-
1
-
-
0031789272
-
The global burden of disease, 1990-2020
-
Lopez AD, Murray CC. The global burden of disease, 1990-2020. Nat Med 1998; 4: 1241-1243.
-
(1998)
Nat Med
, vol.4
, pp. 1241-1243
-
-
Lopez, A.D.1
Murray, C.C.2
-
2
-
-
0141928029
-
Chronic obstructive pulmonary disease: Molecular and cellular mechanisms
-
Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003; 22: 672-688.
-
(2003)
Eur Respir J
, vol.22
, pp. 672-688
-
-
Barnes, P.J.1
Shapiro, S.D.2
Pauwels, R.A.3
-
3
-
-
0012626868
-
New concepts in COPD
-
Barnes PJ. New concepts in COPD. Ann Rev Med 2003; 54: 113-129.
-
(2003)
Ann Rev Med
, vol.54
, pp. 113-129
-
-
Barnes, P.J.1
-
4
-
-
0036598241
-
New treatments for COPD
-
Barnes PJ. New treatments for COPD. Nature Rev Drug Disc 2002; 1: 437-445.
-
(2002)
Nature Rev Drug Disc
, vol.1
, pp. 437-445
-
-
Barnes, P.J.1
-
5
-
-
0034721232
-
Chronic obstructive pulmonary disease
-
Barnes PJ. Chronic obstructive pulmonary disease. New Engl J Med 2000; 343: 269-280.
-
(2000)
New Engl J Med
, vol.343
, pp. 269-280
-
-
Barnes, P.J.1
-
6
-
-
0037320195
-
Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease
-
Fabbri LM, Romagnoli M, Corbetta L, et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 167: 418-424.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 418-424
-
-
Fabbri, L.M.1
Romagnoli, M.2
Corbetta, L.3
-
7
-
-
0036943648
-
Animal models of cigarette smoke-induced COPD
-
Wright JL, Churg A. Animal models of cigarette smoke-induced COPD. Chest 2002; 122: 301S-306S.
-
(2002)
Chest
, vol.122
-
-
Wright, J.L.1
Churg, A.2
-
8
-
-
0035912585
-
Smoking cessation in patients with chronic obstructive pulmonary disease: A double-blind, placebo controlled, randomised trial
-
Tashkin DP, Kanner R, Bailey W, et al. Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo controlled, randomised trial. Lancet 2001; 357: 1571-1575.
-
(2001)
Lancet
, vol.357
, pp. 1571-1575
-
-
Tashkin, D.P.1
Kanner, R.2
Bailey, W.3
-
9
-
-
0037499744
-
Roles of dopamine signaling in nicotine addiction
-
B Dani JA. Roles of dopamine signaling in nicotine addiction. Mol Psychiatry 2003; 8: 255-256.
-
(2003)
Mol Psychiatry
, vol.8
, pp. 255-256
-
-
Dani, J.A.1
-
10
-
-
0037285331
-
Vaccines against drugs of abuse: A viable treatment option?
-
Kantak KM. Vaccines against drugs of abuse: a viable treatment option? Drugs 2003; 63: 341-352.
-
(2003)
Drugs
, vol.63
, pp. 341-352
-
-
Kantak, K.M.1
-
11
-
-
4544264107
-
Global Initiative for Chronic Obstructive Lung Disease (GOLD): Global strategy for the diagnosis, management of chronic obstructive pulmonary disease
-
Global Initiative for Chronic Obstructive Lung Disease (GOLD): Global strategy for the diagnosis, management of chronic obstructive pulmonary disease. NHLBI/WHO Workshop Report 2003. www.goldcopd.com/workshop/ index.html. Date accessed: 1 October 2004.
-
NHLBI/WHO Workshop Report 2003
-
-
-
12
-
-
0036751794
-
Tiotropium bromide: A novel once-daily anticholinergic bronchodilator for the treatment of COPD
-
Hansel TT, Barnes PJ. Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD. Drugs Today 2002; 38: 585-600.
-
(2002)
Drugs Today
, vol.38
, pp. 585-600
-
-
Hansel, T.T.1
Barnes, P.J.2
-
13
-
-
18244368740
-
Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium
-
Vincken W, van Noord JA, Greefhorst AP, et al. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur Respir J 2002; 19: 209-216.
