메뉴 건너뛰기




Volumn 4, Issue 4, 2005, Pages 473-492

Prospects for a T-cell receptor vaccination against myasthenia gravis

Author keywords

Autoimmune disease; Autoreactive T cells; Combined therapies; Immunoregulation; Myasthenia gravis; Pathogenic; T cell receptor; TCR peptide; TCR vaccine; Thymectomy

Indexed keywords

AZATHIOPRINE; CD4 ANTIGEN; CD8 ANTIGEN; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; CHOLINESTERASE INHIBITOR; CYCLOSPORIN; CYTOKINE; GLUCOCORTICOID; HLA DR3 ANTIGEN; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ALPHA; IR 103; IR 208; IR 501; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUROVAX; PREDNISOLONE; PYRIDOSTIGMINE; RAVAX; REIMMUNE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR VACCINE; TOVAXIN; UNCLASSIFIED DRUG; VACCINE; ZORCELL;

EID: 24744467402     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.4.4.473     Document Type: Review
Times cited : (15)

References (124)
  • 1
    • 0035973305 scopus 로고    scopus 로고
    • Myasthenia gravis
    • Vincent A, Palace J, Hilton-Jones D. Myasthenia gravis. Lancet 357, 2122-2128 (2001). Recent review on all aspects of myasthenia gravis (MG), including treatments.
    • (2001) Lancet , vol.357 , pp. 2122-2128
    • Vincent, A.1    Palace, J.2    Hilton-Jones, D.3
  • 2
    • 0036779688 scopus 로고    scopus 로고
    • Unraveling the pathogenesis of myasthenia gravis
    • Vincent A. Unraveling the pathogenesis of myasthenia gravis. Natl Rev. Immunol. 2, 797-804 (2002). Recent review on pathogenesis of MG.
    • (2002) Natl. Rev. Immunol. , vol.2 , pp. 797-804
    • Vincent, A.1
  • 3
    • 0034065330 scopus 로고    scopus 로고
    • Acetylcholine receptors and myasthenia
    • Lindstrom JM. Acetylcholine receptors and myasthenia. Muscle Nerve 23, 453-477 (2000). Excellent review on the muscle nicotinic acetlycholine receptor autoantigen and its role in MG.
    • (2000) Muscle Nerve , vol.23 , pp. 453-477
    • Lindstrom, J.M.1
  • 4
    • 0002750043 scopus 로고    scopus 로고
    • Myasthenia gravis
    • Rose NR, Mackay IP (Eds), San Diego, CA, USA
    • Drachman DB. Myasthenia gravis. In: The Autoimmune Diseases. Rose NR, Mackay IP (Eds), San Diego, CA, USA. 637-662 (1998). Good review on the pathogenesis of MG, antibody action and disease symptoms.
    • (1998) The Autoimmune Diseases , pp. 637-662
    • Drachman, D.B.1
  • 5
    • 0024600918 scopus 로고
    • Autoimmune T-lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene
    • Melms A, Chrestel S, Schalke BC et al. Autoimmune T-lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. J. Clin. Invest. 83, 785-790 (1989).
    • (1989) J. Clin. Invest. , vol.83 , pp. 785-790
    • Melms, A.1    Chrestel, S.2    Schalke, B.C.3
  • 6
    • 0021243562 scopus 로고
    • Autoimmune human T-lymphocytes specific for acetylcholine receptor
    • Hohlfeld R, Toyka KV, Heininger K, Grosse-Wilde H, Kalies I. Autoimmune human T-lymphocytes specific for acetylcholine receptor. Nature 310, 244-246 (1984). One of the first papers indicating that anti-AChR antibodies are produced under the control of T-cells.
    • (1984) Nature , vol.310 , pp. 244-246
    • Hohlfeld, R.1    Toyka, K.V.2    Heininger, K.3    Grosse-Wilde, H.4    Kalies, I.5
  • 7
    • 4344595862 scopus 로고    scopus 로고
    • Genetic control of autoantibody expression in autoimmune myasthenia gravis: Role of the self-antigen and of HLA-linked loci
    • Giraud M, Beaurain G, Eymard B, Tranchant C, Gajdos P, Garchon HJ. Genetic control of autoantibody expression in autoimmune myasthenia gravis: role of the self-antigen and of HLA-linked loci. Genes Immun. 5, 398-404 (2004).
    • (2004) Genes Immun. , vol.5 , pp. 398-404
    • Giraud, M.1    Beaurain, G.2    Eymard, B.3    Tranchant, C.4    Gajdos, P.5    Garchon, H.J.6
  • 8
    • 3042683763 scopus 로고    scopus 로고
    • Seronegative myasthenia gravis
    • Vincent A, McConville J, Farrugia ME, Newsom-Davis J. Seronegative myasthenia gravis. Semin. Neurol. 24, 125-133 (2004). Review on seronegative MG, a clinical subgroup of MG patients with diagnosis problems.
    • (2004) Semin. Neurol. , vol.24 , pp. 125-133
    • Vincent, A.1    McConville, J.2    Farrugia, M.E.3    Newsom-Davis, J.4
  • 9
    • 0043013332 scopus 로고    scopus 로고
    • Seronegative generalised myasthenia gravis: Clinical features, antibodies, and their targets
    • Vincent A, Bowen J, Newsom-Davis J, McConville J. Seronegative generalised myasthenia gravis: clinical features, antibodies, and their targets. Lancet Neurol. 2, 99-106 (2003). Excellent review on the pathogenesis of MG clinical subgroups, with a special focus on all aspects of seronegative MG.
    • (2003) Lancet Neurol. , vol.2 , pp. 99-106
    • Vincent, A.1    Bowen, J.2    Newsom-Davis, J.3    McConville, J.4
  • 10
    • 0036135312 scopus 로고    scopus 로고
    • The agrin/muscle-specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junction
    • Liyanage Y, Hoch W, Beeson D, Vincent A. The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction. Muscle Nerve 25, 4-16 (2002).
    • (2002) Muscle Nerve , vol.25 , pp. 4-16
    • Liyanage, Y.1    Hoch, W.2    Beeson, D.3    Vincent, A.4
  • 11
    • 2942532978 scopus 로고    scopus 로고
    • Is 'seronegative' MG explained by autoantibodies to MuSK?
    • Lindstrom J. Is 'seronegative' MG explained by autoantibodies to MuSK? Neurology 62, 1920-1921 (2004).
    • (2004) Neurology , vol.62 , pp. 1920-1921
    • Lindstrom, J.1
  • 13
    • 0018117040 scopus 로고
    • Thymic hyperplasia and neoplasia: A review of current concepts
    • Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum. Pathol. 9, 495-515 (1978). One of the first articles describing the features of thymic hyperplasia in MG.
    • (1978) Hum. Pathol. , vol.9 , pp. 495-515
    • Levine, G.D.1    Rosai, J.2
  • 14
    • 0028569634 scopus 로고
    • Aetiological factors in the development of myasthenia gravis
    • Vincent A. Aetiological factors in the development of myasthenia gravis. Adv. Neuroimmunol. 4, 355-371 (1994). Review on etiologic aspects of MG, including the role of the thymus.
