Replacement of tyrosine 1251 in the carboxyl terminus of the insulin- like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth

Journal of Biological Chemistry

Volumn 273, Issue 29, 1998, Pages 18411-18422

  Blakesley, Vicky A ^a   Koval, Anatolii P ^a   Stannard, Bethel S ^a   Scrimgeour, Angus ^a   Leroith, Derek ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COMPLEMENTARY DNA; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR SUBUNIT; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TYROSINE; VINCULIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; GROWTH INHIBITION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ACTINS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL ADHESION; CELL DIVISION; CYTOSKELETON; ENZYME ACTIVATION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, NUDE; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN CONFORMATION; RECEPTOR, IGF TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; VINCULIN;

ANIMALIA; MUS MUSCULUS;

EID: 0032541182     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.29.18411     Document Type: Article

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