-
(2002)
Eur Respir J
, vol.19
, pp. 209-216
-
-
Vincken, W.1
Van Noord, J.A.2
Greefhorst, A.P.3
-
14
-
-
0034018232
-
Ongoing airway inflammation in patients with COPD who do not currently smoke
-
Rutgers SR, Postma DS, ten Hacken NH, et al. Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax 2000; 55: 12-18.
-
(2000)
Thorax
, vol.55
, pp. 12-18
-
-
Rutgers, S.R.1
Postma, D.S.2
Ten Hacken, N.H.3
-
15
-
-
0035744437
-
Cytokine modulators as novel therapies for airway disease
-
Barnes PJ. Cytokine modulators as novel therapies for airway disease. Eur Respir J, 2001; Suppl. 34, 67s-77s.
-
(2001)
Eur Respir J
, Issue.SUPPL. 34
-
-
Barnes, P.J.1
-
16
-
-
0038808776
-
Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease. A meta-analysis
-
Highland KB, Strange C, Heffner JE. Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease. A meta-analysis. Ann Intern Med 2003; 138: 969-973.
-
(2003)
Ann Intern Med
, vol.138
, pp. 969-973
-
-
Highland, K.B.1
Strange, C.2
Heffner, J.E.3
-
17
-
-
0037216753
-
Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease
-
Culpitt SV, Rogers DF, Shah P, et al. Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 167: 24-31.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 24-31
-
-
Culpitt, S.V.1
Rogers, D.F.2
Shah, P.3
-
18
-
-
0035315925
-
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages
-
Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 2001; 15: 1100-1102.
-
(2001)
FASEB J
, vol.15
, pp. 1100-1102
-
-
Ito, K.1
Lim, S.2
Caramori, G.3
Chung, K.F.4
Barnes, P.J.5
Adcock, I.M.6
-
19
-
-
1542301591
-
A mechanism of corticosteroid resistance in COPD: Inactivation of histone deacetylase
-
Barnes PJ, Ito K, Adcock IM. A mechanism of corticosteroid resistance in COPD: inactivation of histone deacetylase. Lancet 2004; 363: 731-733.
-
(2004)
Lancet
, vol.363
, pp. 731-733
-
-
Barnes, P.J.1
Ito, K.2
Adcock, I.M.3
-
20
-
-
0037173056
-
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
-
Ito K, Lim S, Caramori G, et al. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002; 99: 8921-8926.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8921-8926
-
-
Ito, K.1
Lim, S.2
Caramori, G.3
-
21
-
-
0037445151
-
Theophylline: New perspectives on an old drug
-
Barnes PJ. Theophylline: new perspectives on an old drug. Am J Respir Crit Care Med 2003; 167: 813-818.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 813-818
-
-
Barnes, P.J.1
-
22
-
-
0037246566
-
Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease
-
Szafranski W, Cukier A, Ramirez A, et al. Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J 2003; 21: 74-81.
-
(2003)
Eur Respir J
, vol.21
, pp. 74-81
-
-
Szafranski, W.1
Cukier, A.2
Ramirez, A.3
-
23
-
-
0037425745
-
Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial
-
Calverley P, Pauwels R, Vestbo J, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361: 449-456.
-
(2003)
Lancet
, vol.361
, pp. 449-456
-
-
Calverley, P.1
Pauwels, R.2
Vestbo, J.3
-
24
-
-
0033833221
-
Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers
-
Montuschi P, Collins JV, Ciabattoni G, et al. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 2000; 162: 1175-1177.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 1175-1177
-
-
Montuschi, P.1
Collins, J.V.2
Ciabattoni, G.3
-
25
-
-
0033837472
-
Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease
-
Paredi P, Kharitonov SA, Leak D, Ward S, Cramer D, Barnes PJ. Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 162: 369-373.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 369-373
-
-
Paredi, P.1
Kharitonov, S.A.2
Leak, D.3
Ward, S.4
Cramer, D.5
Barnes, P.J.6
-
26
-
-
0034034334
-
Oxidants/antioxidants and COPD
-
MacNee W. Oxidants/antioxidants and COPD. Chest 2000; 117: Suppl. 1, 303S-317S.
-
(2000)
Chest
, vol.117
, Issue.SUPPL. 1
-
-
MacNee, W.1
-
27
-
-
0242363130
-
Preventing exacerbations of chronic bronchitis and COPD: Therapeutic potential of mucolytic agents
-
Poole PJ, Black PN. Preventing exacerbations of chronic bronchitis and COPD: therapeutic potential of mucolytic agents. Am J Respir Med 2003; 2: 367-370.