    • (1994) Adv. Neuroimmunol. , vol.4 , pp. 355-371
    • Vincent, A.1
  • 15
    • 0027443936 scopus 로고
    • Myasthenia Gravis
    • Willcox N. Myasthenia Gravis. Curr. Opin. Immunol. 5, 910-917 (1993). Describes the features of thymic hyperplasia in MG.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 910-917
    • Willcox, N.1
  • 16
    • 0032103108 scopus 로고    scopus 로고
    • An acetylcholine receptor α subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis
    • Salmon AM, Bruand C, Cardona A, Changeux JP, Berrih-Aknin S. An acetylcholine receptor α subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis. J. Clin. Invest. 101, 2340-2350 (1998). Excellent article attempting to understand the role of AChR expression in different thymic T-cell compartments.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2340-2350
    • Salmon, A.M.1    Bruand, C.2    Cardona, A.3    Changeux, J.P.4    Berrih-Aknin, S.5
  • 17
    • 0029988314 scopus 로고    scopus 로고
    • The thymus and the pathogenesis of myasthenia gravis
    • Levinson AI, Wheatley LM. The thymus and the pathogenesis of myasthenia gravis. Clin. Immunol. Immunopathol. 78, 1-5 (1996). Role of the thymus in MG.
    • (1996) Clin. Immunol. Immunopathol. , vol.78 , pp. 1-5
    • Levinson, A.I.1    Wheatley, L.M.2
  • 18
    • 0030587964 scopus 로고    scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells: Implications for myasthenia gravis
    • Wakkach A, Guyon T, Bruand C, Tzartos S, Cohen-Kaminsky S, Berrih-Aknin S. Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J. Immunol. 157, 3752-3760 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3    Tzartos, S.4    Cohen-Kaminsky, S.5    Berrih-Aknin, S.6
  • 19
    • 0023841883 scopus 로고
    • Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients
    • Melms A, Schalke BC, Kirchner T, Muller-Hermelink HK, Albert E, Wekerle H. Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. J. Clin. Invest. 81, 902-908 (1988). Isolation of autoreactive T-lymphocytes in the thymus of MG patients.
    • (1988) J. Clin. Invest. , vol.81 , pp. 902-908
    • Melms, A.1    Schalke, B.C.2    Kirchner, T.3    Muller-Hermelink, H.K.4    Albert, E.5    Wekerle, H.6
  • 20
    • 0030914912 scopus 로고    scopus 로고
    • Altered intrathymic T-cell repertoire in human myasthenia gravis
    • Truffault F, Cohen-Kaminsky S, Khalil I, Levasseur P, Berrih-Aknin S. Altered intrathymic T-cell repertoire in human myasthenia gravis. Ann. Neurol. 41, 731-741 (1997). One of the first studies to provide evidence of a biased T-cell repertoire in the MG thymus.
    • (1997) Ann. Neurol. , vol.41 , pp. 731-741
    • Truffault, F.1    Cohen-Kaminsky, S.2    Khalil, I.3    Levasseur, P.4    Berrih-Aknin, S.5
  • 21
    • 0030911161 scopus 로고    scopus 로고
    • Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody
    • Moulian N, Bidault J, Truffault F, Yamamoto AM, Levasseur P, Berrih-Aknin S. Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody. Blood 89, 3287-3295 (1997).
    • (1997) Blood , vol.89 , pp. 3287-3295
    • Moulian, N.1    Bidault, J.2    Truffault, F.3    Yamamoto, A.M.4    Levasseur, P.5    Berrih-Aknin, S.6
  • 22
    • 0025045510 scopus 로고
    • Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T-cells
    • Sommer N, Willcox N, Harcourt GC, Newsom-Davis J. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T-cells. Ann. Neurol. 28, 312-319 (1990). Evidence of autoreactive T-lymphocytes in the thymus of MG patients.
    • (1990) Ann. Neurol. , vol.28 , pp. 312-319
    • Sommer, N.1    Willcox, N.2    Harcourt, G.C.3    Newsom-Davis, J.4
  • 23
    • 0021201050 scopus 로고
    • Antibody to acetylcholine receptor in myasthenia gravis: Production by lymphocytes from thymus or thymoma
    • Fujii Y, Monden Y, Nakahara K, Hashimoto J, Kawashima Y. Antibody to acetylcholine receptor in myasthenia gravis: production by lymphocytes from thymus or thymoma. Neurology 34, 1182-1186 (1984). First evidence of autoantibody production by thymic cells.
    • (1984) Neurology , vol.34 , pp. 1182-1186
    • Fujii, Y.1    Monden, Y.2    Nakahara, K.3    Hashimoto, J.4    Kawashima, Y.5
  • 24
    • 0025029359 scopus 로고
    • Thymic B-cells from myasthenia gravis patients are activated B-cells. Phenotypic and functional analysis
    • Leprince C, Cohen-Kaminsky S, Berrih-Aknin S et al. Thymic B-cells from myasthenia gravis patients are activated B-cells. Phenotypic and functional analysis. J. Immunol. 145, 2115-2122 (1990). Comprehensive study on the phenotype, activation status and functional role in autoantibody production.
    • (1990) J. Immunol. , vol.145 , pp. 2115-2122
    • Leprince, C.1    Cohen-Kaminsky, S.2    Berrih-Aknin, S.3
  • 25
    • 0023632437 scopus 로고
    • The role of the thymus in myasthenia gravis: Immunohistological and immunological studies in 115 cases
    • Berrih-Aknin S, Morel E, Raimond F et al. The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases. Ann. NY Acad. Sci. 505, 50-70 (1987). Role of the thymus in a large series of MG patients, with classification of the patients on the basis of thymic phenotype.
    • (1987) Ann. NY Acad. Sci. , vol.505 , pp. 50-70
    • Berrih-Aknin, S.1    Morel, E.2    Raimond, F.3
  • 26
    • 0019177568 scopus 로고
    • Surgical treatment of myasthenia by thymectomy. A report on 248 cases
    • Le Brigand H, Levasseur P, Miranda AR, Gaud C, Wojakowski I. Surgical treatment of myasthenia by thymectomy. A report on 248 cases. Sem. Hop. 56, 1502-1505 (1980). Clinical effect of thymectomy in large series of MG patients.
    • (1980) Sem. Hop. , vol.56 , pp. 1502-1505
    • Le Brigand, H.1    Levasseur, P.2    Miranda, A.R.3    Gaud, C.4    Wojakowski, I.5
  • 27
    • 0025140118 scopus 로고
    • Myasthenia gravis: Effect of thymectomy in 425 patients. A 15-year experience
    • Molnar J, Szobor A. Myasthenia gravis: effect of thymectomy in 425 patients. A 15-year experience. Eur. J. Cardiothorac. Surg. 4, 8-14 (1990). Clinical effect of thymectomy in large series of MG patients.
    • (1990) Eur. J. Cardiothorac. Surg. , vol.4 , pp. 8-14
    • Molnar, J.1    Szobor, A.2
  • 28
    • 0034641233 scopus 로고    scopus 로고
    • Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Gronseth GS, Barohn RJ. Practice parameter: thymectomy for autoimmune myasthenia gravis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 55, 7-15 (2000).
    • (2000) Neurology , vol.55 , pp. 7-15
    • Gronseth, G.S.1    Barohn, R.J.2
  • 29
    • 0034222459 scopus 로고    scopus 로고
    • Myasthenia gravis: Recommendations for clinical research standards
    • Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America
    • Jaretzki A, Barohn RJ, Ernstoff RM et al. Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Ann. Thorac. Surg. 70, 327-334 (2000). Current view and guidelines for the indication of thymectomy in MG.
