-
1
-
-
0000358195
-
Case of hypertrophy of the spleen and liver in which death took place from suppuration of the blood
-
Bennett JH: Case of hypertrophy of the spleen and liver in which death took place from suppuration of the blood. Edinb Med Surg J 64: 413-423, 1845
-
(1845)
Edinb Med Surg J
, vol.64
, pp. 413-423
-
-
Bennett, J.H.1
-
2
-
-
0000690351
-
Weisses blut
-
Virchow R: Weisses Blut. Froriep's Notizen 36: 151-156, 1845
-
(1845)
Froriep's Notizen
, vol.36
, pp. 151-156
-
-
Virchow, R.1
-
3
-
-
0033869862
-
The story of chronic myeloid leukaemia
-
Geary CG: The story of chronic myeloid leukaemia. Br J Haematol 110: 2-11, 2000
-
(2000)
Br J Haematol
, vol.110
, pp. 2-11
-
-
Geary, C.G.1
-
4
-
-
0000286732
-
A minute chromosome in human chronic granulocytic leukemia
-
Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 132: 1497, 1960
-
(1960)
Science
, vol.132
, pp. 1497
-
-
Nowell, P.C.1
Hungerford, D.A.2
-
5
-
-
0015694748
-
A new consistent abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining
-
Rowley JD: A new consistent abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining. Nature 243: 290-293, 1973
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
6
-
-
0020333906
-
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia
-
de Klein A, van Kessel AG, Grosveld G, et al: A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 300: 765-767, 1982
-
(1982)
Nature
, vol.300
, pp. 765-767
-
-
De Klein, A.1
Van Kessel, A.G.2
Grosveld, G.3
-
7
-
-
0021802841
-
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
-
Shtivelman E, Lifshitz B, Gale RP, et al: Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 315: 550-554, 1985
-
(1985)
Nature
, vol.315
, pp. 550-554
-
-
Shtivelman, E.1
Lifshitz, B.2
Gale, R.P.3
-
8
-
-
0022544401
-
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
-
Ben-Neriah Y, Daley GQ, Mes-Masson A-M, et al: The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science 233: 212-214, 1986
-
(1986)
Science
, vol.233
, pp. 212-214
-
-
Ben-Neriah, Y.1
Daley, G.Q.2
Mes-Masson, A.-M.3
-
9
-
-
0021918972
-
Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties
-
Davis RL, Konopka JB, Witte ON: Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties. Mol Cell Biol 5: 204-213, 1985
-
(1985)
Mol Cell Biol
, vol.5
, pp. 204-213
-
-
Davis, R.L.1
Konopka, J.B.2
Witte, O.N.3
-
10
-
-
0025209916
-
Acute leukaemia in bcr/abl transgenic mice
-
Heisterkamp N, Jenster G, ten Hoeve J, et al: Acute leukaemia in bcr/abl transgenic mice. Nature 344: 251-253, 1990
-
(1990)
Nature
, vol.344
, pp. 251-253
-
-
Heisterkamp, N.1
Jenster, G.2
Ten Hoeve, J.3
-
11
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D: Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 247: 824-830, 1990
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
12
-
-
84979948588
-
A sarcoma of the fowl transmissible by an agent separable from the tumor cells
-
Rous P: A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J Exp Med 13: 397-411, 1911
-
(1911)
J Exp Med
, vol.13
, pp. 397-411
-
-
Rous, P.1
-
13
-
-
0017250977
-
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
-
Stehelin D, Varmus HE, Bishop JM, et al: DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260: 170-173, 1976
-
(1976)
Nature
, vol.260
, pp. 170-173
-
-
Stehelin, D.1
Varmus, H.E.2
Bishop, J.M.3
-
14
-
-
0018580807
-
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates
-
Eckhart W, Hutchinson MA, Hunter T: An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell 18: 925-933, 1979
-
(1979)
Cell
, vol.18
, pp. 925-933
-
-
Eckhart, W.1
Hutchinson, M.A.2
Hunter, T.3
-
15
-
-
0029947186
-
Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al: Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells. Nature Med 2: 561-566, 1996
-
(1996)
Nature Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
16
-
-
0033987746
-
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
-
Druker BJ, Lydon NB: Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 105: 3-7, 2000
-
(2000)
J Clin Invest
, vol.105
, pp. 3-7
-
-
Druker, B.J.1
Lydon, N.B.2
-
17
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta D, et al: Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344: 1031-1037, 2001
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.3
-
18