-
(2003)
Am J Respir Med
, vol.2
, pp. 367-370
-
-
Poole, P.J.1
Black, P.N.2
-
28
-
-
0035101472
-
Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury
-
Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 2001; 53: 135-159.
-
(2001)
Pharmacol Rev
, vol.53
, pp. 135-159
-
-
Cuzzocrea, S.1
Riley, D.P.2
Caputi, A.P.3
Salvemini, D.4
-
29
-
-
0037216754
-
A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia
-
Chang LY, Subramaniam M, Yoder BA, et al. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med 2003; 167: 57-64.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 57-64
-
-
Chang, L.Y.1
Subramaniam, M.2
Yoder, B.A.3
-
30
-
-
0242441578
-
Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD
-
Culpitt SV, Rogers DF, Fenwick PS, et al. Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD. Thorax 2003; 58: 942-946.
-
(2003)
Thorax
, vol.58
, pp. 942-946
-
-
Culpitt, S.V.1
Rogers, D.F.2
Fenwick, P.S.3
-
31
-
-
4544310412
-
Anti-inflammatory effects of resveratrol in lung epithelial cells: Molecular mechanisms
-
Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 2004; 287: L774-L783.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
-
-
Donnelly, L.E.1
Newton, R.2
Kennedy, G.E.3
-
32
-
-
0033841255
-
Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways
-
Ichinose M, Sugiura H, Yamagata S, Koarai A, Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Resp Crit Care Med 2000; 160: 701-706.
-
(2000)
Am J Resp Crit Care Med
, vol.160
, pp. 701-706
-
-
Ichinose, M.1
Sugiura, H.2
Yamagata, S.3
Koarai, A.4
Shirato, K.5
-
33
-
-
0038604348
-
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
-
Hansel TT, Kharitonov SA, Donnelly LE, et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J 2003; 17: 1298-1300.
-
(2003)
FASEB J
, vol.17
, pp. 1298-1300
-
-
Hansel, T.T.1
Kharitonov, S.A.2
Donnelly, L.E.3
-
34
-
-
0032880124
-
The interrelationship of sputum inflammatory markers in patients with chronic bronchitis
-
Hill AT, Bayley D, Stockley RA. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am J Respir Crit Care Med 1999; 160: 893-898.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 893-898
-
-
Hill, A.T.1
Bayley, D.2
Stockley, R.A.3
-
36
-
-
0034618068
-
A second leukotriene B4 receptor BLT2. A new therapeutic target in inflammation and immunological disorders
-
Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B4 receptor BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 2000; 192: 421-432.
-
(2000)
J Exp Med
, vol.192
, pp. 421-432
-
-
Yokomizo, T.1
Kato, K.2
Terawaki, K.3
Izumi, T.4
Shimizu, T.5
-
37
-
-
0034057658
-
Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: In vivo pulmonary studies
-
Silbaugh SA, Stengel PW, Cockerham SL, et al. Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: in vivo pulmonary studies. Naunyn Schmiedebergs Arch Pharmacol 2000; 361: 397-404.
-
(2000)
Naunyn Schmiedebergs Arch Pharmacol
, vol.361
, pp. 397-404
-
-
Silbaugh, S.A.1
Stengel, P.W.2
Cockerham, S.L.3
-
38
-
-
0033951642
-
Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: The role of leukotriene B4
-
Crooks SW, Bayley DL, Hill SL, Stockley RA. Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4. Eur Respir J 2000; 15: 274-280.
-
(2000)
Eur Respir J
, vol.15
, pp. 274-280
-
-
Crooks, S.W.1
Bayley, D.L.2
Hill, S.L.3
Stockley, R.A.4
-
39
-
-
0344088442
-
Neutrophil chemotactic activity of sputum from patients with COPD: Role of interleukin 8 and leukotriene B4
-
Beeh KM, Kornmann O, Buhl R, Culpitt SV, Giembycz MA, Barnes PJ. Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest 2003; 123: 1240-1247.
-
(2003)
Chest
, vol.123
, pp. 1240-1247
-
-
Beeh, K.M.1
Kornmann, O.2
Buhl, R.3
Culpitt, S.V.4
Giembycz, M.A.5
Barnes, P.J.6
-
40
-
-
0036308390
-
A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD
-
Gompertz S, Stockley RA. A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD. Chest 2002; 122: 289-294.
