Ongoing airway inflammation in patients with COPD who do not currently smoke

Thorax

Volumn 55, Issue 1, 2000, Pages 12-18

  Rutgers, Steven R ^a   Postma, Dirkje S ^a   Ten Hacken, Nick H T ^a   Kauffman, Henk F ^a   Van Der Mark, Thomas W ^a   Koëter, Gerard H ^a   Timens, Wim ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Biopsy; Chronic obstructive pulmonary disease; Inflammation

Indexed keywords

CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; EOSINOPHIL CATIONIC PROTEIN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BRONCHOSCOPY; CELL COUNT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG BIOPSY; LUNG LAVAGE; LYMPHOCYTE; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; RESPIRATORY TRACT MUCOSA; SMOKING CESSATION; SPUTUM;

BIOPSY; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LUNG DISEASES, OBSTRUCTIVE; MACROPHAGES; MALE; MIDDLE AGED; NEUTROPHILS; VITAL CAPACITY;

EID: 0034018232     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.55.1.12     Document Type: Article

References (29)

1. 1 Siafakas NM, Vermeire P, Pride NB, et al. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J 1995;8:1398-420.
2. 2 Jeffery PK. Comparative morphology of the airways in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994;150:S6-13.
3. 3 Saetta M, Finkelstein R, Cosio MG. Morphological and cellular basis for airflow limitation in smokers. Eur Respir J 1994;7:1505-15.
4. 4 Lacoste JYL, Bousquet J, Chanez P, et al. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J Allergy Clin Immunol 1993;92:537-48.
5. 5 Saetta MP, Di Stefano A, Maestrelli P, et al. Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis 1993;147:301-6.
6. 6 Maestrelli P, Saetta M, Di Stefano A, et al. Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage. Am J Respir Crit Care Med 1995;152:1926-31.
7. 7 Mueller R, Chanez P, Campbell AM, et al. Different cytokine patterns in bronchial biopsies in asthma and chronic bronchitis. Respir Med 1996;90:79-85.
8. 8 Di Stefano A, Turato G, Maestrelli P, et al. Airflow limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration of the bronchial mucosa. Am J Respir Crit Care Med 1996;153:629-32.
9. 1. Am J Respir Crit Care Med 1997;155:852-7.
10. 10 Saetta M, Di Stefano A, Turato G, et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:822-6.
11. 11 Saetta M, Di Stefano A, Maestrelli P, et al. Airway cosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 1994;150:1646-52.
12. 12 Pesci A, Rossi GA, Bertorelli G, et al. Mast cells in the airway lumen and bronchial mucosa of patients with chronic bronchitis. Am J Respir Crit. Care Med 1994;149:1311-6.
13. 13 Sibille Y. Pulmonary immune cells in health and disease: polymorphonuclear neutrophils. Eur Respir J 1993;6:1529-43.
14. 14 Turnbull LS. Mediators of immediate-type hypersensitivity in sputum from patients with chronic bronchitis and asthma. Lancet 1977;ii:526-9.
15. 15 Keatings V, Jatakanon A, Miin Worsdell Y, et al. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997;155:542-8.
16. 16 Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045-9.
17. 17 Burke WMJ, Roberts CM, Bryant DH, et al. Smoking-induced changes in epithelial lining fluid volume, cell density and protein. Eur Respir J 1992;5:780-4.
18. 18 Hughes DA, Haslam PL, Townsend PJ, et al. Numerical and functional alterations in circulatory lymphocytes in cigarette smokers. Clin Exp Immunol 1985;61:459-66.
19. 19 Miller LG, Goldstein G, Murphy M, et al. Reversible alterations in immunoregulatory T cells in smoking. Analysis by monoclonal antibodies and flow cytometry. Chest 1982;82: 526-9.
20. 20 American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-44.
21. 21 Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Eur Respir J 1993;6:5-40.
22. 22 Garcia Sanz JA, Velotti F, MacDonald HR, et al. Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli. Immunology 1988;64:129-34.
23. 23 Turato G, Di Stefano A, Maestrelli P, et al. Effect of smoking cessation on airway inflammation in chronic bronchitis. Am J Respir Crit Care Med 1995;152:1262-7.
24. 24 Sibille Y. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 1990;141: 471-501.
25. 25 Agostini C. Pulmonary immune cells in health and disease: lymphocytes. Eur Respir J 1993;6:1378-401.
26. 26 Pilewski JM, Albelda SM. Adhesion molecules in the lung. An overview. Am Rev Respir Dis 1993;148:S31-7.
27. 27 Lusuardi M, Capelli A, Cerutti CG, et al. Airways inflammation in subjects with chronic bronchitis who have never smoked. Thorax 1994;49:1211-6.
28. 28 Thompson AB, Daughton D, Robbins RA, et al. Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters. Am Rev Respir Dis 1989;140:1527-37.
29. 29 Lams BEA, Sousa AR, Rees PJ, et al. Immunopathology of the small-airway submucosa in smokers with and whithout chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158:1518-23.