    • (2000) Ann. Thorac. Surg. , vol.70 , pp. 327-334
    • Jaretzki, A.1    Barohn, R.J.2    Ernstoff, R.M.3
  • 30
    • 3042602389 scopus 로고    scopus 로고
    • The epidemiology of myasthenia gravis
    • Phillips LH. The epidemiology of myasthenia gravis. Semin. Neurol. 24, 17-20 (2004). Recent review on the epidemiology of MG.
    • (2004) Semin. Neurol. , vol.24 , pp. 17-20
    • Phillips, L.H.1
  • 31
    • 0034105979 scopus 로고    scopus 로고
    • The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK
    • MacDonald BK, Cockerell OC, Sander JW, Shorvon SD. The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain 123(Pt. 4), 665-676 (2000).
    • (2000) Brain , vol.123 , Issue.PART 4 , pp. 665-676
    • MacDonald, B.K.1    Cockerell, O.C.2    Sander, J.W.3    Shorvon, S.D.4
  • 32
    • 0001902918 scopus 로고    scopus 로고
    • Natural history of myasthenia gravis
    • Engel AG (Ed.) Oxford, UK
    • Grob D. Natural history of myasthenia gravis. In: Myasthenia Gravis and Myasthenic Disorders. Engel AG (Ed.) Oxford, UK. 131-145 (1999).
    • (1999) Myasthenia Gravis and Myasthenic Disorders , pp. 131-145
    • Grob, D.1
  • 33
    • 0347994922 scopus 로고    scopus 로고
    • Treatment of autoimmune myasthenia gravis
    • Richman DP, Agius MA. Treatment of autoimmune myasthenia gravis. Neurology 61, 1652-1661 (2003). Recent review on the current treatments of MG.
    • (2003) Neurology , vol.61 , pp. 1652-1661
    • Richman, D.P.1    Agius, M.A.2
  • 34
    • 0035830461 scopus 로고    scopus 로고
    • Mycophenolate mofetil for myasthenia gravis: An open-label pilot study
    • Ciafaloni E, Massey JM, Tucker-Lipscomb B, Sanders DB. Mycophenolate mofetil for myasthenia gravis: an open-label pilot study. Neurology 56, 97-99 (2001).
    • (2001) Neurology , vol.56 , pp. 97-99
    • Ciafaloni, E.1    Massey, J.M.2    Tucker-Lipscomb, B.3    Sanders, D.B.4
  • 35
    • 0029788252 scopus 로고    scopus 로고
    • Immunotherapy in neuromuscular disorders: Current and future strategies
    • Drachman DB. Immunotherapy in neuromuscular disorders: current and future strategies. Muscle Nerve 19, 1239-1251 (1996).
    • (1996) Muscle Nerve , vol.19 , pp. 1239-1251
    • Drachman, D.B.1
  • 36
    • 0036259807 scopus 로고    scopus 로고
    • High-dose intravenous immunoglobulin G treatment of myasthenia gravis
    • Ferrero B, Durelli L. High-dose intravenous immunoglobulin G treatment of myasthenia gravis. Neurol. Sci. 23(Suppl. 1), S9-S24 (2002).
    • (2002) Neurol. Sci. , vol.23 , Issue.SUPPL. 1
    • Ferrero, B.1    Durelli, L.2
  • 37
    • 0142217505 scopus 로고    scopus 로고
    • Myasthenia gravis and myasthenic syndrome
    • Antozzi C. Myasthenia gravis and myasthenic syndrome. Neurol. Sci. 24(Suppl.4), S260-S263 (2003). Recent review on the current treatments of MG, and discussion on the indication of intravenous human immunoglobulin (Ig) and plasmapheresis.
    • (2003) Neurol. Sci. , vol.24 , Issue.SUPPL. 4
    • Antozzi, C.1
  • 38
  • 39
    • 0041842423 scopus 로고    scopus 로고
    • Therapy in myasthenia gravis and Lambert-Eaton myasthenia syndrome
    • Newsom-Davis J. Therapy in myasthenia gravis and Lambert-Eaton myasthenia syndrome. Semin. Neurol. 23, 191-198 (2003). Recent review on the current treatments of MG and the therapeutic option in each patient subgroup.
    • (2003) Semin. Neurol. , vol.23 , pp. 191-198
    • Newsom-Davis, J.1
  • 40
    • 0031001759 scopus 로고    scopus 로고
    • Clinical trial of plasma exchange and high-dose intravenous immunoglobulin in myasthenia gravis
    • Myasthenia Gravis Clinical Study Group
    • Gajdos P, Chevret S, Clair B, Tranchant C, Chastang C. Clinical trial of plasma exchange and high-dose intravenous immunoglobulin in myasthenia gravis. Myasthenia Gravis Clinical Study Group. Ann. Neurol. 41, 789-796 (1997).
    • (1997) Ann. Neurol. , vol.41 , pp. 789-796
    • Gajdos, P.1    Chevret, S.2    Clair, B.3    Tranchant, C.4    Chastang, C.5
  • 41
    • 0032707209 scopus 로고    scopus 로고
    • Intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: Present status and practical therapeutic guidelines
    • Dalakas MC. Intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: present status and practical therapeutic guidelines. Muscle Nerve 22, 1479-1497 (1999).
    • (1999) Muscle Nerve , vol.22 , pp. 1479-1497
    • Dalakas, M.C.1
  • 42
    • 3042690153 scopus 로고    scopus 로고
    • A history of treatments for myasthenia gravis
    • Keesey JC. A history of treatments for myasthenia gravis. Semin. Neurol. 24, 5-16 (2004). Historic perspective on treatments in MG.
    • (2004) Semin. Neurol. , vol.24 , pp. 5-16
    • Keesey, J.C.1
  • 43
    • 0033955430 scopus 로고    scopus 로고
    • Animal models of myasthenia gravis
    • Christadoss P, Poussin M, Deng C. Animal models of myasthenia gravis. Clin. Immunol. 94, 75-87 (2000). Review on the use of animal models of MG to understand pathogenesis and evaluate treatments.
    • (2000) Clin. Immunol. , vol.94 , pp. 75-87
    • Christadoss, P.1    Poussin, M.2    Deng, C.3
  • 44
    • 17344372846 scopus 로고    scopus 로고
    • Anatomy of the antigenic structure of a large membrane autoantigen, the muscle-type nicotinic acetylcholine receptor
    • Tzartos SJ, Barkas T, Cung MT et al. Anatomy of the antigenic structure of a large membrane autoantigen, the muscle-type nicotinic acetylcholine receptor. Immunol. Rev. 163, 89-120 (1998). Excellent review on the B-cell epitopes and B-cell repertoire of AChR.
    • (1998) Immunol. Rev. , vol.163 , pp. 89-120
    • Tzartos, S.J.1    Barkas, T.2    Cung, M.T.3
  • 45
    • 0026027752 scopus 로고
    • T-cell antigenic sites involved in myasthenia gravis: Correlations with antibody titre and disease severity
    • Berrih-Aknin S, Cohen-Kaminsky S, Lepage V, Neumann D, Bach JF, Fuchs S. T-cell antigenic sites involved in myasthenia gravis: correlations with antibody titre and disease severity. J Autoimmun. 4, 137-153 (1991).