-
(2002)
Chest
, vol.122
, pp. 289-294
-
-
Gompertz, S.1
Stockley, R.A.2
-
41
-
-
0037363770
-
Chemokines and their receptors in asthma and chronic obstructive pulmonary disease
-
Panina-Bordignon P, D'Ambrosio D. Chemokines and their receptors in asthma and chronic obstructive pulmonary disease. Curr Opin Pulm Med 2003; 9: 104-110.
-
(2003)
Curr Opin Pulm Med
, vol.9
, pp. 104-110
-
-
Panina-Bordignon, P.1
D'Ambrosio, D.2
-
42
-
-
0030071687
-
Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma
-
Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996; 153: 530-534.
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 530-534
-
-
Keatings, V.M.1
Collins, P.D.2
Scott, D.M.3
Barnes, P.J.4
-
43
-
-
0036311347
-
Elevated levels of the chemokines GRO-α and MCP-1 in sputum samples from COPD patients
-
Traves SL, Culpitt S, Russell REK, Barnes PJ, Donnelly LE. Elevated levels of the chemokines GRO-α and MCP-1 in sputum samples from COPD patients. Thorax 2002; 57: 590-595.
-
(2002)
Thorax
, vol.57
, pp. 590-595
-
-
Traves, S.L.1
Culpitt, S.2
Russell, R.E.K.3
Barnes, P.J.4
Donnelly, L.E.5
-
44
-
-
0035376543
-
Interleukin-8 receptor antagonists in pulmonary diseases
-
Hay DWP, Sarau HM. Interleukin-8 receptor antagonists in pulmonary diseases. Curr Opin Pharmacol 2001; 1: 242-247.
-
(2001)
Curr Opin Pharmacol
, vol.1
, pp. 242-247
-
-
Hay, D.W.P.1
Sarau, H.M.2
-
45
-
-
0034025481
-
Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD
-
de Boer WI, Sont JK, van Schadewijk A, Stolk J, van Krieken JH, Hiemstra PS. Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol 2000; 190: 619-626.
-
(2000)
J Pathol
, vol.190
, pp. 619-626
-
-
Boer, W.I.1
Sont, J.K.2
Van Schadewijk, A.3
Stolk, J.4
Van Krieken, J.H.5
Hiemstra, P.S.6
-
46
-
-
0037092562
-
Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease
-
Saetta M, Mariani M, Panina-Bordignon P, et al. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 165: 1404-1409.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 1404-1409
-
-
Saetta, M.1
Mariani, M.2
Panina-Bordignon, P.3
-
47
-
-
0036839767
-
Local and systemic inflammation in patients with chronic obstructive pulmonary disease: Soluble tumor necrosis factor receptors are increased in sputum
-
Vernooy JH, Kucukaycan M, Jacobs JA, et al. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Am J Respir Crit Care Med 2002; 166: 1218-1224.
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 1218-1224
-
-
Vernooy, J.H.1
Kucukaycan, M.2
Jacobs, J.A.3
-
48
-
-
0029670951
-
Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients
-
de Godoy I, Donahoe M, Calhoun WJ, Mancino J, Rogers RM. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996; 153: 633-637.
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 633-637
-
-
De Godoy, I.1
Donahoe, M.2
Calhoun, W.J.3
Mancino, J.4
Rogers, R.M.5
-
49
-
-
0142072978
-
TNFα as therapeutic target: New drugs, more applications
-
Reimold AM. TNFα as therapeutic target: new drugs, more applications. Curr Drug Targets Inflamm Allergy 2002; 1: 377-392.
-
(2002)
Curr Drug Targets Inflamm Allergy
, vol.1
, pp. 377-392
-
-
Reimold, A.M.1
-
50
-
-
0034048369
-
Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis antagonist TBC1269: Preferential activity against neutrophil adhesion in vitro
-
Davenpeck KL, Berens KL, Dixon RA, Dupre B, Bochner BS. Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis antagonist TBC1269: preferential activity against neutrophil adhesion in vitro. J Allergy Clin Immunol 2000; 105: 769-775.
