PINCH, N(i)ck and the ILK: Network wiring at cell-matrix adhesions

Trends in Cell Biology

Volumn 15, Issue 9, 2005, Pages 460-466

  Wu, Chuanyue ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; INTEGRIN; INTEGRIN LINKED KINASE; PINCH 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

CELL ADHESION; CYTOSKELETON; DROSOPHILA; EMBRYO DEVELOPMENT; EXTRACELLULAR MATRIX; INVERTEBRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL ADHESION; CYTOSKELETON; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EXTRACELLULAR MATRIX; HUMANS; MODELS, BIOLOGICAL; ONCOGENE PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

INVERTEBRATA; VERTEBRATA;

EID: 24344442980     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2005.07.002     Document Type: Review

References (80)

1. D. Bray Molecular Networks: The Top-Down View Science 301 2003 1864 1865
2. A.L. Barabasi, and Z.N. Oltvai Network biology: understanding the cell's functional organization Proc. Natl. Acad. Sci. U. S. A. 101 2004 1543 1547
3. C. Wu, and S. Dedhar Integrin Linked Kinase (ILK) and Its Interactors: A New Paradigm for the Coupling of Extracellular Matrix to Actin Cytoskeleton and Signaling Complexes J. Cell Biol. 155 2001 505 510
4. C. Brakebusch, and R. Fassler The integrin-actin connection, an eternal love affair EMBO J. 22 2003 2324 2333
5. C. Wu The PINCH-ILK-parvin complexes: assembly, functions and regulation Biochim. Biophys. Acta 1692 2004 55 62
6. G. Hannigan Integrin-linked kinase: a cancer therapeutic target unique among its ILK Nat. Rev. Cancer 5 2005 51 63
7. A. Rearden A new LIM protein containing an autoepitope homologous to "senescent cell antigen" Biochem. Biophys. Res. Commun. 201 1994 1124 1131
8. Y. Tu The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells Mol. Cell. Biol. 19 1999 2425 2434
9. C. Wu Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction J. Cell Sci. 112 1999 4485 4489
10. Y. Zhang Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration J. Biol. Chem. 277 2002 38328 38338
11. T. Fukuda PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival J. Biol. Chem. 278 2003 51324 51333
12. A. Braun PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions Exp. Cell Res. 284 2003 239 250
13. X. Liang PINCH1 Plays an Essential Role in Early Murine Embryonic Development but Is Dispensable in Ventricular Cardiomyocytes Mol. Cell. Biol. 25 2005 3056 3062
14. A. Velyvis Solution Structure of the Focal Adhesion Adaptor PINCH LIM1 domain and Characterization of its Interaction with Integrin Linked Kinase Ankyrin Repeat Domain J. Biol. Chem. 276 2001 4932 4939
15. Y. Zhang A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration J. Biol. Chem. 277 2002 318 326
16. G.E. Hannigan Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase Nature 379 1996 91 96
17. Y. Zhang Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites J. Cell Sci. 115 2002 4777 4786
18. S.N. Nikolopoulos, and C.E. Turner Actopaxin, a New Focal Adhesion Protein That Binds Paxillin LD Motifs and Actin and Regulates Cell Adhesion J. Cell Biol. 151 2000 1435 1448
19. Y. Tu A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading J. Cell Biol. 153 2001 585 598
20. T.M. Olski Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily J. Cell Sci. 114 2001 525 538
21. S. Yamaji A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction J. Cell Biol. 153 2001 1251 1264
22. Y. Zhang Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival J. Biol. Chem. 279 2004 41695 41705
23. T.M. Rogalski The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane J. Cell Biol. 150 2000 253 264
24. A.C. Mackinnon C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes Curr. Biol. 12 2002 787 797
25. Y. Tu Migfilin and mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation Cell 113 2003 37 47
26. S. Kloeker The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion J. Biol. Chem. 279 2004 6824 6833
27. Y. Tu Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase signaling pathways Mol. Biol. Cell 9 1998 3367 3382
28. W. Li Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton Oncogene 20 2001 6403 6417
29. L. Buday The Nck family of adapter proteins: regulators of actin cytoskeleton Cell. Signal. 14 2002 723 731
30. S.N. Nikolopoulos, and C.E. Turner Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions J. Biol. Chem. 276 2001 23499 23505
31. S. Yamaji Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction J. Cell Biol. 165 2004 539 551
32. S.N. Nikolopoulos, and C.E. Turner Molecular Dissection of Actopaxin-Integrin-linked Kinase-Paxillin Interactions and Their Role in Subcellular Localization J. Biol. Chem. 277 2002 1568 1575
33. L. Guo, and C. Wu Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex FASEB J 16 10 2002 1298 1300 (published online June 1297, 2002 as 1210.1096/fj.1202-0089fje)
34. Y. Yang Formation and phosphorylation of the PINCH-1-integrin linked kinase-{alpha}-Parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival J. Am. Soc. Nephrol. 16 2005 1966 1976
35. S. Attwell Integration of cell attachment, cytoskeletal localization and signaling by Integrin-Linked Kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN Mol. Biol. Cell 2003 E03-05-0308
