-
1
-
-
0025937489
-
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
-
Askew, D.S., Ashmun, R.A., Simmons, B.C. and Cleveland, J.L. (1991) Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene, 6, 1915-1922.
-
(1991)
Oncogene
, vol.6
, pp. 1915-1922
-
-
Askew, D.S.1
Ashmun, R.A.2
Simmons, B.C.3
Cleveland, J.L.4
-
2
-
-
0028944444
-
Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein
-
Baldari, C.T., Pelicci, G., Somma, M.M.D., Milia, E., Giuli, S., Pelicci, P.G. and Telford, J.L. (1995) Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein. Oncogene, 10, 1141-1147.
-
(1995)
Oncogene
, vol.10
, pp. 1141-1147
-
-
Baldari, C.T.1
Pelicci, G.2
Somma, M.M.D.3
Milia, E.4
Giuli, S.5
Pelicci, P.G.6
Telford, J.L.7
-
3
-
-
0028879873
-
Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
-
Barone, M.V. and Courtneidge, S.A. (1995) Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature, 378, 509-512.
-
(1995)
Nature
, vol.378
, pp. 509-512
-
-
Barone, M.V.1
Courtneidge, S.A.2
-
4
-
-
0028977847
-
Receptor-tyrosine-kinase-and Gβγ-mediated MAP kinase activation by a common signalling pathway
-
Biesen, T. van, Hawes, B.E., Luttrell, D.K., Krueger, K.M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L.M. and Lefkowitz, R.J. (1995) Receptor-tyrosine-kinase-and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature, 370, 781-784.
-
(1995)
Nature
, vol.370
, pp. 781-784
-
-
Van Biesen, T.1
Hawes, B.E.2
Luttrell, D.K.3
Krueger, K.M.4
Touhara, K.5
Porfiri, E.6
Sakaue, M.7
Luttrell, L.M.8
Lefkowitz, R.J.9
-
5
-
-
0026688162
-
Apoptotic cell death induced by c-myc is inhibited by bcl-2
-
Bissonnette, R.P., Echeverri, F., Mahboubi, A. and Green, D.R. (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature, 359, 552-553.
-
(1992)
Nature
, vol.359
, pp. 552-553
-
-
Bissonnette, R.P.1
Echeverri, F.2
Mahboubi, A.3
Green, D.R.4
-
6
-
-
0025998840
-
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
-
Boyle, W.J., Geer, P. van de and Hunter, T. (1991) Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol., 201, 110-149.
-
(1991)
Methods Enzymol.
, vol.201
, pp. 110-149
-
-
Boyle, W.J.1
Van De Geer, P.2
Hunter, T.3
-
7
-
-
0024388161
-
Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: Conditional regulation of c-myc transcription by temperature- sensitive v-abl
-
Cleveland, J.L., Dean, M., Rosenberg, N., Wang, J.Y.J. and Rapp, U.R. (1989) Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature- sensitive v-abl. Mol. Cell. Biol., 9, 5685-5695.
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 5685-5695
-
-
Cleveland, J.L.1
Dean, M.2
Rosenberg, N.3
Wang, J.Y.J.4
Rapp, U.R.5
-
8
-
-
0028895654
-
Modular binding domains in signal transduction proteins
-
Cohen, G.B., Ren, R. and Baltimore, D. (1995) Modular binding domains in signal transduction proteins. Cell, 80, 237-248.
-
(1995)
Cell
, vol.80
, pp. 237-248
-
-
Cohen, G.B.1
Ren, R.2
Baltimore, D.3
-
9
-
-
0027485538
-
Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hematopoietic cells
-
Cutler, R.L., Liu, L., Damen, J.E. and Krystals, G. (1993) Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hematopoietic cells. J. Biol. Chem., 268, 21463-21465.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 21463-21465
-
-
Cutler, R.L.1
Liu, L.2
Damen, J.E.3
Krystals, G.4
-
10
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan, G.I., Wyllie, A.H., Gilbert, C.S., Littlewood, T.D., Land, H., Brooks, M., Waters, C.M., Penn, L.Z. and Hancock, D.C. (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69, 119-128.
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.I.1
Wyllie, A.H.2
Gilbert, C.S.3
Littlewood, T.D.4
Land, H.5
Brooks, M.6
Waters, C.M.7
Penn, L.Z.8
Hancock, D.C.9
-
11
-
-
0026722655
-
Cooperative interaction between c-myc and bcl-2 proto-oncogene
-
Fanidi, A., Harrington, E.A. and Evan, G.I. (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogene. Nature, 359, 554-556.