-
(2000)
J Allergy Clin Immunol
, vol.105
, pp. 769-775
-
-
Davenpeck, K.L.1
Berens, K.L.2
Dixon, R.A.3
Dupre, B.4
Bochner, B.S.5
-
51
-
-
0031760505
-
Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease
-
Noguera A, Busquets X, Sauleda J, Villaverde JM, MacNee W, Agusti AG. Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158: 1664-1668.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1664-1668
-
-
Noguera, A.1
Busquets, X.2
Sauleda, J.3
Villaverde, J.M.4
MacNee, W.5
Agusti, A.G.6
-
52
-
-
0032847464
-
Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers
-
Takanashi S, Hasegawa Y, Kanehira Y, et al. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. Eur Respir J 1999; 14: 309-314.
-
(1999)
Eur Respir J
, vol.14
, pp. 309-314
-
-
Takanashi, S.1
Hasegawa, Y.2
Kanehira, Y.3
-
53
-
-
0036264724
-
Phosphodiesterase 4 inhibitors for the treatment of COPD
-
Sturton G, Fitzgerald M. Phosphodiesterase 4 inhibitors for the treatment of COPD. Chest 2002; 121: 192S-196S.
-
(2002)
Chest
, vol.121
-
-
Sturton, G.1
Fitzgerald, M.2
-
54
-
-
0035963952
-
Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: A randomised, dose-ranging study
-
Compton CH, Gubb J, Nieman R, et al. Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study. Lancet 2001; 358: 265-270.
-
(2001)
Lancet
, vol.358
, pp. 265-270
-
-
Compton, C.H.1
Gubb, J.2
Nieman, R.3
-
55
-
-
0142012148
-
Anti-inflammatory effects of the phosphodiesterase 4 inhibitor cilomilast (Ariflo) in COPD
-
Gamble E, Grootendorst DC, Brightling CE, et al. Anti-inflammatory effects of the phosphodiesterase 4 inhibitor cilomilast (Ariflo) in COPD. Am J Respir Crit Care Med 2003; 168: 976-982.
-
(2003)
Am J Respir Crit Care Med
, vol.168
, pp. 976-982
-
-
Gamble, E.1
Grootendorst, D.C.2
Brightling, C.E.3
-
56
-
-
0037443097
-
PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
-
Houslay MD, Adams DR. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J 2003; 370: 1-18.
-
(2003)
Biochem J
, vol.370
, pp. 1-18
-
-
Houslay, M.D.1
Adams, D.R.2
-
57
-
-
0035976546
-
Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey
-
Lamontagne S, Meadows E, Luk P, et al. Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey. Brain Res 2001; 920: 84-96.
-
(2001)
Brain Res
, vol.920
, pp. 84-96
-
-
Lamontagne, S.1
Meadows, E.2
Luk, P.3
-
58
-
-
0036790480
-
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor- mediated anesthesia, a behavioral correlate of emesis
-
Robichaud A, Stamatiou PB, Jin SL, et al. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest 2002; 110: 1045-1052.
-
(2002)
J Clin Invest
, vol.110
, pp. 1045-1052
-
-
Robichaud, A.1
Stamatiou, P.B.2
Jin, S.L.3
-
59
-
-
0037188511
-
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses
-
Jin SL, Conti M. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proc Natl Acad Sci U S A 2002; 99: 7628-7633.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 7628-7633
-
-
Jin, S.L.1
Conti, M.2
-
60
-
-
0141630489
-
In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)- [1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
-
Kuss H, Hoefgen N, Johanssen S, Kronbach T, Rundfeldt C. In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5- hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration. J Pharmacol Exp Ther 2003; 307: 373-385.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 373-385
-
-
Kuss, H.1
Hoefgen, N.2
Johanssen, S.3
Kronbach, T.4
Rundfeldt, C.5
-
61
-
-
18544383099
-
Increased expression of NF-kB in bronchial biopsies from smokers and patients with COPD
-
Di Stefano A, Caramori G, Capelli A, et al. Increased expression of NF-kB in bronchial biopsies from smokers and patients with COPD. Eur Resp J 2002; 20: 556-563.
-
(2002)
Eur Resp J
, vol.20
, pp. 556-563
-
-
Di Stefano, A.1
Caramori, G.2
Capelli, A.3
-
62
-
-
0037383155
-
Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations
-
Caramori G, Romagnoli M, Casolari P, et al. Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 2003; 58: 348-351.
-
(2003)
Thorax
, vol.58
, pp. 348-351
-
-
Caramori, G.1
Romagnoli, M.2
Casolari, P.3
-
63
-
-
0034720896
-
Kinase regulation in inflammatory response
-
Delhase M, Li N, Karin M. Kinase regulation in inflammatory response. Nature 2000; 406: 367-368.
