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Volumn 91, Issue 14, 1999, Pages 1233-1241

Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

EDATREXATE; FOLIC ACID ANTAGONIST; FOLYLPOLYGLUTAMATE SYNTHASE; METHOTREXATE;

EID: 0033591840     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/91.14.1233     Document Type: Article
Times cited : (26)

References (46)
  • 2
    • 0019449889 scopus 로고
    • Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro
    • Balinska M, Galivan J, Coward JK. Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro. Cancer Res 1981; 41:2751-6.
    • (1981) Cancer Res , vol.41 , pp. 2751-2756
    • Balinska, M.1    Galivan, J.2    Coward, J.K.3
  • 3
    • 0023935785 scopus 로고
    • Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug
    • Pizzorno G, Mini E, Coronnello M, McGuire JJ, Moroson BA, Cashmore AR, et al. Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug. Cancer Res 1988;48:2149-55.
    • (1988) Cancer Res , vol.48 , pp. 2149-2155
    • Pizzorno, G.1    Mini, E.2    Coronnello, M.3    McGuire, J.J.4    Moroson, B.A.5    Cashmore, A.R.6
  • 4
    • 0028826703 scopus 로고
    • Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription
    • Roy K, Mitsugi K, Sirlin S, Shane B, Sirotnak FM. Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription. J Biol Chem 1995;270:26918-22.
    • (1995) J Biol Chem , vol.270 , pp. 26918-26922
    • Roy, K.1    Mitsugi, K.2    Sirlin, S.3    Shane, B.4    Sirotnak, F.M.5
  • 5
    • 0030954945 scopus 로고    scopus 로고
    • Post-transcriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme
    • Roy K, Egan MG, Sirlin S, Sirotnak FM. Post-transcriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme. J Biol Chem 1997;272:6903-8.
    • (1997) J Biol Chem , vol.272 , pp. 6903-6908
    • Roy, K.1    Egan, M.G.2    Sirlin, S.3    Sirotnak, F.M.4
  • 6
    • 0010535146 scopus 로고    scopus 로고
    • Altered expression of folylpolyglutamate synthetase (FPGS) gene in human leukemia cells with defective polyglutamation of raltitrexed (ZD1694)
    • Takemura Y, Kobayashi H, Miyachi H, Furihata K. Altered expression of folylpolyglutamate synthetase (FPGS) gene in human leukemia cells with defective polyglutamation of raltitrexed (ZD1694) [abstract]. Br J Cancer 1997;75(suppl 1):31.
    • (1997) Br J Cancer , vol.75 , Issue.SUPPL. 1 , pp. 31
    • Takemura, Y.1    Kobayashi, H.2    Miyachi, H.3    Furihata, K.4
  • 7
    • 0022830104 scopus 로고
    • Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells
    • Rodenhuis S, McGuire JJ, Narayanan R, Bertino JR. Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells. Cancer Res 1986;46:6513-9.
    • (1986) Cancer Res , vol.46 , pp. 6513-6519
    • Rodenhuis, S.1    McGuire, J.J.2    Narayanan, R.3    Bertino, J.R.4
  • 9
    • 0025329072 scopus 로고
    • Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action
    • Rumberger BG, Barrueco JR, Sirotnak FM. Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action. Cancer Res 1990;50: 4639-43.
    • (1990) Cancer Res , vol.50 , pp. 4639-4643
    • Rumberger, B.G.1    Barrueco, J.R.2    Sirotnak, F.M.3
  • 10
    • 0027442503 scopus 로고
    • Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gammaglutamate synthetase in methotrexate metabolism and cytotoxicity
    • Kim JS, Lowe KE, Shane B. Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gammaglutamate synthetase in methotrexate metabolism and cytotoxicity. J Biol Chem 1993;268: 21680-5.
    • (1993) J Biol Chem , vol.268 , pp. 21680-21685
    • Kim, J.S.1    Lowe, K.E.2    Shane, B.3
  • 11
    • 0021328814 scopus 로고
    • New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties
    • Sirotnak FM, DeGraw JI, Moccio DM, Samuels LL, Goutas LJ. New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties. Cancer Chemother Pharmacol 1984;12:18-25.