    • (1991) J. Autoimmun. , vol.4 , pp. 137-153
    • Berrih-Aknin, S.1    Cohen-Kaminsky, S.2    Lepage, V.3    Neumann, D.4    Bach, J.F.5    Fuchs, S.6
  • 46
    • 0027263471 scopus 로고
    • Myasthenia gravis: Recognition of a human autoantigen at the molecular level
    • Protti MP, Manfredi AA, Horton RM, Bellone M, Conti-Tronconi BM. Myasthenia gravis: recognition of a human autoantigen at the molecular level. Immunol Today. 14, 363-368 (1993). Review on the diversity of T-cell epitopes in MG.
    • (1993) Immunol. Today , vol.14 , pp. 363-368
    • Protti, M.P.1    Manfredi, A.A.2    Horton, R.M.3    Bellone, M.4    Conti-Tronconi, B.M.5
  • 47
    • 0033381974 scopus 로고    scopus 로고
    • Induction of oral tolerance to the acetylcholine receptor for treatment of myasthenia gravis
    • Weiner HL. Induction of oral tolerance to the acetylcholine receptor for treatment of myasthenia gravis. J. Clin. Invest. 104, 1667-1668 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1667-1668
    • Weiner, H.L.1
  • 48
    • 0033400810 scopus 로고    scopus 로고
    • Suppression of ongoing experimental myasthenia by oral treatment with an acetylcholine receptor recombinant fragment
    • Im SH, Barchan D, Fuchs S, Souroujon MC. Suppression of ongoing experimental myasthenia by oral treatment with an acetylcholine receptor recombinant fragment. J. Clin. Invest. 104, 1723-1730 (1999). Evidence of the beneficial effect of an oral treatment with recombinant acetylcholine receptor in experimental autoimmune MG.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1723-1730
    • Im, S.H.1    Barchan, D.2    Fuchs, S.3    Souroujon, M.C.4
  • 49
    • 3042656879 scopus 로고    scopus 로고
    • Immunosuppression of rat myasthenia gravis by oral administration of a syngeneic acetylcholine receptor fragment
    • Maiti PK, Feferman T, Im SH, Souroujon MC, Fuchs S. Immunosuppression of rat myasthenia gravis by oral administration of a syngeneic acetylcholine receptor fragment. J. Neuroimmunol. 152, 112-120 (2004). Use of syngeneic AChR fragments for oral tolerance in rats.
    • (2004) J. Neuroimmunol. , vol.152 , pp. 112-120
    • Maiti, P.K.1    Feferman, T.2    Im, S.H.3    Souroujon, M.C.4    Fuchs, S.5
  • 50
    • 3042520983 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy in myasthenia gravis: Failed promise and new hope
    • Pachner AR. Antigen-specific immunotherapy in myasthenia gravis: failed promise and new hope. J. Neuroimmunol. 152, vii-viii (2004). Use of syngeneic AChR fragments for oral tolerance in rats.
    • (2004) J. Neuroimmunol. , vol.152
    • Pachner, A.R.1
  • 51
    • 0034037417 scopus 로고    scopus 로고
    • Immunomodulation of experimental autoimmune diseases via oral tolerance
    • Krause I, Blank M, Shoenfeld Y. Immunomodulation of experimental autoimmune diseases via oral tolerance. Crit. Rev. Immunol. 20, 1-16 (2000).
    • (2000) Crit. Rev. Immunol. , vol.20 , pp. 1-16
    • Krause, I.1    Blank, M.2    Shoenfeld, Y.3
  • 52
    • 0033066588 scopus 로고    scopus 로고
    • Oral tolerance: Mechanisms and therapeutic applications
    • Faria AM, Weiner HL. Oral tolerance: mechanisms and therapeutic applications. Adv. Immunol 73, 153-264 (1999).
    • (1999) Adv. Immunol , vol.73 , pp. 153-264
    • Faria, A.M.1    Weiner, H.L.2
  • 53
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a Phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a Phase II clinical trial with an altered peptide ligand. Nature Med. 6, 1167-1175 (2000). Clinical trial showing that treatment with autoantigen fragments can be harmful.
    • (2000) Nature Med. , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 54
    • 0037992519 scopus 로고    scopus 로고
    • Rational design of peptide vaccines for autoimmune disease: Harnessing molecular recognition to fix a broken network
    • Weathington NM, Blalock JE. Rational design of peptide vaccines for autoimmune disease: harnessing molecular recognition to fix a broken network. Expert Rev. Vaccines 2, 61-73 (2003). Review of the use of complementary autoantigen peptides in the treatment of autoimmune diseases.
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 61-73
    • Weathington, N.M.1    Blalock, J.E.2
  • 55
    • 1842508029 scopus 로고    scopus 로고
    • Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3
    • Pendergraft WF III, Preston GA, Shah RR et al. Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nature Med. 10, 72-79 (2004). Suggests that a complementary peptide can initiate an autoimmune disease.
    • (2004) Nature Med. , vol.10 , pp. 72-79
    • Pendergraft III, W.F.1    Preston, G.A.2    Shah, R.R.3
  • 56
    • 0029930328 scopus 로고    scopus 로고
    • T-cell receptor peptides in treatment of autoimmune disease: Rationale and potential
    • Vandenbark AA, Hashim GA, Offner H. T-cell receptor peptides in treatment of autoimmune disease: rationale and potential. J Neurosci. Res. 43, 391-402 (1996). Review on the potential of T-cell receptor (TCR) peptide therapy in MG, discussing the different possibilities for the choice of the therapeutic peptide.
    • (1996) J. Neurosci. Res. , vol.43 , pp. 391-402
    • Vandenbark, A.A.1    Hashim, G.A.2    Offner, H.3
  • 57
    • 0029778421 scopus 로고    scopus 로고
    • + T-cell subsets of myasthenia gravis patients: A role for superantigen(s)?
    • + T-cell subsets of myasthenia gravis patients: a role for superantigen(s)? Mol. Med. 2, 452-459 (1996). Evidence of a diverse T-cell repertoire in MG.
    • (1996) Mol. Med. , vol.2 , pp. 452-459
    • Gigliotti, D.1    Lefvert, A.K.2    Jeddi-Tehrani, M.3
  • 58
    • 0025041611 scopus 로고
    • Increased incidence of certain TCR and HLA genes associated with myasthenia gravis in Italians
    • Mantegazza R, Oksenberg JR, Baggi F et al. Increased incidence of certain TCR and HLA genes associated with myasthenia gravis in Italians. J. Autoimmun. 3, 431-440 (1990). Evidence of a diverse T-cell repertoire in MG.
    • (1990) J. Autoimmun. , vol.3 , pp. 431-440
    • Mantegazza, R.1    Oksenberg, J.R.2    Baggi, F.3
  • 60
    • 0027194314 scopus 로고
    • Approaches for studying the pathogenic T-cells in autoimmune patients
    • Willcox N, Baggi F, Batocchi AP et al. Approaches for studying the pathogenic T-cells in autoimmune patients. Ann. NY Acad. Sci. 681, 219-237 (1993).
    • (1993) Ann. NY Acad. Sci. , vol.681 , pp. 219-237
    • Willcox, N.1    Baggi, F.2    Batocchi, A.P.3
  • 61
    • 0027293045 scopus 로고
    • T-cell receptor gene usage of acetylcholine receptor-specific T-helper cells
    • Melms A, Oksenberg JR, Malcherek G et al. T-cell receptor gene usage of acetylcholine receptor-specific T-helper cells. Ann. NY Acad. Sci. 681, 313-314 (1993). Evidence of a diverse T-cell repertoire in MG.