36. T. Sakai Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation Genes Dev. 17 2003 926 940
37. L. Terpstra Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes J. Cell Biol. 162 2003 139 148
38. C. Grashoff Integrin-linked kinase regulates chondrocyte shape and proliferation EMBO Rep. 4 2003 432 438
39. V. Vouret-Craviari ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells J. Cell Sci. 117 2004 4559 4569
40. C. Tan Regulation of tumor angiogenesis by integrin-linked kinase (ILK) Cancer Cell 5 2004 79 90
41. S. Persad Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells Proc. Natl. Acad. Sci. U. S. A. 97 2000 3207 3212
42. S. Attwell The integrin-linked kinase (ILK) suppresses anoikis Oncogene 19 2000 3811 3815
43. D.S. Gary Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons J. Neurochem. 84 2003 878 890
44. A.A. Troussard Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation J. Biol. Chem. 278 2003 22374 22378
45. E.B. Friedrich Integrin-Linked Kinase Regulates Endothelial Cell Survival and Vascular Development Mol. Cell. Biol. 24 2004 8134 8144
46. C.Y.F. Yau Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts Cancer Res. 65 2005 1497 1504
47. L.A. Edwards Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth Oncogene 24 2005 3596 3605
48. T. Yasunaga Xenopus ILK (integrin-linked kinase) is required for morphogenetic movements during gastrulation Genes Cells 10 2005 369 379
49. M. Marsden, and D.W. DeSimone Regulation of cell polarity, radial intercalation and epiboly in Xenopus: novel roles for integrin and fibronectin Development 128 2001 3635 3647
50. O. Hobert A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans J. Cell Biol. 144 1999 45 57
51. C.G. Zervas Drosophila Integrin-linked Kinase Is Required at Sites of Integrin Adhesion to Link the Cytoskeleton to the Plasma Membrane J. Cell Biol. 152 2001 1007 1018
52. K.A. Clark Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes Development 130 2003 2611 2621
53. X. Lin C. elegans PAT-6/Actopaxin Plays a Critical Role in the Assembly of Integrin Adhesion Complexes in vivo Curr. Biol. 13 2003 922 932
54. J.L. Kadrmas The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1 J. Cell Biol. 167 2004 1019 1024
55. A. Velyvis Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling Nat. Struct. Biol. 10 2003 558 564
56. J. Vaynberg Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility Mol. Cell 17 2005 513 523
57. Xu, Z. et al. Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. J. Biol. Chem. (in press)
58. F. Jobard Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome Hum. Mol. Genet. 12 2003 925 935
59. D.H. Siegel Loss of Kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome Am. J. Hum. Genet. 73 2003 174 187
60. R.M. Haber, and W.M. Hanna Kindler syndrome. Clinical and ultrastructural findings Arch. Dermatol. 132 1996 1487 1490
61. H. Shimizu Immunohistochemical, ultrastructural, and molecular features of Kindler syndrome distinguish it from dystrophic epidermolysis bullosa Arch. Dermatol. 133 1997 1111 1117
62. G.H.S. Ashton Kindler syndrome Clin. Exp. Dermatol. 29 2004 116 121
63. A. Oloumi Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase Biochim. Biophys. Acta 1691 2004 1 15
64. C. Grashoff Integrin-linked kinase: integrin's mysterious partner Curr. Opin. Cell Biol. 16 2004 565 571
65. I. Bock-Marquette Thymosin [beta]4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair Nature 432 2004 466 472
66. T. Huff beta-Thymosins, small acidic peptides with multiple functions Int. J. Biochem. Cell Biol. 33 2001 205 220
67. K.M. Malinda Thymosin beta4 accelerates wound healing J. Invest. Dermatol. 113 1999 364 368
68. G. Sosne Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo Exp. Eye Res. 72 2001 605 608
69. G. Sosne Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury Exp. Eye Res. 74 2002 293 299
70. D. Philp Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice Wound Repair Regen. 11 2003 19 24
71. G.W. Dougherty The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions Exp. Cell Res. 306 2005 168 179
72. L. Masuelli, and M. Cutler Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation Mol. Cell. Biol. 16 1996 5466 5476
73. W.A.K.M. Khyrul The Integrin-linked Kinase Regulates Cell Morphology and Motility in a Rho-associated Kinase-dependent Manner J. Biol. Chem. 279 2004 54131 54139
74. T. Fukuda CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt J. Cell Biol. 160 2003 1001 1008
75. Li, F. et al. (1999a) Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J. Cell Sci. 112, 4589-4599
76. C. Leung-Hagesteijn Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1 EMBO J. 20 2001 2160 2170
77. A. Meyer Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cells Biochemistry 44 2005 932 938
78. J.L. Kadrmas, and M.C. Beckerle The LIM domain: from the cytoskeleton to the nucleus Nat. Rev. Mol. Cell Biol. 5 2004 920 931
79. P.S. Mongroo Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer Oncogene 23 2004 8959 8970
80. A. Watahiki Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas Nat Methods 1 2004 233 239