-
(1992)
Nature
, vol.359
, pp. 554-556
-
-
Fanidi, A.1
Harrington, E.A.2
Evan, G.I.3
-
12
-
-
0028049245
-
Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity
-
Gotoh, N., Tojo, A., Muroya, K., Hashimoto, Y., Hattori, S., Nakamura, S., Takenawa, T., Yazaki, Y. and Shibuya, M. (1994) Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. Proc. Natl Acad. Sci. USA, 91, 167-171.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 167-171
-
-
Gotoh, N.1
Tojo, A.2
Muroya, K.3
Hashimoto, Y.4
Hattori, S.5
Nakamura, S.6
Takenawa, T.7
Yazaki, Y.8
Shibuya, M.9
-
13
-
-
0029586406
-
The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner
-
Gotoh, N., Muroya, K., Hattori, S., Nakamura, S., Cnida, K. and Shibuya, M. (1995) The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner. Oncogene, 11, 2525-2533.
-
(1995)
Oncogene
, vol.11
, pp. 2525-2533
-
-
Gotoh, N.1
Muroya, K.2
Hattori, S.3
Nakamura, S.4
Cnida, K.5
Shibuya, M.6
-
14
-
-
0028897113
-
Transcriptional regulation by extracellular signals: Mechanisms and specificity
-
Hill, C.S. and Treisman, R. (1995) Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell, 80, 199-211.
-
(1995)
Cell
, vol.80
, pp. 199-211
-
-
Hill, C.S.1
Treisman, R.2
-
15
-
-
0028921573
-
Jaks and stats in signaling by the cytokine receptor superfamily
-
Ihle, J.N. and Kerr, I.M. (1995) Jaks and stats in signaling by the cytokine receptor superfamily. Trends Genet., 11, 69-74.
-
(1995)
Trends Genet.
, vol.11
, pp. 69-74
-
-
Ihle, J.N.1
Kerr, I.M.2
-
16
-
-
0028559163
-
A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells
-
Kabarowski, J.H.S., Allen, P.B. and Wiedemann, L.M. (1994) A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells. EMBO J., 13, 5887-5895.
-
(1994)
EMBO J.
, vol.13
, pp. 5887-5895
-
-
Kabarowski, J.H.S.1
Allen, P.B.2
Wiedemann, L.M.3
-
17
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr, J.F., Wyllie, A.H. and Currie, A.R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 25, 239-257.
-
(1972)
Br. J. Cancer
, vol.25
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
18
-
-
0028837491
-
Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors
-
Kinoshita, T., Yokota, T., Arai, K. and Miyajima, A. (1995) Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J., 14, 266-275.
-
(1995)
EMBO J.
, vol.14
, pp. 266-275
-
-
Kinoshita, T.1
Yokota, T.2
Arai, K.3
Miyajima, A.4
-
19
-
-
0029148041
-
A Drosophila Shc gene product is implicated in signaling by the der receptor tyrosine kinase
-
Lai, K.M., Olivier, J.P., Gish, G.D., Henkemeyer, M., McGlade, J. and Pawson, T. (1995) A Drosophila Shc gene product is implicated in signaling by the DER receptor tyrosine kinase. Mol. Cell Biol., 15, 4810-4818.
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 4810-4818
-
-
Lai, K.M.1
Olivier, J.P.2
Gish, G.D.3
Henkemeyer, M.4
McGlade, J.5
Pawson, T.6
-
20
-
-
0028968362
-
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/Sos and Grb2/p140 complexes to the β receptor subunit
-
Lanfrancone, L., Pelicci, G., Brizzi, M.F., Arouica, M.G., Casciari, C., Giuli, S., Pegoraro, L., Pawson, T. and Pelicci, P.G. (1995) Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/Sos and Grb2/p140 complexes to the β receptor subunit. Oncogene, 10, 907-917.
-
(1995)
Oncogene
, vol.10
, pp. 907-917
-
-
Lanfrancone, L.1
Pelicci, G.2
Brizzi, M.F.3
Arouica, M.G.4
Casciari, C.5
Giuli, S.6
Pegoraro, L.7
Pawson, T.8
Pelicci, P.G.9
-
21
-
-
0028123457
-
A new function for a phosphotyrosine phosphatase: Linking Grb2-SOS to a receptor tyrosine kinase
-
Li, W., Nishimura, R., Kashishian, A., Batzer, A.G., Kim, W.J.H., Cooper, J.A. and Schlessinger, J. (1994) A new function for a phosphotyrosine phosphatase: linking Grb2-SOS to a receptor tyrosine kinase. Mol. Cell. Biol., 14, 509-517.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 509-517
-
-
Li, W.1
Nishimura, R.2
Kashishian, A.3
Batzer, A.G.4
Kim, W.J.H.5
Cooper, J.A.6
Schlessinger, J.7
-
22
-
-
0027939947
-
BCR/ABL
-
BCR/ABL. J. Biol. Chem., 269, 5016-5021.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5016-5021
-
-
Matsuguchi, T.1
Salgia, R.2
Hallek, M.3
Eder, M.4
Druker, B.5
Ernst, T.J.6
Griffin, J.D.7
-
23
-
-
0024502040
-
The molecular control of cell division, differentiation commitment and maturation in haematopoietic cells
-
Metcalf, D. (1989) The molecular control of cell division, differentiation commitment and maturation in haematopoietic cells. Nature, 339, 27-30.