    • (1984) Cancer Chemother Pharmacol , vol.12 , pp. 18-25
    • Sirotnak, F.M.1    DeGraw, J.I.2    Moccio, D.M.3    Samuels, L.L.4    Goutas, L.J.5
  • 13
    • 0023690573 scopus 로고
    • Methotrexate analogues. 33. N-δ-Acyl-Nα-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: Synthesis and in vitro antitumor activity
    • Rosowsky A, Bader H, Cucchi CA, Moran RG, Kohler W, Freisheim JH. Methotrexate analogues. 33. N-δ-Acyl-Nα-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity. J Med Chem 1988;31:1332-7.
    • (1988) J Med Chem , vol.31 , pp. 1332-1337
    • Rosowsky, A.1    Bader, H.2    Cucchi, C.A.3    Moran, R.G.4    Kohler, W.5    Freisheim, J.H.6
  • 14
    • 0029844849 scopus 로고    scopus 로고
    • Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells
    • Fraefel C, Song S, Lim F, Lang P, Yu L, Wang Y, et al. Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J Virol 1996;70:7190-7.
    • (1996) J Virol , vol.70 , pp. 7190-7197
    • Fraefel, C.1    Song, S.2    Lim, F.3    Lang, P.4    Yu, L.5    Wang, Y.6
  • 16
    • 0000031556 scopus 로고
    • Genetically modified rat 9L gliosarcoma cells facilitate detection of infiltrating tumor cells in a rat model of brain neoplasms
    • Scharf JM, Boviatsis EJ, Fleet C, Breakefield XO, Chiocca EA. Genetically modified rat 9L gliosarcoma cells facilitate detection of infiltrating tumor cells in a rat model of brain neoplasms. Transgenics 1994;1:219-24.
    • (1994) Transgenics , vol.1 , pp. 219-224
    • Scharf, J.M.1    Boviatsis, E.J.2    Fleet, C.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 17
    • 0014364322 scopus 로고
    • Long term culture of normal and neoplastic human glia
    • Ponten J, Macintyre EH. Long term culture of normal and neoplastic human glia. Acta Pathol Microbiol Scand 1968;74:465-86.
    • (1968) Acta Pathol Microbiol Scand , vol.74 , pp. 465-486
    • Ponten, J.1    Macintyre, E.H.2
  • 18
    • 0014430979 scopus 로고
    • Differentiated rat glial cell strain in tissue culture
    • Benda P, Lightbody J, Sato G, Levine L, Sweet W. Differentiated rat glial cell strain in tissue culture. Science 1968;161:370-1.
    • (1968) Science , vol.161 , pp. 370-371
    • Benda, P.1    Lightbody, J.2    Sato, G.3    Levine, L.4    Sweet, W.5
  • 19
    • 0025972397 scopus 로고
    • Transfection of C6 glioma cells with connexin 43 cDNA: Analysis of expression, intercellular coupling, and cell proliferation
    • Zhu D, Caveney S, Kidder GM, Naus CC. Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation. Proc Natl Acad Sci U S A 1991;88:1883-7.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 1883-1887
    • Zhu, D.1    Caveney, S.2    Kidder, G.M.3    Naus, C.C.4
  • 20
    • 0032481577 scopus 로고    scopus 로고
    • Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies
    • Aghi M, Kramm CM, Chou TC, Breakefield XO, Chiocca EA. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst 1998;90:370-80.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 370-380
    • Aghi, M.1    Kramm, C.M.2    Chou, T.C.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 21
    • 0000169232 scopus 로고
    • An algorithm for least square estimate of non-linear parameters
    • Marquardt DW. An algorithm for least square estimate of non-linear parameters. SIAM J Appl Math 1963;11:431-41.
    • (1963) SIAM J Appl Math , vol.11 , pp. 431-441
    • Marquardt, D.W.1
  • 22
    • 0030907756 scopus 로고    scopus 로고
    • Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy
    • Friedlos F, Denny WA, Palmer BD, Springer CJ. Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. J Med Chem 1997;40: 1270-5.