    • (1993) Ann. NY Acad. Sci. , vol.681 , pp. 313-314
    • Melms, A.1    Oksenberg, J.R.2    Malcherek, G.3
  • 62
    • 0031879061 scopus 로고    scopus 로고
    • + T-cells in myasthenia gravis patients have individual, but restricted TCR V beta usage
    • + T-cells in myasthenia gravis patients have individual, but restricted TCR V beta usage. Ann. NY Acad. Sci. 841, 324-328 (1998). Evidence of a diverse T-cell repertoire in MG.
    • (1998) Ann. NY Acad. Sci. , vol.841 , pp. 324-328
    • Raju, R.1    Navaneetham, D.2    Protti, M.P.3
  • 63
    • 0042520847 scopus 로고    scopus 로고
    • Evidence of a diverse T-cell receptor repertoire for acetylcholine receptor, the autoantigen of myasthenia gravis
    • Infante AJ, Baillargeon J, Kraig E et al. Evidence of a diverse T-cell receptor repertoire for acetylcholine receptor, the autoantigen of myasthenia gravis. J. Autoimmun. 21, 167-174 (2003).
    • (2003) J. Autoimmun. , vol.21 , pp. 167-174
    • Infante, A.J.1    Baillargeon, J.2    Kraig, E.3
  • 64
    • 0036481263 scopus 로고    scopus 로고
    • Epitope spreading in immune-mediated diseases: Implications for immunotherapy
    • Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nature Rev. Immunol. 2, 85-95 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 85-95
    • Vanderlugt, C.L.1    Miller, S.D.2
  • 65
    • 0032834013 scopus 로고    scopus 로고
    • Prevention of autoimmune attack by targeting specific T-cell receptor in a SCID mice model of myasthenia gravis
    • Aissaoui A, Klingel-Schmitt I, Couderc J et al. Prevention of autoimmune attack by targeting specific T-cell receptor in a SCID mice model of myasthenia gravis. Ann. Neurol. 46, 559-567 (1999). Demonstrates the pathogenicity of a dominant T-cell population from the thymus of MG patients in a humanized severe combined immune deficient (SCID) mouse model.
    • (1999) Ann. Neurol. , vol.46 , pp. 559-567
    • Aissaoui, A.1    Klingel-Schmitt, I.2    Couderc, J.3
  • 66
    • 0018943586 scopus 로고
    • Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis
    • Compston DA, Vincent A, Newsom-Davis J, Batchelor JR. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103, 579-601 (1980). Human leukocyte antigen (HLA)-DR3 association in MG patients.
    • (1980) Brain , vol.103 , pp. 579-601
    • Compston, D.A.1    Vincent, A.2    Newsom-Davis, J.3    Batchelor, J.R.4
  • 68
    • 0041742401 scopus 로고    scopus 로고
    • Circulating regulatory anti-TCR antibodies in patients with myasthenia gravis
    • Jambou F, Zhang W, Menestrier M et al. Circulating regulatory anti-TCR antibodies in patients with myasthenia gravis. J. Clin. Invest. 112, 265-274 (2003). Demonstration of the regulatory and protective role of spontaneous anti-TCR antibodies targeting a dominant T-cell population in MG.
    • (2003) J. Clin. Invest. , vol.112 , pp. 265-274
    • Jambou, F.1    Zhang, W.2    Menestrier, M.3
  • 69
    • 0141727692 scopus 로고    scopus 로고
    • Rationale for a T-cell receptor peptide therapy in Myasthenia Gravis
    • Jambou F, Menestrier M, Klingel-Schmitt I et al. Rationale for a T-cell receptor peptide therapy in Myasthenia Gravis. Ann. NY Acad. Sci. USA. 988, 320-323 (2003).
    • (2003) Ann. NY Acad. Sci. USA. , vol.988 , pp. 320-323
    • Jambou, F.1    Menestrier, M.2    Klingel-Schmitt, I.3
  • 70
    • 1542677994 scopus 로고    scopus 로고
    • Immunoregulation by Vβ specific antibodies in myasthenia gravis: Mining physiological T-cell homeostasis for TCR specific therapy
    • Jambou F, Cohen-Kaminsky S. Immunoregulation by Vβ specific antibodies in myasthenia gravis: mining physiological T-cell homeostasis for TCR specific therapy. Cell Mol. Biol, (Noisy-legrand) 181-192 (2003). Review on the physiologic and regulatory role of anti-TCR antibodies in adaptive immunity and autoimmunity.
    • (2003) Cell Mol. Biol, (Noisy-Legrand) , pp. 181-192
    • Jambou, F.1    Cohen-Kaminsky, S.2
  • 71
    • 0025647834 scopus 로고
    • T-cell vaccination in experimental myasthenia gravis: A double-edged sword
    • Kahn CR, McIntosh KR, Drachman DB. T-cell vaccination in experimental myasthenia gravis: a double-edged sword. J. Autoimmun. 3, 659-669 (1990). One of the first studies on T-cell vaccination in MG.
    • (1990) J. Autoimmun. , vol.3 , pp. 659-669
    • Kahn, C.R.1    McIntosh, K.R.2    Drachman, D.B.3
  • 72
    • 0037096223 scopus 로고    scopus 로고
    • Therapeutic vaccines: Realities of today and hopes for the future
    • Sela M, Arnon R, Schechter B. Therapeutic vaccines: realities of today and hopes for the future. Drug Discov. Today. 7, 664-673 (2002). Review on the concept of therapeutic as opposed to prophylactic preventive vaccines.
    • (2002) Drug Discov. Today , vol.7 , pp. 664-673
    • Sela, M.1    Arnon, R.2    Schechter, B.3
  • 73
    • 0035852315 scopus 로고    scopus 로고
    • T-cell vaccination for autoimmune disease: A panorama
    • Cohen IR. T-cell vaccination for autoimmune disease: a panorama. Vaccine 20, 706-710 (2001). Good review on T-cell vaccination in autoimmune diseases: history, rationale, state of the art and mechanisms of action of T-cell vaccination.
    • (2001) Vaccine , vol.20 , pp. 706-710
    • Cohen, I.R.1
  • 74
    • 0031573087 scopus 로고    scopus 로고
    • Recombinant T-cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: Dose effects and involvement of both CD4 and CD8 T-cells
    • Kumar V, Coulsell E, Ober B, Hubbard G, Sercarz E, Ward ES. Recombinant T-cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T-cells. J. Immunol 159, 5150-5156 (1997). TCR vaccination using recombinant fragments in protection (prevention and reversal) of autoimmune encephalomyelitis (EAE).
    • (1997) J. Immunol. , vol.159 , pp. 5150-5156
    • Kumar, V.1    Coulsell, E.2    Ober, B.3    Hubbard, G.4    Sercarz, E.5    Ward, E.S.6
  • 75
    • 0032168560 scopus 로고    scopus 로고
    • Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice
    • Offner H, Adlard K, Bebo BF Jr et al. Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. J. Immunol. 161, 2178-2186 (1998). TCR vaccination using recombinant fragments in protection (prevention and reversal) of EAE.
