 2001; 22:60.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 60
    • MacFarlane, M.1
  • 48
    • 7244243900 scopus 로고    scopus 로고
    • Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor
    • Shah N, Asch RJ, Lysholm AS, LeBien TW. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor. Blood 2004; 104:2873-8.
    • (2004) Blood , vol.104 , pp. 2873-2878
    • Shah, N.1    Asch, R.J.2    Lysholm, A.S.3    LeBien, T.W.4
  • 50
    • 0036240251 scopus 로고    scopus 로고
    • STI-571 must select for drug-resistant cells but 'no cell breathes fire out of its nostrils like a dragon'
    • Blagosklonny MV. STI-571 must select for drug-resistant cells but 'no cell breathes fire out of its nostrils like a dragon'. Leukemia 2002; 16:570-2.
    • (2002) Leukemia , vol.16 , pp. 570-572
    • Blagosklonny, M.V.1
  • 51
    • 20844444898 scopus 로고    scopus 로고
    • Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3
    • George P, Bali P, Annavarapu S, Scuto A, Fiskus W, Guo F, Sigua C, Sondarva G, Moscinski L, Atadja P, Bhalla K. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 2005; 105:1768-76.
    • (2005) Blood , vol.105 , pp. 1768-1776
    • George, P.1    Bali, P.2    Annavarapu, S.3    Scuto, A.4    Fiskus, W.5    Guo, F.6    Sigua, C.7    Sondarva, G.8    Moscinski, L.9    Atadja, P.10    Bhalla, K.11
  • 52
    • 0038054117 scopus 로고    scopus 로고
    • Cross-resistance of imatinib mesylate and 17-AAG in imatinib-resistant cells that overexpress BCR-ABL
    • Topaly J, Schad M, Laufs S, Melo JV, Zeller WJ, Fruehauf S. Cross-resistance of imatinib mesylate and 17-AAG in imatinib-resistant cells that overexpress BCR-ABL. Br J Haematol 2003; 121:672-3.
    • (2003) Br J Haematol , vol.121 , pp. 672-673
    • Topaly, J.1    Schad, M.2    Laufs, S.3    Melo, J.V.4    Zeller, W.J.5    Fruehauf, S.6
  • 54
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, Arlinghaus R, Talpaz M. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003; 101:690-8.
    • (2003) Blood , vol.101 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5    Arlinghaus, R.6    Talpaz, M.7
  • 56
    • 4544343214 scopus 로고    scopus 로고
    • A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
    • Dai Y, Rahmani M, Corey SJ, Dent P, Grant S. A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J Biol Chem 2004; 279:34227-39.
    • (2004) J Biol Chem , vol.279 , pp. 34227-34239
    • Dai, Y.1    Rahmani, M.2    Corey, S.J.3    Dent, P.4    Grant, S.5
  • 57
    • 17144391819 scopus 로고    scopus 로고
    • Flavopiridol, an inhibitor of transcription: Implications, problems and solutions
    • Blagosklonny MV. Flavopiridol, an inhibitor of transcription: Implications, problems and solutions. Cell Cycle 2004; 3:1537-42.
    • (2004) Cell Cycle , vol.3 , pp. 1537-1542
    • Blagosklonny, M.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.