Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: A metabolic basis for efficacy in rheumatoid arthritis?

Biochemical Journal

Volumn 342, Issue 1, 1999, Pages 143-152

  Fairbanks, Lynette D ^a   Rückemann, Katarzyna ^a,b   Qiu, Ying ^a,c   Hawrylowicz, Catherine M ^a   Richards, David F ^a   Swaminathan, Ramasamyiyer ^a   Kirschbaum, Bernhard ^d   Simmonds, H Anne ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

^d SANOFI   (France)

Author keywords

5 Amino 4 imidazolecarboxamide riboside 5' monophosphate; Adenosine; Amidophosphoribosyltransferase; Leflunomide; Phosphoribosylpyrophosphate

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; AMIDOPHOSPHORIBOSYLTRANSFERASE; BICARBONATE; CARBON 14; FOLIC ACID ANTAGONIST; GLYCINE; GUANOSINE TRIPHOSPHATE; HYPOXANTHINE; METHOTREXATE; MITOGENIC AGENT; PHOSPHORIBOSYL PYROPHOSPHATE; PHYTOHEMAGGLUTININ; PURINE; PYRIMIDINE; RIBONUCLEOTIDE; URIDINE TRIPHOSPHATE;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BASAL METABOLIC RATE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE TRANSFORMATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PURINE SYNTHESIS; PYRIMIDINE SYNTHESIS; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

AMIDOPHOSPHORIBOSYLTRANSFERASE; ARTHRITIS, RHEUMATOID; BICARBONATES; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; HUMANS; HYPOXANTHINE; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; METHOTREXATE; NUCLEOTIDES; PHOSPHORIBOSYL PYROPHOSPHATE; PHYTOHEMAGGLUTININS; PROTEIN BIOSYNTHESIS; PROTEINS; PURINES; PYRIMIDINES; RIBONUCLEOTIDES; T-LYMPHOCYTES; URIDINE;

EID: 2442740070     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3420143     Document Type: Article

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