Gating of Shaker-type Channels Requires the Flexibility of S6 Caused by Prolines

Journal of Biological Chemistry

Volumn 278, Issue 50, 2003, Pages 50724-50731

  Labro, Alain J ^a   Raes, Adam L ^a   Bellens, Iris ^a   Ottschytsch, Natacha ^a   Snyders, Dirk J ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLIZATION; POTASSIUM; SUBSTITUTION REACTIONS;

DESTABILIZATION;

BIOCHEMISTRY;

PROLINE; VOLTAGE GATED POTASSIUM CHANNEL;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ION PERMEABILITY; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN MOTIF; STRUCTURE ANALYSIS;

ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EVOLUTION, MOLECULAR; GLYCINE; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROLINE; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS;

ANIMALIA;

EID: 0346118860     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306097200     Document Type: Article

References (27)

1. Snyders, D. J., Tamkun, M. M., and Bennett, P. B. (1993) J. Gen. Physiol, 101, 513-543
2. Heginbotham, L., Lu, Z., Abramson, T., and MacKinnon, R. (1994) Biophys. J. 66, 1061-1067
3. Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., and MacKinnon, R. (1998) Science 280, 69-77
4. Morais-Cabral, J. H., Zhou, Y., and MacKinnon, R. (2001) Nature 414, 37-42
5. Zhou, Y., Morais-Cabral, J. H., Kaufman, A., and MacKinnon, R. (2001) Nature 414, 43-48
6. Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B. T., and MacKinnon, R. (2003) Nature 423, 33-41
7. Bezanilla, F. (2000) Physiol. Rev. 80, 555-592
8. Armstrong, C. M. (1971) J. Gen. Physiol. 58, 413-437
9. Choi, K. L., Mossman, C., Aube, J., and Yellen, G. (1993) Neuron 10, 533-541
10. Holmgren, M., Smith, P. L., and Yellen, G. (1997) J. Gen. Physiol. 109, 527-535
11. Liu, Y., Holmgren, M., Jurman, M. E., and Yellen, G. (1997) Neuron 19, 175-184
12. del Camino, D., and Yellen, G. (2001) Neuron 32, 649-656
13. Hackos, D. H., Chang, T. H., and Swartz, K. J. (2002) J. Gen. Physiol. 119, 521-532
14. Blaber, M., Zhang, X. J., and Matthews, B. W. (1993) Science 260, 1637-1640
15. MacArthur, M. W., and Thornton, J. M. (1991) J. Mol. Biol. 218, 397-412
16. O'Neil, K. T., and DeGrado, W. F. (1990) Science 250, 646-651
17. von Heijne, G. (1991) J. Mol. Biol. 218, 499-503
18. Barlow, D. J., and Thornton, J. M. (1988) J. Mol. Biol. 201, 601-619
19. del Camino, D., Holmgren, M., Liu, Y., and Yellen, G. (2000) Nature 403, 321-325
20. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002) Nature 417, 523-526
21. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002) Nature 417, 515-522
22. Yifrach, O., and MacKinnon, R. (2002) Cell 111, 231-239
23. Kuo, A., Gulbis, J. M., Antcliff, J. F., Rahman, T., Lowe, E. D., Zimmer, J., Cuthbertson, J., Ashcroft, F. M., Ezaki, T., and Doyle, D. A. (2003) Science 300, 1922-1926
24. Neher, E. (1992) Methods Enzymol. 207, 123-131
25. Bright, J. N., Shrivastava, I. H., Cordes, F. S., and Sansom, M. S. (2002) Bippolymers 64, 303-313
26. Tieleman, D. P., Shrivastava, I. H., Ulmschneider, M. R., and Sansom, M. S. (2001) Proteins 44, 63-72
27. Jin, T., Peng, L., Mirshahi, T., Rohacs, T., Chan, K. W., Sanchez, R., and Logothetis, D. E. (2002) Mol. Cell 10, 469-481