-
(2000)
Nature
, vol.406
, pp. 367-368
-
-
Delhase, M.1
Li, N.2
Karin, M.3
-
65
-
-
0033538340
-
Differential IKK activation and IkBa degradation by interleukin-1b and tumor necrosis factor-a in human U937 monocytic cells: Evidence for additional regulatory steps in kB-dependent transcription
-
Nasuhara Y, Adcock IM, Catley M, Barnes PJ, Newton R. Differential IKK activation and IkBa degradation by interleukin-1b and tumor necrosis factor-a in human U937 monocytic cells: evidence for additional regulatory steps in kB-dependent transcription. J Biol Chem 1999; 274: 19965-19972.
-
(1999)
J Biol Chem
, vol.274
, pp. 19965-19972
-
-
Nasuhara, Y.1
Adcock, I.M.2
Catley, M.3
Barnes, P.J.4
Newton, R.5
-
66
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298: 1911-1912.
-
(2002)
Science
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
67
-
-
0142026209
-
p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
Kumar S, Boehm J, Lee JC. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003; 2: 717-726.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Boehm, J.2
Lee, J.C.3
-
68
-
-
13844288120
-
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
-
Underwood DC, Osborn RR, Bochnowicz S, et al. SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol 2000; 279: L895-L902.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.279
-
-
Underwood, D.C.1
Osborn, R.R.2
Bochnowicz, S.3
-
69
-
-
0034635264
-
Function of P13Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T, Irie-Sasaki J, Jones RG, et al. Function of P13Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000; 287: 1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
-
70
-
-
0037350266
-
Therapeutic potential of phosphoinositide 3-kinase inhibitors
-
Ward S, Sotsios Y, Dowden J, Bruce I, Finan P. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Chem Biol 2003; 10: 207-213.
-
(2003)
Chem Biol
, vol.10
, pp. 207-213
-
-
Ward, S.1
Sotsios, Y.2
Dowden, J.3
Bruce, I.4
Finan, P.5
-
71
-
-
0037373271
-
Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: Relevance for chronic obstructive pulmonary disease therapy
-
Patel HJ, Belvisi MG, Bishop-Bailey D, Yacoub MH, Mitchell JA. Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J Immunol 2003; 170: 2663-2669.
-
(2003)
J Immunol
, vol.170
, pp. 2663-2669
-
-
Patel, H.J.1
Belvisi, M.G.2
Bishop-Bailey, D.3
Yacoub, M.H.4
Mitchell, J.A.5
-
72
-
-
0038446506
-
Induction of apoptosis in mouse T cells upon peroxisome proliferator-activated receptor gamma (PPAR-g) binding
-
Harris SG, Phipps RP. Induction of apoptosis in mouse T cells upon peroxisome proliferator-activated receptor gamma (PPAR-g) binding. Adv Exp Med Biol 2002; 507: 421-425.
-
(2002)
Adv Exp Med Biol
, vol.507
, pp. 421-425
-
-
Harris, S.G.1
Phipps, R.P.2
-
73
-
-
0037674024
-
Epidemiological studies in mucus hypersecretion
-
Vestbo J. Epidemiological studies in mucus hypersecretion. Novartis Found Symp 2002; 248: 3-12.
-
(2002)
Novartis Found Symp
, vol.248
, pp. 3-12
-
-
Vestbo, J.1
-
74
-
-
0037674016
-
Current and future therapies for airway mucus hypersecretion
-
Barnes PJ. Current and future therapies for airway mucus hypersecretion. Novartis Found Symp 2002; 248: 237-249.
-
(2002)
Novartis Found Symp
, vol.248
, pp. 237-249
-
-
Barnes, P.J.1
-
75
-
-
0035378557
-
The role of epidermal growth factor in mucus production
-
Nadel JA, Burgel PR. The role of epidermal growth factor in mucus production. Curr Opin Pharmacol 2001; 1: 254-258.
-
(2001)
Curr Opin Pharmacol
, vol.1
, pp. 254-258
-
-
Nadel, J.A.1
Burgel, P.R.2
-
76
-
-
0038011900
-
A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction
-
Zhou Y, Shapiro M, Dong Q, et al. A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. Novartis Found Symp 2002; 248: 150-165.