    • (1997) J Med Chem , vol.40 , pp. 1270-1275
    • Friedlos, F.1    Denny, W.A.2    Palmer, B.D.3    Springer, C.J.4
  • 23
    • 0011286643 scopus 로고
    • Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer
    • Price J, Turner D, Cepko C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci U S A 1987;84:156-60.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 156-160
    • Price, J.1    Turner, D.2    Cepko, C.3
  • 24
    • 0027514853 scopus 로고
    • A cosmid-based system for constructing mutants of herpes simplex virus type 1
    • Cunningham C, Davison AJ. A cosmid-based system for constructing mutants of herpes simplex virus type 1. Virology 1993;197:116-24.
    • (1993) Virology , vol.197 , pp. 116-124
    • Cunningham, C.1    Davison, A.J.2
  • 25
    • 0028986625 scopus 로고
    • Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation
    • Egan MG, Sirlin S, Rumberger BG, Garrow TA, Shane B, Sirotnak FM. Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation. J Biol Chem 1995;270:5462-8.
    • (1995) J Biol Chem , vol.270 , pp. 5462-5468
    • Egan, M.G.1    Sirlin, S.2    Rumberger, B.G.3    Garrow, T.A.4    Shane, B.5    Sirotnak, F.M.6
  • 26
    • 0023257268 scopus 로고
    • Metabolism of methotrexate and γ-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro
    • Wright JE, Rosowsky A, Waxman DJ, Trites D, Cucchi CA, Flatow J, et al. Metabolism of methotrexate and γ-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro. Biochem Pharmacol 1987;36:2209-14.
    • (1987) Biochem Pharmacol , vol.36 , pp. 2209-2214
    • Wright, J.E.1    Rosowsky, A.2    Waxman, D.J.3    Trites, D.4    Cucchi, C.A.5    Flatow, J.6
  • 27
    • 0024414914 scopus 로고
    • Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates
    • Ellenberger TE, Wright JE, Rosowsky A, Beverley SM. Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates. J Biol Chem 1989;264:15960-6.
    • (1989) J Biol Chem , vol.264 , pp. 15960-15966
    • Ellenberger, T.E.1    Wright, J.E.2    Rosowsky, A.3    Beverley, S.M.4
  • 29
    • 0024451424 scopus 로고
    • Evaluation of anti-tumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose
    • Inaba M, Kobayashi T, Tashiro T, Sakurai Y, Maruo K, Ohnishi Y, et al. Evaluation of anti-tumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose. Cancer 1989;64:1577-82.
    • (1989) Cancer , vol.64 , pp. 1577-1582
    • Inaba, M.1    Kobayashi, T.2    Tashiro, T.3    Sakurai, Y.4    Maruo, K.5    Ohnishi, Y.6
  • 30
    • 0027426072 scopus 로고
    • Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines
    • Peters GJ, van der Wilt CL, Cloos J, Pinedo HM. Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines. Adv Exp Med Biol 1993;338:651-4.
    • (1993) Adv Exp Med Biol , vol.338 , pp. 651-654
    • Peters, G.J.1    Van Der Wilt, C.L.2    Cloos, J.3    Pinedo, H.M.4
  • 31
    • 0029924620 scopus 로고    scopus 로고
    • Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
    • Manome Y, Wen PY, Dong Y, Tanaka T, Mitchell BS, Kufe DW, et al. Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med 1996;2:567-73.
    • (1996) Nat Med , vol.2 , pp. 567-573
    • Manome, Y.1    Wen, P.Y.2    Dong, Y.3    Tanaka, T.4    Mitchell, B.S.5    Kufe, D.W.6
  • 32
    • 0024377226 scopus 로고
    • Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase
    • Moran RG, Colman PD, Jones TR. Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase. Mol Pharmacol 1989;36:736-43.
    • (1989) Mol Pharmacol , vol.36 , pp. 736-743
    • Moran, R.G.1    Colman, P.D.2    Jones, T.R.3
  • 33
  • 34
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber BE, Austin EA, Richards CA, Davis ST, Good SS. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci U S A 1994;91: 8302-6.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8302-8306
    • Huber, B.E.1    Austin, E.A.2    Richards, C.A.3    Davis, S.T.4    Good, S.S.5
  • 35
    • 0020686617 scopus 로고
    • Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity
    • Fry DW, Anderson LA, Borst M, Goldman ID. Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity. Cancer Res 1983;43: 1087-92.