-
(1989)
Nature
, vol.339
, pp. 27-30
-
-
Metcalf, D.1
-
24
-
-
0029054455
-
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
-
Miyazaki, T., Liu, Z.-J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsoumian, E.L., Perimutter, R.M. and Taniguchi, T. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell, 81, 223-231.
-
(1995)
Cell
, vol.81
, pp. 223-231
-
-
Miyazaki, T.1
Liu, Z.-J.2
Kawahara, A.3
Minami, Y.4
Yamada, K.5
Tsujimoto, Y.6
Barsoumian, E.L.7
Perimutter, R.M.8
Taniguchi, T.9
-
25
-
-
0028938419
-
V-abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation
-
Owen-Lynch, P.J., Wong, A.K. and Whetton, A.D. (1995) V-abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation. J. Biol. Chem., 270, 5956-5962.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 5956-5962
-
-
Owen-Lynch, P.J.1
Wong, A.K.2
Whetton, A.D.3
-
26
-
-
0028179006
-
Lymphocyte responses and cytokines
-
Paul, W.E. and Seder, R.A. (1994) Lymphocyte responses and cytokines. Cell, 76, 241-251.
-
(1994)
Cell
, vol.76
, pp. 241-251
-
-
Paul, W.E.1
Seder, R.A.2
-
27
-
-
0028859279
-
Protein modules and signalling networks
-
Pawson, T. (1995) Protein modules and signalling networks. Nature, 373, 573-580.
-
(1995)
Nature
, vol.373
, pp. 573-580
-
-
Pawson, T.1
-
28
-
-
0026777369
-
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
-
Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicolletti, I., Pawson, T. and Pelicci, P.G. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell, 70, 93-104.
-
(1992)
Cell
, vol.70
, pp. 93-104
-
-
Pelicci, G.1
Lanfrancone, L.2
Grignani, F.3
McGlade, J.4
Cavallo, F.5
Forni, G.6
Nicolletti, I.7
Pawson, T.8
Pelicci, P.G.9
-
29
-
-
0029007694
-
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
-
Pelicci, G., Giordano, S., Zhen, Z., Salcini, A.E., Lanfrancone, L., Bardell, A., Panayotou, G., Waterfield, M.D., Ponzetto, C., Pelicci, P.G. and Comoglio, P.M. (1995) The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene, 10, 1631-1638.
-
(1995)
Oncogene
, vol.10
, pp. 1631-1638
-
-
Pelicci, G.1
Giordano, S.2
Zhen, Z.3
Salcini, A.E.4
Lanfrancone, L.5
Bardell, A.6
Panayotou, G.7
Waterfield, M.D.8
Ponzetto, C.9
Pelicci, P.G.10
Comoglio, P.M.11
-
30
-
-
0028147448
-
Ber-Abl oncoproteins bind directly to activators of the Ras signalling pathway
-
Puil, L., Liu, J., Gish, G., Mbamalu, G., Bowtell, D., Pelicci, P.G., Arlinghaus, R. and Pawson, T. (1994) Ber-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J., 13, 764-773.
-
(1994)
EMBO J.
, vol.13
, pp. 764-773
-
-
Puil, L.1
Liu, J.2
Gish, G.3
Mbamalu, G.4
Bowtell, D.5
Pelicci, P.G.6
Arlinghaus, R.7
Pawson, T.8
-
31
-
-
0026504147
-
Social controls on cell survival and cell death
-
Raff, M.C. (1992) Social controls on cell survival and cell death. Nature, 356, 397-400.
-
(1992)
Nature
, vol.356
, pp. 397-400
-
-
Raff, M.C.1
-
33
-
-
0024994285
-
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidyl inositol 3-kinase, or induction of c-fos and jun B genes
-
Roussel, M.F., Shurtleff, S.A., Downing, J.R. and Sherr, C.J. (1990) A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidyl inositol 3-kinase, or induction of c-fos and jun B genes. Proc. Natl Acad. Sci. USA, 87, 6738-6742.