    • (1998) J. Immunol. , vol.161 , pp. 2178-2186
    • Offner, H.1    Adlard, K.2    Bebo Jr., B.F.3
  • 76
    • 0029796099 scopus 로고    scopus 로고
    • Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2
    • Waisman A, Ruiz PJ, Hirschberg DL et al. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 Immunity Nature Med. 2, 899-905 (1996). Use of genetic vaccination in prevention of EAE.
    • (1996) Immunity Nature Med. , vol.2 , pp. 899-905
    • Waisman, A.1    Ruiz, P.J.2    Hirschberg, D.L.3
  • 77
    • 0029819563 scopus 로고    scopus 로고
    • Genetic vaccination: The advantages of going naked
    • Kumar V, Sercarz E. Genetic vaccination: the advantages of going naked. Nature Med 2, 857-859 (1996). Review of genetic vaccination.
    • (1996) Nature Med. , vol.2 , pp. 857-859
    • Kumar, V.1    Sercarz, E.2
  • 78
    • 0034651569 scopus 로고    scopus 로고
    • Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR
    • Matsumoto Y, Jee Y, Sugisaki M. Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR. J. Immunol. 164, 2248-2254 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 2248-2254
    • Matsumoto, Y.1    Jee, Y.2    Sugisaki, M.3
  • 79
    • 0037438597 scopus 로고    scopus 로고
    • Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the Vξ 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10
    • Braciak TA, Pedersen B, Chin J et al. Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the Vξ 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10. J. Immunol. 170, 765-774 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 765-774
    • Braciak, T.A.1    Pedersen, B.2    Chin, J.3
  • 80
    • 0034871273 scopus 로고    scopus 로고
    • TCR peptide therapy in human autoimmune diseases
    • Vandenbark AA, Morgan E, Bartholomew R et al. TCR peptide therapy in human autoimmune diseases. Neurochem. Res. 26, 713-730 (2001). Comprehensive review on 14 clinical trials (completed or ongoing) using TCR peptides for the treatment of autoimmune diseases mulitple sclerosis (MS), rheumatoid arthritis (RA) and psoriasis in large numbers of patients.
    • (2001) Neurochem. Res. , vol.26 , pp. 713-730
    • Vandenbark, A.A.1    Morgan, E.2    Bartholomew, R.3
  • 81
    • 16044361810 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial
    • Vandenbark AA, Chou YK, Whitham R et al. Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nature Med. 2, 1109-1115 (1996). First published double-blind trial using TCR peptide vaccine in MS.
    • (1996) Nature Med. , vol.2 , pp. 1109-1115
    • Vandenbark, A.A.1    Chou, Y.K.2    Whitham, R.3
  • 82
    • 3042733559 scopus 로고    scopus 로고
    • T-cell vaccination in multiple sclerosis: Update on clinical application and mode of action
    • Hellings N, Raus J, Stinissen P. T-cell vaccination in multiple sclerosis: update on clinical application and mode of action. Autoimmun. Rev. 3, 267-275 (2004). T-cell vaccination in MS, presenting all the completed and ongoing trials.
    • (2004) Autoimmun. Rev. , vol.3 , pp. 267-275
    • Hellings, N.1    Raus, J.2    Stinissen, P.3
  • 83
  • 84
    • 0037509927 scopus 로고    scopus 로고
    • T-cell vaccination for autoimmune diseases: Immunologic lessons and clinical experience in multiple sclerosis
    • Zhang J. T-cell vaccination for autoimmune diseases: immunologic lessons and clinical experience in multiple sclerosis. Expert Rev. Vaccines 1, 285-292 (2002). Review on T-cell vaccination in EAE and MS.
    • (2002) Expert Rev. Vaccines , vol.1 , pp. 285-292
    • Zhang, J.1
  • 85
    • 0036035624 scopus 로고    scopus 로고
    • Peptide therapy for Type I diabetes: The immunological homunculus and the rationale for vaccination
    • Cohen IR. Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination. Diabetologia 45, 1468-1474 (2002).
    • (2002) Diabetologia , vol.45 , pp. 1468-1474
    • Cohen, I.R.1
  • 86
    • 1642495763 scopus 로고    scopus 로고
    • TCR vaccines against a murine T-cell lymphoma: A primary role for antibodies of the IgG2c class in tumor protection
    • Lambert SL, Okada CY, Levy R. TCR vaccines against a murine T-cell lymphoma: a primary role for antibodies of the IgG2c class in tumor protection. J. Immunol. 172, 929-936 (2004). Demonstration of a primary role of anti-TCR antibodies in TCR vaccine against a murine lymphoma. The mechanisms and cell population involved are delineated using several knockout mouse models.
    • (2004) J. Immunol. , vol.172 , pp. 929-936
    • Lambert, S.L.1    Okada, C.Y.2    Levy, R.3
  • 88
    • 0036774999 scopus 로고    scopus 로고
    • Recent advances in mucosal vaccines and adjuvants
    • Eriksson K, Holmgren J. Recent advances in mucosal vaccines and adjuvants. Curr. Opin. Immunol. 14, 666-672 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 666-672
    • Eriksson, K.1    Holmgren, J.2
  • 89
    • 0028221789 scopus 로고
    • Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ 5.2 and Vβ 6.1 CDR2 peptides
    • Bourdette DN, Whitham RH, Chou YK et al. Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ 5.2 and Vβ 6.1 CDR2 peptides. J. Immunol. 152, 2510-2519 (1994). Preclinical data to assess immunogenicity of TCR peptide vaccines in MS patients.
    • (1994) J. Immunol. , vol.152 , pp. 2510-2519
    • Bourdette, D.N.1    Whitham, R.H.2    Chou, Y.K.3
  • 90
    • 0028221790 scopus 로고
    • Immunity to TCR peptides in multiple sclerosis. II. T-cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides
    • Chou YK, Morrison WJ, Weinberg AD et al. Immunity to TCR peptides in multiple sclerosis. II. T-cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides. J. Immunol. 152, 2520-2529 (1994). Preclinical data to assess immunogenicity of TCR peptide vaccines in MS patients.
    • (1994) J. Immunol. , vol.152 , pp. 2520-2529
    • Chou, Y.K.1    Morrison, W.J.2    Weinberg, A.D.3
  • 91
    • 0029886958 scopus 로고    scopus 로고
    • Immunization with T-cell receptor V beta chain peptides deletes pathogenic T-cells and prevents the induction of collagen-induced arthritis in mice
    • Haqqi TM, Qu XM, Anthony D, Ma J, Sy MS. Immunization with T-cell receptor V beta chain peptides deletes pathogenic T-cells and prevents the induction of collagen-induced arthritis in mice. J. Clin. Invest. 97, 2849-2858 (1996). Demonstration of the regulation of anti-TCR antibodies in TCR vaccination.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2849-2858
    • Haqqi, T.M.1    Qu, X.M.2    Anthony, D.3    Ma, J.4    Sy, M.S.5
  • 92
    • 9344245755 scopus 로고    scopus 로고
    • V beta 17 T-cell receptor peptide vaccination in rheumatoid arthritis: Results of Phase I dose escalation study
    • Moreland LW, Heck LW Jr, Koopman WJ et al. V beta 17 T-cell receptor peptide vaccination in rheumatoid arthritis: results of Phase I dose escalation study. J. Rheumatol. 23, 1353-1362 (1996).