-
(2002)
Novartis Found Symp
, vol.248
, pp. 150-165
-
-
Zhou, Y.1
Shapiro, M.2
Dong, Q.3
-
77
-
-
0036605457
-
Pharmacological regulation of the neuronal control of airway mucus secretion
-
Rogers DF. Pharmacological regulation of the neuronal control of airway mucus secretion. Curr Opin Pharmacol 2002; 2: 249-255.
-
(2002)
Curr Opin Pharmacol
, vol.2
, pp. 249-255
-
-
Rogers, D.F.1
-
78
-
-
0032416948
-
Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease
-
de Boer WI, van Schadewrjk A, Sont JK, et al. Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158: 1951-1957.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1951-1957
-
-
De Boer, W.I.1
Van Schadewrjk, A.2
Sont, J.K.3
-
79
-
-
17044453955
-
Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
-
Takizawa H, Tanaka M, Takami K, et al. Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001; 163: 1476-1483.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 1476-1483
-
-
Takizawa, H.1
Tanaka, M.2
Takami, K.3
-
80
-
-
0037077212
-
Proteolysis of latent transforming growth factor-β (TGF-β)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-b from bone matrix
-
Dallas SL, Rosser JL, Mundy GR, Bonewald LF. Proteolysis of latent transforming growth factor-β (TGF-β)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-b from bone matrix. J Biol Chem 2002; 277: 21352-21360.
-
(2002)
J Biol Chem
, vol.277
, pp. 21352-21360
-
-
Dallas, S.L.1
Rosser, J.L.2
Mundy, G.R.3
Bonewald, L.F.4
-
82
-
-
0037533039
-
Inhibitory effects of interferon-gamma on the heterologous desensitization of beta-adrenoceptors by transforming growth factor-β1 in tracheal smooth muscle
-
Ishikawa T, Kume H, Kondo M, Ito Y, Yamaki K, Shimokata K. Inhibitory effects of interferon-gamma on the heterologous desensitization of beta-adrenoceptors by transforming growth factor-β1 in tracheal smooth muscle. Clin Exp Allergy 2003; 33: 808-815.
-
(2003)
Clin Exp Allergy
, vol.33
, pp. 808-815
-
-
Ishikawa, T.1
Kume, H.2
Kondo, M.3
Ito, Y.4
Yamaki, K.5
Shimokata, K.6
-
83
-
-
1342265719
-
SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7
-
DaCosta BS, Major C, Laping NJ, Roberts AB. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2004; 65: 744-752.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 744-752
-
-
DaCosta, B.S.1
Major, C.2
Laping, N.J.3
Roberts, A.B.4
-
84
-
-
0036159183
-
Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers
-
Miotto D, Hollenberg MD, Bunnett NW, et al. Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers. Thorax 2002; 57: 146-151.
-
(2002)
Thorax
, vol.57
, pp. 146-151
-
-
Miotto, D.1
Hollenberg, M.D.2
Bunnett, N.W.3
-
85
-
-
0034502357
-
Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells
-
Vliagoftis H, Schwingshackl A, Milne CD, et al. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol 2000; 106: 537-545.
-
(2000)
J Allergy Clin Immunol
, vol.106
, pp. 537-545
-
-
Vliagoftis, H.1
Schwingshackl, A.2
Milne, C.D.3
-
86
-
-
0037069333
-
Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARy: Possible relevance to human fibrotic disorders
-
Frungieri MB, Weidinger S, Meineke V, Kohn FM, Mayerhofer A. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARy: Possible relevance to human fibrotic disorders. Proc Natl Acad Sci USA 2002; 99: 15072-15077.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15072-15077
-
-
Frungieri, M.B.1
Weidinger, S.2
Meineke, V.3
Kohn, F.M.4
Mayerhofer, A.5
-
87
-
-
0033146096
-
Matrix metalloproteinases. Matrix degradation and more
-
Shapiro SD, Senior RM. Matrix metalloproteinases. Matrix degradation and more. Am J Respir Cell Mol Biol 1999; 20: 1100-1102.
-
(1999)
Am J Respir Cell Mol Biol
, vol.20
, pp. 1100-1102
-
-
Shapiro, S.D.1
Senior, R.M.2
-
88
-
-
0030476672
-
Bioengineering: Alpha 1-proteinase inhibitor site-specific mutagenesis. The prospect for improving the inhibitor
-
Luisetti M, Travis J. Bioengineering: alpha 1-proteinase inhibitor site-specific mutagenesis. The prospect for improving the inhibitor. Chest 1996; 110: 278S-283S.
