Altered intrathymic T-cell repertoire in human myasthenia gravis

Annals of Neurology

Volumn 41, Issue 6, 1997, Pages 731-741

  Truffault, Frédérique ^a   Cohen Kaminsky, Sylvia ^a   Khalil, Iman ^b   Levasseur, Philippe ^a   Berrih Aknin, Sonia ^a  

^a CENTRE CHIRURGICAL MARIE LANNELONGUE   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; FEMALE; FLOW CYTOMETRY; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; MYASTHENIA GRAVIS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS HYPERPLASIA; TISSUE INDUCTION;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INFANT; MALE; MYASTHENIA GRAVIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REFERENCE VALUES; STEM CELLS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND; THYMUS HYPERPLASIA;

EID: 0030914912     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410410609     Document Type: Article

References (33)

1. Berrih S, Morel E, Gaud C, et al. Anti-AChR antibodies, thymic histology and T cell subsets in myasthenia gravis. Neurology 1984;34:66-71
2. Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol 1978;9:495-515
3. Willcox HNA, Newsom-Davis J, Calder LR. Cell types required for anti-acetylcholine receptor antibody synthesis by cultured thymocytes and blood lymphocytes in myasthenia gravis. Clin Exp Immunol 1984;58:97-106
4. Safar D, Berrih-Aknin S, Morel E. In vitro anti-acetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes. Correlations with thymic histology and thymic epithelial cell interactions. J Clin Immunol 1987;3:225-234
5. Mulder DG, Graves M, Herrmann C. Thymectomy for myasthenia gravis: recent observations and comparisons with past experience. Ann Thorac Surg 1989;48:551-555
6. Molnar J, Szobor A. Myasthenia gravis: effect of thymectomy in 425 patients. A 15-year experience. Eur J Cardiothorac Surg 1990;4:8-14
7. Naeim F, Keesey JC, Herrman C, et al. Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. Tissue Antigens 1979;12:381-386
8. Lepage V, Berrih S, Morel E, et al. HLA and myasthenia gravis: a new association. Dis Markers 1983;1:181-187
9. Khalil I, Berrih-Aknin S, Lepage V, et al. Trans-encoded DQ αβ heterodimers confer susceptibility to myasthenia gravis disease. CR Acad Sci III 1993;22:45-54
10. Levinson AI, Zweiman B, Lisak RP, et al. Thymic B-cell activation in myasthenia gravis. Neurology 1984;34:462-468
11. Berrih-Aknin S, Morel E, Raimond F, et al. The role of the thymus in myasthenia gravis. Immunohistological and immunological studies in 115 cases. Ann NY Acad Sci 1987;505: 50-70
12. Leprince C, Cohen-Kaminsky S, Berrih-Aknin S, et al. Thymic B cells from myasthenia gravis (MG) patients are activated B cells: phenotypic and functional analysis. J Immunol 1990;145: 2115-2122
13. Cohen-Kaminsky S, Levasseur P, Binet JP, Berrih-Aknin S. Evidence of enhanced recombinant interleukin-2 sensitivity of thymic lymphocytes from patients with myasthenia gravis: possible role in the autoimmune pathogenesis. J Neuroimmunol 1989;24:75-85
14. Melms A, Schalke BCG, Kirchner T, et al. Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotine acetylcholine receptor from thymuses of myasthenic patients. J Clin Invest 1988;81:902-908
15. Sommer N, Willcox N, Harcourt GC, Newsom-Davis J. Myasthenic thymus and thymoma are selectively enriched in AChR-reactive T cells. Ann Neurol 1990;28:312-319
16. Fujii N, Itoyama Y, Goto I. Increase in differentiated type of T lineage cells in the myasthenic thymus: two-color fluorocytometric analysis. Ann Neurol 1990;27:642-646
17. Berrih-Aknin S, Cohen-Kaminsky S, Truffault F. T cell receptor expression in the thymus from patients with myasthenia gravis. Ann NY Acad Sci 1995;756:438-440
18. Nossal GJV. Negative selection of lymphocytes. Cell 1994;76: 229-239
19. Von Boehmer H. Positive selection of lymphocytes. Cell 1994; 76:219-228
20. Perlo VP, Poskanzer DC, Schwab RS, et al. Myasthenia gravis: evaluation of treatment in 1,355 patients. Neurology 1966;16: 431-439
21. Berrih S, Safar D, Levasseur P, et al. The in vivo effects of corticosteroids on thymocyte subsets in myasthenia gravis. J Clin Immunol 1984;4:92-97
22. Akolkar PN, Gulwani-Akolkar B, Pergolizzi R, et al. Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes. J Immunol 1993;150:2761-2773
23. Fuller KA, Kanagawa O, Nahm MH. T cells within germinal centers are specific for the immunizing antigen. J Immunol 1993;151:4505-4512
24. Kappler J, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987;49:273-280
25. Fowlkes BJ, Schwartz RH, Pardoll DM. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature 1988;334:620-623
26. Grunewald J, Ahlberg R, Lefvert AK, et al. Abnormal T-cell expansion and V-gene usage in myasthenia gravis patients. Scand J Immunol 1991;34:161-168
27. Cooper SM, Lipsky PE. T-cell receptor use in rheumatoid arthritis. Ann NY Acad Sci 1995;756:229-240
28. Bach JF. T-cell receptor use in organ-specific human autoimmune diseases other than rheumatoid arthritis and multiple sclerosis. Ann NY Acad Sci 1995;756:453-459
29. Emilie D, Crevon MC, Cohen-Kaminsky S, et al. In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients. Hum Pathol 1991;22:461-468
30. Yi Q, Pirskanen R, Lefvert AK. Human muscle acetylcholine receptor reactive T and B lymphocytes in the peripheral blood of patients with myasthenia gravis. J Neuroimmunol 1993;42: 215-222
31. Rieux-Laucat F, Le Deist F, Selz F, et al. Normal T cell receptor Vβ usage in a primary immunodeficiency associated with HLA class II deficiency. Eur J Immunol 1993;23:928-934
32. Hawes GE, Struyk L, van den Elsen PJ. Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins. J Immunol 1993;150: 2033-2045
33. Posnett DN. Environmental and genetic factors shape the human T-cell receptor repertoire. Ann NY Acad Sci 1995;756: 71-79