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, et al: Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346: 645-652, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
19
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver RT, Druker BJ, et al: Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study. Blood 99: 1928-1937, 2002
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
20
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myeloid leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, et al: Imatinib induces hematologic and cytogenetic responses in patients with chronic myeloid leukemia in myeloid blast crisis: Results of a phase II study. Blood 99: 3530-3539, 2002
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
21
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al: Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348: 994-1004, 2003
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
22
-
-
0028142490
-
CRKL is the major tyrosine phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia
-
Oda T, Heaney C, Hagopian J, et al: CRKL is the major tyrosine phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem 269: 22925-22928, 1994
-
(1994)
J Biol Chem
, vol.269
, pp. 22925-22928
-
-
Oda, T.1
Heaney, C.2
Hagopian, J.3
-
23
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, et al: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293: 876-880, 2001
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
24
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S, Rudzki Z, Walsh S, et al: High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99: 3472-3475, 2002
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
25
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A, Kreil S, Corbin AS, et al: Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 16: 2190-2196, 2002
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
-
26
-
-
0036493544
-
Ph(-) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
-
Hofmann WK, Jones LC, Lemp NA, et al: Ph(-) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood 99: 1860-1862, 2002
-
(2002)
Blood
, vol.99
, pp. 1860-1862
-
-
Hofmann, W.K.1
Jones, L.C.2
Lemp, N.A.3
-
27
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, et al: Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100: 1014-1018, 2002
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
Soenen-Cornu, V.2
Grardel-Duflos, N.3
-
28
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, et al: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2: 117-125, 2002
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
29
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosomepositive leukaemia to STI571: A prospective study
-
von Bubnoff N, Schneller F, Peschel C, et al: BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosomepositive leukaemia to STI571: A prospective study. Lancet 359: 487-491, 2002
-
(2002)
Lancet
, vol.359
, pp. 487-491
-
-
Von Bubnoff, N.1
Schneller, F.2
Peschel, C.3
-
30
-
-
0037199996
-
Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571
-
Corbin AS, Buchdunger E, Pascal F, et al: Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571. J Biol Chem 277: 32214-32219, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 32214-32219
-
-
Corbin, A.S.1
Buchdunger, E.2
Pascal, F.3
-
31
-
-
0038375012
-
Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
-
Corbin AS, La Rosée P, Stoffregen E, et al: Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 101: 4611-4614, 2003
-
(2003)
Blood
, vol.101
, pp. 4611-4614
-
-
Corbin, A.S.1
La Rosée, P.2
Stoffregen, E.3
-
32
-
-
0037115644
-
Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571)
-
La Rosee P, Corbin AS, Stoffregen EP, et al: Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res 62: 7149-7153, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 7149-7153
-
-
La Rosee, P.1
Corbin, A.S.2
Stoffregen, E.P.3
-
33
-
-
0036301722
-
Diagnosis of gastrointestinal stromal tumors: A consensus approach
-
Fletcher CD, Berman JJ, Corless C, et al: Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 33: 459-465, 2002
-
(2002)
Hum Pathol
, vol.33
, pp. 459-465
-
-
Fletcher, C.D.1
Berman, J.J.2
Corless, C.3
-
34
-
-
15644363454
-
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
-
Hirota S, Isozaki K, Moriyama Y, et al: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279: 577-580, 1998
