New targets for an old drug: A chemical proteomics approach to unraveling the molecular mechanism of action of methotrexate

Clinical Proteomics

Volumn 1, Issue 1, 2004, Pages 45-67

  Toledo Sherman, Leticia M ^a   Desouza, Leroi ^a   Hosfield, Christopher M ^a   Liao, Linda ^a   Boutillier, Kelly ^a   Taylor, Paul ^a   Climie, Shane ^a   McBroom Cerajewski, Linda ^a   Moran, Michael F ^a  

^a MDS Proteomics Inc   (Canada)

Author keywords

Chemical proteomics; Inverse docking; Mechanism of action; Metabolome; Methotrexate; Pharmaco proteomics; Substrate channeling; Targets

Indexed keywords

METHOTREXATE; PURINE;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PREDICTION; PRIORITY JOURNAL; PROTEOMICS; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

EID: 24644453418     PISSN: 15426416     EISSN: None     Source Type: Journal    
DOI: 10.1385/cp:1:1:045     Document Type: Article

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