Coupled ion movement underlies rectification in an inward-rectifier K+ channel

Journal of General Physiology

Volumn 112, Issue 2, 1998, Pages 211-221

  Spassova, Maria ^a   Lu, Zhe ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Inward rectifier K+ channel; Ionic blocker; Magnesium; Rectification; Tetraethylammonium

Indexed keywords

MAGNESIUM; POTASSIUM CHANNEL; POTASSIUM ION; QUATERNARY AMMONIUM DERIVATIVE; TETRABUTYLAMMONIUM; TETRAMETHYLAMMONIUM; TETRAPENTYLAMMONIUM; TETRAPROPYLAMMONIUM; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; NONHUMAN; OOCYTE; POTASSIUM CURRENT; XENOPUS LAEVIS;

ANIMALS; EXTRACELLULAR SPACE; ION CHANNEL GATING; KINETICS; MAGNESIUM; OOCYTES; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; TETRAETHYLAMMONIUM; XENOPUS LAEVIS;

EID: 0031853008     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.112.2.211     Document Type: Article

References (51)

1. Adelman, W.J., Jr., and R.J. French. 1978. Blocking of the squid axon potassium channel by external cesium ions. J. Physiol. (Camb.). 276:13-25.
2. Adrian, R.H. 1969. Rectification in muscle membrane. Prog. Biophys. Mol. Biol. 19:340-369.
3. +-induced anomalous rectification in squid giant axons. J. Gen. Physiol. 50:491-503.
4. Armstrong, C.M. 1969. Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injected in squid axons. J. Gen. Physiol. 54:553-575.
5. Armstrong, C.M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axon. J. Gen. Physiol. 58:413-437.
6. Armstrong, C.M., and L. Binstock. 1965. Anomalous rectification in the squid giant axon injected with tetraethylammonium. J. Gen. Physiol. 48:859-872.
7. Armstrong, C.M., and J. Neyton. 1992. Ion permeation through calcium channels: a one-site model. Ann. NY Acad. Sci. 635:18-25.
8. Armstrong, C.M., R.P. Swenson, and S. Taylor. 1982. Block of squid axon K channels by internally and externally applied barium ions. J. Gen. Physiol. 80:663-682.
9. + channel. Science. 271:653-656.
10. Bezanilla, F., and C.M. Armstrong. 1972. Negative conductance caused by the entry of sodium and cesium ions into the potassium channels of squid axons. J. Gen. Physiol. 60:588-608.
11. + channel from smooth muscle. Biophys. J. 52:707-716.
12. Choi, K.L., C. Mossman, J. Aube, and G. Yellen. 1993. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron. 10:533-541.
13. + conduction and selectivity. Science. 280:69-77.
14. + channels is caused by intracellular spermine. Cell. 80:149-154.
15. + channels. Science. 266:1068-1072.
16. French, R.J., and J.J. Shoukimas. 1981. Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes. Biophys. J. 34:271-291.
17. + causes a voltage-dependent block of inward K currents in resting skeletal muscle fibers. Nature. 267:169-170.
18. Hagiwara, S., and K. Takahashi. 1974. The anomalous rectification and cation selectivity of the membrane of a starfish egg cell. J. Membr. Biol. 18:61-80.
19. Hagiwara, S., S. Miyazaki, and N.P. Rosenthal. 1976. Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish. J. Gen. Physiol. 67:621-638.
20. Hille, B. 1975. Ionic selectivity of Na and K channels of nerve membranes. In Membranes. A Series of Advances. G. Eisenman, editor. Marcel Dekker, New York. 3:255-323.
21. Hille, B. 1992. Ionic Channels of Excitable Membranes. 2nd edition. Sinauer Associates Inc., Sunderland, MA.
22. Hille, B., and W. Schwarz. 1978. Potassium channels as multi-ion single-file pores. J. Gen. Physiol. 72:409-442.
23. Ho, K., C.G. Nichols, W.J. Lederer, J. Lytton, P.M. Vassilev, M.V. Kanazirska, and S.C. Hebert. 1993. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 263:31-38.
24. Hodgkin, A.L., and R.D. Keynes. 1955. The potassium permeability of a giant nerve fiber. J. Physiol. (Camb.). 128:61-88.
25. Hodgkin, A.L., and P. Horowicz. 1959. The influence of potassium and chloride ions on the membrane potential of single muscle fibers. J. Physiol. (Camb.). 148:127-160.
26. + channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109:527-535.
27. Horie, M., H. Irisawa, and H. Noma. 1987. Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells. J. Physiol. (Camb.). 387: 251-272.
28. Horowicz, P., P.W. Gage, and R.S. Eisenberg. 1968. The role of the electrochemical gradient in determining potassium fluxes in frog striated muscle. J. Gen. Physiol. 51:193s.
29. Katz, B. 1949. Les constantes electriques de la membrane du muscle. Arch. Sci. Physiol. 2:285-299.
30. Kohler, H.H., and K. Heckmann. 1979. Unidirectional fluxes in saturated single file pores of biological and artificial membranes. I. Pores containing no more than one vacancy. J. Theor. Biol. 79: 381-401.
31. + channel. Neuron. 19:175-184.
32. Lopatin, A.N., E.N. Makhaaina, and C.G. Nichols. 1994. Potassium channel block by cytoplasmic polyamines as the mechanisms of intrinsic rectification. Nature. 372:366-369.
33. +] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK, Kir2.1). J. Gen. Physiol. 108:105-113.
34. Lu, Z., and R. MacKinnon. 1994a. A conductance maximum observed in an inward-rectifier potassium channel. J. Gen. Physiol. 104:477-486.
35. + channel. Nature. 371:243-246.
36. Lu, Z., and R. MacKinnon. 1995. Probing a potassium channel pore with an engineered protonable site. Biochemistry. 34:13133-13138.
37. + channels in guinea-pig heart cells. J. Physiol. (Camb.). 435:83-99.
38. 2+. Nature. 325:156-159.
39. + channel. J. Gen. Physiol. 92: 549-567.
40. 2+-dependent inward rectification of ROMK1 potassium channel expressed in Xenopus oocytes. J. Physiol. (Camb.). 476:399-409.
41. Noble, D., and R.W. Tsien. 1968. The kinetics and rectifier properties of the slow potassium current in calf Purkinje fibers. J. Physiol. (Camb.). 195:185-214.
42. Schumaker, M.F., and R. MacKinnon. 1990. A simple model for multi-ion permeation. Single vacancy conduction in a simple pore model. Biophys. J. 58:975-984.
43. 2+ of the inward-rectifier, IRK1. J. Physiol. (Camb.). 478:1-6.
44. + channel IRK1. EMBO (Eur. Mol. Biol. Organ.) J. 14:5532-5541.
45. + channels. Science. 264:844-847.
46. Vandenberg, C.A. 1987. Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proc. Natl. Acad. Sci. USA. 84:2560-2564.
47. + channels localized to a single negatively charged residue. Nature. 371:246-249.
48. Woodhull, A.M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
49. + channel. Neuron. 14:1047-1054.
50. + channels of bovine chromaffin cells. J. Gen. Physiol. 94:157-186.
51. + channel. Science. 251:939-942.