    • (1996) J. Rheumatol. , vol.23 , pp. 1353-1362
    • Moreland, L.W.1    Heck Jr., L.W.2    Koopman, W.J.3
  • 93
    • 0031671602 scopus 로고    scopus 로고
    • T-cell receptor peptide vaccination in the treatment of rheumatoid arthritis
    • Bridges SL Jr, Moreland LW. T-cell receptor peptide vaccination in the treatment of rheumatoid arthritis. Rheum. Dis. Clin. North Am. 24, 641-650 (1998).
    • (1998) Rheum. Dis. Clin. North Am. , vol.24 , pp. 641-650
    • Bridges Jr., S.L.1    Moreland, L.W.2
  • 94
    • 0034897403 scopus 로고    scopus 로고
    • Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
    • Garren H, Ruiz PJ, Watkins TA et al. Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 15, 15-22 (2001).
    • (2001) Immunity , vol.15 , pp. 15-22
    • Garren, H.1    Ruiz, P.J.2    Watkins, T.A.3
  • 95
    • 0035191130 scopus 로고    scopus 로고
    • An integrative model of regulation centered on recognition of TCR peptide/MHC complexes
    • Kumar V, Sercarz E. An integrative model of regulation centered on recognition of TCR peptide/MHC complexes. Immunol. Rev. 182, 113-121 (2001). Excellent review of the innate T-T circuitry involving TCR recognition, which is thought to be boosted after TCR vaccination.
    • (2001) Immunol. Rev. , vol.182 , pp. 113-121
    • Kumar, V.1    Sercarz, E.2
  • 96
    • 2142828439 scopus 로고    scopus 로고
    • Seven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune system
    • Sercarz E, Maverakis E, van den Elzen P, Madakamutil L, Kumar V. Seven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune system. Novartis Found. Symp. 252, 165-171 (2003). Excellent review of the innate T-T circuitry involving TCR recognition, which is thought to be boosted after TCR vaccination.
    • (2003) Novartis Found. Symp. , vol.252 , pp. 165-171
    • Sercarz, E.1    Maverakis, E.2    Van Den Elzen, P.3    Madakamutil, L.4    Kumar, V.5
  • 97
    • 0037443404 scopus 로고    scopus 로고
    • Regulatory T-cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes
    • Madakamutil LT, Maricic I, Sercarz E, Kumar V. Regulatory T-cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes. J. Immunol. 170, 2985-2992 (2003). First evidence of in vivo apoptotic depletion mediated by regulatory T-cells in the control of autoimmunity.
    • (2003) J. Immunol. , vol.170 , pp. 2985-2992
    • Madakamutil, L.T.1    Maricic, I.2    Sercarz, E.3    Kumar, V.4
  • 98
    • 0032881571 scopus 로고    scopus 로고
    • Cellular and humoral immune responses against autoreactive T-cells in multiple sclerosis patients after T-cell vaccination
    • Hermans G, Denzer U, Lohse A, Raus J, Stinissen P. Cellular and humoral immune responses against autoreactive T-cells in multiple sclerosis patients after T-cell vaccination. J. Autoimmun. 13, 233-246 (1999).
    • (1999) J. Autoimmun. , vol.13 , pp. 233-246
    • Hermans, G.1    Denzer, U.2    Lohse, A.3    Raus, J.4    Stinissen, P.5
  • 99
    • 2442452758 scopus 로고    scopus 로고
    • Vaccination with an immunodominant peptide of bovine Type II collagen induces an anti-TCR response, and modulates the onset and severity of collagen-induced arthritis
    • Honda A, Ametani A, Matsumoto T et al. Vaccination with an immunodominant peptide of bovine Type II collagen induces an anti-TCR response, and modulates the onset and severity of collagen-induced arthritis. Int. Immunol. 16, 737-745 (2004). Indicates that during tolerance induction, an effective anti-TCR response is mounted naturally and regulates the pathogenic autoimmune response. This indicates that probably common T-T circuitry and mechanisms are involved in tolerance induction to antigen and T-cell and TCR vaccination.
    • (2004) Int. Immunol. , vol.16 , pp. 737-745
    • Honda, A.1    Ametani, A.2    Matsumoto, T.3
  • 100
    • 0032992703 scopus 로고    scopus 로고
    • Regulation of NOD mouse autoimmune diabetes by T-cells that recognize a TCR CDR3 peptide
    • Elias D, Tikochinski Y, Frankel G, Cohen IR. Regulation of NOD mouse autoimmune diabetes by T-cells that recognize a TCR CDR3 peptide. Int. Immunol. 11, 957-966 (1999). Indicates that during tolerance induction, an effective anti-TCR response is mounted naturally and regulates the pathogenic autoimmune response. This indicates that probably common T-T circuitry and mechanisms are involved in tolerance induction to antigen and T-cell and TCR vaccination.
    • (1999) Int. Immunol. , vol.11 , pp. 957-966
    • Elias, D.1    Tikochinski, Y.2    Frankel, G.3    Cohen, I.R.4
  • 103
    • 11244291391 scopus 로고    scopus 로고
    • + T-cells in the thymus of patients with autoimmune myasthenia gravis
    • + T-cells in the thymus of patients with autoimmune myasthenia gravis. Blood 105, 735-741 (2005). Analysis of the T-regulatory (Treg) cells in the MG thymus, indicating that these cells are defective.
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lecart, S.2    Saoudi, A.3    Berrih-Aknin, S.4
  • 104
    • 85047690619 scopus 로고    scopus 로고
    • Homeostatic control of immunity by TCR peptide-specific Tregs
    • Kumar V. Homeostatic control of immunity by TCR peptide-specific Tregs. J. Clin. Invest. 114, 1222-1226 (2004). Demonstration of the existence of anti-TCR T-cells in Treg cells in EAE.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1222-1226
    • Kumar, V.1
  • 105
    • 11144356793 scopus 로고    scopus 로고
    • + T-cells for self-T-cell receptor determinants
    • + T-cells for self-T-cell receptor determinants. J. Neurosci. Res. 76, 129-140 (2004). Demonstrates that Treg cells are specific for TCR determinants.
    • (2004) J. Neurosci. Res. , vol.76 , pp. 129-140
    • Buenafe, A.C.1    Tsaknaridis, L.2    Spencer, L.3
  • 106
    • 0037107998 scopus 로고    scopus 로고
    • Estrogen inhibition of EAE involves effects on dendritic cell function
    • Liu HY, Buenafe AC, Matejuk A et al. Estrogen inhibition of EAE involves effects on dendritic cell function. J. Neurosci. Res. 70, 238-248 (2002).
    • (2002) J. Neurosci. Res. , vol.70 , pp. 238-248
    • Liu, H.Y.1    Buenafe, A.C.2    Matejuk, A.3
  • 108
    • 0034029069 scopus 로고    scopus 로고
    • Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis
    • Offner H, Adlard K, Zamora A, Vandenbark AA. Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis. J. Clin. Invest. 105, 1465-1472 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1465-1472
    • Offner, H.1    Adlard, K.2    Zamora, A.3    Vandenbark, A.A.4
  • 109
    • 0031127366 scopus 로고    scopus 로고
    • Humoral mechanisms in T-cell vaccination: Induction and functional characterization of antilymphocytic autoantibodies
    • Herkel J, Brunner S, Meyer zum Buschenfelde KH, Lohse AW. Humoral mechanisms in T-cell vaccination: induction and functional characterization of antilymphocytic autoantibodies. J. Autoimmun. 10, 137-146 (1997). Humoral mechanisms and anti-idiotypic antibodies induced by T-cell vaccination.