-
(1996)
Chest
, vol.110
-
-
Luisetti, M.1
Travis, J.2
-
89
-
-
0037271797
-
Gene therapy progress and prospects: Alpha-1 antitrypsin
-
Stecenko AA, Brigham KL. Gene therapy progress and prospects: alpha-1 antitrypsin. Gene Ther 2003; 10: 95-99.
-
(2003)
Gene Ther
, vol.10
, pp. 95-99
-
-
Stecenko, A.A.1
Brigham, K.L.2
-
90
-
-
8944254696
-
MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: A double-blind, randomized, placebo-controlled clinical trial
-
Luisetti M, Sturani C, Sella D, et al. MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial. Eur Respir J 1996; 9: 1482-1486.
-
(1996)
Eur Respir J
, vol.9
, pp. 1482-1486
-
-
Luisetti, M.1
Sturani, C.2
Sella, D.3
-
92
-
-
0037361991
-
The role of matrix metallo-proteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): A therapeutic role for inhibitors of MMPs?
-
Belvisi MG, Bottomley KM. The role of matrix metallo-proteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): a therapeutic role for inhibitors of MMPs? Inflamm Res 2003; 52: 95-100.
-
(2003)
Inflamm Res
, vol.52
, pp. 95-100
-
-
Belvisi, M.G.1
Bottomley, K.M.2
-
93
-
-
0036010527
-
Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease
-
Russell RE, Culpitt SV, DeMatos C, et al. Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2002; 26: 602-609.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 602-609
-
-
Russell, R.E.1
Culpitt, S.V.2
DeMatos, C.3
-
94
-
-
16944366965
-
Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats
-
Massaro G, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nature Med 1997; 3: 675-677.
-
(1997)
Nature Med
, vol.3
, pp. 675-677
-
-
Massaro, G.1
Massaro, D.2
-
95
-
-
0034032758
-
Effects of all-trans-retinoic acid in promoting alveolar repair
-
Belloni PN, Garvin L, Mao CP, Bailey-Healy I, Leaffer D. Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000; 117: 235S-241S.
-
(2000)
Chest
, vol.117
-
-
Belloni, P.N.1
Garvin, L.2
Mao, C.P.3
Bailey-Healy, I.4
Leaffer, D.5
-
96
-
-
0038751985
-
Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysema
-
Lucey EC, Goldstein RH, Breuer R, Rexer BN, Ong DE, Snider GL. Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysema. Respiration 2003; 70: 200-205.
-
(2003)
Respiration
, vol.70
, pp. 200-205
-
-
Lucey, E.C.1
Goldstein, R.H.2
Breuer, R.3
Rexer, B.N.4
Ong, D.E.5
Snider, G.L.6
-
97
-
-
0036499505
-
A pilot study of all-trans-retinoic acid for the treatment of human emphysema
-
Mao JT, Goldin JG, Dermand J, et al. A pilot study of all-trans-retinoic acid for the treatment of human emphysema. Am J Respir Crit Care Med 2002; 165: 718-723.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 718-723
-
-
Mao, J.T.1
Goldin, J.G.2
Dermand, J.3
-
98
-
-
0036063049
-
Lung epithelial stem cells
-
Otto WR. Lung epithelial stem cells. J Pathol 2002; 197: 527-535.
-
(2002)
J Pathol
, vol.197
, pp. 527-535
-
-
Otto, W.R.1
-
99
-
-
0036346760
-
Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction
-
Sandford AJ, Silverman EK. Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction. Thorax 2002; 57: 736-741.
-
(2002)
Thorax
, vol.57
, pp. 736-741
-
-
Sandford, A.J.1
Silverman, E.K.2
-
101
-
-
0035891572
-
Longitudinal changes in physiological, radiological, and health status measurements in α1-antitrypsin deficiency and factors associated with decline
-
Dowson LJ, Guest PJ, Stockley RA. Longitudinal changes in physiological, radiological, and health status measurements in α1-antitrypsin deficiency and factors associated with decline. Am J Respir Crit Care Med 2001; 164: 1805-1809.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 1805-1809
-
-
Dowson, L.J.1
Guest, P.J.2
Stockley, R.A.3
|