The structure of adp-ribose pyrophosphatase reveals the structural basis for the versatility of the nudix family

Nature Structural Biology

Volumn 8, Issue 5, 2001, Pages 467-472

  Gabelli, Sandra B ^a   Bianchet, Mario A ^a   Bessman, Maurice J ^b   Amzel, L Mario ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE PYROPHOSPHATASE; ADENOSINE PHOSPHATE; HELIX LOOP HELIX PROTEIN; INORGANIC PYROPHOSPHATASE; RIBOSE 5 PHOSPHATE; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CATALYSIS; DIMERIZATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN FAMILY;

ADENOSINE DIPHOSPHATE RIBOSE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOENZYMES; BACTERIAL PROTEINS; BINDING SITES; CATIONS, DIVALENT; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME ACTIVATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN STRUCTURE, TERTIARY; PYROPHOSPHATASES; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0035026968     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/87647     Document Type: Article

References (38)

1. Cysteine-specific ADP-ribosylation of actin
2. Poly(ADP-ribosy)ation of nuclear proteins. Enzymatic elongation of chemically synthesized ADP-ribose-histone adducts
3. Interaction of two classes of ADP-ribose transfer reactions in immune signaling
4. ADP-ribosylation: Metabolic effects and regulatory function
5. Enzymatic and nonenzymatic ADP-ribosylation of cysteines
6. Specific ADP-ribose pyrophosphatase from Artemia cysts and rat liver: Effects of nitroprusside, fluoride and ionic strength
7. ADP-ribose Pyrophosphatase-I partially purified from livers of rats overdosed with acetaminophen reveals enzyme inhibition in vivo reverted in vitro by dithiothreitol
8. Purification and characterization of adenosine diphosphate ribose pyrophosphatase from human erythrocytes
9. Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance
10. Cloning, expression and characterization of YSA1H, a human adenosine 5′-diphosphosugar pyrophosphatase possesing a Mutt motif
11. Orf186 represents a new member of the Nudix hydrolases, active on adenosine(5′)triphospho(5′) adenosine, ADP-ribose and NADH
12. Synechocystis sp. s1r0787 protein is a novel bifunctional enzyme endowed with both nicotinamide mononucleotide adenylyltransferase and Nudix hydrolase activityies
13. Identification and characterization of the Nudix hydrolase from the Archaeon, Methanococcus jannaschii, as a highly specific ADP-ribose pyrophosphatase
14. Cloning and characterization of a new member of the nudix hydrolases from human and mouse
15. The Mutt proteins or 'Nudix' hydrolases, a family of versatile, widely distributed, 'housecleaning' enzymes
16. Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase
17. The three dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L
18. 3] system
19. 3D search and research using the Cambridge Structural Database
20. Three dimensional structure of aspartyl protease from human imnunodeficiency virus HIV-1
21. When fold is not important: A common structural framework for adenine and AMP binding in 12 unrelated protein families
22. Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex
23. Gapped BLAST and PSI-BLAST a new generation of protein database search programs
24. Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action
25. Processing of X-ray diffraction data collected in oscillation mode
26. Automated structure solution for Mir and Mad
27. An automated procedure for phase improvement by density modification. Joint CCP4 and ESF-EACBM Newstett
28. Software for handling macromolecular envelopes
29. Halloween...Masks and Bones
30. Improved methods for binding protein models to electron density maps and the location of errors in these models
31. Electron-density map interpretation
32. Crystallography & NMR system: A new software suite for macromolecular structure determination
33. Value: Cross-validation in crystallography
34. PROCHECK: A program to check the sterochemical quality of protein structures
35. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structure
36. Further additions to MOLSCRIPT version 1.4, including reading and countouring of electron density maps
37. Raster3D: Photorealistic molecular graphics