Impaired Shc, Ras, and MAPK Activation but Normal Akt Activation in FL5.12 Cells Expressing an Insulin-like Growth Factor I Receptor Mutated at Tyrosines 1250 and 1251

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 18306-18313

  Leahy, Madeline ^a   Lyons, Anthony ^a   Krause, Darren ^a,b   O'Connor, Rosemary ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INSULIN; PROTEINS; TUMORS;

PHOSPHORYLATION; TYROSINES;

BIOCHEMISTRY;

ADAPTOR PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLALANINE; PROTEIN GAB2; PROTEIN KINASE B; PROTEIN SHC; PROTEIN TYROSINE KINASE; RAS PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROTECTION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; FIBROBLAST; LYMPHOCYTE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELL LINE, TUMOR; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOMA, B-CELL; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION, MISSENSE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; RECEPTOR, IGF TYPE 1; TYROSINE;

ANIMALIA;

EID: 2442563691     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309234200     Document Type: Article

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