-
(1998)
Science
, vol.279
, pp. 577-580
-
-
Hirota, S.1
Isozaki, K.2
Moriyama, Y.3
-
35
-
-
0035890740
-
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
-
Rubin BP, Singer S, Tsao C, et al: KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 61: 8118-8121, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 8118-8121
-
-
Rubin, B.P.1
Singer, S.2
Tsao, C.3
-
36
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347: 472-480, 2002
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
-
37
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
van Oosterom AT, Judson I, Verweij J, et al: Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study. Lancet 358: 1421-1423, 2001
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
-
38
-
-
0003222976
-
KIT mutational status predicts response to STI571 in patients with metastatic gastrointestinal stromal tumors (GISTs
-
Heinrich MC, Corless CL, Blanke CD, et al: KIT mutational status predicts response to STI571 in patients with metastatic gastrointestinal stromal tumors (GISTs). Proc Am Soc Clin Oncol 21: 2a, 2002
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 2a
-
-
Heinrich, M.C.1
Corless, C.L.2
Blanke, C.D.3
-
39
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
Heinrich MC, Corless CL, Duensing A, et al: PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299: 708-710, 2003
-
(2003)
Science
, vol.299
, pp. 708-710
-
-
Heinrich, M.C.1
Corless, C.L.2
Duensing, A.3
-
40
-
-
0037105560
-
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosomepositive acute lymphoid leukemias
-
Ottmann OG, Druker BJ, Sawyers CL, et al: A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosomepositive acute lymphoid leukemias. Blood 100: 1965-1971, 2002
-
(2002)
Blood
, vol.100
, pp. 1965-1971
-
-
Ottmann, O.G.1
Druker, B.J.2
Sawyers, C.L.3
-
41
-
-
0028224348
-
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation
-
Golub TR, Barker GF, Lovett M, et al: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation. Cell 77: 307-316, 1994
-
(1994)
Cell
, vol.77
, pp. 307-316
-
-
Golub, T.R.1
Barker, G.F.2
Lovett, M.3
-
42
-
-
0037143794
-
Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans
-
Maki RG, Awan RA, Dixon RH, et al: Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 100: 623-626, 2002
-
(2002)
Int J Cancer
, vol.100
, pp. 623-626
-
-
Maki, R.G.1
Awan, R.A.2
Dixon, R.H.3
-
43
-
-
0036727124
-
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
-
Rubin BP, Schuetze SM, Eary JF, et al: Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 20: 3586-3591, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 3586-3591
-
-
Rubin, B.P.1
Schuetze, S.M.2
Eary, J.F.3
-
44
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
Apperley JF, Gardembas M, Melo JV, et al: Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med 347: 481-487, 2002
-
(2002)
N Engl J Med
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
-
45
-
-
0036682958
-
Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene
-
Magnusson MK, Meade KE, Nakamura R, et al: Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene. Blood 100: 1088-1091, 2002
-
(2002)
Blood
, vol.100
, pp. 1088-1091
-
-
Magnusson, M.K.1
Meade, K.E.2
Nakamura, R.3
-
46
-
-
0031012850
-
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
-
Simon MP, Pedeutour F, Sirvent N, et al: Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet 15: 95-98, 1997
-
(1997)
Nat Genet
, vol.15
, pp. 95-98
-
-
Simon, M.P.1
Pedeutour, F.2
Sirvent, N.3
-
47
-
-
0037018763
-
Treatment of hypereosinophilic syndrome with imatinib mesilate
-
Gleich GJ, Leiferman KM, Pardanani A, et al: Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet 359: 1577-1578, 2002
-
(2002)
Lancet
, vol.359
, pp. 1577-1578
-
-
Gleich, G.J.1
Leiferman, K.M.2
Pardanani, A.3
-
48
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J, DeAngelo DJ, Gotlib J, et al: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348: 1201-1214, 2003
-
(2003)
N Engl J Med
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
-
49
-
-
0037596569
-
Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome
-
Griffin JH, Leung J, Bruner RJ, et al: Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A 100: 7830-7835, 2003
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 7830-7835
-
-
Griffin, J.H.1
Leung, J.2
Bruner, R.J.3
|