    • (1997) J. Autoimmun. , vol.10 , pp. 137-146
    • Herkel, J.1    Brunner, S.2    Meyer Zum Buschenfelde, K.H.3    Lohse, A.W.4
  • 110
    • 0034671943 scopus 로고    scopus 로고
    • Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T-cell vaccination
    • Hong J, Zang YC, Tejada-Simon MV et al. Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T-cell vaccination. J. Immunol. 165, 6858-6864 (2000). Humoral mechanisms and anti-idiotypic antibodies induced by T-cell vaccination.
    • (2000) J. Immunol. , vol.165 , pp. 6858-6864
    • Hong, J.1    Zang, Y.C.2    Tejada-Simon, M.V.3
  • 111
    • 0035217962 scopus 로고    scopus 로고
    • Modes of action of Freunds adjuvants in experimental models of autoimmune diseases
    • Billiau A, Matthys P. Modes of action of Freunds adjuvants in experimental models of autoimmune diseases. J. Leukoc. Biol. 70, 849-860 (2001).
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 849-860
    • Billiau, A.1    Matthys, P.2
  • 112
    • 0038330766 scopus 로고    scopus 로고
    • CpG DNA as a vaccine adjuvant
    • Klinman DM. CpG DNA as a vaccine adjuvant. Expert Rev. Vaccines 2, 305-315 (2003).
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 305-315
    • Klinman, D.M.1
  • 113
    • 0031240055 scopus 로고    scopus 로고
    • Epidemiology and estimated population burden of selected autoimmune diseases in the United States
    • Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol. 84, 223-243 (1997).
    • (1997) Clin. Immunol. Immunopathol. , vol.84 , pp. 223-243
    • Jacobson, D.L.1    Gange, S.J.2    Rose, N.R.3    Graham, N.M.4
  • 114
    • 0141819043 scopus 로고    scopus 로고
    • The epidemiology of autoimmune diseases
    • Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun. Rev. 2, 119-125 (2003). Recent review on epidemiology of the most well characterized autoimmune diseases.
    • (2003) Autoimmun. Rev. , vol.2 , pp. 119-125
    • Cooper, G.S.1    Stroehla, B.C.2
  • 115
    • 0035340718 scopus 로고    scopus 로고
    • Vaccination with a CDR2 BV6S2/6S5 peptide in adjuvant induces peptide-specific T-cell responses in patients with multiple sclerosis
    • Morgan EE, Nardo CJ, Diveley JP et al. Vaccination with a CDR2 BV6S2/6S5 peptide in adjuvant induces peptide-specific T-cell responses in patients with multiple sclerosis. J. Neurosci. Res. 64, 298-301 (2001).
    • (2001) J. Neurosci. Res. , vol.64 , pp. 298-301
    • Morgan, E.E.1    Nardo, C.J.2    Diveley, J.P.3
  • 116
    • 17344364795 scopus 로고    scopus 로고
    • T-cell receptor peptide vaccination in rheumatoid arthritis: A placebo-controlled trial using a combination of Vβ3, Vβ14, and Vβ17 peptides
    • Moreland LW, Morgan EE, Adamson TC III et al. T-cell receptor peptide vaccination in rheumatoid arthritis: a placebo-controlled trial using a combination of Vβ3, Vβ14, and Vβ17 peptides. Arthritis Rheum. 41, 1919-1929 (1998). Use of TCR peptide cocktails as vaccines in RA.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1919-1929
    • Moreland, L.W.1    Morgan, E.E.2    Adamson III, T.C.3
  • 117
    • 0027251463 scopus 로고
    • The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments
    • Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M, Kourilsky P. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl Acad. Sci. USA 90, 4319-4323 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4319-4323
    • Pannetier, C.1    Cochet, M.2    Darche, S.3    Casrouge, A.4    Zoller, M.5    Kourilsky, P.6
  • 118
    • 0037020847 scopus 로고    scopus 로고
    • Quantitative and qualitative changes in V-J α rearrangements during mouse thymocytes differentiation: Implication for a limited T-cell receptor α chain repertoire
    • Pasqual N, Gallagher M, Aude-Garcia C et al. Quantitative and qualitative changes in V-J α rearrangements during mouse thymocytes differentiation: implication for a limited T-cell receptor α chain repertoire. J. Exp. Med. 196, 1163-1173 (2002). New powerful technique to analyze exhaustively the T-cell repertoire of all TCR chains, which can better define an immune signature and the dominant TCRs in each patient.
    • (2002) J. Exp. Med. , vol.196 , pp. 1163-1173
    • Pasqual, N.1    Gallagher, M.2    Aude-Garcia, C.3
  • 119
    • 0034565201 scopus 로고    scopus 로고
    • Rapid identification of local T-cell expansion in inflammatory organ diseases by flow cytometric T-cell receptor Vβ analysis
    • Muraro PA, Jacobsen M, Necker A et al. Rapid identification of local T-cell expansion in inflammatory organ diseases by flow cytometric T-cell receptor Vβ analysis. J. Immunol. Methods 246, 131-143 (2000).
    • (2000) J. Immunol. Methods , vol.246 , pp. 131-143
    • Muraro, P.A.1    Jacobsen, M.2    Necker, A.3
  • 120
    • 0035479924 scopus 로고    scopus 로고
    • TCR usage in naive and committed alloreactive cells: Implications for the understanding of TCR biases in transplantation
    • Guillet M, Sebille F, Soulillou J. TCR usage in naive and committed alloreactive cells: implications for the understanding of TCR biases in transplantation. Curr. Opin. Immunol. 13, 566-571 (2001).
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 566-571
    • Guillet, M.1    Sebille, F.2    Soulillou, J.3
  • 121
    • 0033850229 scopus 로고    scopus 로고
    • Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed (with a hedge on this bet)
    • Steinman L. Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed (with a hedge on this bet). J. Autoimmun. 14, 278-282 (2000).
    • (2000) J. Autoimmun. , vol.14 , pp. 278-282
    • Steinman, L.1
  • 122
    • 0031785532 scopus 로고    scopus 로고
    • Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis
    • Vincent A, Willcox N, Hill M, Curnow J, MacLennan C, Beeson D. Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis. Immunol. Rev. 164, 157-168 (1998). Review on the contribution of determinant spreading to MG pathogenesis.
    • (1998) Immunol. Rev. , vol.164 , pp. 157-168
    • Vincent, A.1    Willcox, N.2    Hill, M.3    Curnow, J.4    MacLennan, C.5    Beeson, D.6
  • 123
    • 0035002763 scopus 로고    scopus 로고
    • Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T-cells
    • Xu L, Villain M, Galin FS, Araga S, Blalock JE. Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T-cells. Cell Immunol. 208, 107-114 (2001).
    • (2001) Cell Immunol. , vol.208 , pp. 107-114
    • Xu, L.1    Villain, M.2    Galin, F.S.3    Araga, S.4    Blalock, J.E.5
  • 124
    • 0037992889 scopus 로고    scopus 로고
    • Cytokines as clinical adjuvants: How far are we?
    • Villinger F. Cytokines as clinical adjuvants: how far are we? Expert Rev. Vaccines 2, 317-326 (2003).
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 317-326
    • Villinger, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.