    • (1983) Cancer Res , vol.43 , pp. 1087-1092
    • Fry, D.W.1    Anderson, L.A.2    Borst, M.3    Goldman, I.D.4
  • 36
    • 0022642429 scopus 로고
    • Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells
    • Matherly LH, Barlowe CK, Goldman ID. Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells. Cancer Res 1986;46:588-93.
    • (1986) Cancer Res , vol.46 , pp. 588-593
    • Matherly, L.H.1    Barlowe, C.K.2    Goldman, I.D.3
  • 37
    • 0029883624 scopus 로고    scopus 로고
    • Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy
    • Black ME, Newcomb TG, Wilson HM, Loeb LA. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc Natl Acad Sci U S A 1996;93: 3525-9.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3525-3529
    • Black, M.E.1    Newcomb, T.G.2    Wilson, H.M.3    Loeb, L.A.4
  • 38
    • 0031463632 scopus 로고    scopus 로고
    • Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
    • Ram Z, Culver KW, Oshiro EM, Viola JJ, DeVroom HL, Otto E, et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med 1997;3:1354-61.
    • (1997) Nat Med , vol.3 , pp. 1354-1361
    • Ram, Z.1    Culver, K.W.2    Oshiro, E.M.3    Viola, J.J.4    DeVroom, H.L.5    Otto, E.6
  • 39
    • 0029995247 scopus 로고    scopus 로고
    • In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine
    • Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, et al. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther 1996;7:713-20.
    • (1996) Hum Gene Ther , vol.7 , pp. 713-720
    • Dong, Y.1    Wen, P.2    Manome, Y.3    Parr, M.4    Hirshowitz, A.5    Chen, L.6
  • 40
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth JA, Cristiano RJ. Gene therapy for cancer: what have we done and where are we going? J Natl Cancer Inst 1997;89:21-39.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 21-39
    • Roth, J.A.1    Cristiano, R.J.2
  • 41
    • 0017389271 scopus 로고
    • High-dose methotrexate in malignant gliomas
    • Shapiro WR. High-dose methotrexate in malignant gliomas. Cancer Treat Rep 1977;61: 753-6.
    • (1977) Cancer Treat Rep , vol.61 , pp. 753-756
    • Shapiro, W.R.1
  • 43
    • 0030011021 scopus 로고    scopus 로고
    • Therapy of primary CNS lymphoma with methotrexate-based chemotherapy and deferred radiotherapy: Preliminary results
    • Cher L, Glass J, Harsh GR, Hochberg FH. Therapy of primary CNS lymphoma with methotrexate-based chemotherapy and deferred radiotherapy: preliminary results. Neurology 1996;46:1757-9.
    • (1996) Neurology , vol.46 , pp. 1757-1759
    • Cher, L.1    Glass, J.2    Harsh, G.R.3    Hochberg, F.H.4
  • 44
    • 0019989460 scopus 로고
    • Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model
    • Yamada K, Ushio Y, Hayakawa T, Kato A, Yamada N, Mogami H. Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model. J Neurosurg 1982;57:394-8.
    • (1982) J Neurosurg , vol.57 , pp. 394-398
    • Yamada, K.1    Ushio, Y.2    Hayakawa, T.3    Kato, A.4    Yamada, N.5    Mogami, H.6
  • 45
    • 0021828040 scopus 로고
    • Osmotic blood-brain barrier modification: Monoclonal antibody, albumin, and methotrexate delivery to cerebro-spinal fluid and brain
    • Neuwelt EA, Barnett PA, McCormick CI, Frenkel EP, Minna JD. Osmotic blood-brain barrier modification: monoclonal antibody, albumin, and methotrexate delivery to cerebro-spinal fluid and brain. Neurosurgery 1985;17: 419-23.
    • (1985) Neurosurgery , vol.17 , pp. 419-423
    • Neuwelt, E.A.1    Barnett, P.A.2    McCormick, C.I.3    Frenkel, E.P.4    Minna, J.D.5
  • 46
    • 0027973489 scopus 로고
    • Intracarotid infusion of RMP-7, a bradykinin analog: A method for selective drug delivery to brain tumors
    • Inamura T, Nomura T, Bartus RT, Black KL. Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors. J Neurosurg 1994;81:752-8.
    • (1994) J Neurosurg , vol.81 , pp. 752-758
    • Inamura, T.1    Nomura, T.2    Bartus, R.T.3    Black, K.L.4


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