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 6738-6742
-
-
Roussel, M.F.1
Shurtleff, S.A.2
Downing, J.R.3
Sherr, C.J.4
-
34
-
-
0026678172
-
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
-
Rozakis-Adcock, M. et al. (1992) Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature, 360, 689-692.
-
(1992)
Nature
, vol.360
, pp. 689-692
-
-
Rozakis-Adcock, M.1
-
35
-
-
0027196547
-
Control of programmed cell death in normal and leukemic cells: New implications for therapy
-
Sachs, L. and Lotem, J. (1993) Control of programmed cell death in normal and leukemic cells: new implications for therapy. Blood, 82, 15-21.
-
(1993)
Blood
, vol.82
, pp. 15-21
-
-
Sachs, L.1
Lotem, J.2
-
36
-
-
0027934261
-
Formation of Shc-Grb2 complex is necessary to induce neoplastic transformation by overexpression of Shc proteins
-
Salcini, A.E., McGlade, J., Pelicci, G., Nicoletti, I., Pawson, T. and Pelicci, P.G. (1994) Formation of Shc-Grb2 complex is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene, 9, 2827-2836.
-
(1994)
Oncogene
, vol.9
, pp. 2827-2836
-
-
Salcini, A.E.1
McGlade, J.2
Pelicci, G.3
Nicoletti, I.4
Pawson, T.5
Pelicci, P.G.6
-
37
-
-
0027494821
-
Signal transduction by the high affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common β subunit responsible for different signaling
-
Sato, N., Sakamaki, K., Terada, N., Arai, K. and Miyajima, A. (1993) Signal transduction by the high affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for different signaling. EMBO J., 12, 4181-4189.
-
(1993)
EMBO J.
, vol.12
, pp. 4181-4189
-
-
Sato, N.1
Sakamaki, K.2
Terada, N.3
Arai, K.4
Miyajima, A.5
-
38
-
-
0028798083
-
A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF
-
Seetharam, Gotoh, N., Maru, Y., Neufeld, G., Yamaguchi, S. and Shibuya, M. (1995) A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene, 10, 135-147.
-
(1995)
Oncogene
, vol.10
, pp. 135-147
-
-
Seetharam1
Gotoh, N.2
Maru, Y.3
Neufeld, G.4
Yamaguchi, S.5
Shibuya, M.6
-
39
-
-
0028095488
-
The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells
-
Shoji, W., Yamamoto, T. and Obinata, M. (1994) The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells. J. Biol. Chem., 269, 5078-5084.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5078-5084
-
-
Shoji, W.1
Yamamoto, T.2
Obinata, M.3
-
40
-
-
0026096540
-
Control of c-myc regulation in normal and neoplastic cells
-
Spencer, C.A. and Groudine, M. (1991) Control of c-myc regulation in normal and neoplastic cells. Adv. Cancer Res., 56, 1-48.
-
(1991)
Adv. Cancer Res.
, vol.56
, pp. 1-48
-
-
Spencer, C.A.1
Groudine, M.2
-
41
-
-
0028964465
-
Cytokine signaling through nonreceptor protein tyrosine kinases
-
Taniguchi, T. (1995) Cytokine signaling through nonreceptor protein tyrosine kinases. Science, 268, 251-255.
-
(1995)
Science
, vol.268
, pp. 251-255
-
-
Taniguchi, T.1
-
42
-
-
0028802360
-
Ras is not required for the interleukin 3-induced proliferation of a mouse pro-B cell line, BaF3
-
Terada, K., Kaziro, Y. and Satoh, T. (1995) Ras is not required for the interleukin 3-induced proliferation of a mouse pro-B cell line, BaF3. J. Biol. Chem., 270, 27880-27886.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27880-27886
-
-
Terada, K.1
Kaziro, Y.2
Satoh, T.3
-
43
-
-
0025091773
-
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
-
Williams, G.T., Smith, C.A., Spooncer, E., Dexter, T.M. and Taylor, D.R. (1990) Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature, 343, 76-79.
-
(1990)
Nature
, vol.343
, pp. 76-79
-
-
Williams, G.T.1
Smith, C.A.2
Spooncer, E.3
Dexter, T.M.4
Taylor, D.R.5
-
44
-
-
0027479796
-
Apoptosis (The 1992 Frank Rose Memorial Lecture)
-
Wyllie, A.H. (1993) Apoptosis (The 1992 Frank Rose Memorial Lecture). Br. J. Cancer. 67, 205-208.
-
(1993)
Br. J. Cancer.
, vol.67
, pp. 205-208
-
-
Wyllie, A.H.1
-
45
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. and Greenberg, M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science, 270, 1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
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